• 제목/요약/키워드: Suppression Methods

검색결과 732건 처리시간 0.022초

Glycolytic and oxidative muscles under acute glucose supplementation differ in their metabolic responses to fatty acyl-CoA synthetase gene suppression

  • Jung, Yun Hee;Bu, So Young
    • Journal of Nutrition and Health
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    • 제55권1호
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    • pp.70-84
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    • 2022
  • Purpose: Skeletal muscles display significant heterogeneity in metabolic responses, owing to the composition of metabolically distinct fiber types. Recently, numerous studies have reported that in skeletal muscles, suppression of genes related to fatty acid channeling alters the triacylglycerol (TAG) synthesis and switches the energy substrates. However, such responses may differ, depending on the type of muscle fiber. Hence, we conducted in vitro and animal studies to compare the metabolic responses of different types of skeletal muscle fibers to the deficiency of fatty acyl-CoA synthetase (Acsl)6, one of the main fatty acid-activating enzymes. Methods: Differentiated skeletal myotubes were transfected with selected Acsl6 short interfering RNA (siRNA), and C57BL/6J mice were subjected to siRNA to induce Acsl6 deficiency. TAG accumulation and expression levels of insulin signaling proteins in response to acute glucose supplementation were measured in immortalized cell-based skeletal myotubes, oxidative muscles (OM), and glycolytic muscles (GM) derived from the animals. Results: Under conditions of high glucose supplementation, suppression of the Acsl6 gene resulted in decreased TAG and glycogen synthesis in the C2C12 skeletal myotubes. The expression of Glut4, a glucose transporter, was similarly downregulated. In the animal study, the level of TAG accumulation in OM was higher than levels determined in GM. However, a similar decrease in TAG accumulation was obtained in the two muscle types in response to Acsl6 suppression. Moreover, Acsl6 suppression enhanced the phosphorylation of insulin signaling proteins (Foxo-1, mTORc-1) only in GM, while no such changes were observed in OM. In addition, the induction ratio of phosphorylated proteins in response to glucose or Acsl6 suppression was significantly higher in GM than in OM. Conclusion: The results of this study demonstrate that Acsl6 differentially regulates the energy metabolism of skeletal muscles in response to glucose supplementation, thereby indicating that the fiber type or fiber composition of mixed muscles may skew the results of metabolic studies.

자기계측 기능을 이용한 압전 빔의 잔류진동 제어 (Residual Vibration Suppression of a Piezoelectric Beam Using a Self-sensing Technology)

  • 남윤수;장후영;박종수
    • 한국정밀공학회지
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    • 제24권3호
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    • pp.67-75
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    • 2007
  • This paper deals with a problem of vibration suppression of a piezoelectric beam using a self-sensing algorithm. Two methods, which are PPF(positive position feedback) and SRF(strain rate feedback), are considered to suppress a residual vibration of a piezoelectric beam developed during the step positioning of a beam end point. A self-sensing algorithm treated here is basically a strain rate estimator of a beam movement and is to be used for the closed loop control. The efficacy of the proposed idea is evaluated through experiments.

2-관성 공진계의 진동 억제를 위한 기준 입력 궤적에 관한 연구 (Study on Reference Trajectory Planning for Vibration Suppression of 2-Mass System)

  • 권혁성;이학성
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 A
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    • pp.123-126
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    • 2003
  • This paper presents an speed reference trajectory planning methods for vibration suppression in a t-mass resonant system which has a flexible coupling between a load and a driving motor. Due to this flexibility, the system often suffers vibration especially when the motor is controlled for higher speed command. The steady state conditions are utilized to derive desired load speed trajectory which does not cause the torsional vibration. And the desired motor speed trajectory is synthesized base on the relation between load and motor speed. The simulation and experiment result suggest that the proposed method effectively suppress the vibration.

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LFM 신호의 펄스압축에 대한 부엽억제 성능향상 기법연구 (A Study on the Performance Improvement in Sidelobe Suppression for Pulse Compression of LFM Signal)

  • 신정훈
    • 한국군사과학기술학회지
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    • 제9권3호
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    • pp.95-100
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    • 2006
  • The pulse compression technique using Linear FM signal is commonly used for improving the performance of both the detection range and range resolution in radar system. In general, the compressed LFM waveform has relatively large sidelobe level which may prevent a target from being detected when strong jammer or clutter signal is near the target signal. In this paper, we propose a new weighting method which uses the square-root weight to suppress the sidelobe level. Typical applications are missile seekers and tracking radar systems where target tracking range is available prior to the signal processing. By computer simulation, we show that the performance of the proposed method is better than that of the conventional weighting methods in terms of sidelobe suppression.

FASCAM을 이용한 적 진지 지역 화력 억제 분석 절차 연구 (Analysis Procedure for Fire Power Suppression on Enemy Artillery Base Using FASCAM)

  • 김태구;서성철;정경원
    • 한국군사과학기술학회지
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    • 제18권6호
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    • pp.743-754
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    • 2015
  • FASCAM is a newly introduced mean against enemy fire power and supposed to be scattered on base areas in front of a tunnel so as to deter maneuver and shooting of enemy artilleries. However, for its characteristics different from conventional munitions, only a few studies have been undertaken on operations system using this new measure. In this research, we propose a procedure to describe and analyze mathematically an operation system for suppression of enemy fire power using FASCAM. Two suggested simulation methods, impact point generation and density integration, both can describe the actual operation rationally and each has advantages of its own respectively. Further, we demonstrated an example analysis to derive an optimal suppression plan based on the proposed procedure.

