• Nutrition Research and Practice
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• 제5권3호
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• pp.198-204
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• 2011

Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such as hyperlipidemia, atherosclerosis, and hypertension. One component of these two herbs has been reported to have anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. However, there have been no reports about the effects of the mixed extract of these two herbs on metabolic diseases. In this study, we investigated the metabolic effects of THI using a diet-induced obesity (DIO) mouse model. High-fat diet (HFD) mice were orally administered daily with 250 mg/kg of THI. After 10 weeks of treatment, the THI-administered HFD mice showed reduction of body weights and epididymal white adipose tissue weights as well as improved glucose tolerance. In addition, the level of total cholesterol in the serum was markedly reduced. To elucidate the molecular mechanism of the metabolic effects of THI in vitro, 3T3-L1 cells were treated with THI, after which the mRNA levels of adipogenic transcription factors, including C/$EBP{\alpha}$ and $PPAR{\gamma}$, were measured. The results show that the expression of these two transcription factors was down regulated by THI in a dose-dependent manner. We also examined the combinatorial effects of THI and swimming exercise on metabolic status. THI administration simultaneously accompanied by swimming exercise had a synergistic effect on serum cholesterol levels. These findings suggest that THI could be developed as a supplement for improving metabolic status.

• 대한한방내과학회지
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• 제29권4호
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• pp.922-938
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• 2008

Objectives : Rhodiola rosea has been used in herbal medicine to treat various conditions, such as antimelancholia, antifatigue, improvement of work competence and prevention of altitude sickness. In this study, we investigated effects of Rhodiola rosea extract (KH101) on fatigue in forced swimming rats. Methods : Sprague-Dawley rats were induced with fatigue by forced swimming, then rats in each group were treated with KH101. We observed changes of glucose, LDH and cortisol in serum and LDH, glycogen, hexokinase, citrate synthase MDH, SDH and CK in muscle. Results : Obtained results were as follows: 1. Continuance times of exercise significantly increased in all groups at day 1, in the 50 mg/kg concentration group at day 2, in all groups at day 3 and in the 50 mg/kg conc. group at day 4. 2. In serum, glucose significantly decreased in all concentration groups. 3. In the soleus muscle, LDH significantly decreased in the 50 mg/kg concentration group. HK significantly decreased in the 100 mg/kg conc. group. SDH significantly increased in the 100 mg/kg conc. MDH were significantly decreased in all conc. groups. 4. In the gastrocnemius muscle, HK significantly decreased in all concentration groups, while MDH significantly increased all conc. groups. Conclusions : It is concluded that the KH101 has and anti-fatigue effect in rats. Additional studies are needed to find the mechanism of the association between each single herb.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.259-272
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• 1994

The authors reviewed the etiology and essential treatment of temporomandibular disorders. The principal etiology was thought to the the myospasm of masticatory musculatures by stress (major cause) and dental irritation. Therefore, we attempted to control the myospasm by stress management, isometric exercise and regular daily physical exercises (walking, Jogging, bycycling, rope skipping, swimming & gymnastic exercise). The result was more favorable (95% success rate) without recurrence in 123 patients, who was referred to our department of dentistry(Oral & Maxillofacial surgery), Wonju Christian Hospital.

• 한국식품영양과학회지
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• 제39권1호
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• pp.78-84
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• 2010

본 연구는 부산시 해운대구 보건소에서 과체중 이상인 30세 이상 중년여성을 대상으로 스스로 평생 자기 건강관리를 할 수 있는 능력을 키울 수 있는 건강 체중조절 프로그램을 개발하여 운영하고, 효과적인 영양교육의 필요성과 체계적이고 지속적인 체중조절 프로그램의 운영방안을 마련하고자 하였다. 상반기, 하반기로 2차례에 걸쳐서 과체중 이상인 해운대구 거주 주민 여자 53명을 선착순 모집하여 프로그램을 운영하였다. 프로그램 시작 전후에 건강검진, 체력측정, 체성분측정, 설문조사를 하고, 건강상태와 비만도에 따른 결과를 개인상담으로 실시하였으며, 영양교육은 비만 특강(1시간)을 시작으로, 소그룹별로 4주간 매주 1회 실시한 결과는 다음과 같다. 영양교육과 운동프로그램 전후의 대상자의 체중, BMI는 유의적으로 감소(p<0.001)하였으며 체격 및 체력검사결과 허리둘레, 엉덩이둘레, 상완배부, 견갑하연부는 유의적으로 감소하였으며(p<0.001), 배근력(p<0.001), 악력(p<0.01)은 유의적으로 증가하였다. 또한 영양교육과 운동프로그램 실시 후에 공복 시 혈당(p<0.001), 중성지방(p<0.01)의 농도는 유의적으로 감소하였다(p<0.01). 건강 상태에 대한 평가 결과, 스스로의 건강상태에 대해 긍정적으로 변화되었고, 프로그램 실시 후에 건강관리를 위해서 운동을 중요시하는 양상을 보였다. 영양소 섭취 상태 조사 결과 비타민 D의 섭취량은 유의적으로 증가하였으며(p<0.05). 식습관 조사와 영양지식평가 결과, 평균점수가 유의적인 증가를 보였다(p<0.001). 4주간의 영양교육과 운동프로그램 실시 후 대상자의 식습관과 비만도, 혈액수치에 있어서 긍정적인 영향을 미쳤다고 사료되며, 교육효과를 더 증진시키기 위한 보다 체계적이고 지속적인 영양교육 프로그램의 개발이 필요하며 잘못된 식습관으로 인한 영양불균형이 성인병 등을 유발하지 않도록 평소 균형된 식생활이 이루어지도록 하여야 할 것이다.

