• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.395-401
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• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• Mass Spectrometry Letters
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• v.14 no.3
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• pp.104-109
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• 2023

Anabolic-androgenic steroids (AAS) are used illegally to enhance muscle development and increase strength and power. In this study, a reliable, and sensitive quantitative method was developed and validated using heptafluorobutyric acid anhydride (HFPA) derivatives for the simultaneous detection of prohibited AAS (testosterone [TS], boldenone [BD], 5α-estrane-3β,17α-diol [EAD]) using gas chromatography-tandem mass spectrometry (GC-MS/MS). For processing the samples, solid phase extraction, methanolic hydrolysis, and liquid-liquid extraction were used. For detection using mass spectrometry, the multiple reaction monitoring (MRM) mode was used with the electron ionization (EI) positive mode. The method was evaluated for selectivity, linearity, lower limit of quantification, intra- and inter-day precision, accuracy, and stability. The results showed that the method was accurate and reproducible for the quantitation of the three steroids. The developed method was finally applied to the analysis of a suspect gelding urine sample received from the Asian Quality Assurance Program (AQAP).

• Journal of The Korean Society of Inherited Metabolic disease
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• v.23 no.2
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• pp.21-30
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• 2023

Inherited metabolic disorders (IMD) are a group of disorders caused by defects in specific biochemical pathways. Up to 85% of IMD display predominantly neurological manifestations by affecting neurodevelopment or causing neurodegeneration. These neurometabolic disorders present with a variety of neurological and non-neurological manifestations. Early diagnosis of IMD is important because some disorders can be treated or improved with specific treatment if detected early. For prompt diagnosis and treatment, it is important to suspect IMD by being familiar with the clinical characteristics, biochemical abnormalities, and characteristic neuroimaging patterns that appear in IMD. Genetic testing, including next-generation sequencing, is also important in diagnosing IMD. During the follow-up of patients with IMD, it is necessary to conduct regular physical and neurological examinations in addition to disease-specific management.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.546-554
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• 2019

Typically, closed-circuit television (CCTV) monitoring is mainly used for post-processes (i.e. to provide evidence after an incident has occurred), but by using a streaming video feed, machine-based learning, and advanced image recognition techniques, current technology can be extended to respond to crimes or reports of missing persons in real time. The multi-CCTV cooperation technique developed in this study is a program model that delivers similarity information about a suspect (or moving object) extracted via CCTV at one location and sent to a monitoring agent to track the selected suspect or object when he, she, or it moves out of range to another CCTV camera. To improve the operating efficiency of local government CCTV control centers, we describe here the partial automation of a CCTV control system that currently relies upon monitoring by human agents. We envisage an integrated crime prevention service, which incorporates the cooperative CCTV network suggested in this study and that can easily be experienced by citizens in ways such as determining a precise individual location in real time and providing a crime prevention service linked to smartphones and/or crime prevention/safety information.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.1
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• pp.79-80
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• 2008

Including malignancy, various disease can show abnormal uptake in bone marrow. We report a case of non-specific inflammatory FDG uptake in bone marrow mimicking malignancy. A 35-year old woman with fever of unknown origin (FUO) underwent $^{18}F$-FDG PET/CT to find out fever $^{18}F$-FDG and unknown malignancy. $^{18}F$-FDG was injected and imaged 1hr after injection with Discovery ST (GE, USA), $^{18}F$-FDG PET/CT whole body image showed abnormal uptake in lower extremities (Fig. 1). MRI and biopsy was also done in the sites of abnormal uptake. PET and MRI suspect malignancy (Fig. 2, 3), but biopsy result was non-specific inflammatory process (Fig. 4). The patient was improved her clinical condition after antibiotics therapy.

