• Title/Summary/Keyword: Suzuki Method

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Solid-phase Synthesis of 7-Aryl-benzo[b][1,4]oxazin-3(4H)-one Derivatives on a BOMBA Resin Utilizing the Smiles Rearrangement

  • Lee, Ji-Min;Yu, Eun-Ae;Park, Joo-Yeon;Ryu, In-Ae;Shin, Dong-Soo;Gong, Young-Dae
    • Bulletin of the Korean Chemical Society
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    • v.30 no.6
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    • pp.1325-1330
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    • 2009
  • A general method has been developed for the solid phase synthesis of drug-like 7-aryl-benzo[b][1,4]oxazin-3(4H)- one derivatives 6. The method relies on a novel, microwave irradiation promoted cyclization reaction of the BOMBA resin bound, N-substituted-$\alpha$-(2-chloro-4-bromophenoxy)acetamide 3 that takes place via a Smiles rearrangement. The 7-bromobenzo[1,4]oxazine 4, produced in this process is converted to 7-aryloxazin analogs 5 by utilizing Suzuki coupling with various substituted arylboronic acids. Finally, the target 7-aryl-benzo[b][1,4]oxazin-3(4H)-ones 6 are liberated from the resin by treatment with 5% TFA. The progress of the reactions involved in this preparative route can be monitored by using ATR-FTIR spectroscopy on a single bead. The target compounds, obtained by using this five-step sequence, are produced in high yields and purities.

Network-based Cooperative TV Program Production System

  • H.Sumiyoshi;Y.Mochizuki;S.Suzuki;Y.Ito;Y.Orihara;N.Yagi;Na, M.kamura;S.Shimoda
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • 1997.06a
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    • pp.75-81
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    • 1997
  • A new DTPP (Desk-Top Program Production) system has been developed that enables multiple program producers (directors) working at different locations to collaborate over a computer network and prepare a single program for broadcasting. In this system, information is shared among users by exchanging data edited on non-linear editing terminals in program post-production work over a network in real time. In short, the new DTPP system provides a collaborative work space for producing TV programs. The system does not make use of a special server for collaborative work but rather multiple interconnected editing terminals having the same functions. In this configuration, data at a terminal which has just been edited by some operation is forwarded to all other connected terminals for updating. This form of information sharing, however, requires that some sort of data synchronizing method be established since multiple terminals are operating on the same data simultaneously. We therefore adopt a method whereby the system synchronizes the clocks on each terminal at the time of connection and sends an operation time stamp together with edited data. This enables most recently modified data to be identified and all information on all terminals to be updated appropriately. This paper provides an overview of this new collaborative DTPP system and describes the techniques for exchanging edited data and synchronizing data.

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Complications of endoscopic resection in the upper gastrointestinal tract

  • Takeshi Uozumi;Seiichiro Abe;Mai Ego Makiguchi;Satoru Nonaka;Haruhisa Suzuki;Shigetaka Yoshinaga;Yutaka Saito
    • Clinical Endoscopy
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    • v.56 no.4
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    • pp.409-422
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    • 2023
  • Endoscopic resection (ER) is widely utilized as a minimally invasive treatment for upper gastrointestinal tumors; however, complications could occur during and after the procedure. Post-ER mucosal defect leads to delayed perforation and bleeding; therefore, endoscopic closure methods (endoscopic hand-suturing, the endoloop and endoclip closure method, and over-the-scope clip method) and tissue shielding methods (polyglycolic acid sheets and fibrin glue) are developed to prevent these complications. During duodenal ER, complete closure of the mucosal defect significantly reduces delayed bleeding and should be performed. An extensive mucosal defect that comprises three-quarters of the circumference in the esophagus, gastric antrum, or cardia is a significant risk factor for post-ER stricture. Steroid therapy is considered the first-line option for the prevention of esophageal stricture, but its efficacy for gastric stricture remains unclear. Methods for the prevention and management of ER-related complications in the esophagus, stomach, and duodenum differ according to the organ; therefore, endoscopists should be familiar with ways of preventing and managing organ-specific complications.

