• Title/Summary/Keyword: Synthetic control method

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Development of Antagonistic Microorganism for Biological Control of Dollar Spot of Turfgrass (잔디 동전마름병의 생물학적 방제를 위한 길항 미생물의 선발과 효력 검정)

  • Shim, Taek-Su;Jung, Woo-Cheol;Do, Ki-Seok;Shim, Gyu-Yul;Lee, Jae-Ho;Choi, Kee-Hyun
    • Asian Journal of Turfgrass Science
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    • v.20 no.2
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    • pp.191-201
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    • 2006
  • Dollar spot caused by Sclerotinia homeocarpa is one of major diseases in putting greens. Microorganisms antagonistic to S. homeocarpa, a pathogen of dollar spot, were primarily screened through in vitro tests, including dual culture method and triple layer agar diffusion method. In vivo tests were also conducted to select the best candidate for a biocontrol microorganism, using pot experiment. Bacillus subtilis EW42-1 and Trichoderma harziaum GBF-0208 were finally selected as biocontrol agents against dollar spot. Relative Performance Index(RPI) was used as a criterion of selecting potential biocontrol agents. B. subtilis EW42-1 and T. harzianum GBF-0208 showed resistance to several agrochemicals mainly used in a golf course. B. subtilis EW42-1 and T. harzianum GBF-0208 suppressed effectively the disease progress of dollar spot like synthetic fungicide tebuconazole in the nursery where dollar spot had seriously occurred. B. subtilis EW42-1 and T. harzianum GBF-0208 have a potential to be biocontrol agents for the control of dollar spot.

The Estimations of A Conceptual Time Distribution of Rainfall and Design Flood (강우의 개념적 시간분포와 설계홍수량 산정에 관한 연구)

  • Lee Byung Woon;Jang Dae Won;Kim Hung Soo;Seoh Byung Ha
    • Proceedings of the Korea Water Resources Association Conference
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    • 2005.05b
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    • pp.937-942
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    • 2005
  • It is necessary to estimate the runoff hydrograph and peak flood discharge using law of probability for synthetic flood control policy and design of hydraulic structures. Rainfall analysis is needed in the process of peak flood discharge estimation and the time distribution of a design rainfall is a very important process in the analysis. In this study, we estimate design flood for a small urban basin and a rural basin of medium scale which have different travel times. The Huff method is widely used in Korea for the time distribution of design rainfall to estimate design flood. So, we use Huff method and a conceptual method which is suggested in this study for the comparative purpose. The 100-year frequency rainfall is used to estimate design flood for each basin and the design flood is compared with the existing design flood. As the result, the design flood is overestimated $14.6m^3/sec$ by Huff method and is underestimated $70.9m^3/sec$ by a conceptual method for the rural basin. For the small urban basin, the design flood is excessively overestimated $294.65m^3/sec$ by Huff method and is overestimated $173m^3/sec$ by a conceptual method. The reason of excessive overestimation by Huff method in the small urban basin is that the increased rate of rainfall intensity according to the decrease of duration is large and the duration exceeds the time of concentration when the increased rainfall intensity is concentrated in a quartile. Therefore, we suggested a conceptual method for the time distribution of design rainfall by considering the rainless period and duration. Especially, the conceptual method might be useful for the small urban basin with short concentration time which the design flood is overestimated by Huff method.

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Statistical Selection of Amino Acids Fortifying a Minimal Defined Medium for a High-level Production of the Kringle Fragments of Human Apolipoprotein(a)

  • Lim, Hyung-Kwon;Kim, Sung-Geun;Jung, Kyung-Hwan;Seo, Jin-Ho
    • Journal of Microbiology and Biotechnology
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    • v.14 no.1
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    • pp.90-96
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    • 2004
  • A synthetic defined medium, fortified with amino acids, was developed for the stable production of the kringle fragments of human apolipoprotein(a) (apo(a)), rhLK68. Using a complex rich medium containing yeast extract and a high-cell-density fed-batch culture, the expression level of rhLK68 reached 17% of the total cellular protein, which corresponded to $5\;g\;l^{-1}$ of the culture. To replace the complex media with chemically defined media, several amino acids that positively affect cell growth and gene expression were chosen by a statistical method. The various combinations of the selected amino acids were tested for its fortifying effect on a minimal defined medium. When glutamine only was added, the overall expression level of rhLK68 reached 93% of the complex rich medium increasing the specific expression level by 22.4% and decreasing the cell growth by 24%. Moreover, the addition of glutamine resulted in a 2-fold increase in the concentration of rhLK68 in the culture broth, compared with the minimal defined medium. The synthetic defined media developed in this study could be generally applied to high-cell-density cultures of the recombinant Escherichia coli BL21(DE3), especially for the production of therapeutic proteins that require a strict quality control of the culture media and fermentation processes.

