• Title/Summary/Keyword: Survival Period

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Chemoradiotherapy in squamous cell carcinoma of the anal canal: a single institution experience

  • Kim, Kyung Hwan;Chang, Jee Suk;Keum, Ki Chang;Ahn, Joong Bae;Lee, Chang Geol;Koom, Woong Sub
    • Radiation Oncology Journal
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    • v.31 no.1
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    • pp.25-33
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    • 2013
  • Purpose: We reviewed the treatment outcomes and prognostic factors for patients with anal canal carcinoma who were treated with curative intent chemoradiotherapy (CRT) at Severance Hospital from 2005 to 2011. Materials and Methods: Data for 38 eligible patients treated during this period were reviewed. All patients were treated with curative intent using radiotherapy (RT) with (n = 35) or without concomitant chemotherapy (n = 3). Among 35 patients who received CRT, most of the chemotherapeutic regimens were either 5-fluorouracil (5-FU) plus mitomycin C (23 patients) or 5-FU plus cisplatin (10 patients). Recurrence-free survival (RFS), colostomy-free survival (CFS), overall survival (OS), and locoregional control (LRC) rates were calculated using the Kaplan-Meier method and survival between subgroups were compared using the log-rank test. Cox's proportional hazard model was used for multivariate analysis. Results: Over a median follow-up period of 44 months (range, 11 to 96 months), 3-year RFS, CFS, OS, and LRC were 80%, 79%, 85%, and 92%, respectively. In multivariate analysis, tumor size >4 cm was an independent predicting factor for poorer RFS (hazard ratio [HR], 6.35; 95% confidence interval [CI], 1.42 to 28.5; p = 0.006) and CFS (HR, 6.25; 95% CI, 1.39-28.0; p = 0.017), while the presence of external iliac lymph node metastasis was an independent prognosticator for poorer OS (HR, 9.32; 95% CI, 1.24 to 70.3; p = 0.030). No treatment-related colostomies or deaths occurred during or after treatment. Conclusion: Curative intent CRT resulted in excellent outcomes that were comparable to outcomes in previous randomized trials. No severe treatment-related toxicities were observed.

Effect of cold storage method for 'Sulhyang' strawberry mother plants on mother plant growth and the number of runners and daughters

  • Lee, Inha;Kim, Hyun-Sook;Nam, Myeong Hyeon;Oh, Sang-Keun
    • Korean Journal of Agricultural Science
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    • v.47 no.3
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    • pp.625-632
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    • 2020
  • This test was conducted to determine the appropriate conditions of temperature, storage period, and soil moisture content when using cold storage of potted mother plants of as a means of sufficient dormant breaking and safe overwintering of the strawberry (Fragaria × ananassa Duch. cv. Sulhyang) mother plants. In the treatment by temperature for the dormant breaking of strawberry mother plants, the survival rate of natural overwintering was 91%, whereas the survival rate was 100% at 0, - 2, and - 5℃. As the storage temperature was decreased, the plant height of the mother plants became shorter which tended to decrease after planting. Survival of the mother plants was possible at - 5℃, but after planting, the growth and number of daughter plants decreased significantly. The number of daughter plants was highest at 22.8 per plant at - 2℃ storage. The strawberry mother plants could be stored for up to 8 months in cold storage. However, when the mother plants were stored for a long period, the number of daughter plants was small. When they were stored for 4 months, the growth of the mother plants was vigorous, and the number of runners and daughter plants was high. When the water content of the soil was less than 10 percent (%, w/w) in the cold storage of the pot, the survival rate was 85 percent, which was high due to the dryness. The survival rate was 100 percent at 30 and above, and the growth of the mother plants after planting and the number of daughter plants were high at 30 to 50.

Empirical Analysis of Credit Card Delinquency Effect by Market Competition (시장 경쟁이 신용카드 연체부도율에 미치는 효과에 대한 실증분석)

  • Ko, Hyuk-Jin;Seo, Jong-Hyen
    • Journal of the Korea Safety Management & Science
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    • v.11 no.4
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    • pp.261-267
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    • 2009
  • The purposes of this article is to analyse how market competition of credit card company affect price(interest rate) and survival length of card users. This paper uses individual account data from a large Korean credit card company during the periods from 2002 to 2006. The findings of our study are as follows. First, market competition of credit card company have a negative effect with interest rate of credit card. Second, market competition of credit card company have a affirmative effect with survival length. Finally, The effect of Increasing delinquency rate due to price increase is smaller than decreasing delinquency rate due to extending survival length.

