• 한국양식학회지
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• 제13권1호
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• pp.1-7
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• 2000

The effect of various dietary protein levels on growth and body composition of young common carp raised from 56 g to 170 g in recirculating system was investigated for 15 weeks when they were fed to visual satiety three times daily. Five experiemtal diets were formulated to contain 40, 35, 30, 25 and 21% protein levels and 3.56, 3.59. 3.63, 3.66 and 3.69 kcal/g diet GE levels respectively. Mean survival rates of the fish fed the 40, 35, 30 and 25% protein diets were not different but sig-nificantly higher than that of the fish fed the 40, 35, 30 and 25% protein diets were not different but sig-nificantly higher than that of o the fish fed the 21% protein diet(P<0.05) Weight gain (g/tank) of common carp fed the 30% protein diet was the best. However weight gain of the fish fed the 25, 30, 35 and 40% protein diets were not different but significantly better than that of the fish fed the 21% protein diet. Feed efficiency ratio of the 21% protein diet was significantly lower (P<0.05) than for other groups of diets which were not different among them. Protein efficiency ratio for the 21% protein diet was significantly lower (P<0.05) than for other groups of diets which were not different among them(P>0.05) Dietary protein level had no effect on hemoglobin content in the fish(P>0.05) Crude protein contents of whole body of the fish fed the 35 and 40% protein diets were significantly higher than that of the fish fed the 21$$\mid$% or 25% protein diet(P<0.05) Body crude lipid contents of the fish fed the 21 and 25% protein diets were significantly higher than that of the fish fed the 30% or 35% protein diet. Crude ash contents of the fish fed the 35 and 40% protein diets were significantly higher than that of the fish fed the 21% or 25% protein diet(P<0.05) Moisture content of the fish fed the 35% protein diet was significantly higher than that of the fish fed the 21% protein diet(P<0.05) In considering growth performance of common carp and efficiency of diet dietary protein level could be lowered up to 25% without the reduction of young common carp production in recirculating system.

• 사상체질의학회지
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• 제22권4호
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• pp.85-97
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• 2010

1. Objectives The purpose of this study is to investigate the effects of oral administration of distilled Suhwagije-tang in aging rats. 2. Methods The SD rats used in this experiment were 6, 48 and 68 weeks old. These groups were treated with distilled water(DW), 1% Vitamin C(Vit. C) and 50% Suhwagije-tang(SGT) distillate respectively, once a day for 4 weeks. Blood samples were taken from heart and the levels of various parameters in serum were analysed. 3. Results and Conclusions (1) At all concentration of SGT, survival rates of liver cells were higher than the control group. (2) The rate of which the 10W-SGT group gained weight was significantly higher than that of the control groups. (3) The levels of albumin in serum of 10W-SGT group were significantly increased in comparison to those of the DW group. The levels of ALP, total cholesterol and HDL-cholesterol in serum of 52W-SGT group were significantly decreased in comparison to those of the DW group. (4) The levels of testosterone in serum of SGT groups showed no significantly changes in comparison to those of the control groups. Testosterone levels were naturally decreased with advancing years, so 72W-DW group's testosterone level was significantly decreased in comparison to those of 10W-DW group's. In contrast, 72W-SGT group's level was the highest in comparison to those of the control groups and those of deviation from 10W, 52W and 72W in SGT groups was also smaller than control groups'. (5) The levels of glucose, total-bilirubin, ALT, AST, BUN, CRP, hs-CRP, homocystein, Na, K, Na/K ratio, Cl and Ca in serum of SGT groups showed no significantly changes in comparison to those of the control groups. These results suggest that oral administration of Suhwagije-tang distillate should be effective in promoting growth and preventing rapid decline of testosterone in aging rats does not cause any imbalance in liver, kidney and electrolyte.