• 대한본초학회지
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• 제31권5호
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• pp.99-106
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• 2016

Objectives : Salvianolic acid B (SAB) is an active ingredient in Salvia miltiorrhiza frequently used for cardiovascular and cerebrovascular diseases. The present study investigated the antioxidant effects of SAB on the skeletal muscle and the brain tissue of rats following exhaustive exercise.Methods : The rats were treated with oral administration of SAB (30 mg/kg) daily for 5 days prior to the exhaustive exercise. The exhaustive exercise was performed as swimming for 150 min with 5% body weight attached to the tail on the 5th day. The antioxidant effects of SAB was evaluated by measuring the superoxide generation in the gastrocnemius and the 4-HNE expression in the hippocampal tissue. In addition, c-Fos-expressing cells in the brain tissue was observed using immunohistochemistry.Results : Histological features and muscle fiber type composition were not different between the SAB group and the exhaustive exercise group. SAB significantly reduced the upregulation of superoxide generation in the muscle tissue. SAB significantly reduced the increase of c-Fos-expressing cells in the cerebral cortex, paraventricular thalamic nucleus, dorsomedial hypothalamic nucleus, the CA1, CA3, and DG regions of hippocampus. SAB significantly reduced the upregulation of 4-HNE expression in the CA1 and DG regions of hippocampus caused by the exhaustive exercise.Conclusions : The results suggest that SAB exerts antioxidative effect against oxidative stress in the skeletal muscle and the brain tissue following exhaustive exercise, while SAB may has an anti-stress effect on stress responses in the brain.

• Journal of Nutrition and Health
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• 제38권8호
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• pp.637-648
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• 2005

This study was performed to investigate the effect of feeding garcinia cambogia extract (HCA) and/or L-carnitine and exercise (swimming) on body weight in rats. Forty-eight male rats (Charles River CD (SD) IGS) of eight weeks old and weighing $323.5\pm2.4g$ were raised for two months with high fat diet ($40\%$ fat as calorie) to induce obesity. After induction of obesity, rats weighing $552.8\pm5.8g$ were blocked into eight groups according to body weight and raised for six weeks with diet containing HCA and/or L-carnitine. Plasma aspartate aminotransferase, alanine aminotransferase, total protein and albumin levels were in normal ranges. Food and calorie intakes of H + C and H + C/H groups were highest among non-exercise (m) groups and exercise (I) groups. Food and calorie intakes of m groups were higher than those of I groups. E groups showed significantly lower body weight gain and calorie efficiency ratio than m groups and H/E group was the lowest among all groups. Perirenal fat pad weights of E groups were lower than m groups, and epididymal fat pad weights of H and H + C groups were lower than CO and C groups among m groups regardless of exercise treatment. Brown adipose tissue weights of I groups were higher than fn groups and highest in H/E group among all groups. Liver citrate lyase activities of H and C groups were lower than CO and H + C groups regardless of exercise treatment. The differences between NE groups and E groups were not found to be significantly. Liver carnitine acyltranferase activity was not significantly different among all groups. Fecal total lipid, triglyceride and total cholesterol excretions were found to be higher in H and H + C uoups compared to CO and C groups both in NE and E animals, those of lipid excretions of NE groups were higher than E groups. In conclusion, HCA was more effective in reduction of body weight and body fat than L-carnitine or HCA + L-carnitine. HCA ingestion with exercise was far more effective than without exercise treatment in reducing body weight and body fat.

• 한국체육학회지인문사회과학편
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• 제51권3호
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• pp.437-445
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• 2012