Effects of Temperature and Salinity on Early Development, Survival and Growth Rate in Seabass, Lateolabrax Japonicus (농어, Lateolabrax Japonicus의 초기 발달, 성장 및 생존율에 미치는 수온과 염분의 영향)

  • 한형균;강덕영;허성범;김성원
    • Journal of Aquaculture
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    • v.14 no.1
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    • pp.17-27
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    • 2001
  • Effects of temperature (10, 12, 14, 16, 18 and 2$0^{\circ}C$) and salinity (22.0, 24.5, 27.0, 29.5, 32.0 and 34.5 ppt) were studied on incubation period, hatching success, survival and growth of alevin and juvenile seabass, L. japonicus. Embryonic development was accelerated with increasing temperature but it was not influenced by salinity. Hatching success was the highest at 14$^{\circ}C$ and 34.5 ppt. Higher temperature also accelerated the development of mouth opening, absorption of yolk and oil globules, and alevin growth. Survival of the 5-day old Juvenile was accelerated in the following order : 14<16<18<20<12$^{\circ}C$. Rearing experiment of the juvenile for 30-day indicated the faster growth at 13, 20 and 27 ppt than at 34 ppt.

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Radiotherapy Results of Brain Astrocytomas (성상세포종의 방사선치료성적)

  • Suh, Chang-Ok;Kim, Gwi-Eon;Suh, Jung-Ho
    • Radiation Oncology Journal
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    • v.2 no.2
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    • pp.177-184
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    • 1984
  • A retrospective analysis of survival data of i2 cases with brain astrocytomas was presented. All patients received post·operative radiotherapy in the period of $1973\~1983$ at YUMC, Yonsei Cancer Center. There were 24 patients with Grade II, 12 patients with Grade III and 16 patients with Grade IV astrocytomas. Survival rates o ere analyzed according to histologic grade of malignancy, age, tumor location, radiation dose and extent of surgical tumor resection. 5year actuarial survival for patients with Grade II astrocytomas was $32.9\%$ and Grade III was $42.9\%$. The 1 year and 2 year survival rate of Grade astrocytomas were $46.7\%$ and $0\%$. Histologic grade of tumor was important prognostic factor in brain astrocytomas. Age and extent of surgical resection were significant prognostic (actors in all grades of astrocytomas and tumor location and radiation dose were significant in Grade f astrocytomas.

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Surgical Management of Metastatic Lung cancer (전이성 폐암의 외과적 고찰)

  • Kim, Gil-Dong;Jeong, Gyeong-Yeong
    • Journal of Chest Surgery
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    • v.27 no.4
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    • pp.281-286
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    • 1994
  • From 1973 through June 1993, 25 patients underwent pulmonary resection for pulmonary metastases from carcinoma or sarcoma at our institution. There were 11 carcinomas and 14 sarcomas. 24 patients[96% complete] could follow-up and the median follow-up time was 20 months with a range of 4 months to 271 months and total follow-up period was 1105 months-patients. In our patients, actuarial 5-year survival rate was 49%, mean survival time was 66.6$\pm$12.6 months and median survival time was 84 months. Patients with sarcoma, more than 24 months of the tumor-free interval, postoperative adjuvant therapy had a better survival than did those with carcinoma, less than 24 months of the tumor-free interval, no postoperative adjuvant therapy. But there were no statistical differences between two groups[P>0.05]. This results recommend more aggressive surgical treatment for pulmonary metastases.

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Survival Prediction of Rats with Hemorrhagic Shocks Using Support Vector Machine (지원벡터기계를 이용한 출혈을 일으킨 흰쥐에서의 생존 예측)

  • Jang, K.H.;Choi, J.L.;Yoo, T.K.;Kwon, M.K.;Kim, D.W.
    • Journal of Biomedical Engineering Research
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    • v.33 no.1
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    • pp.1-7
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    • 2012
  • Hemorrhagic shock is a common cause of death in emergency rooms. Early diagnosis of hemorrhagic shock makes it possible for physicians to treat patients successfully. Therefore, the purpose of this study was to select an optimal survival prediction model using physiological parameters for the two analyzed periods: two and five minutes before and after the bleeding end. We obtained heart rates, mean arterial pressures, respiration rates and temperatures from 45 rats. These physiological parameters were used for the training and testing data sets of survival prediction models using an artificial neural network (ANN) and support vector machine (SVM). We applied a 5-fold cross validation method to avoid over-fitting and to select the optimal survival prediction model. In conclusion, SVM model showed slightly better accuracy than ANN model for survival prediction during the entire analysis period.