• 농업과학연구
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• 제13권2호
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• pp.193-197
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• 1986

본(本) 시험(試驗)은 임신말기(姙娠末期) 및 초기포유기간(初期哺乳期間)의 모돈(母豚)에 아미노산 킬레이트 철분제(鐵分齊)를 급여(給與)함으로써 자돈(仔豚)에게 철분제(鐵分劑)를 경구투여(經口投與)하거나 주사(注射)하지 않고 자돈(仔豚)의 철분결핍성(鐵分缺乏性) 빈혈(貧血)을 예방(豫防)할 수 있는 지를 구명(究明)하기 위해서 모돈(母豚) 20두(頭)를 가지고 4처리(處理)로 나누어 실시(實施)한 바, 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. 생시체중(生時體重)은 각(各) 처리군(處理群)들 간(間)에 차이(差異)가 없었으나, 15일령(日齡)의 체중(體重)에서는 킬레이트 철분급여군(鐵分給與群)이 제일 무거웠고, 35일령(日齡)의 체중(體重)에서는 대조군(對照群)이 제일 가벼웠다. 2. 이유시(離乳時) 생존율(生存率)은 각(各) 처리군(處理群)들 간(間)에 차이(差異)를 인정(認定)할 수 없었다. 3. 헤모그로빈, 적혈구(赤血球) 및 헤마토크리트의 수준(水準)은 출산시(出生時)와 15일령(日齡)에서 킬레이트 직분(織分) 급여군(給與群)이 대조군(對照群)에 의하여 높은 수준(水準)을 보였으며(p<.05) 35일령(日齡) 이유시(離乳時)에는 각(各) 처리군(處理群)들 간(間)에 차이(差異)가 없었다.

• 한국임상수의학회지
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• 제31권5호
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• pp.389-393
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• 2014

애완 페렛의 부신질환은 우리 나라에서도 많이 접하게 되는 질병이다. 하지만 아직 페렛의 부신질환에 대한 연구가 우리나라에서는 이뤄지지 않고 그 실태 보고도 없는 상태이다. 그러므로 본 연구는 부신절제술을 실시한 48마리의 페렛을 대상으로 국내 애완 페렛의 부신질환 발생상황을 알아보고자 하였다. 부신 질환이 있는 애완 페렛은 주로 3~5년령에 다발하였으며, 중성화한 암컷에서 58.3%의 높은 발생을 보였다. 부신질환은 왼쪽 부신 72.9%, 오른쪽 부신 10.4%, 양쪽 부신에 16.7% 있었으며, 초음파상에서 부신크기(길이 *두께)는 왼쪽 부신 8.96 * 5.08 mm, 오른쪽 부신 12.91 * 8.26 mm 로 나타났다. Alopecia가 82.2%로 주요 임상증상이었고 vulvar swelling은 암컷중 32.1%에서 나타났으며, 주된 병발질환으로 renal cyst 29.2%, splenomegaly 25%를 보였다. 조직학적 소견에서 pheochromocytoma, adenoma, hyperplasia 가 각각 44.7%, 14.9%, 12.8% 이었다. 수술후 생존률은 1년과 2년에서 각각 87.5%, 74.0% 였으며, alopecia 및 vulvar swelling은 각각 수술후 평균 3.4개월 및 평균 12일경에 개선되었다.

• Journal of Chest Surgery
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• 제32권1호
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• pp.32-37
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• 1999

