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A Questionnaire Study to Investigate the Symptoms and Solutions of Wearing-off in Parkinson's Disease Patients (파킨슨병 환자의 개인별 Wearing-off 증상 및 해결책 현황 조사를 위한 설문 연구)

  • Miso S. Park;Sang Soo Park;Horyong Yoo;Jaeson Pyeon;Wang Jung Hur;Shin Young Park
    • Journal of TMJ Balancing Medicine
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    • v.13 no.sup
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    • pp.1-8
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    • 2023
  • Objectives: Parkinson's disease (PD) is currently the most rapidly increasing degenerative brain disease due to population aging and westernization of lifestyle. Levodopa is the most commonly used drug to manage PD symptoms. However, levodopa has a problem in that the wearing-off phenomenon occurs as the duration and dose of administration increase. In order to investigate the wearing-off phenomenon in PD patients and devise countermeasures, we conducted a questionnaire survey in Korea. Methods: For the study, a questionnaire with a total of seven items was prepared. Part IV of the MDS-UPDRS (Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale) and the WOQ-9 (9-symptom Wearing-off Questionnaire) were used as references. Results: Of the 48 patients who completed the questionnaire, all 47 patients who completed the questionnaire experienced the wearing-off phenomenon. Only one of the patients diagnosed with PD a year ago did not experience the wearing-off phenomenon. Patients frequently mentioned a lack of sleep and stress as aggravating factors for wearing-off. They also stated that in order to resolve the off-state, they walked, massaged, warmed up the body, stretched and exercised. Conclusions: Because wearing-off is such a common occurrence, it is thought necessary to develop wearing-off prevention and resolution measures that PD patients can use in their daily lives.

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Evaluation of Structural Performance of Unhangak in Suwon Hwaryeongjeon by Three-Dimensional Structural Analysis (3차원 구조해석에 의한 수원 화령전 운한각의 구조성능 평가)

  • Yeong-Min Kim
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.37 no.3
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    • pp.197-204
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    • 2024
  • In this paper, the structural performance of Suwon Hwaryeongjeon Unhangak, a representative traditional timber structure in the late Joseon Dynasty, was evaluated. Based on the structure composition of Unhangak, an analysis model was elaborately constructed with Midas Gen, a 3-dimensional structural analysis software. The safety and serviceability of major structural members were evaluated by static analysis, and the dynamic behavior characteristics were evaluated by eigenvalue analysis. Most of the members satisfied the safety and serviceability standards with a margin; however, the bending stress ratio in the oemogdori exceeds the standard by 20.7%, so it is considered that long-term monitoring is needed for this member. The natural period of Unhangak is 1.079 seconds, which is slightly longer than traditional timber buildings of similar scale. In particular, it is analyzed that torsional movement occurred in the secondary mode due to the influence of the rear masonry firewall.

Effects of aeration and centrifugation conditions on omega-3 fatty acid production by the mixotrophic dinoflagellate Gymnodinium smaydae in a semi-continuous cultivation system on a pilot scale

  • Ji Hyun You;Hae Jin Jeong;Sang Ah Park;Se Hee Eom;Hee Chang Kang;Jin Hee Ok
    • ALGAE
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    • v.39 no.2
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    • pp.109-127
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    • 2024
  • High production and efficient harvesting of microalgae containing high omega-3 levels are critical concerns for industrial use. Aeration can elevate production of some microalgae by providing CO2 and O2. However, it may lower the production of others by generating shear stress, causing severe cell damage. The mixotrophic dinoflagellate Gymnodinium smaydae is a new, promising microalga for omega-3 fatty acid production owing to its high docosahexaenoic acid content, and determining optimal conditions and methods for high omega-3 fatty acid production and efficient harvest using G. smaydae is crucial for its commercial utilization. Therefore, to determine whether continuous aeration is required, we measured densities of G. smaydae and the dinoflagellate prey Heterocapsa rotundata in a 100-L semi-continuous cultivation system under no aeration and continuous aeration conditions daily for 9 days. Furthermore, to determine the optimal conditions for harvesting through centrifugation, different rotational speeds of the continuous centrifuge and different flow rates of the pump injecting G. smaydae + H. rotundata cells into the centrifuge were tested. Under continuous aeration, G. smaydae production gradually decreased; however, without aeration, the production remained stable. Harvesting efficiency and the dry weights of omega-3 fatty acids of G. smaydae + H. rotundata cells at a rotational speed of 16,000 rpm were significantly higher than those at 2,000-8,000 rpm. However, these parameters did not significantly differ at injection pump flow rates of 1.0-4.0 L min-1. The results of the present study provide a basis for optimized production and harvest conditions for G. smaydae and other microalgae.

Edge Detection and ROI-Based Concrete Crack Detection (Edge 분석과 ROI 기법을 활용한 콘크리트 균열 분석 - Edge와 ROI를 적용한 콘크리트 균열 분석 및 검사 -)

  • Park, Heewon;Lee, Dong-Eun
    • Korean Journal of Construction Engineering and Management
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    • v.25 no.2
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    • pp.36-44
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    • 2024
  • This paper presents the application of Convolutional Neural Networks (CNNs) and Region of Interest (ROI) techniques for concrete crack analysis. Surfaces of concrete structures, such as beams, etc., are exposed to fatigue stress and cyclic loads, typically resulting in the initiation of cracks at a microscopic level on the structure's surface. Early detection enables preventative measures to mitigate potential damage and failures. Conventional manual inspections often yield subpar results, especially for large-scale infrastructure where access is challenging and detecting cracks can be difficult. This paper presents data collection, edge segmentation and ROI techniques application, and analysis of concrete cracks using Convolutional Neural Networks. This paper aims to achieve the following objectives: Firstly, achieving improved accuracy in crack detection using image-based technology compared to traditional manual inspection methods. Secondly, developing an algorithm that utilizes enhanced Sobel edge segmentation and ROI techniques. The algorithm provides automated crack detection capabilities for non-destructive testing.

