• Biomolecules & Therapeutics
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• v.3 no.4
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• pp.316-321
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• 1995

All the pharmacological studies of LB17522 described here were carried out with high doses (fifteen to sixty times of the therapeutic dose) to determine an indication of potential side effects in clinical use in terms of the acute clinical signs, cardiovascular and central nervous system. LB10522 does not produce any observable clinical signs except for the symptoms such as moist eye, skin rash, slight salivation, vomitting, and slightly reduced activity. The effects of LB10522 on the hemodynamics and cardiac function of anesthetized beagle dogs are as follows; heart rates and mean arterial blood pressure had a tendency to increase mildly, which is a normal finding in anesthetized dogs. All the animals except for one showed relatively stable respiratory rates throughout the observation period. Each animal treated with LB10522 showed slight increase in the left cardiac work and left ventricular stroke work which are mainly related to corresponding increases in cardiac output. Femoral blood flow were shown to be increased in some animals treated with LB10522. The epileptogenic activities of various cephalosporins were assessed by a direct intracerebral injection of appropriate concentration of test articles. The CD$_{50}$ values (nmol) obtained from the analysis of the dose-response data are as follows; 78.2, 175.3, 156.3, and 53.5 for cefazolin, cephaloridine, ceftazidime, and LB 10522, respectively. LB10522 seems to be equipotent with cefazolin or to be three times more potent than cephaloridine and ceftazidime in causing adverse CNS stimulation. Taken into consideration all the information obtained, LB10522 is not supposed to induce much changes in the functions examined in these studies in man at therapeutic doses.s.

• Earthquakes and Structures
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• v.17 no.2
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• pp.143-162
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• 2019

Motivated by a simpler and more compact hybrid active tuned mass damper (ATMD) system with wide frequency spacing (i.e., high robustness) but not reducing the effectiveness using the least number of ATMD units, the active tuned tandem mass dampers (ATTMD) have been proposed to attenuate undesirable oscillations of structures under the ground acceleration. Likewise, it is expected that the frequency spacing of the ATTMD is comparable to that of the active multiple tuned mass dampers (AMTMD) or the multiple tuned mass dampers (MTMD). In accordance with the mode generalised system in the specific vibration mode being controlled (simply referred herein to as the structure), the closed-form expression of the dimensionless displacement variances has been derived for the structure with the attached ATTMD. The criterion for the optimum searching may then be determined as minimization of the dimensionless displacement variances. Employing the gradient-based optimization technique, the effects of varying key parameters on the performance of the ATTMD have been scrutinized in order to probe into its superiority. Meanwhile, for the purpose of a systematic comparison, the optimum results of two active tuned mass dampers (two ATMDs), two tuned mass dampers (two TMDs) without the linking damper, and the TTMD are included into consideration. Subsequent to work in the frequency domain, a real-time Simulink implementation of dynamic analysis of the structure with the ATTMD under earthquakes is carried out to verify the findings of effectiveness and stroke in the frequency domain. Results clearly show that the findings in the time domain support the ones in the frequency domain. The whole work demonstrates that ATTMD outperforms two ATMDs, two TMDs, and TTMD. Thereinto, a wide frequency spacing feature of the ATTMD is its highlight, thus deeming it a high robustness control device. Furthermore, the ATTMD system only needs the linking dashpot, thus embodying its simplicity.