• Tuberculosis and Respiratory Diseases
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• v.74 no.2
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• pp.70-73
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• 2013

Dyskeratosis congenita is a rare congenital disorder characterized by a triad of reticular pigmentation of the skin, dystrophic nails, and leukoplakia of the mucous membrane. Sometimes it is associated with bone marrow failure, secondary malignancy and interstitial lung disease. Though it is rare, Dyskeratosis congenita is diagnosed relatively easily when clinicians suspect it. It can be diagnosed just by gross inspection with care. Dyskeratosis congenita should be considered as one cause associated with interstitial lung disease. In Korea, interstitial lung disease with dyskeratosis congenita has not been reported. We report a case and review the literature.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.12
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• pp.181-193
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• 2020

This study examines the relationship between gender diversity (women on the board and women on the audit committee) and a firm's financial stability. The ordinary least square analysis was used to determine the relationship. To measure the financial stability of Malaysian suspect firms, i.e., firms with the lowest positive earnings, the Altman (1993) Z-Score measurement was utilized. The results indicate that women on the board are significantly and negatively associated with the firm's financial stability. That is, they are related to low financial stability, which contradicts the agency and resource dependence theories. Regarding women directors on the audit committee, there is no significant relationship with financial stability, meaning that they cannot protect the company against financial distress. These results are robust and do not change when using different measurements of gender diversity, one-year lag of independent variables, and other methods of analysis, namely random effect panel data. This study is the first to alert policymakers, stakeholders, researchers, and society in general to the need to re-evaluate and strengthen the role of women directors in improving firms' financial stability, particularly in emerging economies like Malaysia.

• Proceedings of the Korean Fiber Society Conference
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• 2003.10a
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• pp.55-56
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• 2003

An old castle in a tranquil setting. At first glance, no-one would suspect that this was the backdrop for the research and services centre providing expertise from all areas of the textile-clothing supply chain, textile care and other associated sectors. The Hohenstein Institutes are a modern communications centre with the latest research equipment where highly qualified scientists carry out their research and exchange knowledge. This combination of high-calibre staff and the philosophy of the unity of research, training and application have guaranteed the Hohenstein team of their position as an internationally respected institution offering high levels of expertise in all areas of the textile-clothing chain. At the beginning of the 21st century, the team of scientists at Hohenstein made the research and development of high-tech textile and garment innovations their number one priority. They recognise a rapidly developing market for "intelligent textiles" and "Smart Clothes" capable of adapting their function to the existing environmental conditions. Clients for the research projects, which are often carried out in conjunction with other institutions and industry, are research associations, federal ministries, the European Union and numerous leading companies both in Germany and abroad. The Hohenstein Institutes dispose of four international offices at the moment: in Turkey (since 1996), USA (since 1999), Lima (since 2002) and Mexico (since 2003).

• Journal of Korean Foot and Ankle Society
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• v.10 no.1
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• pp.80-83
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• 2006

Purpose: To compare ultrasonographic size of morton's neuroma measured to actual size. Materials and Methods: Thirty-two (twenty-eight patients) of symptomic Morton's neuroma were measured by ultrasonography preoperatively and by manual method that designed by authors intraoperatively from January, 2002 to May, 2003. Two results were stastically compared by paired T-test. Results: Except one, all of cases were women and the mean age of patients was 50.6 years (32-62 years). The most common associated disease was hallux valgus deformity (17 cases). Six of Morton's neuromas located on second intermetatarsal space, sixteen of them did third intemetatarsal space and ten of neuromas located simultaneously second and third intermetatarsal space. The ultrasonographic size of neuroma averaged 3.48 mm and real size was 3.99 mm. The size checked by manual method was larger than by ultrasound with statical meaning. Conclusion: The size of Morton's interdigital neuroma checked by ultrasonography on plantar aspect is smaller than real size. If you checked Morton's interdigital neuroma size by ultrasonography, you can suspect that real size of Morton's interdigital neuroma is larger than that size.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4529-4548
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• 2016

DDoS attacks have had a devastating effect on the Internet, which can cause millions of dollars of damage within hours or even minutes. In this paper we propose a practical dynamic defense approach that overcomes the shortage of static defense mechanisms. Our approach employs a group of SDN-based proxy switches to relay data flow between users and servers. By substituting backup proxy switches for attacked ones and reassigning suspect users onto the new proxy switches, innocent users are isolated and saved from malicious attackers through a sequence of remapping process. In order to improve the speed of attacker segregation, we have designed and implemented an efficient greedy algorithm which has been demonstrated to have little influence on legitimate traffic. Simulations, which were then performed with the open source controller Ryu, show that our approach is effective in alleviating DDoS attacks and quarantining the attackers by numerable remapping process. The simulations also demonstrate that our dynamic defense imposes little effect on legitimate users, and the overhead introduced by remapping procedure is acceptable.