• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.77-86
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• 2005

In this study, we examined the morphine-induced modulation of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in the spontaneous activity of nociceptive dorsal horn neurons. In naive cats before the injection of formalin, iontophoretically applied morphine attenuated the naturally and electrically evoked neuronal responses of dorsal horn neurons. However, neuronal responses after the formalin-induced inflammation were significantly increased by morphine. Bicuculline, $GABA_A$ antagonist, increased the naturally and electrically evoked neuronal responses of dorsal horn neurons. This increase in neuronal responses due to bicuculline after the formalin-induced inflammation was larger than that in the naive state, suggesting that basal $GABA_A$ tone increased after the formalin injection. Muscimol, $GABA_A$ agonist, reduced the neuronal responses before the treatment with formalin, but not after formalin treatment, again indicating an increase in the GABAergic basal tone after the formalin injection which saturated the neuronal responses to GABA agonist. Morphine-induced increase in the spinal nociceptive responses after formalin treatment was inhibited by co-application of muscimol. These data suggest that formalin-induced inflammation increases $GABA_A$ basal tone and the inhibition of this augmented $GABA_A$ basal tone by morphine results in a paradoxical morphineinduced increase in the spinal nociceptive neuronal responses after the formalin-induced inflammation.

• 대한한방부인과학회지
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• 제19권4호
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• pp.269-278
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• 2006

Purpose : The purpose of this study is to report the effect of TKM to both lower extremities weakness after parturition who is diagnosed as Subacute inflammatory demyelinating peripheral neuropathy. Methods : The patient was a 31-year-old woman who couldn't walk at all by herself because of both lower extremities weakness after parturition. The patient was demonstrated as shin-yang-heo, and treated by Pal-mi-ji-hwang-hwan, Acupuncture treatment of Shin-jeong-gyeok, and Moxa treatment of Gwan-won. And the progress of symtoms was evaluated by observation of her walking status, cheking the change of VAS, and inspecting the DITI. Results : The patient could walk by herself. The feeling of both lower extremities weakness improved to VAS 2. The paraesthesia of the soles of feet improved to VAS 4. And the DITI state slightly got better. Conclusion : TKM is expected to have positive effect on puerperium disease especially the symptoms of pain, weakness, paraesthesia, etc.

• 대한한방체열의학회지
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• 제5권1호
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• pp.14-20
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• 2006

Purpose: The purpose of this study is to report the effect of TKM to both lower extremities weakness after parturition who is diagnosed as Subacute inflammatory demyelinating peripheral neuropathy. Methods: The patient was a 31-year-old woman who couldn't walk at all by herself because of both lower extremities weakness after parturition. The patient was demonstrated as shin-yang-heo, and treated by Pal-mi-ji-hwang-hwan, Acupuncture treatment of Shin-jeong-gyeok, and Moxa treatment of Gwan-won. And the progress of symtoms was evaluated by observation of her walking status, cheking the change of VAS, and inspecting the DITI. Result: The patient could walk by herself. The feeling of both lower extremities weakness improved to VAS 2. The paraesthesia of the soles of feet improved to VAS 4. And the DITI state slightly got better. Conclusion: TKM is expected to have positive effect on puerperium disease especially the symptoms of pain, weakness, paraesthesia, etc.