배경: 폐암의 완치를 위한 가장 효과적인 치료 방법은 조기 진단과 외과적인 절제술이다. 고령의 환자군에서는 젊은 환자군에 비하여 폐암으로 진단된 경우 전신 건강 상태, 잔여 폐기능의 제한에 의하여 사용 가능한 모든 유용한 치료 방법을 최대한 이용하는 것이 불가능한 경우가 많다. 저자들은 외과적인 폐절제술을 시행한 환자군을 대상으로 후향적인 연구를 통하여 연령인자가 폐암의 병기, 조직학적 진단, 수술 방법, 합병증의 이환율과 사망률에 어떤 영향을 미치는 지 조사하였다. 대상 및 방법: 비소세포 폐암으로 진단받고 외과적인 절제술을 시행한 211명의 환자를 대상으로 하였다. 환자는 1994년 10월부터 1997년 6월까지 수술 받은 환자였다. 환자들을 인위적으로 70세 이상군(35명)과 미만군(176 명)으로 나누어 두 군을 의무기록을 참조로 비교 조사하였다. 결과: 폐암의 병기및 조직학적 진단은 두 군에서 차이가 없었다. 그러나 수술 방법, 합병증의 이환율, 사망률은 두 군 사이에 차이가 있었고, 70세 이상군에서 합병증의 이환율이 높은 것으로 나타났다(p = 0.02). 수술 방법에서 70세 이상군에서는 가능한 잔여 폐기능을 보존하는 덜 침습적인 시술이 선호되었다. 결론: 수술후 합병증의 이환율과 사망률은 70세이상 군에서 높아서 수술의 위험도가 높은 것으로 나타났다. 흉부 수술이 폐암의 완치를 목적으로 권유되어 질 수 있는 최선의 치료 방법이다. 그렇지만, 고령의 환자에서는 합병증의 이환율 및 사망률이 높게 발생한다. 따라서, 고령의 폐암 환자의 수술을 결정할 때, 수술 적응증과 수술 방법을 신중히 고려하여야 된다고 생각한다.

• 한국수산과학회지
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• 제33권5호
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• pp.469-474
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• 2000

넙치 배합사료의 어분 대체 단백질원으로서 대두박의 이용성을 조사하기 위하여 평균체중 359인 넙치를 각 수조마다 20마리씩 2반복 수용하여 대두박 함량을 $0{\%}, 10{\%}, 20{\%}$ 및 $30{\%}$로 조절한 사료로 45일간 사육실험하였다. 그 결과, 모든 실험구에서 $100{\%}$의 생존율을 나타내었으며, 증중량은 대조구와 대두박 $10{\%}$ 첨가구간에는 차이가 없었지만, 대두박 $20{\%}$ 및 $30{\%}$ 첨가구는 대조구보다 유의하게 낮았다 (P < 0.05). 사료효율과 단백질효율은 사료의 대두박 첨가수준이 높을수록 감소하는 경향을 보였으나, 대조구와 대두박 $10{\%}$ 및 $20{\%}$ 첨가구간에 유의한 차이를 보이지 않았다(P > 0.05). 이와 반대로, 일일사료섭취율과 일일단백질섭취율은 사료의 대두박 첨가수준이 높을수록 증가하는 경향을 보였다. 어체간의 일반성분은 각 실험구간에 유의차가 없었으나 (P > 0.05), 사료의 대두박 첨가수준이 높을수록 단백질과 수분함량은 증가하고, 지질함량은 감소하였다. 혈장 총 콜레스테롤 농도는 사료의 대두박 첨가수준이 높을수록 감소하는 경향을 나타내었으나, 대조구와 대두박 $10{\%}$ 첨가구간에 유의차가 없었다 (P > 0.05) 혈장 GOT는 사료의 대두박 첨가수준이 높을수록 증가하는 경향을 보였다. 이상의 결과로부터, 본 실험 사료 조성으로 넙치 치어를 사육하였을 때, 어분 대체단백질원으로서 대두박을 사료의 $10{\%}$까지 첨가할 수 있을 것으로 판단된다.

• 미생물학회지
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• 제33권3호
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• pp.199-202
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• 1997

방선균(Streptomyces) 포자와 효모(Saccharomyces) 반수체 및 배수체 세포를 대상으로 전기충격(AC 38V/1.3 cm)이 화학적 돌연변이원인 N-methyl-N'-nitro-N-nitrosoguanidine(NTG)의 세포치사효과와 돌연변이 유발에 미치는 영향을 조사하였다. 방선균의 경우 전기충격 단독 처리로는 180분 처리하였을 때 생존율이 100%이었으나 960분 처리한 경우에는 모두 사멸하였다. 전기충격과 NTG처리를 병행한 바 방성균의 경우 180분 처리시, NTG 단독 처리시보다 생존율이 72%에서 48%로 감소되었고, 반수체 효모의 경우 40분 처리시 8%에서 3%로, 배수체 효모의 경우 25%에서 10%로 각각 감소되었다. 전기충격과 NTG에 의한 영양요구 돌연변이 형성율에 있어서는 전기충격이 NTG에 의한 돌연변이율을 120분 처리 후 1.8%에서, 13.6%로, 반수체효모의 경우 40분 처리후 2.4%에서 4.8%로 각각 증가시켰다.

