• Journal of Genetic Medicine
• /
• v.2 no.1
• /
• pp.7-10
• /
• 1998

The present report describes a case that showed a normal fetal karyotype in an antenatal genetic study but an abnormal placental karyotype of 46,XX,r (15) on postnatal examination. The pregnancy was complicated by fetal nuchal translucency in the first trimester and intrauterine growth restriction in the second and third trimesters. A 1780 gm female baby was born after 40 weeks of gestation, but died of respiratory distress and sepsis on the 10th day of life. Our case was unique in that the placental chromosomal aberration was a structural abnormality instead of a numerical aberration that is seen in most reported cases of confined placental mosaicism.

• Structural Engineering and Mechanics
• /
• v.31 no.4
• /
• pp.393-405
• /
• 2009

The Purpose of this paper is to show the applicability of a methodology, developed by the authors, with which to perform the mechanical optimization of space truss structures strongly restricted. This methodology use a parameter call "Volumetric Displacement", as the Objective Function of the optimization process. This parameter considers altogether the structure weight and deformation whose effects are opposed. The Finite Element Method is employed to calculate the stress/strain state and the natural frequency of the structure through a structural linear static and natural frequency analysis. In order to show the potentially of this simple methodology, its application on a large diameter telescope structure (10 m) considering the strongly restriction that became of its use, is presented. This methodology, applied in previous works on continuous structures, such as shell roof and fluid storage vessels, is applied in this case to a space truss structure, with the purpose of generalize its applicability to different structural topology. This technique could be useful in the morphology design of deployable and retractable roof structures, whose use has extensively spread in the last years.

• East Asian Economic Review
• /
• v.22 no.3
• /
• pp.371-400
• /
• 2018

Although asset price is an important factor in determining changes in external balances, no studies have investigated it from the Chinese perspective. In this study, I empirically examine the underlying driving forces of China's trade balances, particularly the role of asset price and the real exchange rate. To this end, I estimate a sign-restricted structural vector autoregressive model with quarterly time series data for China, using the Bayesian method. The results show that changes in asset price affect China's trade balances through private consumption and investment. Also, an appreciation of the real exchange rate tends to deteriorate trade balances in China. Furthermore, forecast error variance decomposition results indicate that changes in asset price (stock price and housing price) explain about 20% variability of trade balances, while changes in the real exchange rate can explain about 10%.

• Journal of the Korean Society for Precision Engineering
• /
• v.22 no.8 s.173
• /
• pp.108-117
• /
• 2005

In modern industrial society, many kinds of valves have been used to control fluid flow. For the optimization of a ball valve, a quarter of spherical ball was modeled and evaluated. However, there is a difficulty in the application of the optimization technique because of the complexity of the fluid and the restriction of analysis. Therefore, in this study, it is performed to evaluate the stability of an initial model using FEM(Finite Element Method) and CFD. In addition, a shape optimization design of the valve is accomplished using an orthogonal arrangement and characteristic functions. From the result, a new design method is represented that could overcome the time and space restriction in structural design, such as the divided ball valve with less experiment.

• YAKHAK HOEJI
• /
• v.37 no.5
• /
• pp.504-510
• /
• 1993

Human insulin gene is consisted of the polymorphic region with the repeating units, the regulatory sequence, the structural gene including the intervening sequence, and 3'-flanking region. The polymerase chain reaction, which amplifies the target DNA between two specific primers, has been performed for the amplification of human insulin gene and simple one-step cloning of it into Escherichia coli. Out of 1727 nuceotides compared, only 4 sites were variable: 5'-regulatory region(G2101$\rightarrow$AGG); IVS I(T2401$\rightarrow$A); Exon II(C2411 deletion); IVS II(A2740 dejection). The variations at the G2101 and T2401 were the same as those found in one American allele. The other two variations were observed only in the specific Korean allele. And, the enzyme digestion patterns among normal, insulin dependent diabetes mellitus, and non-insulin dependent diabetes mellitus were the same. On the other hand, PCR method showed the possibility of the quickaccess for the polymorphic region in terms of the restriction fragment length of polymorphism.

• Structural Engineering and Mechanics
• /
• v.77 no.6
• /
• pp.721-734
• /
• 2021

The seismic analysis of structures without applying the effects of soil can undermine functional objectives of structure so that it can affect all the desired purposes at the design and control stages of the structure. In this research, employing OpenSees and MATLAB software simultaneously and developing a definite three-dimensional finite element model of a high-rise concrete structure, designed using performance-based plastic design approach, the performance of Tuned Mass Damper (TMD) and Active Mass Damper (AMD) is both examined and compared. Moreover some less noted aspects such as nonlinear interaction of soil and structure, uplift, nonlinear behavior of structure and structural torsion have received more attention. For this purpose, the analysis of time history on the structural model has been performed under 22 far-field accelerogram records. Examining a full range of all structural seismic responses, including lateral displacement, acceleration, inter-story drift, lost plastic energy, number of plastic hinges, story shear force and uplift. The results indicate that TMD performs better than AMD except for lateral displacement and inter-story drift to control other structural responses. Because on the one hand, nonlinear structural parameters and soil-structure interaction have been added and on the other hand, the restriction on the control force applied that leads up to saturation phenomenon in the active control system affect the performance of AMD. Moreover, the control force applied by structural control system has created undesirable acceleration and shear force in the structure.

