• 한국의학물리학회지:의학물리
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• 제13권1호
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• pp.1-8
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• 2002

치료방사선 선형가속기에서 출력되는 광자선의 선속 (flux)에는 gantry head로부터 발생되는 오염전자를 포함하고 있으며, 오염전자의 발생은 주로 gantry head의 부속장비 또는 방사선 치료를 위해 gantry head 밑에 설치되는 부속장치 등에서 광자선과 매질의 전자쌍생성, 또는 컴프톤 산란전자 등의 물리적 현상으로 발생된다. 오염전자는 표면영역의 수cm 깊이의 선량 분포에 영향을 주고 있으며, 이것은 방사선 치료 시 skin-sparing 효과를 감소시키는 등 임상적인 측면에 영향을 주고 있다. 그러므로 선형가속기에서 발생되는 오염전자의 특성을 이해 할 필요가 있다. 본 연구는 선형가속기 (Clinac 1800, Varian )에서 출력되는 15MV 광자 선속에서 조사야의 크기가 0.0$\times$10.0 to 30.0$\times$30.0 $\textrm{cm}^2$에서 30.0$\times$30.0 $\textrm{cm}^2$ 대해 구리판(Cu)의 부분적 오염전자 제거 능력과, 조사야의 부분 차폐 방법을 이용하여 물팬톰 내의 선량분포의 변화를 측정하므로써 오염전자의 특성을 분석하였다. 그 결과 오염전자는 조사야의 중심축으로부터 넓게 퍼진 cone 모양의 분포를 하고 있었으며, 또한 오염전자가 갖는 평균 에너지는 약 3.0MeV로 나타났다. 그러므로 오염전자는 표면으로부터 2.5cm 깊이까지 분포하였다. 이러한 결과로써 광자선속에 포함된 오염전자를 제거하고 순수한 광자선을 이용한다면 buildup 영역 및 표면선량이 감소되고, 최대선량지점이 좀더 깊어진다.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.105-113
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• 2016

Purpose: Susceptibility vessel sign (SVS) on gradient echo image, which is caused by MR signal loss due to arterial thrombosis, has been reported in acute middle cerebral artery (MCA) infarction. However, the reported sensitivity and diagnostic accuracy of SVS have been variable. Susceptibility-weighted imaging (SWI) is a newly developed MR sequence. Recent studies have found that SWI may be useful in the field of cerebrovascular diseases, especially for detecting the presence of prominent veins, microbleeds and the SVS. The purpose of this study was to evaluate the diagnostic values of SWI for the detection of hyperacute MCA occlusion. Materials and Methods: Sixty-nine patients (37 males, 32 females; 46-89 years old [mean, 69.1]) with acute stroke involving the MCA territory underwent MR imaging within 6 hours after the symptom onset. MR examination included T2, FLAIR (fluid-attenuated inversion recovery), DWI, SWI, PWI (perfusion-weighted imaging), contrast-enhanced MR angiography (MRA) and contrast-enhanced T1. Of these patients, 28 patients also underwent digital subtraction angiography (DSA) within 2 hours after MR examination. Presence or absence of SVS on SWI was assessed without knowledge of clinical, DSA and other MR imaging findings. Results: On MRA or DSA, 34 patients (49.3%) showed MCA occlusion. Of these patients, SVS was detected in 30 (88.2%) on SWI. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of SWI were 88.2%, 97.1%, 96.8%, 89.5% and 92.8%, respectively. Conclusion: SWI was sensitive, specific and accurate for the detection of hyperacute MCA occlusion.

