• Investigative Magnetic Resonance Imaging
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• v.4 no.2
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• pp.128-135
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• 2000

Purpose : The aim of this study is to develope the Magnetic Resonance Spectroscopy(MRS) data processing S/W which plays an important role as a diagnostic tool in clinical field. Materials and methods : Post-processing software of MRS based on graphical user interface(GUI) under windows operating system of personal computer(PC) was developed using MATLAB(Mathwork, U.S.A.). This tool contains many functions to increase the quality of spectrum data such as DC correction, zero filling, line broadening, Gauss-Lorentzian filtering, phase correction, etc. And we obtained the normal human brain $^1H$ MRS data from parietal white matter, basal ganglia and occipital grey matter region using 1.5T Gyroscan ACS-NT R6 (philips, Amsterdam, Netherland) MRS package. The analysis of the MRS peaks were performed by obtaining the ratio of peak area. Results : The peak ratios of NAA/Cr, Cho/Cr, MI/Cr for the different MRS machines have a little different values. But these peak ratios were not significantly different between different echo time MRS peak ratios in the same machine (p<0.05). Conclusion : MRS post-processing S/W based on GUI using PC was developed and applied to the analysis of normal human brain $^1H$ MRS. This independent MRS processing job increases the performance and throughput of patient scan of main console. Finally, we suggest that the database for normal in-yivo human MRS data should be obtained before clinical applications.

• IMMUNE NETWORK
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• v.20 no.4
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• pp.33.1-33.19
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• 2020

We tested how adjuvants effect in a cancer vaccine model using an epitope derived from an autoactivation loop of membrane-type protease serine protease 14 (PRSS14; loop metavaccine) in mouse mammary tumor virus (MMTV)-polyoma middle tumor-antigen (PyMT) system and in 2 other orthotopic mouse systems. Earlier, we reported that loop metavaccine effectively prevented progression and metastasis regardless of adjuvant types and TH types of hosts in tail-vein injection systems. However, the loop metavaccine with Freund's complete adjuvant (CFA) reduced cancer progression and metastasis while that with alum, to our surprise, were adversely affected in 3 tumor bearing mouse models. The amounts of loop peptide specific antibodies inversely correlated with tumor burden and metastasis, meanwhile both T_H1 and T_H2 isotypes were present regardless of host type and adjuvant. Tumor infiltrating myeloid cells such as eosinophil, monocyte, and neutrophil were asymmetrically distributed among 2 adjuvant groups with loop metavaccine. Systemic expression profiling using the lymph nodes of the differentially immunized MMTV-PyMT mouse revealed that adjuvant types, as well as loop metavaccine can change the immune signatures. Specifically, loop metavaccine itself induces T_H2 and T_H17 responses but reduces T_H1 and T_reg responses regardless of adjuvant type, whereas CFA but not alum increased follicular T_H response. Among the myeloid signatures, eosinophil was most distinct between CFA and alum. Survival analysis of breast cancer patients showed that eosinophil chemokines can be useful prognostic factors in PRSS14 positive patients. Based on these observations, we concluded that multiple immune parameters are to be considered when applying a vaccine strategy to cancer patients.

• Progress in Medical Physics
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• v.28 no.4
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• pp.135-143
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• 2017