이 연구는 유산소운동이 1형 당뇨쥐의 체장세포질 GAPDH 및 미토콘드리아 MnSOD 활성에 미치는 영향을 알아보기 위한 것이다. 실험동물로는 SD계열 흰쥐를 대상으로 strepzotosine을 주입하여 당뇨를 유발시킨 후 수영운동을 8주간 적용시켰다. 실험 종료 후 췌장조직을 적출하여 시료를 분리한 다음 Western Blotting을 실시하여 GAPDH와 MnSOD를 분석하였다. 본 실험결과 췌장세포질 GAPDH의 그룹 간 활성정도는 정상 대조군(CON)과 당뇨군(D.M) 및 당뇨 운동군(D.M-Ex)의 MnSOD 활성 정도는 각 그룹 간 유의한 활성차이를 나타냈다[F(3, 27) = 57.9, P = .000]. 대조군과 비교했을 때 당뇨그룹의 활성은 나타났으며, 당뇨운동그룹 또한 대조군에 비해 낮은 활성을 나타냈다. 반면 당뇨운동그룹은 당뇨그룹과 비교했을 때 상대적으로 높은 활성을 보였다. 췌장의 미토콘드리아 MnSOD 활성 또한 유사한 결과를 보여 이들 또한 각 그룹 간 유의한 활성차이를 나타냈다[F(3, 27) = 572.472, P = .000]. 따라서 본 연구결과를 종합해 볼 때 유산소운동에 의한 GAPDH와 MnSOD 활성증가는 당뇨병 병소와 관련된 다양한 경로의 활성을 억제하고 미토콘드리아 기능회복에 긍정적인 영양을 미쳐 당뇨병 발병의 진행을 막는데 효과적인 것으로 생각된다.

• 대한지역사회영양학회지
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• 제12권1호
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• pp.80-89
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• 2007

This study was performed to investigate the effectiveness of nutritional education and exercise intervention on reduction and maintenance of weight. The subjects were 24 obese women whose body mass index(BMI) was over $25kg/m^2$. Nutritional education was performed once a week and swimming was done three times a week throughout this 12 week program. The subjects were recalled 1 month after the program was complete. Nutrient intakes were assessed by 24 hour recall method. Also food habits, dietary behaviors and nutritional knowledge were investigated by self-administered questionnaires before and after the weight control program and one month after completing the program. Height, weight, body composition and blood levels were measured before and after the weight control program and one month after completing the program. During the 12 weeks of the weight control program, body weight significantly decreased from an average of 69.7kg to 65.8kg and to 65.1kg after one month(p<0.05). Body fat and BMI also significantly decreased(p<0.01). Cholesterol and blood sugar levels decreased after 12 weeks and increased one month after completing the program. After taking nutritional education, the nutritional knowledge scores increased. Calcium intake significantly increased after completing the education and one month after completing the program(p<0.01). Iron intake significantly decreased from an average of 12.1g to 11.3g after completing the program and increased to 15.5g one month after completing the progrom(p<0.001). We concluded that our nutritional education and exercise program was effective for reducing and maintaining weight.

• Physical Therapy Rehabilitation Science
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• 제6권2호
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• pp.77-82
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• 2017

Objective: Swimming and water-based exercise (WE) programs can provide vigorous physical activity in a fun and a motivating environment. The properties of water, may make it easier for children with cerebral palsy (CP) to move and to participate in an WE program. The aims of this study was to evaluate the effect of WEs on postural control in children with spastic CP. Design: Quasi-experimental design (one group pretest-posttest design). Methods: Twenty preschoolers with spastic CP participated in this study. Prior to the application, sufficient warm-up training was performed to allow the subjects to adapt to the water. Afterwards, three different types of underwater leg exercises for the flexor, extensor, and adductor/abductor of muscles of the lower limb were performed. The WE program lasted during 8 weeks, with one-40 minute sessions per week (8 training session). The usual care was performed during the training session. The Korean-trunk control measurement scale (K-TCMS) and weight distribution variability (difference of both Fz) were measured before and after training session. Results: According to the results, the K-TCMS scores of the three sub-levels, including static sitting, dynamic sitting, and dynamic reaching, was significantly increased after the training session (p<0.05). Also, the weight distribution variability was significantly decreased after 8 weeks (p<0.05). Conclusions: We suggest that WEs may improve the postural control ability in children with spastic CP. Furthermore, we support the need for additional research on the effect of WE on gait or activity of daily living performance with a control group included.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2006년도 추계 종합학술대회 논문집
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• pp.141-144
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• 2006

본 연구는 2006년 현재 대전광역시에 소재의 수영장의 성인여성회원 총 300명을 대상으로 298부의 설문지를 회수하여 사용하였다. 조사도구로 정신건강 대한 설문문항은 박지나(200l), 조석주(2000)의 연구를 기초로 요인 분석을 실시한 후 신뢰도 및 타당도를 검증, 사용하였다. 수집된 자료는 일원변량분석의 통계기법을 사용하였다. 이와 같은 연구방법 및 절차를 통하여 본 연구에서는 다음과 같은 결과를 도출하였다. 첫째, 성인 여성의 수영참가 빈도는 정신건강에 영향을 미친다. 둘째, 성인 여성의 수영참가 기간은 정신건강에 영향을 미친다. 셋째, 성인 여성의 수영참가 강도는 정신건강에 영향을 미친다. 이상의 결론을 종합하면 성인 여성이 수영에 참가함으로서 정신건강에 차이가 있는 것으로 나타났으며 성인 여성의 수영 참가를 높여 정신건강에 긍정적인 영향을 향상시키는데 기여한다고 할 수 있다.