• 대한전자공학회논문지SP
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• 제42권4호
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• pp.79-86
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• 2005

본 논문에서는 실시간 얼굴인식 시스템을 위한 새로운 LINF(Linear Independent Non-negative Factorization) 알고리즘을 제안한다. 시스템은 크게 얼굴추출 부분과 얼굴인식 부분으로 구성 되어 있으며, 얼굴추출 부분에는 차영상, 눈과 입의 영역 검출 그리고 정규화 방법을 사용하였고, 얼굴인식 부분에는 추출된 얼굴 후보 영역 영상에 LINF 를 적용하였다. 기존의 PCA(Principal Component Analysis)만을 사용한 인식시스템은 낮은 인식률을 보였으며, LDA(Linear Discriminants Analysis)만을 사용한 인식시스템에서는 학습데이터의 수에 비하여 영상의 화소 개수가 많은 경우 LDA를 그대로 적용하기 곤란하였다. 이러한 단점을 극복하기 위하여, 본 논문에서 제안하는 시스템은 기존의 고유얼굴과 달리 비음수 값을 갖는 행렬로 차원을 축소하여 LDA를 적용하였다. 제안한 시스템의 성능을 평가하기 위하여 자체 제작한 DAUface 데이터베이스와 영국 Cambridge 에 있는 AT&T 연구소에서 제공하는 ORL 데이터베이스를 가지고 실험을 하였다. 실험 결과, 제안된 방법이 PCA 방법과 LDA 방법, ICA(Independent Component Analysis) 방법, 그리고 PLMA(PCA-based LDA mixture algorithm)에 비해 인식률이 상당히 우수함을 알 수 있었다.

• 전자공학회논문지
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• 제54권2호
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• pp.123-129
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• 2017

본 논문에서는 이중 마이크로폰 배열을 이용하여 비음수 행렬분해(nonnegative matrix factorization, NMF) 기반으로 다중음원의 도래각을 추정하는 새로운 방법을 제안한다. 우선 이중 마이크로폰 배열에 들어온 음향 신호들을 연속된 분석프레임으로 분할한 후, 각 프레임에 대해 조향응답파워 위상변환(steered-response power phase transform, SRP-PHAT) 빔형성기를 적용하여 스테레오 신호들을 시간-방향 영역으로 표현한다. 이러한 SRP-PHAT의 시간-방향 출력값들은 사전에 정의된 프레임 수만큼 누적하여 시간-방향 블록으로 정의한다. 다음으로, 잡음에 강건한 도래각 추정을 위하여, 각 시간-방향 블록을 블록차감 기법을 사용하여 매 프레임에 대해 정규화한다. 이후, 다중음원 환경에서 각 음원의 방향을 클러스터링하기 위해 정규화된 시간-방향 블록에 비지도(unsupervised) NMF를 적용한다. 구체적으로, 음원의 개수와 이들의 도래각을 추정하는데 각각 활성 및 기저 행렬들을 사용한다. 제안된 방법의 도래각 추정 성능을 평가하기 위해 이중 마이크로폰 배열로부터 입력된 [$-35{\circ}$, 5m], [$12{\circ}$, 4m], 그리고 [$38{\circ}$, 4.m]에 각각 위치한 세 가지 음원들에 대한 추정 오차의 절대 평균(mean absolute error, MAE) 및 오차의 표준편차를 측정하였다. 실험 결과. 제안된 방법은 기존의 SRP-PHAT 기반 도래각 추정방법에 비해 상대적으로 MAE를 56.83% 줄일 수 있었다.

• 사상체질의학회지
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• 제10권2호
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• pp.455-471
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• 1998