The Comparative Analysis of Financial Factors that influence on Corporate's Survival and Bankruptcy : Before and After Foreign Exchange Crisis in Korea (기업의 생존과 도산에 영향을 미치는 재무요인에 대한 실증분석 : 우리나라 외환위기 전.후 비교)

  • Bae, Young-Im;Song, Sung-Hwan;Hong, Soon-Ki;Yu, Sung-Yoon
    • IE interfaces
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    • v.21 no.4
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    • pp.385-393
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    • 2008
  • Corporate's survival or bankruptcy has been determined by interaction of macroeconomic environment, industrial dynamic environment and internal process of corporate. This study attempts to examine financial factors' differences that have influence on corporate's survival or bankruptcy before and after foreign exchange crisis in Korea. The first previous empirical study that researched the cause of corporate's survival or bankruptcy in the financial ratios was attempted by Altman in 1968. Recently various survival analysis models have been published. In this paper, Multiple Discriminant Analysis model is used. We divide analytical periods into before and after foreign exchange crisis and sample randomly survival or bankruptcy firms for each period. Independent variables are financial ratios which represent growth, profitability, activity, liquidity and productivity. In conclusion, this paper examines hypothesis as "There are differences of significant financial factors before and after foreign exchange crisis."

The Prognostic Factors and Survival Rate in Thyroid Carcinoma (갑상선암의 예후적 인자와 생존율)

  • Lee Seung-Jae;Kim Sang-Hyo;Paik Nak-Whan
    • Korean Journal of Head & Neck Oncology
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    • v.9 no.1
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    • pp.33-41
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    • 1993
  • A multivariate analysis of the prognostic factors and five year survival rate was carried out on a series of 72 thyroid cancers treated surgically from 1980 to 1987 and followed for 1 to 11 years. The prognosis of the disease was significantly influenced by age at diagnosis, extracapsular invasion, angioinvasion and pathologic type, but the disease was not influenced by sex, lymph node metastasis, and 'risk' category. The overall five year survival rate was 89.7%. Six patients were dead of tumor after surviving for six months to two and half years, and the cause of death was local recurrence in three, lung metastasis in two and bone metastasis in one patient. Five year survival rate in age above fifty, presence of capsule and angioinvasion, follicular carcinoma, and extrathyroidal lesion was significantly shorter than that of patients with age below fifty, absence of capsule and angioinvasion, papillary carcinoma, and intrathyroidal lesion. Patients at low risk or with small carcinomas had long survival over 5 years with only lobectomy. Lymph node dissection was done with a limited type in no jugular metastasis, radical neck disscetion was performed only therapeutically in proved jugular node metastasis. Thyroid hormone was administered for the period of 3 to 5 years to suppress endogenous TSH production.

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One-year Survival Rate of Patients with Primary Malignant Central Nervous System Tumors after Surgery in Kazakhstan

  • Akshulakov, Serik;Igissinov, Nurbek;Aldiyarova, Nurgul;Akhmetzhanova, Zauresh;Ryskeldiyev, Nurzhan;Auezova, Raushan;Zhukov, Yevgeniy
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6973-6976
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    • 2014
  • This study was conducted to evaluate the one-year survival rate of patients with primary malignant central nervous system (CNS) tumors after surgical treatment in Kazakhstan. Retrospective data of patients undergoing operations in the Department of Central Nervous System Pathology in the JSC National Centre for Neurosurgery in the period from 2009 to 2011 were used as the research material. Kaplan-Meier survival analysis was performed with the following information: gender, date of birth, place of residence, diagnosis according to ICD-10, the date of the operation, the morphological type of tumor, clinical stage, state at the end of the first year of observation, and the date of death. The study was approved by the ethical committee of the JSC National Centre for Neurosurgery. The overall one-year overall survival rate (n=152) was 56.5% (95% confidence interval (CI): 50.2-62.7), and 79.5% (95% CI 72.2-86.8) and 33.1% (95% CI: 21.0-42.3) for Grades I-II (n=76) and Grades III-IV (n=76), respectively. Significant prognostic factors which affected the survival rate were age and higher tumor grade (Grades III-IV), corresponding with results described elsewhere in the world.