• Transactions of the Korean Society of Automotive Engineers
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• v.9 no.5
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• pp.46-53
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• 2001

To optimize the intake flow condition in the heavy-duty LPG SI engine, five different swirl ratios of intake port were investigated experimentally by oil spot method, LDV and single cylinder engine test. The flow characteristics near the piston surface were observed by oil spot method and magnitudes of swirl flow were measured quantatively by LDV method in the steady flow rig. The engine performances of various swirl flow were also tested with the heavy-duty LPG SI single cylinder engine. In the results, high swirl ratio, above $R_s$=2.3, was not suitable to develope a stable flame kernel and to produce high engine performance. Especially it was more serious under lean burn conditions, since turbulence intensity was smaller than bulk flow though those are increased together. These results were also confirmed by LDV measurement and oil spot method. On the contrary, low swirl ratio($R_s$=1.3) is not good to propagate a flame since the turbulence intensity and bulk flow are vanished during compression stroke and low swirl ratio has too weak initial energy for stable combustion. Therefore, the of optimized swirl ratio f3r the heavy-duty LPG engine in this work was found around $R_s$=2.0.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.4
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• pp.22-28
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• 2013

It is important to begin left ventricular assist device (LVAD) treatment at appropriate time for heart failure patients who expect cardiac recovery after the therapy. In order to predict the optimal timing of LVAD implantation, we predicted pumping efficacy of LVAD according to the severity of heart failure theoretically. We used LVAD-implanted cardiovascular system model which consist of 8 Windkessel compartments for the simulation study. The time-varying compliance theory was used to simulate ventricular pumping function in the model. The ventricular systolic dysfunction was implemented by increasing the end-systolic ventricular compliance. Using the mathematical model, we predicted cardiac responses such as left ventricular peak pressure, cardiac output, ejection fraction, and stroke work according to the severity of ventricular systolic dysfunction under the treatments of continuous and pulsatile LVAD. Left ventricular peak pressure, which indicates the ventricular loading condition, decreased maximally at the 1st level heart-failure under pulsatile LVAD therapy and 2nd level heart-failure under continuous LVAD therapy. We conclude that optimal timing for pulsatile LVAD treatment is 1st level heart-failure and for continuous LVAD treatment is 2nd level heart-failure when considering LVAD treatment as "bridge to recovery".

• Journal of the Korean Society for Precision Engineering
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• v.28 no.7
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• pp.761-768
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• 2011

The large surface micro machining system includes the equipments and processes for manufacturing the ultra precision micro patterned products with large surface through the mechanical machining. Recent major issue on the micro machining technology may be the development of optical parts for the back light unit of display which has the largest market. This special issue makes up with three parts; the large surface micro machining system and machine, machining process and forming process. In this paper, the state-of-the-art and core technology of large surface micro machining system is introduced with focus on the manufacturing technology for the back light unit of LCD TV. Then, some research results on the development of a roll die lathe is introduced which involves the concept of machine design, improvement of thermal characteristics in the spindle system, improvement of relative parallelism and straightness between spindle system and long stroke feed table, machining of micro pitch patterns. Finally, the direct forming process is introduced as the future work in the large surface micro machining field.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.9
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• pp.538-544
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• 2004

This paper presents the interruption capability of serial-hybrid type GCB (gas circuit breaker) compared with that of puffer type. First a puffer type model interrupter which has the stroke length of 80 mm has been designed and manufactured. And also, a serial-hybrid type interrupter which has the same design parameters as the puffer type interrupter except the serially arranged thermal-expansion chamber and puffer cylinder has been fabricated. Using a simplified synthetic test facility, the critical interruption capabilities of the two GCBs have been estimated. The critical di/dt, the critical dV/dt of ITRV (initial transient recovery voltage) and the minimum arcing time of the puffer type model GCB were 10.7 A/${\mu}\textrm{s}$, 5.5 kV/${\mu}\textrm{s}$, and 15.0 ms respectively. In the case of serial-hybrid type model GCB, each of the values was 16.6A/${\mu}\textrm{s}$, 11.5 kV/${\mu}\textrm{s}$ and 13.0 ms. As a conclusion of this work, it has been quantitatively confirmed that the hybrid type interrupter can obtain the sufficient interruption capability at the operating force which is so low that puffer type interrupter has not the interruption capability.