1. 연구배경 및 목적 소양인(少陽人) 신정방(新定方)의 하나인 양격산화탕(凉膈散火湯)의 효능(效能)과 활용(活用)에 대한 임상적(臨床的) 연구(硏究)를 통해 사상체질병증(四象體質病證)의 이해(理解)와 방제(方劑)의 운용(運用)에 도움을 주고자 한다. 2. 방법 1997년 3월부터 1998년 2월까지 1년간 동국대학교 분당한방병원 체질의학클리닉에 내원(來院)한 환자들 중 양격산화탕(凉膈散火湯)이 20첩 이상 투여되고 경과관찰(經過觀察)이 가능했던 65명(남자 40명, 여자 25명)을 대상으로 양격산화탕(凉膈散火湯)이 투여된 환자의 특성, 치료효과, 부작용 등에 관하여 조사하고 분석하였다. 3. 결과 소양인(少陽人)의 양격산화탕(凉膈散火湯)은 남녀 구별 없이 모든 연령층에서 사용되었으며, 대상환자들의 주소증은 흉민(胸悶), 수족병(手足病), 운동장애(運動障碍), 구건(口乾), 상열감(上熱感) 등 37종류였다. 치료효과의 분포는 호전이 58.5%, 우수가 12.3%, 별무변화가 29.3%였으며 악화는 없었다. 전신상태(全身狀態)의 특징으로는 설태(舌苔)가 백태(白苔) 또는 황태(黃苔)를 띄거나 간출이상(刊出異常)이 있는 경우가 많았다. 처방(處方)을 활용할 때는 처방의 변경없이 양격산화탕(凉膈散火湯)만을 사용한 경우가 많았으며 병증(病症)에 따라 약물을 증량(增量)하거나 가미(加味)하여 사용하였다. 양격산화탕(凉膈散火湯)의 치료효과(治療效果)에는 약물의 가감유무(加減有無)가 영향을 미쳤으며, 효과발현시간(效果發顯時間)은 연령이 젊을수록 빠른 것으로 나타났다. 부작용으로는 심계(心悸), 복통(腹痛) 및 소화불량(消化不良) 등이 있었다.

• The Korean Journal of Physiology
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• 제2권2호
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• pp.93-99
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• 1968

The Present study attempted to analyze the fate of CO diffused into the circulating blood through the alveoli. Dogs were induced to CO poisoning by rebreathing CO gas mixture contained in Krog's spirometer, by closed circuit method, for 60 minutes. The spirometer was filled initially with 282 ml of CO and 20 liters of air and oxygen, so the composition of gases were arranged as 1.4% in CO and 50% in $O_2$ at the begining of the rebreathing. Oxygen was added corresponding to the utilization of $O_2$ by the animal in proceeding of the experiment. At 60th minutes of CO rebreathing, the concentration of CO in arterial blood and in mixed venous blood were analysed and compared with each other after the CO contents were corrected with the hematocrit measured in the arterial and mixed venous blood. The distribution of CO gas to other tissues was estimated by the analysis of CO diffused into the cystic bile and into the peritoneal gas pocket which was formed by injection of 300 ml air into the peritoneal cavity prior to the CO gas rebreathing. The blood volume was measured by dilution method using $^{51}Chromium$ tagged red cells. CO amount vanished in the animal body was calculated by subtraction of total CO content in blood stream and the CO remained in closed circuit breathing system from the CO amount given to the breathing system at the begining of the experiment. Results obtained are summarized as follows: 1. The content of CO corrected by the hematocrit value was slightly less in mixed venous blood than in arterial blood. The amount of CO diffused into the cystic bile and into the peritoneal cavity was averaged to 0.1% and 0.4% of the CO amount in 100 ml of blood, respectively. 2. For 60 minutes of CO rebreathing, CO-hemoglobin saturation reached about 77% at the 60th minutes, CO amount vanished in the experimental animal averaged 36.1 ml/dog/hr., or 21% of the total CO volume in the blood stream. The average vanishing rate of CO during 60 minutes of CO rebreathing per kg of body weight was 2.71 ml/hr. Production of CO measured in ten dogs under hypoxic condition averaged 0.023 ml/kg/hr. The major part of the CO vanished in the dogs seemed to be oxidized to $CO_2$ by various tissues of the animal. The conclusion might be delivered as such oxidation of CO to $CO_2$ by animal tissues can play a role in part of the process of recovery and protection of animal from CO-poisoning.

