• Tuberculosis and Respiratory Diseases
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• v.68 no.3
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• pp.125-139
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• 2010

Patients with chronic obstructive pulmonary disease (COPD) frequently complain of dyspnea on exertion and reduced exercise capacity, which has been attributed to an increase in the work of breathing and in impaired of gas exchange. Although COPD primarily affects the pulmonary system, patients with COPD exhibit significant systemic manifestations of disease progression. These manifestations include weight loss, nutritional abnormalities, skeletal muscle dysfunction (SMD), cardiovascular problems, and psychosocial complications. It has been documented that SMD significantly contributes to a reduced exercise capacity in patients with COPD. Ventilatory and limb muscle in these patients show structural and functional alteration, which are influenced by several factors, including physical inactivity, hypoxia, smoking, aging, corticosteroid, malnutrition, systemic inflammation, oxidative stress, apoptosis, and ubiquitin-proteasome pathway activation. This article summarizes briefly the evidence and the clinical consequences of SMD in patients with COPD. In addition, it reviews contributing factors and therapeutic strategies.

• Journal of the Korean Ceramic Society
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• v.50 no.3
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• pp.180-185
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• 2013

We investigated the characteristics of hot-pressed pure yttria ceramics, and annealed them in an oxidation atmosphere. Regardless of the heat treatment in the oxidation atmosphere, XRD analysis showed that all the samples had a $Y_2O_3$ phase without structural change. Even though the color variation of the hot-pressed $Y_2O_3$ ceramics was due to the sintering temperatures, the oxidation process turned the color of the $Y_2O_3$ ceramics into white. The color change during oxidation treatment appears to be related to oxygen defects. In addition, oxygen defects also affected the weight change and microstructure of the $Y_2O_3$ ceramics. The $Y_2O_3$ ceramic sintered at $1600^{\circ}C$ had a $5.03g/cm^3$ density, which is close to the theoretical density of $Y_2O_3$. As the sintering temperature increased, small homogeneous grains grew to large grains which affected the Vickers hardness. $Y_2O_3$ ceramics hot-pressed at $1600^{\circ}C$ and annealed at $1200^{\circ}C$ had a flexural strength of 140MPa.

• Steel and Composite Structures
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• v.22 no.4
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• pp.821-835
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• 2016

The paper presents an experimental study of the structural behavior of circular flyash-concrete-filled steel tubular stub columns under axial compressive loads. In this study, 90% and 100% by weight of the cement in the concrete core was replaced with flyash. Twenty-seven specimens were tested to study the influence of flyash content, wall thickness of the steel tube, and curing age on the ultimate capacity and confinement effect. The experimental results were compared with the design values calculated using AISC-LRFD (1999), ACI (1999), AIJ (1997) and Eurocode 4 (1994). From the experimental study, it was determined that the confinement effect of circular steel tubes filled with high content flyash concrete was better than that of specimens filled with ordinary Portland cement concrete. The 5.88-mm-thick steel tube filled with 100% flyash concrete was equivalent in strength to a steel tube filled with C30 concrete at 28 days.

• Structural Engineering and Mechanics
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• v.67 no.3
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• pp.283-290
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• 2018

This paper presents the results of a study that investigated the influence of using recycled coarse aggregate (RCA) and recycled asphalt pavement (RAP) on the properties of pervious concrete (PC). The natural aggregate (NA) was replaced by RCA and RAP in the PC with replacement levels of 0%, 20%, 40%, 60% and 80% by the total weight of NA, respectively. In addition to incorporating RAP and RCA in the same mixes with replacement levels of: (1) 20% RAP and 80% RCA; (2) 60% RAP and 40% RCA; and (3) 80% RAP and 20% RCA. Water permeability, thermal conductivity, density, porosity, void content, and compressive, splitting tensile and flexural strengths were studied in this paper. The results showed that using RCA, RAP, and (RAP-RCA) enhanced the properties of PC in general and improved the mechanical properties significantly in particular. The optimum mix was reported to be the 60% RAP and 40% RCA. Accordingly, the RAP has the potential to be used in PC in order to reduce the negative impact of RAP on the human health and environment.

• Steel and Composite Structures
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• v.37 no.1
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• pp.99-115
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• 2020

This article deals with the dynamic analysis in pad concrete foundation containing Silica nanoparticles (SiO₂) subject to seismic load. In order to control the foundation smartly, a piezoelectric layer covered the foundation. The weight of the building by a column on the foundation is assumed with an external force in the middle of the structure. The foundation is located in soil medium which is modeled by spring elements. The Mori-Tanaka law is utilized for calculating the equivalent mechanical characteristics of the concrete foundation. The Kevin-Voigt model is adopted to take into account the structural damping. The concrete structure is modeled by a thick plate and the governing equations are deduced using Hamilton's principle under the assumption of higher-order shear deformation theory (HSDT). The differential quadrature method (DQM) and the Newmark method are applied to obtain the seismic response. The effects of the applied voltage to the smart layer, agglomeration and volume percent of SiO₂ nanoparticles, damping of the structure, geometrical parameters and soil medium of the structure are assessed on the dynamic response. It has been demonstrated by the numerical results that by applying a negative voltage, the dynamic deflection is reduced significantly. Moreover, silica nanoparticles reduce the dynamic deflection of the concrete foundation.