Risk identification, assessment and monitoring design of high cutting loess slope in heavy haul railway

  • Zhang, Qian;Gao, Yang;Zhang, Hai-xia;Xu, Fei;Li, Feng
    • Structural Monitoring and Maintenance
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    • v.5 no.1
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    • pp.67-78
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    • 2018
  • The stability of cutting slope influences the safety of railway operation, and how to identify the stability of the slope quickly and determine the rational monitoring plan is a pressing problem at present. In this study, the attribute recognition model of risk assessment for high cutting slope stability in the heavy haul railway is established based on attribute mathematics theory, followed by the consequent monitoring scheme design. Firstly, based on comprehensive analysis on the risk factors of heavy haul railway loess slope, collapsibility, tectonic feature, slope shape, rainfall, vegetation conditions, train speed are selected as the indexes of the risk assessment, and the grading criteria of each index is established. Meanwhile, the weights of the assessment indexes are determined by AHP judgment matrix. Secondly, The attribute measurement functions are given to compute attribute measurement of single index and synthetic attribute, and the attribute recognition model was used to assess the risk of a typical heavy haul railway loess slope, Finally, according to the risk assessment results, the monitoring content and method of this loess slope were determined to avoid geological disasters and ensure the security of the railway infrastructure. This attribute identification- risk assessment- monitoring design mode could provide an effective way for the risk assessment and control of heavy haul railway in the loess plateau.

The Quantitative Analysis by Digital Subtraction Radiography on the Effect of Platelet Rich Plasma Combined with Synthetic Bone Graft on Grade II Furcation Involvement (2급 치근 이개부 치료 시 합성골 이식 및 혈소판 농축 혈장의 골재생 효과에 대한 디지털 공제술의 정량적 분석)

  • Oh, Ji-Soo;Lim, Sung-Bin;Chung, Chin-Hyung
    • Journal of Periodontal and Implant Science
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    • v.31 no.2
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    • pp.465-475
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    • 2001
  • The purpose of this study was to evaluate effect of platelet rich plasma on the treatment of Grade II furcation involvement, with and without porous resorbable calcium carbonate($Biocoral^{(R)}$)in humans by digital subtraction radiography. 15 teeth(control group) were treated with porous resorbable calcium carbonate($Biocoral^{\(R)}$), and 15 teeth(test group) were treated with porous resorbable calcium carbonate($Biocoral^{(R)}$) and Platelet Rich Plasma. The change of bone density was assessed by digital subtraction radiography in this study. The change of mineral content by as much as 5%(vol) could be perceived in the subtracted images. The change of mineral content was assessed in the method that two radiographs are put into computer program to be overlapped and the previous image is subtracted by the later one. Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-whitney Test using SPSS program(5% significance level). The results were as follows: 1. In test group, the radiolucency in 3 months after surgry were significantly increased than 1 month after surgery(p<0.05). 2. In test group, there were no significant difference between 1 month after surgery and 6 months after surgery(p>0.05). 3. In test group, the radiopacity in 6 months after surgery were significantly increased than 3 months after surgery(p<0.05). 4. In control group, the radiolucency in 3 months and 6 months after surgery were significantly increased than 1 month after surgery(p<0.05). 5. In control group, the radiopacity in 6 months after surgery were significantly increased than 3 months after surgery(p<0.05). 6. There were no significant difference between test group and control group at 1 month, 3 months after surgery, but radiopacity in test group were significantly increased than control group at 6 months after surgery(p<0.05). In conclusion, Platelet Rich Plasma can enhance bone density.

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Flood Season Reservoir Operations Considering Water Supply Objective (용수공급을 고려한 홍수기 저수지 운영방안)

  • Lee, Seung-Hyeon;Kim, Young-Oh
    • Journal of Korea Water Resources Association
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    • v.35 no.6
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    • pp.639-650
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    • 2002
  • Reservoir operations during the flood season should consider both the flood control and water supply objectives. This study proposed Set Control Algorithm (SCA) as a reservoir operation method, which guarantees both objectives. The concept behind SCA is to provide operators with a set of actions that guarantee feasibility, given a set of operational constraints, and to let them select decisions within a set that satisfies other considerations. The inflow sets used in this study included; observed data, synthetic data, and ESP(Ensemble Streamflow Prediction) scenarios. Applied to the Chungju Dam operations, SCA was compared to the variable flood restricted elevation, as well as the current flood restricted elevation. A 5-year simulation analysis showed that SCA performed better than the other operation methods, and that SCA coupled with ESP performed best among the SCA cases.