• 대한핵의학회지
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• 제24권1호
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• pp.29-36
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• 1990

Most of the diagnostic methods currently used for the detection of neoplastic masses provide indirect evidence. To obtain greater specificity in the interpretation of neoplasias by in vivo methods, the immunological approach appears to be most promising. Two problems that interfered with progress in this field were the lack of tumor specific antigen and the lack of well-defined and reproducible antibodies. To improve the sensitivity and specificity of radioimmunoscintigraphy as a technique for tumor localization, the use of monoclonal antibodies, fragments of antibodies and single photon emission computerized tomography (SPECT) are reasonable. The obvious advantages of monoclonal antibodies are their homogeneity, their specificity for the immunizing antigen and the reaction with a single determinant-thus no large immunecomplexes with antigen are formed. Monoclonal antibody technique has recently provided an opportunity to reevaluate the role of nuclear medicine for the diagnosis of malignant diseases by using the immunological approach. Out first results by means of radioimmunoscintigraphy of CEA and CA 19-9 producing tumors using a cocktail of fragments F $(ab')_2$, of mocolonal antibodies to CA 19-9 and CEA labeled with $^{131}I$ (IMACIS-1) are reported. The aims of this investigation was to evaluate the role of immunoscintigraphy in patients with colorectal and other cancers for diagnosis of local recurrences and metastasis. This report contains results of the first 8 colorectal and pancreas cancer patients with the elevation of the level of serum CEA and/or CA 19-9. IMACIS-1 was injected intravenously during 30 minutes in 100 ml saline solution after skin test. Planar scintigrams were recorded 3, 5 and 7 days after the injection of the IMACIS-1. Anterior, lateral and posterior views of the liver as well as anterior and posterior views of the pelvis were obtained in each patients as an $^{131}I-antibody$ image. We were able to localize exactly the malignant process with the double-nuclide double-compound $^{99m}Tc\;^{131}I$ (Tc+l) scintigrams. In Tc & I double-nuclide scintigraphy, computer subtraction display provided more clear localization of the tumor. We compared the results of radioimmunoscintigraphy with CT, ultrasonograms, conventional scintigrams. The results were as follows: 1) The sensitivity and specificity of radioimmunoscintigraphy using the fragments $F(ab')_2$ of the cocktails of CEA and CA 19-9 monoclonal antibodies were 80% and 100% respectively. 2) Tumor detection rate was not proportionated to the level of serum tumor markets. 3) Second tracer technique was essential for tumor localization as an anatomic landmark using double-nuclide scintigraphy. 4) A slow infusion of the antibodies was necessary to prevent the formation of large immune complexes. 5) Tumor/non-tumor radioactivity was most elevated at 7 days delayed imaging. 6) Using planar scintigraphic technique of $^{131}I$ labeled monoclonal antibodies are possible for imaging most of the tumors.

• Animal Systematics, Evolution and Diversity
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• nspc2호
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• pp.233-241
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• 1988

강화도 동남단 초지진 조간대 개펼에서 1983년 6, 7, 9, 11월 에 각각 무작위 채집한 칠게 (Macrophthalmus (Mareotis) japonicus De Haan 1835) 의 갑핍, 갑장, 체고를 각각 측정하여 이들의 빈도분포와 확률도를 비교분석하여 성장을 분석하고 이들 각 부위간의 상관성도 분석하였다. 철게의 성장은 가을철보다 여름철에 우세하였으며 6월에 여러 무리의 크기가 출현하였으나 가을에는 이들이 크기로는 한 무리로 나타났으며 여름의 성장도는 갑핍이 10%를 웃돌았다. 그리고 성장관계를 규명하기 위하여는 갑핍의 측정이 가장 유용하다. 그리고 칠게가 성장함에 따라 갑장에 대한 갑핍의 비율이 커지며, 갑핍을 독립변수로 할 때 갑장과의 상관관계식의 기울기는 개체가 성장함에 따라 작아진다. 여름에 칠게의 성장이 가을보다 빠른 것은 중역도지방생물의 계절적 주기에서 생리현상이 활성화되는 시기인데다가 동시에 수반되는 영양상태의 호조건이 부합된 때문이다. 가을이 되면 이 활성이 점차 감소되기도 하고 칠게 개체가 성장한계에 다다르기도 하여 성장이 둔화된다. 그리고 칠게가 성장함에 따라 갑장보다는 갑핍의 성장0이 빠른 것도 하나의 형태적 특정일 수 있겠다.

