• Clean Technology
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• v.13 no.1 s.36
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• pp.34-45
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing dichloromethane as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of dichloromethane and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the dichloromethane composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature. The second half of this work is focused on the particle formation of the simvastatin drug by a supercritical anti-solvent recrystallization process in a cylindrical high-pressure vessel equipped with an impeller. Microparticles of the simvastatin drug were prepared as functions of pressure (8 MPa to 12 MPa), temperature (303.15 K, 313,15 K), feed flow rate of carbon dioxide, and stirring speed (up to 3000 rpm), in order to observe the effect of those process parameters on the size and shape of the drug microparticles recrystallized.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2017.05a
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• pp.803-810
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• 2017

the liquid oxygen transitions to a supercritical state, causing rapid changes in properties and pseudo boiling in supercritical combustion. the combustion reaction operating in a supercritical state depends on the turbulence diffusion caused by difference of density, therefore, a study of the diffusion flow and pseudo boiling is required. Many researchers have studied these phenomena in the supercritical combustion, but A case study by various variables is inadequate. In this study, the flow field and flame structure were investigated numerically by changing the recirculation flow and liquid oxygen core length through oxygen-fuel ratio(O/F), combustor diameter and recess ratio at supercritical pressure condition.

• Journal of ILASS-Korea
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• v.9 no.3
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• pp.8-14
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• 2004

Characteristics of droplet vaporization at high ambient pressures and temperatures which are supercritical conditions is studied numerically by formulating one dimensional vaporization model in liquid dodecane and air. Modified Soave-Redlich-Kwong state equation is used to condider real gas effect. Non-ideal behavior of properties at near critical and supercritical conditions is considered in the high pressure condition. Characteristic spatial distribution of properties with various conditions of pressure and temperature is evaluated in order to understand vaporizing evolution.

• Clean Technology
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• v.10 no.4
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• pp.215-220
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• 2004

Micronized acetaminophen was precipitated from ethanol solution using supercritical $CO_2$ as antisolvent. A coaxial nozzle was used to introduce the supercritical $CO_2$ and the acetaminophen/ethanol solution. The effects of pressure, temperature, $CO_2$ flow rate and solvent flow rate were studied in the constant pressure and temperature condition. The particle size and morphology were influenced by the variations of precipitation condition. The particle size and morphology were analyzed with scanning electron microscopy.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.11a
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• pp.597-600
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• 2010

Cold flow injection test was conducted to investigate the characteristics of cryogenic liquid nitrogen jet at sub to supercritical condition. Single jet injector element was installed in high pressure chamber to investigate the effect of ambient pressure around the jet, injector geometry and flow conditions. Experimental results showed obvious differences between jet characteristics under subcritical and supercritical condition. Effect of injector inlet shape also was investigated.

• 한국연소학회:학술대회논문집
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• 2014.11a
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• pp.311-313
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• 2014

High pressure combustion with multiphase--liquid, gas, and supercritical phase--mixtures are widely used technology in the high efficiency liquid propellent rocket engine. This is the typical characteristics differentiate from the combustor of conventional air-breathing engines. Therefore, successful research of high pressure combustion at supercritical condition is essential to develope a high efficiency liquid rocket engine. Numerical studies have been carried out to explore capabilities of numerical method for LOx-CH4 non-premixed flames at high pressure. In this paper, corresponding numerical results are presented and compared with experimental result of MASCOTTE facility.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.11
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• pp.1595-1603
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• 2003

Droplet combustion at high ambient pressures is studied numerically by formulating one dimensional combustion model in the mixture of n-heptane fuel and air. The ambient pressure is supercritical conditions. The modified Soave-Redlich-Kwong state equation is used in the evaluation of thermophysical properties to account for the real gas effect on fluid p-v-T properties in high pressure conditions. Non-ideal thermodynamic and transport property at near critical and supercritical conditions are also considered. Several parametric studies are performed by changing ambient pressure and initial droplet diameter. Droplet lifetime decreased with increasing pressure. Surface temperature increased with increasing pressure. Ignition time increased with increasing initial droplet diameter. Temporal or spatial distribution of mass fraction, mass diffusivity, Lewis number, thermal conductivity, and specific heat were presented.

• Nuclear Engineering and Technology
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• v.36 no.5
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• pp.403-414
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• 2004

An experimental study of heat transfer characteristics near the critical pressure has been performed with an internally-heated vertical annular channel cooled by R-134a fluid. Two series of tests have been completed: (a) steady-state critical heat flux (CHF) tests, and (b) heat transfer tests for pressure reduction transients through the critical pressure. In the present experimental range, the steady-state CHF decreases with increase of the system pressure for fixed inlet mass flux and subcooling. The CHF falls sharply at about 3.8 MPa and shows a trend towards converging to zero as the pressure approaches the critical point of 4.059 MPa. The CHF phenomenon near the critical pressure does not lead to an abrupt temperature rise of the heated wall, because the CHF occurs at remarkably low power levels. In the pressure reduction transients, as soon as the pressure passes below the critical pressure from the supercritical pressure, the wall temperatures rise rapidly up to very high values due to the departure from nucleate boiling. The wall temperature reaches a maximum at the saturation point of the outlet temperature, and then tends to decrease gradually.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3395-3400
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• 2007

Heat transfer experiments at a vertical annulus passage were carried out in the SPHINX(Supercritical Pressure Heat Transfer Investigation for NeXt Generation) to investigate the heat transfer behaviors of supercritical $CO_2$. The collected test data are to be used for the reactor core design of the SCWR (SuperCritical Water-cooled Reactor). The mass flux was in the range of 400${\sim}$1200 kg/$m^2$s and the heat flux was chosen up to 150 kW/$m^2$. The selected pressures were 7.75 and 8.12 MPa. The heat transfer data were analyzed and compared with the previous tube test data. The test results showed that the heat transfer characteristics were similar to those of the tube in case of a normal heat transfer mode and degree of heat transfer deterioration became smaller than that in the tube. Comparison of the experimental heat transfer coefficients with the predicted ones by the existing correlations showed that there was not a distinct difference between the correlations.

• Journal of environmental and Sanitary engineering
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• v.16 no.4
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• pp.69-76
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• 2001

The catalytic oxidation of volatile organic compounds (VOCs), which were benzene and toluene, was studied in the supercritical carbon dioxide($SC-CO_2$) media. In $SC-CO_2$ media, the deep oxidation conversion of VOCs was increased with the temperature and pressure. The deep oxidation conversion in SC -$CO_2$ media is better than that in air media at same pressure condition. This can be explained by the solubility of VOCs in $SC-CO_2$. The many intermediates produced by the partial oxidation of VOCs were detected from off-line samples. The intermediates were Identified as benzene, toluene, benzaldehyde, phenol, naphthalene, 1,1`-biphenyl, benzoic acid, 3-methylphenol, 1,1'-(1,2-ethanediyl)bis- benzene, 1,1'-(1,2-ethene- diyl)bis-benzene, anthracene, and so on. The amount of intermediates was decreased as the molar radio of oxygen to carbon dioxide was decreased. When the molar ratio of oxygen to carbon dioxide was 1 : 16, the deep conversion was kept constant. Thus, the catalytic oxidation process in $SC-CO_2$ media can be combined on-line with supercritical fluid extraction of environmental matrices and supercritical regeneration of used adsorbent. Thus, the nontoxic $SC-CO_2$ media process was suggested as the new VOCs control technology.