Chemical Exchange Saturation Transfer (CEST) imaging is a method to detect solutes based on the chemical exchange of mobile protons with water. The solute protons exchange with three different patterns, which are fast, slow, and intermediate rates. The CEST contrast can be obtained from the exchangeable protons, which are hydroxyl protons, amine protons, and amide protons. The CEST MR imaging is useful to evaluate tumors, strokes, and other diseases. The purpose of this study is to review the mathematical model for CEST imaging and for measurement of the chemical exchange rate, and to measure the chemical exchange rate using a 3T MRI system on several amino acids. We reviewed the mathematical models for the proton exchange. Several physical models are proposed to demonstrate a two-pool, three-pool, and four-pool models. The CEST signals are also evaluated by taking account of the exchange rate, pH and the saturation efficiency. Although researchers have used most commonly in the calculation of CEST asymmetry, a quantitative analysis is also developed by using Lorentzian fitting. The chemical exchange rate was measured in the phantoms made of asparagine (Asn), glutamate (Glu), ${\gamma}-aminobutyric$ acid (GABA), glycine (Gly), and myoinositol (MI). The experiment was performed at a 3T human MRI system with three different acidity conditions (pH 5.6, 6.2, and 7.4) at a concentration of 50 mM. To identify the chemical exchange rate, the "lsqcurvefit" built-in function in MATLAB was used to fit the pseudo-first exchange rate model. The pseudo-first exchange rate of Asn and Gly was increased with decreasing acidity. In the case of GABA, the largest result was observed at pH 6.2. For Glu, the results at pH 5.6 and 6.2 did not show a significant difference, and the results at pH 7.4 were almost zero. For MI, there was no significant difference at pH 5.6 or 7.4, however, the results at pH 6.2 were smaller than at the other pH values. For the experiment at 3T, we were only able to apply 1 s as the maximum saturation duration due to the limitations of the MRI system. The measurement of the chemical exchange rate was limited in a clinical 3T MRI system because of a hardware limitation.

• Journal of Animal Environmental Science
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• v.17 no.sup
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• pp.61-68
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• 2011

To assess the total cost with all stages of facilities, the feasibility of Life Cycle Cost (LCC) analysis was examined in this study to estimate the livestock manure treatment system and optimal decision making process. For the economic evaluation, the plant/equipment investment and annual operation cost of four Public Livestock Recycling Facilities, whose treatment capacity is 100 ton piggery manure per day, was compared. The initial cost was in the range of 2,699 million won to 3,202 million won, where T and E methods were highest and lowest, respectively. The annual operation cost was in the level of 378 million to 498 million won, which decreased in the following order : T method > J method > E method > B method. For the LCC analysis, 4.7% of interest rate, 3.13% of inflation rate, and 1.52% of net discount rate was considered by the data received from Bank of Korea and Statics Korea in the period of 2000 to 2009. Also, for the calculation of present value factor, the durable years of civil engineering & construction, machinery and electric instrument was 30 years, 10 years and 15 years, respectively. Based on these consideration, operation cost was in the range of 17,570 won/ton to 20,661 won/ton, and E method (17,570 won/ton) was economical and B method (20,661 won/ton) was non-economical. Though initial cost of T method was higher than that of B method, LCC analysis of T method was lower than that of T method due to the lower operation cost. Therefore, LCC analysis, which considers both initial cost and operation cost, is more reasonable evaluation method than either initial cost or annual operation cost. For the change of LCC analysis according to the uncertainty, the sensitivity analysis was carried out using fluctuation magnitude of discount rate in the period of 2000 to 2009. As a result, LCC analysis evaluated by discount rate was stable for the uncertain factors since the cost leadership did not change even though the sensitivity analysis varied. In summary, the economic evaluation using LCC analysis could be an efficient reference to choose the suitable livestock manure treatment plants. Furthermore, standardization of statement calculation for the actual cost analysis should be conducted and more detailed study is necessary to validate this summary. Therefore, the application of comprehensive technology evaluation, which considers LCC analysis, should contribute in obtaining objectivity and enhancing reliability for the 'Evaluation of Livestock Manure Treatment System and its Technology'.