• International Journal of Naval Architecture and Ocean Engineering
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• v.5 no.4
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• pp.493-501
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• 2013

Taking into account the increasingly stringent legislation on emissions from marine engines, this work aims to analyze several internal engine modifications to reduce $NO_x$ (nitrogen oxides) and other pollutants. To this end, a numerical model was employed to simulate the operation cycle and characterize the exhaust gas composition. After a preliminary validation process was carried out using experimental data from a four-stroke, medium-speed marine engine, the numerical model was employed to study the influence of several internal modifications, such as water addition from 0 to 100% water to fuel ratios, exhaust gas recirculation from 0 to 100% EGR rates, modification of the overlap timing from 60 to $120^{\circ}$, modification of the intake valve closing from 510 to $570^{\circ}$, and modification of the cooling water temperature from 70 to $90^{\circ}C$. $NO_x$ was reduced by nearly 100%. As expected, it was found that, by lowering the combustion temperature, there is a notable reduction in $NO_x$, but an increase in CO (carbon monoxide), HC (hydrocarbons) and consumption.

• Corrosion Science and Technology
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• v.14 no.6
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• pp.288-295
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• 2015

The present work addresses crevice and galvanic corrosion processes occurring at the cylinder head gasket/cylinder head interface and cylinder head gasket/cylinder liner interface of four-stroke medium-speed diesel engines for marine applications. The contact between these systems and the marine environment can promote formation of demanding corrosion conditions, therefore influencing the lifetime of the engine components. The electrochemical behavior of various metals and alloys used as head gasket materials (both ferrous alloys and copper alloys) was investigated. The efficacy of corrosion inhibitors was determined by comparing electrochemical behavior with and without inhibitors. In particular, crevice corrosion has been investigated by electrochemical tests using an experimental set-up developed starting from the requirements of the ASTM G-192-08, with adaptation of the test to the conditions peculiar to this application. In addition to the crevice corrosion resistance, the possible problems of galvanic coupling, as well as corrosive reactivity, were evaluated using electrochemical tests, such as potentiodynamic measurements. It was possible to quantify, in several cases, the corrosion resistance of the various coupled materials, and in particular the resistance to crevice corrosion, providing a basis for the selection of materials for this specific application.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.3
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• pp.877-885
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• 1995

Cold forging die for metal scissor is made by electric discharge machine. The impression of female die is made by electric discharge machine, the heat treatment is applied, and the impression is polished. When we forge goods by using this kind of die, the abrasion is severe and the crack occurs after forging about 240 strokes. Because the die should be frequently produced in the case, the cost rises, the work is delayed, and the precesion of goods is not good. Therefore, the electric discharge machine was not used in this study. Main die was produced by making hob, installing the hob to cold hobbing press, indenting the die material, and cold hobbing the impression. The die life was increased to 5,000-6,000 strokes in this case. In the future study, the die life will be increased to 10,000 strokes by changing the following : (1) the pre-treatment of slug, (2) the structure of die block, (3) the heat treatment of die material

• Journal of KSNVE
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• v.10 no.4
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• pp.615-622
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• 2000

Discharge valve mechanism for an electrodynamic-oscillating compressor is different from that of a conventional reciprocating compressor. It has a larger discharge port area, heavier valve mass and stiffer valve spring comparing with the reciprocating one. Since the motion of piston is not kinematically restricted as in conventional reciprocating compressors, the stroke of the piston can change sensitively with supplied boltage and load. Thus piston can impact with discharge valve occasionally. This work deals on dynamic analysis of discharge valve considering all of those different characteristics. Impact is considered by a spring-mass model, and the pressure fluctuation at the both sides of the valve is also included considering the discharge port area and valve spring preload. It is assumed that piston moves in the region of between top and bottom dead center not by calculating piston motion from an electrodynamic equation but by getting values through experiment. Discharge pressure fluctuation is calculated using Helmholtz modeling. Finally, dynamic model for a discharge valve is constructed. In order to validate the model analysis results, the valve motion is experimentally measured and compared with analysis.