Suppression of IEEE 802.11a Interference in TH-UWB Systems Using Singular Value Decomposition in Wireless Multipath Channels

  • Xu, Shaoyi;Kwak, Kyung-Sup
    • Journal of Communications and Networks
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    • 제10권1호
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    • pp.63-70
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    • 2008
  • Narrow-band interference (NBI) from the coexisting narrow-band services affects the performance of ultra wideband (UWB) systems considerably due to the high power of these narrow-band signals with respect to the UWB signals. Specifically, IEEE 802.11a systems which operate around 5 GHz and overlap the band of UWB signals may interfere with UWB systems significantly. In this paper, we suggest a novel NBI suppression technique based on singular value decomposition (SVD) algorithm in time hopping UWB (TH-UWB) systems. SVD is used to approximate the interference which then is subtracted from the received signals. The algorithm precision and closed-form bit error rate (BER) expression are derived in the wireless multipath channel. Comparing with the conventional suppression methods such as a notch filter and a RAKE receiver, the proposed method is simple and robust and especially suitable for UWB systems.

초고층 건물의 재난 발생 시 작전전술 방안 (The Way of operations and tactics for Disaster plan of High-rise Buildings)

  • 이정일
    • 대한안전경영과학회지
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    • 제14권3호
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    • pp.77-83
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    • 2012
  • Recently, For the most efficient use of spaceis, high-rise buildings tend to increase. So it is with Korea, too. Besides, today high-rise buildings grows due to fire damage to life and property at large. In this study, Through analysis of domestic and foreign fire case and listen to the high-rise building fire managers, tenants, professionals advice, when the fire from the high-rise building, effective fire suppression tactics should we wish to research ways. In addition, we have used the car gondola was installed outside the fire suppression methods in studying. So that fire-fighting is a fire place can be reached quickly, many casualties and property damage, will be reduced.

CFD/CSD 및 최적제어기법을 연계한 3-자유도계 에어포일의 플러터 억제 (Flutter Suppression of a 3-DOF Airfoil Using CFD/CSD with Integrated Optimal Control Method)

  • 김동현;김현정
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2005년도 추계학술대회논문집
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    • pp.929-929
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    • 2005
  • In this study, computational demonstrations for the flutter suppression are presented for the 3-DOF airfoil system with oscillating flap. Advanced computational methods such as computational fluid dynamics (CFD) and computational structural dynamics (CSD) are used and a simultaneous coupling method has been developed to accurately conduct flutter analyses. In addition, optimal control theory is integrated into the CFD based flutter analysis method to construct the coupled aeroservoelastic analysis system for the airfoil with oscillating flap. For a well-defined typical section model, fundamental unsteady aerodynamics and flutter characteristics are investigated. Finally, to show the effectiveness of flutter control the physical aeroelastic responses are directly compared between the open loop and the closed loop systems.

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물리치료사의 정서억제와 직무탈진이 직무만족에 미치는 영향 (Effects of the Emotional Suppression and Burnout on the Job Satisfaction among Physical Therapists)

  • 배원식;이건철;오혜원
    • 대한물리의학회지
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    • 제6권2호
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    • pp.177-187
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    • 2011
  • Purpose: The purpose of this study was to identify the effect of emotional suppression and burnout on the job satisfaction. Methods: We distributed questionnaires to 216 physical therapists and collected completed questionnaires from 193. We analyzed the data using frequency analysis, independent t-tests, analysis of variance. and multiple regression. Results: The results were as follows; 1) General characteristics of participants were 62.7% male, 43.5% less 30 years old, 31.6% working over 10 years in the hospital. 27.1% participants treated 31 patients or more a day, most(85.5%) participants were regular staff members. 2) Emotional Suppression, exhaustion and diminished self-efficacy were significantly correlated with job satisfaction. According to result of regression analysis on the job satisfaction, the job satisfaction negatively related with the diminished self-efficacy, exhaustion but positively related with the emotional supression. Their power of explanation regarding job satisfaction was 31.2%. Conclusion: These results showed that diminished self-efficacy was importantly influenced on the job satisfaction. So this result of the study means that we must improve the stratege for keeping efficient management.

FMCW 전파고도계의 재밍 탐지 및 회피 알고리즘 (Jamming Detection and Suppression Algorithm for an FMCW Radar Altimeter)

  • 이재환;장종훈;노진입;유경주;최재현
    • 한국전자파학회논문지
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    • 제27권2호
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    • pp.147-155
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    • 2016
  • 본 논문에서는 주파수 변조 연속파(FMCW) 전파고도계의 재밍 환경에서의 강인한 고도 측정을 위한 재밍 탐지/회피 알고리즘을 제안한다. 전파고도계 재밍 탐지 알고리즘은 재밍 탐지를 위해 송수신 구간 앞에 노이즈 측정구간을 두어 노이즈 레벨을 측정하고, 샘플링한 노이즈파형에 대해 재밍 임계치를 넘는 포인트를 산출하여 재밍을 탐지한다. 재밍 회피 알고리즘으로 시간영역에서의 재밍 회피, 송신 출력 및 수신 이득 제어, 주파수 도약을 설계하였다. 제안한 알고리즘은 실제적인 환경에서 평가하기 위한 야외시험을 통해 성공적으로 검증하였다.