ACCURACY OF THE IMPRESSION TECHNIQUE USING THERMOFORMING POLYMETHYL METHACRYLATE TRAY

  • Miyashita, Yuko;Suzuki, Hiroki;Kishi, Masataka;Ko, Sok-Min
    • The Journal of Korean Academy of Prosthodontics
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    • v.45 no.3
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    • pp.389-400
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    • 2007
  • Statement of problem. Use of the conventional dental impression procedure is problematic in patients who have difficulty opening their mouth, difficulty breathing through their nose or tendency to gag. Purpose. It is necessary to make individual trays more comfortable for patients during impression taking procedure. It was reported at the KAP Annual Meeting 2001 Seoul that an improved impression technique was suitable for this purpose. In this study, the accuracy of the improved dental impression method for implant was compared with the conventional dental impression method. Material and methods. An oral simulator was made from clear acrylic resin block which had similar form of edentulous ridge. For setting up the standard, five fixtures were installed on it. Study casts were made using two kinds of impression techniques. One was the conventional method that was taken using silicone impression material and an individual resin tray under connection of inter-fixture relation. The other was the improved method in which was the connection of the impression coping and the thermoformed polymethyl methacrylate tray. In addition, two different study casts were made from the improved impression body. The coordinates of the fixture on the study model were measured by three-dimensional coordinate measuring equipment. Then the distances between each fixture were calculated and compared with that of oral simulator. Accuracy of the each impression method was also assessed. Results. The differences of inter-fixture dimension between study casts and simulator in the improved impression technique showed $0.014{\pm}0.016mm$ and $0.017{\pm}0.022mm$, respectively and that of the conventional method was $0.017{\pm}0.014mm$. There was no significant difference between the improved impression technique and conventional method. Conclusion. The improved impression technique is useful for multiple support implants.

Language-Independent Word Acquisition Method Using a State-Transition Model

  • Xu, Bin;Yamagishi, Naohide;Suzuki, Makoto;Goto, Masayuki
    • Industrial Engineering and Management Systems
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    • v.15 no.3
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    • pp.224-230
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    • 2016
  • The use of new words, numerous spoken languages, and abbreviations on the Internet is extensive. As such, automatically acquiring words for the purpose of analyzing Internet content is very difficult. In a previous study, we proposed a method for Japanese word segmentation using character N-grams. The previously proposed method is based on a simple state-transition model that is established under the assumption that the input document is described based on four states (denoted as A, B, C, and D) specified beforehand: state A represents words (nouns, verbs, etc.); state B represents statement separators (punctuation marks, conjunctions, etc.); state C represents postpositions (namely, words that follow nouns); and state D represents prepositions (namely, words that precede nouns). According to this state-transition model, based on the states applied to each pseudo-word, we search the document from beginning to end for an accessible pattern. In other words, the process of this transition detects some words during the search. In the present paper, we perform experiments based on the proposed word acquisition algorithm using Japanese and Chinese newspaper articles. These articles were obtained from Japan's Kyoto University and the Chinese People's Daily. The proposed method does not depend on the language structure. If text documents are expressed in Unicode the proposed method can, using the same algorithm, obtain words in Japanese and Chinese, which do not contain spaces between words. Hence, we demonstrate that the proposed method is language independent.

A Study on the Sensitivity Compensation of Three-dimensional Acoustic Intensity Probe in the Higher Frequency Range (3차원 음향 인텐시티 프로브의 고주파 영역 감도 보상 연구)

  • Kim, Suk-Jae;Hideo, Suzuki;Kim, Chun-Duck
    • The Journal of the Acoustical Society of Korea
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    • v.13 no.5
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    • pp.40-50
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    • 1994
  • In this paper, the sensitivity compensation method for three-dimensional acoustic intensity probe in the higher frequency range has been studied. The measurement error in the higher frequency range is generated from the phase mismatch between microphone's signals of the probe. If the wavelength of sound signal measured is less than those of the distance between microphones of the probe, that is, the higher frequency of the sound signal, the bigger measurement error is generated. In this study, we proposed the compensation methods for one-dimensional acoustic intensity probe with two-microphones, and the efficiency of those methods were investigated by numerical calculation of computer. It was most effective method to compensate the phase mismatch between microphone for the acoustic intensity probe was investigated for the sound estimated. and the efficiency of this method in a three-dimensional probe was investigated for the sound wave travelling in the arbitrary direction by numerical calculation of computer. In this result, the efficiency was proved that, for the measurement error of 1dB or less with the three-dimensional probe of 60mm space, the frequency should be less than 1.2kHz without the error compensation method, but the frequency increased up to 2.8kHz with the error compensation method.

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Real-Time Recognition Method of Counting Fingers for Natural User Interface

  • Lee, Doyeob;Shin, Dongkyoo;Shin, Dongil
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.10 no.5
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    • pp.2363-2374
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    • 2016
  • Communication occurs through verbal elements, which usually involve language, as well as non-verbal elements such as facial expressions, eye contact, and gestures. In particular, among these non-verbal elements, gestures are symbolic representations of physical, vocal, and emotional behaviors. This means that gestures can be signals toward a target or expressions of internal psychological processes, rather than simply movements of the body or hands. Moreover, gestures with such properties have been the focus of much research for a new interface in the NUI/NUX field. In this paper, we propose a method for recognizing the number of fingers and detecting the hand region based on the depth information and geometric features of the hand for application to an NUI/NUX. The hand region is detected by using depth information provided by the Kinect system, and the number of fingers is identified by comparing the distance between the contour and the center of the hand region. The contour is detected using the Suzuki85 algorithm, and the number of fingers is calculated by detecting the finger tips in a location at the maximum distance to compare the distances between three consecutive dots in the contour and the center point of the hand. The average recognition rate for the number of fingers is 98.6%, and the execution time is 0.065 ms for the algorithm used in the proposed method. Although this method is fast and its complexity is low, it shows a higher recognition rate and faster recognition speed than other methods. As an application example of the proposed method, this paper explains a Secret Door that recognizes a password by recognizing the number of fingers held up by a user.