• Korean Journal of Remote Sensing
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• v.16 no.2
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• pp.117-133
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• 2000

We studied the sea level variations at Kerguelen island in the South Indian Ocean with ARGOS data and meteorological data during about 1 year(May 1993~April 1994) through using filter, spectral analysis, coherency and phase, and found characteristics for the two oceanic signal levels(detided oceanic signal level, h$_{detided}$ and seasonal oceanic level, h$_{corr.ib}$). The forms of atmospheric pressure variations are good agreed to between ARGOS data and meteorological data in the observed periods. This Kerguelen area shows the inflow of an air temperature(gain of a radiant heat) into the sea water and the stagnation of high atmospheric pressure bands in summer, and the outflow of a sea water temperature(loss of sensible and latent heat) toward the atmosphere and the stagnation of low atmospheric pressure bands in winter. The seasonal difference of sea level between summer and winter is about 1.6cm. Both the detided oceanic signal level(h$_{detided}$) variation and the inverted barometer level(h$_{ib}$) variation have a strong correlation for T>1day period bands. The characteristics of h$_{detided}$ variation are not decided by the influence of any meteorological distributions (atmospheric pressure), but the influence of other factors(bottom water temperature) for T>2days periods bands. h$_{corr.ib}$ plays a very important role of sea level variation in the observed periods (especially T>about 180days period bands).

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.871-876
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• 2005

Currently, the marketable truck has the cab tilting system which highly absorb the vibrations and impacts of cab. The cab tilting system is equipped with the hydraulic system for maintenance and inspection of truck. And it is very important to improve the user's feeling of driving and convenience. To have the better performance, it is important to confirm the dynamic characteristics of each parts of the system. In this study, a mathematical model of the system was derived and the parameters in the model were identified from experimental data. The results of the simulation were compared with those of experiments. These results of the computer simulation and experiments show that the proposed analysis can be applied effectively to design the system. Our results can be utilized for the future research to improve the capability of the truck cab tilting system.

• Proceedings of the KIEE Conference
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• 2002.07b
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• pp.776-779
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• 2002

This paper describes the magnetizer design of highly saturated magnetic circuit by high external field. The magnetizer is loaded by a capacitor bank with impulse currents to reach high magnetic flux-density(typically 5[T]). Magnetizing current come out from magnetizing system is simulated by analytic method and transient FEM, also field distributions of the magnetizer are analyzed.

• Electronics and Telecommunications Trends
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• v.28 no.3
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• pp.47-56
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• 2013

부채널 분석은 암호 알고리즘이 장치 내에서 동작하는 동안에 장치의 전력이나 전자파 등의 부가 정보의 수집, 가공 및 통계적인 분석을 통해 키 정보를 추출해내는 매우 강력한 공격 방법이다. 부채널 분석 시스템은 암호 모듈이 탑재되는 장치가 부채널 공격에 대해 안전한지를 사전 검증 및 시험할 수 있는 방법들을 제공한다. 본고에서는 다양한 부채널 분석 방법 및 이를 제공하는 부채널 분석 시스템에 대한 현황 및 전망을 기술한다.

• Proceedings of the KIEE Conference
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• 2002.11a
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• pp.176-178
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• 2002

Surface states of silicone polymer treated by plasma were investigated by the analysis by x-ray photoelectron spectroscopy(XPS) and surface voltage decay after corona charging. Plasma treatment causes the silica -like oxidative layer, which was confirmed with XPS, and lowers surface resistivity with increasing the plasma treatment time. Using the decay time constant of surface voltage, the calculated surface resistivity was compared with the value directly measured by voltage-current method using three electrodes system. A good agreement between two methods was obtained. In addition, we estimated the thermal activation energy for surface conduction, Based on our results, we could understand the relationship between surface chemical states and surface electrical properties.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.495-498
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• 2002

This article deals with the introduction of longitudinal instability of liquid rocket (pogo) and the analytical results on the frequency responses of KSR-III propulsion feeding system. Both the stiffness of bellows and the cavitation volume of venturi affect the frequency response of the feeding system. Especially, bellows has a great roll to reduce the natural frequency of the feeding system. Also, oxidizer and fuel feeding systems of the KSR-III have natural frequencies of ${\~}280Hz\;and\;{\~}90Hz$, respectively.