• 한국수산과학회지
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• 제44권2호
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• pp.149-154
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• 2011

Two experiments were conducted to investigate the effects of dietary moisture content on the growth and gastrointestinal evacuation of sub-adult olive flounder (Paralichthys olivaceus) in the summer and winter seasons. In the first experiment, three experimental diets containing different moisture levels (7%, 15%) and additives were prepared by adding water and commercial additives (1% nutrients, 1% digestives) to commercial extruded pellets. Fish (initial weight: $332{\pm}9.2$ g) were distributed randomly into six 3000 L tanks (25 fish/tank) in a flow-through tank system. Two replicate groups of fish were fed the experimental diets to satiation for 14 weeks during the summer season ($21.4{\pm}2.5^{\circ}C$). Survival, weight gain, feed efficiency, and daily feed intake did not differ significantly among groups. In the second experiment, two experimental diets containing different moisture levels (8%, 23%) were prepared by adding water to commercial extruded pellets. Fish (initial weight: $646{\pm}6.7$ g) were randomly distributed into six 3000 L tanks (20 fish/tank) in a flow-through tank system. Three replicate groups of fish were fed the experimental diets to satiation for 19 weeks during the winter season ($12.2{\pm}1.2^{\circ}C$). Weight gain, feed efficiency, and daily feed intake did not differ significantly among groups. Gastrointestinal evacuation rates were determined after the end of the winter feeding trials. The stomach contents of fish fed diets containing different moisture levels peaked within 3 h after feeding and then decreased gradually over 40 h to approach pre-feeding levels. Intestinal contents began to accumulate 3 h after feeding and reached a maximum at 32 h, then declined until nearly complete evacuation around 56 h. The stomach contents reached moisture levels of approximately 70% within 3 h after feeding and then increased gradually. No considerable difference in moisture levels was observed in the stomach contents of fish fed diets with different moisture contents. The results of this study suggest that the gastric evacuation of sub-adult olive flounder was not affected by dietary moisture level and the addition of water to the diet had no beneficial effect on the growth of sub-adult olive flounder in the summer and winter seasons.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.120-131
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• 2017

Purpose: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. Materials and Methods: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). Results: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. Conclusions: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).

• Advances in pediatric surgery
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• 제14권1호
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• pp.37-47
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• 2008

Recently, the survival rates of extremely low-birth-weight (ELBW) infants have improved with the development of neonatal intensive care. However, these infants were susceptible to intestinal perforation due to prematurity, fluid restriction, and injection of indomethacin, etc. Because of the risks of transportation, anesthesia and surgery itself, peritoneal drainage has been compared with laparotomy. Through our experience, we investigate the usefulness of peritoneal drainage retrospectively. From 1997 to 2007, six ELBW (M:F=5:1) underwent primary peritoneal drainage for intestinal perforation. Their median birth weight was 685g (405~870) and gestational age was $25^{+1}$ weeks ($24^{+3}{\sim}27^{+0}$). We noticed the intestinal perforation at median 10.5 days (8~18) after birth, and placed Penrose drain or Jackson-Pratt drain through right lower quadrant incision under local anesthesia. The cause of intestinal perforation was necrotizing enterocolitis in one patient, but that of the others was not clear. Three patients who showed normal platelet count and stable vital signs recovered uneventfully. Two patients (birth weight less than 500g) who showed unstable vital signs and low platelet count (12,000 / $mm^3$ to 30,000 / $mm^3$)expired despite aggressive resuscitation. One patient required laparotomy due to persistent intestinal obstruction after drain removal and survived. Our experience shows that peritoneal drainage was an acceptable treatment for ELBW infants and the prognosis was related to vital sign and platelet count at the time of intestinal perforation, and birth weight.