Prediction of 305 Days Milk Production from Early Records in Dairy Cattle Using an Empirical Bayes Method

  • Pereira, J.A.C.;Suzuki, M.;Hagiya, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.11
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    • pp.1511-1515
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    • 2001
  • A prediction of 305 d milk production from early records using an empirical Bayes method (EBM) was performed. The EBM was compared with the best predicted estimation (BPE), test interval method (TIM), and the linearized Wood's model (LWM). Daily milk yields were obtained from 606 first lactation Japanese Holstein cows in three herds. From each file of 305 daily records, 10 random test day records with an interval of approximately one month were taken. The accuracies of these methods were compared using the absolute difference (AD) and the standard deviation (SD) of the differences between the actual and the estimated 305 d milk production. The results showed that in the early stage of the lactation, EBM was superior in obtaining the prediction with high accuracy. When all the herds were analyzed jointly, the AD during the first 5 test day records were on average 373, 590, 917 and 1,042 kg for EBM, BPE, TIM, and LWM, respectively. Corresponding SD for EBM, BPE, TIM, and LWM were on average 488, 733, 747 and 1,605 kg. When the herds were analyzed separately, the EBM predictions retained high accuracy. When more information on the actual lactation was added to the prediction, TIM and LWM gradually achieved better accuracies. Finally, in the last period of the lactation, the accuracy of both of the methods exceeded EBM and BPM. The AD for the last 2 samples analyzing all the herds jointly were on average 141, 142, 164, and 214 kg for LWM, TIM, EBM, and BPE, respectively. In the current practices of collecting monthly records, early prediction of future milk production may be more accurate using EBM. Alternatively, if enough information of the actual lactation is accumulated, TIM may obtain better accuracy in the latter stage of lactation.

A novel coupled finite element method for hydroelastic analysis of FG-CNTRC floating plates under moving loads

  • Nguyen, Vu X.;Lieu, Qui X.;Le, Tuan A.;Nguyen, Thao D.;Suzuki, Takayuki;Luong, Van Hai
    • Steel and Composite Structures
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    • v.42 no.2
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    • pp.243-256
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    • 2022
  • A coupled finite element method (FEM)-boundary element method (BEM) for analyzing the hydroelastic response of functionally graded carbon nanotube-reinforced composite (FG-CNTRC) floating plates under moving loads is firstly introduced in this article. For that aim, the plate displacement field is described utilizing a generalized shear deformation theory (GSDT)-based FEM, meanwhile the linear water-wave theory (LWWT)-relied BEM is employed for the fluid hydrodynamic modeling. Both computational domains of the plate and fluid are coincidentally discretized into 4-node Hermite elements. Accordingly, the C1-continuous plate element model can be simply captured owing to the inherent feature of third-order Hermite polynomials. In addition, this model is also completely free from shear correction factors, although the shear deformation effects are still taken into account. While the fluid BEM can easily handle the free surface with a lower computational effort due to its boundary integral performance. Material properties through the plate thickness follow four specific CNT distributions. Outcomes gained by the present FEM-BEM are compared with those of previously released papers including analytical solutions and experimental data to validate its reliability. In addition, the influences of CNT volume fraction, different CNT configurations, water depth, and load speed on the hydroelastic behavior of FG-CNTRC plates are also examined.

Prediction of Cascade Performance of Circular-Arc Blades with CFD

  • Suzuki, Masami;Setoguchi, Toshiaki;Kaneko, Kenji
    • International Journal of Fluid Machinery and Systems
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    • v.4 no.4
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    • pp.360-366
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    • 2011
  • Thin circular-arc blade is often used as a guide vane, a deflecting vane, or a rotating blade of low pressure axial-flow turbomachine because of its easy manufacture. Ordinary design of the blade elements of these machines is done by use of the carpet diagrams for a cascade of circular-arc blades. However, the application of the carpet diagrams is limited to relatively low cambered blade operating under optimum inlet flow conditions. In order to extend the applicable range, additional design data is necessary. Computational fluid dynamics (CFD) is a promising method to get these data. In this paper, two-dimensonal cascade performances of circular-arc blade are widely analyzed with CFD. The results have been compared with the results of experiment and potential theory, and useful information has been obtained. Turning angle and total pressure loss coefficients are satisfactorily predicted for lowly cambered blade. For high camber angle of $67^{\circ}$, the CFD results agree with experiment for the angle of attack less than that for shockless inlet condition.