• Annals of Pediatric Endocrinology and Metabolism
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• 제23권4호
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• pp.196-203
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• 2018

Purpose: The hemoglobin glycation index (HGI) represents the degree of nonenzymatic glycation and has been positively associated with cardiometabolic risk factors (CMRFs) and cardiovascular disease in adults. This study aimed to investigate the association between HGI, components of metabolic syndrome (MS), and alanine aminotransferase (ALT) in a pediatric nondiabetic population. Methods: Data from 3,885 subjects aged 10-18 years from the Korea National Health and Nutrition Examination Survey (2011-2016) were included. HGI was defined as subtraction of predicted glycated hemoglobin ($HbA1_c$) from measured $HbA1_c$. Participants were divided into 3 groups according to HGI tertile. Components of MS (abdominal obesity, fasting glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure), and proportion of MS, CMRF clustering (${\geq}2$ of MS components), and elevated ALT were compared among the groups. Results: Body mass index (BMI) z-score, obesity, total cholesterol, ALT, abdominal obesity, elevated triglycerides, and CMRF clustering showed increasing HGI trends from lower-to-higher tertiles. Multiple logistic regression analysis showed the upper HGI tertile was associated with elevated triglycerides (odds ratio, 1.65; 95% confidence interval, 1.18-2.30). Multiple linear regression analysis showed HGI level was significantly associated with BMI z-score, $HbA1_c$, triglycerides, and ALT. When stratified by sex, age group, and BMI category, overweight/obese subjects showed linear HGI trends for presence of CMRF clustering and ALT elevation. Conclusion: HGI was associated with CMRFs in a Korean pediatric population. High HGI might be an independent risk factor for CMRF clustering and ALT elevation in overweight/obese youth. Further studies are required to establish the clinical relevance of HGI for cardiometabolic health in youth.

• Investigative Magnetic Resonance Imaging
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• 제25권1호
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• pp.35-42
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• 2021

Purpose: To evaluate and analyze the adequacy of breast magnetic resonance imaging (MRI)s taken before publication of the 2018 recommendation in South Korea. Materials and Methods: We enrolled 87 cases of breast MRIs, from January 2010 to November 2013, taken at external hospitals in the study. Breast MRI protocol elements are divided into three categories based on the recommendation by the Breast Imaging Study Group of the Korean Society of Magnetic Resonance: (1) Essential elements for breast MRI protocol; (2) Element to consider when evaluating imaging quality; and (3) Optional element for breast MRI protocol. Also, we divided enrolled cases into three groups based on their conducting locations -- (1) Primary hospitals, (2) Secondary hospitals, and (3) Tertiary hospitals-and analyzed them for the adequacy of imaging protocols based on the 2018 recommendation. We used a Chi-square test and Fisher's exact test to identify differences between categorical variables. Results: Over 98% of the criteria for 'essential elements for breast MRI protocol' were satisfied when compared with the 2018 Recommendation. Over 96% of the criteria for 'elements to consider when evaluating imaging quality' were also satisfied, except for the slice thickness (83.9%). Optional elements for breast MRI protocol were satisfied with various percentages. There were no statistically significant differences between groups of tertiary, secondary, and primary hospitals; however, 3 tesla of MRI (P = 0.04), subtraction image protocol (P = 0.032), and DWI protocol (P = 0.03) were used more frequently in the tertiary hospitals than in the others. Conclusion: We found that the categories of 'essential elements' and 'elements to consider when evaluating imaging quality' were satisfied at 98% and 96%, respectively, when compared with the 2018 Recommendation by the Breast Imaging Study Group of the Korean Society of Magnetic Resonance.