• BMB Reports
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• v.34 no.5
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• pp.408-414
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• 2001

Ornithine decarboxylase (EC 4.1.1.17) is an essential enzyme for polyamine synthesis and growth in mammalian cells and plants. We compared the biochemical and immunological properties of rat and Nicotiana glutinosa ODC by cloning and expressing the recombinant proteins. The primary amino acid sequence between rat and N. glutinosa ODC had a 40% homology The molecular weight of the overexpressed rat ODC was 53 kDa, and that of N. glutinosa was 46.5 kDa. Adding 1 mM of putrescine to the enzyme reaction mixture inhibited both rat and N. glutinosa ODC activity to 30%. Agmatine had an inhibitory effect only on N. glutinosa ODC. Cysteine and lysine modifying reagents reduced both ODC activities, verifying the key roles of cysteine and lysine residues in the catalytic mechanism of ODC. ELISA was performed to characterize the immunological difference between the rat and plant ODC. Both the rat and N. glutinosa ODC were recognized by the polyclonal antibody that was raised against purified N. glutinosa ODC, but the rat ODC was 50-fold less sensitive to the antibody binding. These results indicate that even though both ODCs have the same evolutionary origin, there seems to be a structural distinction between the species.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2003.04a
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• pp.129-134
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• 2003

The importance of understanding the response of structural composites to impact and CAI cannot be overstated to develop analytical models for impact damage and CAI strength predictions. This paper presents experimental findings observed from quasi-static lateral load tests, low velocity impact tests, CAI strength and open hole compressive strength tests using 3mm thick composite plates ($[45/-45/0/90]_{3s}$ - IM7/8552). The conclusion is drawn that damage areas for both quasi-static lateral load and impact tests are similar and the curves of several drop weight impacts with varying energy levels (between 5.4 J and 18.7 J) fallow the static curve well. In addition, at a given energy the peak force is in good agreement between the static and impact cases. From the CAI strength and open hole compressive strength tests, it is identified that the failure behaviour of the specimens was very similar to that observed in laminated plates with open holes under compression loading. The residual strengths are in good agreement with the measured open hole compressive strengths, considering the impact damage site as an equivalent hole. The experimental findings suggest that simple analytical models for the prediction of impact damage area and CAI strength can be developed on the basis of the failure mechanism observed from the experimental tests.

• Proceedings of the KSME Conference
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• 2000.04a
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• pp.254-260
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• 2000

The spacer grid is one of the main structural components in fuel assembly, which supports the fuel rods, guides cooling water, and protects the fuel assembly from the external impact load such as earthquakes. The nonlinear dynamic impact analysis is conducted by using the finite element code ABAQUS/Explicit. Boundary condition for dynamic analysis is well applied to the test condition. Simulation results also similarly predict the local buckling phenomena. In addition to the buckling parameter, the local buckling cause is examined by both simulation and test method. It is found to correspond well with the test results. Impact tests are also carried out for some specimens of the spacer grid in order to compare the results between the test and the simulation. This test is accomplished by a free fall dummy weight onto the specimen. From this test, only the uppermost and lowermost layers of the multi-cell are buckled, which implies the local buckling at the weakest point of the grid structure.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.6
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• pp.526-532
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• 2008

Structure evaluation for 70/15 $T{\times}105\;m$ LLC(Level Luffing Crane)'s boom was conducted by Finite Element Method. Boom modeled with beam element was fixed by luff rope and boom mount and was received loads from self weight, luff hoisting, traveling motion, slewing motion, and wind force, etc. These applied loads were calculated using various factors presented in the reference standards and were inputted in the analysis model after considering about the adverse conditions of LLC. In the research, deformation, stresses, buckling of boom were evaluated by ANSYS. Structural safety of boom was confirmed in the results of numerical analysis.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.565-570
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• 2008

Recently, the intelligent service robot is applied for the purpose of guiding the building or providing information to the visitors of the public institution. The intelligent robot which is on development has a sensor to recognize its location at the bottom of it. Four wheels which are arranged in the form of a lozenge support the weight of the components and structures of the robot. The operating environment of this robot is restricted at the uneven place because the driving part and internal structure is designed in one united body. The impact from the ground is transferred to the internal equipments and structures of the robot. This continuous impact can cause the unusual state of the precise components and weaken the connection between each structural part. In this paper, a suspension system which can be applied to the intelligent robot is designed. The dynamic model of the robot is created, and the driving characteristics of the actual robot and the robot with suspension are compared. The road condition which the robot can operate is expanded by the application of the suspension system. Additionally, the suspension system is optimized to reduce the impact to the robot components.