• Proceedings of the KSR Conference
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• 2008.11b
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• pp.679-686
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• 2008

There has been an increasing demand of introducing innovative public transport modes meriting high flexibilities of a bus mode along with on-time accuracy and quality environment-friendliness of a rail mode, as it is considered to significantly contribute to reducing huge social expenditures on the traffic congestion and environmental pollution agenda, and to be an alternative solution to better the urban transport problems. In order to comply with the need, Seoul Municipal Government has recently decided to build up GRT system of a new concept in Nangok area in Seoul, the first in its kind in Korea. The concession has been awarded to Seoul Metro. This thesis will study and benchmark similar systems abroad under operation, and further review necessary requirements overall which would secure full readiness for the operation of Nangok GRT system.

• International Journal of Stem Cells
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• v.15 no.1
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• pp.14-25
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• 2022

Glia have been known for its pivotal roles in physiological and pathological conditions in the nervous system. To study glial biology, multiple approaches have been applied to utilize glial cells for research, including stem cell-based technologies. Human glial cells differentiated from pluripotent stem cells are now available, allowing us to study the structural and functional roles of glia in the nervous system, although the efficiency is still low. Direct conversion is an advanced strategy governing fate conversion of diverse cell types directly into the desired lineage. This novel strategy stands as a promising approach for preliminary research and regenerative medicine. Direct conversion employs genetic and environmental cues to change cell fate to that with the required functional cell properties while retaining maturity-related molecular features. As an alternative method, it is now possible to obtain a variety of mature cell populations that could not be obtained using conventional differentiation methods. This review summarizes current achievements in obtaining glia, particularly oligodendrocytes and Schwann cells.

• Journal of Korean Society of Rural Planning
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• v.20 no.1
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• pp.147-159
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• 2014

This study aims to draw up a basic plan to construct an agricultural theme park in a farming city as a way of establishing its regional identity represented by "Three Whites". Sangju, Kyongsangbuk-do which is the subject area of the study has been well-known for "Three Whites (rice, silkworm cocoon and dried persimmon)." The purpose of the study is to take a closer look at the folk life and culture of Sangju and develop tourism resources to promote regional development and competitiveness of the city. This study was conducted in several phases in consideration of the characteristics of plan and design, on the basis of the theoretical review of agricultural tourism. In the first phase, planning conditions were analyzed as per development objectives. In the second phase, strategies and concepts were established for the theme park, based on which development methods were decided by phase and facility. Then, a preliminary review was conducted on functions and facilities to introduce to the theme park. In the third phase, a comprehensive plan was drawn up, which includes basic plans for respective parts. In consideration of the characteristics of the study, construction was not looked at in detail. The total size of land subject to the study is approx. $97,960m^2$, which was divided into four separate zones--Sambaek Cultural Experience Zone, Natural Observation & Experience Zone, Agricultural Life Experience Zone and other facilities zone--in order to connect facilities, functions and experience with the physical characteristics of the city, and separate space planning was conducted for each zone. The outcome of the study carries significance as an example of alternative tourism which considers regional characteristics, develops local resources and makes use of obsolete rural facilities, in what is called the eco-friendly development where nature and eco-system, landscape and culture, and recreation and leisure come together as one.

• IMMUNE NETWORK
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• v.4 no.1
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• pp.1-6
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• 2004

Transplantation would be the only way to cure the end-stage organ failure involving heart, lung, liver, kidney and pancreas. The replacement of the parts of the body damaged to lose its function or lost to trauma must be a dream of human-being. Human history is replete with chimeras, from sphinxes to mermaids, making one wonder if the ancients might actually have dreamed of what now is called 'xenotransplantation'. In the 20th century, the transplantation of organs and tissues to cure disease has become a clinical reality. The development in the fields of surgical techniques, physiology and immunology attributed to the successful transplantation in human. In the center of the successful transplantation lies the progress in understanding the cellular and molecular biology of immune system which led to the development of immunosuppressive drugs and the invention of the concept of immunological tolerance. The mandatory side effects of immunosuppressive drugs including infection and cancer forced us to search alternative approaches along with the development of new immunosuppressive agents. Among the alternative approaches, the induction of a state of immunologic tolerance would be the most promising and the most generic applicability as a future therapy. Recent reports documenting long-term graft survival without immunosuppression suggest that tolerance-based therapies may become a clinical reality. Last year, we saw the epoch making success of overcoming hyperacute rejection in porcine to primate xenotransplantation which will lead porcine to human xenotransplantation to clinical reality. In this review, I dare to summarize the development of transplantation immunology from the perspective of history.