• Asian-Australasian Journal of Animal Sciences
• /
• v.17 no.7
• /
• pp.910-913
• /
• 2004

Insulin-like growth factor binding protein-3 (IGFBP-3) gene is a structural gene associated with the growth and development of the animals. The present investigation was carried out to unravel nucleotide sequence and polymerase chain reactionrestriction fragment polymorphism (PCR-RFLP) of IGFBP-3 gene in buffalo. Genomic DNA was isolated from a total of 157 animals belonging to Murrah, Surti, Jaffarabadi and Nagpuri breeds of Indian riverine buffalo. A 655 bp of IGFBP-3 gene was amplified in all the breeds and amplicons were digested with Hae III, Taq I and Msp I restriction enzymes. On digestion with Hae III yielded single restriction pattern of 8 fragments of sizes 201, 165, 154, 56, 36, 19, 16 and 8 bp in all the animals studied. Similarly Taq I and Msp I also revealed single restriction pattern yielding fragments of sizes 240 and 415 bp and 145 and 510 bp, respectively. This shows nonpolymorphic nature of restriction sites in buffalo. Nucleotide sequencing of 587 bp of IGFBP-3 gene in Murrah buffalo was done and submitted to the GenBank (Accession No. AY304829). Nucleotide sequencing revealed an addition of 4 bases in the intronic region as compared to cattle.

• Journal of Microbiology and Biotechnology
• /
• v.26 no.12
• /
• pp.2184-2191
• /
• 2016

The time-consuming and high-cost preparation of soluble peptide-major histocompatibility complexes (pMHC) currently limits their wide uses in monitoring antigen-specific T cells. The single-chain trimer (SCT) of peptide-${\beta}2m$-MHC class I heavy chain was developed as an alternative strategy, but its gene fusion is hindered in many cases owing to the incompatibility between the multiple restriction enzymes and the restriction endonuclease sites of plasmid vectors. In this study, overlap extension PCR and one-step cloning were adopted to overcome this restriction. The SCT gene of the $OVA_{257-264}$ peptide-$(GS_4)_3-{\beta}2m-(GS_4)_4-H-2K^b$ heavy chain was constructed and inserted into plasmid pET28a by overlap extension PCR and one-step cloning, without the requirement of restriction enzymes. The SCT protein was expressed in Escherichia coli, and then purified and refolded. The resulting $H-2K^b/OVA_{257-264}$ complex showed the correct structural conformation and capability to bind with $OVA_{257-264}$-specific T-cell receptor. The overlap extension PCR and one-step cloning ensure the construction of single-chain MHC class I molecules associated with random epitopes, and will facilitate the preparation of soluble pMHC multimers.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.12 no.2
• /
• pp.236-247
• /
• 2009

In Korea, the driving system restriction criteria is strictly applied(gross weight 400kN, axial load 100kN). Especially after the Seoungsu Bridge accident, safety factor has been strictly applied. The Safety factor is applied to the cumulative results for each steps like design, construction, maintenance of the Bridge. Because of it, the bridge is undervalued compared to its capacity. So, this generates loss for both private and military sector(eg. logistical delays, structural damage, etc.). But analyzing data from many existing researches we have confirmed that the military heavy vehicle may pass through the first class bridges. In consequence, this study have focused on determining whether HETS vehicles can pass over the first class bridge, without safety issues, using MIDAS structural analysis program. The results have confirmed that the military heavy vehicle may pass over the bridge.

• Proceeding of EDISON Challenge
• /
• 2015.03a
• /
• pp.207-211
• /
• 2015

In this paper, 2 kinds of models about bike frame are simulated with static structural analysis. A bike frame with diamond type is compared with another model that Down tube is eliminated from original diamond frame. About both types of models, Property of a material and conditions of restriction & load are the same. This study shows reinforcement effects of a partial frame by adding down tube and impacts generated by applying a load at the frame such as weak points & high stress parts as well as expected deformation. The structural result of this study indicates that the equivalent stress or total deformation decreases by 57.1% or 36.4%, respectively. Also stress concentration sites are leg connecting parts, front/rear wheels fixed region and Max deformation is generated from Seat tube. In conclusion, A Down tube is highly efficient as reinforcement than frame without non down tube. Furthermore, The safety rises in case of reducing top tube thickness and increasing a reinforcement at leg connecting parts or concentration regions.