Analysis of Changes in Power Generation of Each Power Generation Company by the Fine-Dust Seasonal Management System (미세먼지 계절관리제로 인한 발전사별 전력생산량 변화 분석)

  • Kim, Bu-Kwon;Won, Doo Hwan
    • Environmental and Resource Economics Review
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    • v.30 no.4
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    • pp.627-648
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    • 2021
  • The fine-dust season management system refers to the policy of implementing enhanced reduction measures in transportation, power, business and living sectors in winter, when fine dust levels are high. The fine dust season management system is a regulatory policy that causes social costs and transfers to various economic players. Equity is an important issue for the cost burden. Therefore, in this study, the cost of each power generator was analyzed using the coal power generation reduction amount of each power generator to verify that the cost of the power sector is evenly distributed. In particular, the effect of the fine dust season management system on coal power generation of power generators was analyzed by applying a synthetic control method that can identify the time-variable effect of the policy. It was confirmed that the fine dust season management system reduced volume of fuel and power generation in coal power plants, resulting in an increase in the cost of the power generation sector, even considering the effect of some power demand due to the COVID-19 crisis. However, it could be seen that these costs were not distributed equally among the generators, and that they were more costly to the specific generators.Social costs incurred by fine dust season management need to be improved so that stakeholders are equally burdened.

HPLC Chromatographic Methods for Simultaneous Determination of Pholcodine and Ephedrine HCI with Other Active Ingredients in Antitussive-Antihistamine Oral Liquid Formulations

  • Abdallah, Rokia M.
    • Natural Product Sciences
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    • v.12 no.1
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    • pp.55-61
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    • 2006
  • A description of simple, isocratic and precise reversed phase HPLC methods is given for simultaneous quantification of pholcodine and ephedrine hydrochloride together with either carbinoxamine maleate or terfenadine in antitussive-antihistaminic oral pharmaceutical formulations. Separations were carried out on X-Terra and symmetry shield C18 column $(250\;{\times}\;4.6\;mm,\;5\;{\mu}m)$. The used isocratic elution systems were either $0.02\;M\;KH_2PO_4-acetonitrile$ in the ratio of 75 : 25 and pH adjusted to 7.70 with orthophosphoric acid or sodium hydroxide, for syrup (method A), or 0.02 octanesulphonic acid sodium salt solution-acetonitrile-acetic acid in the ratio of 75 : 25 : 0.5 for suspension (method B). The elution of both mixtures was achieved with a flow rate of 1 ml/min. Detection was carried out by UV absorbance at wavelengths of 220 and 250 nm for syrup and suspension, respectively. The quantification of the components in synthetic mixtures and actual syrup and suspension were calculated using the internal standard technique with metoclopramide HCl and codeine phosphate as internal standards (IS), respectively. The methods, for both mixtures, were validated and met all the requirements for the quality control analysis recommended by FDA and ICH.

Similarity-Based Subsequence Search in Image Sequence Databases (이미지 시퀀스 데이터베이스에서의 유사성 기반 서브시퀀스 검색)

  • Kim, In-Bum;Park, Sang-Hyun
    • The KIPS Transactions:PartD
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    • v.10D no.3
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    • pp.501-512
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    • 2003
  • This paper proposes an indexing technique for fast retrieval of similar image subsequences using the multi-dimensional time warping distance. The time warping distance is a more suitable similarity measure than Lp distance in many applications where sequences may be of different lengths and/or different sampling rates. Our indexing scheme employs a disk-based suffix tree as an index structure and uses a lower-bound distance function to filter out dissimilar subsequences without false dismissals. It applies the normaliration for an easier control of relative weighting of feature dimensions and the discretization to compress the index tree. Experiments on medical and synthetic image sequences verify that the proposed method significantly outperforms the naive method and scales well in a large volume of image sequence databases.

A Study on the Stress Corrosion Cracking Evaluation for Weld Joint of TMCP steel by SP-SSRT Method (SP-SSRT법에 의한 TMCP강 용접부의 응력부식균열 평가에 관한 연구)

  • 유효선;정희돈;정세희
    • Journal of Welding and Joining
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    • v.15 no.1
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    • pp.46-54
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    • 1997
  • The object of this paper is to evaluate SCC(stress corrosion cracking) susceptibility for parent metal and bond line region of weld joints which have the various weld heat input condtions in TMCP(thermo-mechanical control process) steel by SP-SSRT(small punch-slow strain rate test) method. And the SCC test results of TMCP steel are compared with those of the conventional HT50 steel which has te almost same tensile strength level like TMCP steel. The loading rate used was $3\times10^{-4}$mm/min and the corrosive environment was synthetic sea water. According to the test results, in the case of parent metal, TMCP steel showed higher SCC susceptibility than HT50 steel because of the high plastic strain level of ferrite microstructure obtained by accelerated cooling. And in the case of bond line, the both TMCP steel and HT50 steel showed low load-displacement behaviors and higher SCC susceptibility above 0.6. These results may be caused by theembrittled martensite structure on HT50 steel and by the coarsened grain and the proeutectoid ferrite structure obtained by the impart of accelerated cooling effect on TMCP steel.

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