• The Journal of Korean Medicine
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• v.28 no.3 s.71
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• pp.116-125
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• 2007

Objective : To overview the protocols of clinical acupuncture research on cancer in the USA. Methods : Using 'acupuncture' and 'cancer' as keyword search terms in Clinical Trials. gov, 28 clinical studies were found. Three studies by non-American institutions were excluded and 25 studies were analyzed. Analytic parameters were cancer condition, primary outcome, research institution, study design, and acupuncture intervention. Results : Breast cancer was the most frequent single condition in the searched protocols. Pain and quality of life were the primary outcomes in many studies. Memorial Sloan-Kettering Cancer Centerin New York has performed the largest number of acupuncture cancer studies. The majority of studies were randomized controlled trials with active controls or placebo/sham controls. Total enrollment varied between the range of 10 and 700 subjects and ages of these subjects were at least above 18 years old (except one protocol). Most protocols had strict exclusion criteria for acupuncture needling such as bleeding disorders, infection, heart disorder, and central nervous system disorder. Conclusions : Clinical acupuncture studies for cancer patients have focused on pain, quality of life, and side effects induced by anti-cancer therapies. Re-evaluation and cautions for strict exclusion criteria in foreign countries are required to perform multi-national acupuncture trials.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.10 no.5
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• pp.60-70
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• 2011

Vehicle location detection and wireless communication method have be designed along the same lines as GPS, CDMA and WLAN, which is based upon the selecting factors such as state-of-art technology trend, accuracy, stability, and economic feasibility, in order to select the optimum method of information communication networks for integrated "Transportation-Power-Facilities" on the electric bus. In addition, the key features of each alternative for an efficient linkage have been review and the integration methodology for linking among Transportation Charging Center, Transportation(ITS, BIS) Center and smart Grid Center has been drawn up based on a technical level of difficulty of each alternative, political and administrative difficulties, and expense justification.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.5
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• pp.299-310
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• 2009

Fuel cells are expected to be promising future power sources in both aspects of thermal efficiency and environmental friendliness. Accordingly, worldwide research and development efforts have been enormously increasing recently in various applications such as power plants, transportation and portable power sources. Among others, high temperature fuel cells, such as solid oxide fuel cells and molten carbonate fuel cells, are suitable for electric power plants. Moreover, their high operating temperature is quite appropriate to construct further advanced integrated systems. This paper reviews recent literatures on research and development of integrated power generation systems based on high temperature fuel cells. Research and development efforts are summarized in the area of fuel cell/ gas turbine hybrid systems, application of carbon capture technology to fuel cell systems, integration of coal gasification with fuel cells, and the use of alternative fuels.

• Management & Information Systems Review
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• v.3
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• pp.257-285
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• 1999

Korea Postal Service(KPS) nowadays lies in competitive environment with alternative business such as door-to-door delivery service. Customers began to complain about postal service quality and ask the government to reform a public firm through management innovation. But, Korea Postal Service has not met the break-even point between it's revenue and expenditure because the service is under the government system and cannot independently make major decisions on products, pricing, services, personnel management, financial policies and etc. The objective of this study is to provide marketing planners and practitioners with some guidelines when they establish marketing strategies and to help marketers on theories and practical instructions about postal service marketing when they interact with customers. I. A field survey on both customer satisfaction and internal staff satisfaction was conducted to get some ideas for the marketing strategy planning. II. Practical guidelines and instructions were made for marketers to communicate with customers in various areas such as pricing, product, service demand, marketing channel, promotion, and etc. III. Some suggestions on marketing policies for planners and mangers in the marketing strategy were described including personnel resource as well as physical resource. IV. Special issues on small packet market and direct mail market were discussed and some alternative solutions were proposed. V. Database marketing strategy was emphasized to get new business opportunities such as direct mail, and to provide differential services to customers as much as their contribution into the profitability for KPS. VI. Cyber Post Office should be constructed on Internet to provide new services which are combined with physical material flow and information technologies.

• International Commerce and Information Review
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• v.14 no.2
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• pp.81-119
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• 2012

In order to maintain high level of control over and close coordination of foreign marketing activities, export manufacturers often consider vertical integration strategy into global distribution. However, full integration is not always a feasible option. The purpose of this study is to investigate the alternative ways to achieve optimal level of control over export channel system for desirable channel performance. This study investigates different options for integration of the vertical channel structure, and examines their effect on the performance. The findings of this study suggest different combination of ownership and coordination level has varying impact upon channel performance: efficiency, effectiveness, and adaptiveness. This implies exporters may achieve desirable performance control over export channel without fully integrating the channel via ownership.

• BMB Reports
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• v.55 no.1
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• pp.39-47
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• 2022

Adoptive cell transfer (ACT), a form of cell-based immunotherapy that eliminates cancer by restoring and strengthening the body's immune system, has revolutionized cancer treatment. ACT entails intravenous transfer of either tumor-resident or peripheral blood-modified immune cells into cancer patients to mediate anti-tumor response. Although these immune cells control and eradicate cancer via enhanced cytotoxicity against specific tumor antigens, several side effects have been frequently reported in clinical trials. Recently, exosomes, potential cell-free therapeutics, have emerged as an alternative to cell-based immunotherapies, due to their higher stability under same storage condition, lower risk of GvHD and CRS, and higher resistance to immunosuppressive tumor microenvironment. Exosomes, which are nano-sized lipid vesicles, are secreted by living cells, including immune cells. Exosomes contain proteins, lipids, and nucleic acids, and the functional role of each exosome is determined by the specific cargo derived from parental cells. Exosomes derived from cytotoxic effectors including T cells and NK cells exert anti-tumor effects via proteins such as granzyme B and FasL. In this mini-review, we describe the current understanding of the ACT and immune cell-derived exosomes and discuss the limitations of ACT and the opportunities for immune cell-derived exosomes as immune therapies.