Artificial intelligence design for dependence of size surface effects on advanced nanoplates through theoretical framework

  • Na Tang;Canlin Zhang;Zh. Yuan;A. Yvaz
    • Steel and Composite Structures
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    • v.52 no.6
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    • pp.621-626
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    • 2024
  • The work researched the application of artificial intelligence to the design and analysis of advanced nanoplates, with a particular emphasis on size and surface effects. Employing an integrated theoretical framework, this study developed a more accurate model of complex nanoplate behavior. The following analysis considers nanoplates embedded in a Pasternak viscoelastic fractional foundation and represents the important step in understanding how nanoscale structures may respond under dynamic loads. Surface effects, significant for nanoscale, are included through the Gurtin-Murdoch theory in order to better describe the influence of surface stresses on the overall behavior of nanoplates. In the present analysis, the modified couple stress theory is utilized to capture the size-dependent behavior of nanoplates, while the Kelvin-Voigt model has been incorporated to realistically simulate the structural damping and energy dissipation. This paper will take a holistic approach in using sinusoidal shear deformation theory for the accurate replication of complex interactions within the nano-structure system. Addressing different aspectsof the dynamic behavior by considering the length scale parameter of the material, this work aims at establishing which one of the factors imposes the most influence on the nanostructure response. Besides, the surface stresses that become increasingly critical in nanoscale dimensions are considered in depth. AI algorithms subsequently improve the prediction of the mechanical response by incorporating other phenomena, including surface energy, material inhomogeneity, and size-dependent properties. In these AI- enhanced solutions, the improvement of precision becomes considerable compared to the classical solution methods and hence offers new insights into the mechanical performance of nanoplates when applied in nanotechnology and materials science.

Impacts of Ocean Currents on the South Indian Ocean Extratropical Storm Track through the Relative Wind Effect

  • Hyodae Seo;Hajoon Song;Larry W. O'Neill;Matthew R. Mazloff;Bruce D. Cornuelle
    • Journal of Climate Change Research
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    • v.34 no.22
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    • pp.9093-9113
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    • 2021
  • This study examines the role of the relative wind (RW) effect (wind relative to ocean current) in the regional ocean circulation and extratropical storm track in the south Indian Ocean. Comparison of two high-resolution regional coupled model simulations with and without the RW effect reveals that the most conspicuous ocean circulation response is the significant weakening of the overly energetic anticyclonic standing eddy off Port Elizabeth, South Africa, a biased feature ascribed to upstream retroflection of the Agulhas Current (AC). This opens a pathway through which the AC transports the warm and salty water mass from the subtropics, yielding marked increases in sea surface temperature (SST), upward turbulent heat flux (THF), and meridional SST gradient in the Agulhas retroflection region. These thermodynamic and dynamic changes are accompanied by the robust strengthening of the local low-tropospheric baroclinicity and the baroclinic wave activity in the atmosphere. Examination of the composite life cycle of synoptic-scale storms subjected to the high-THF events indicates a robust strengthening of the extratropical storms far downstream. Energetics calculations for the atmosphere suggest that the baroclinic energy conversion from the basic flow is the chief source of increased eddy available potential energy, which is subsequently converted to eddy kinetic energy, providing for the growth of transient baroclinic waves. Overall, the results suggest that the mechanical and thermal air-sea interactions are inherently and inextricably linked together to substantially influence the extratropical storm tracks in the south Indian Ocean.

Screening of salt-tolerance plants using transgenic Arabidopsis that express a salt cress cDNA library (Salt cress 유전자의 형질전환을 통한 내염성 식물체 선별)

  • Baek, Dongwon;Choi, Wonkyun;Kang, Songhwa;Shin, Gilok;Park, Su Jung;Kim, Chanmin;Park, Hyeong Cheol;Yun, Dae-Jin
    • Journal of Plant Biotechnology
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    • v.41 no.2
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    • pp.81-88
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    • 2014
  • Salt cress (Thellungiella halophila or Thellungiella parvula), species closely related to Arabidopsis thaliana, represents an extremophile adapted to harsh saline environments. To isolate salt-tolerance genes from this species, we constructed a cDNA library from roots and leaves of salt cress plants treated with 200 mM NaCl. This cDNA library was subsequently shuttled into the destination binary vector [driven by the cauliflower mosaic virus (CaMV) 35S promoter] designed for plant transformation and expression via recombination- assisted cloning. In total, 305,400 pools of transgenic BASTA-resistant lines were generated in Arabidopsis using either T. halophila or T. parvula cDNA libraries. These were used for functional screening of genes involved in salt tolerance. Among these pools, 168,500 pools were used for primary screening to date from which 7,157 lines showed apparent salt tolerant-phenotypes in the initial screen. A secondary screen has now identified 165 salt tolerant transgenic lines using 1,551 (10.6%) lines that emerged in the first screen. The prevalent phenotype in these lines includes accelerated seed germination often accompanied by faster root growth compared to WT Arabidopsis under salt stress condition. In addition, other lines showed non-typical development of stems and flowers compared to WT Arabidopsis. Based on the close relationship of the tolerant species to the target species we suggest this approach as an appropriate method for the large-scale identification of salt tolerance genes from salt cress.

Characteristics of Sleep Patterns in Korean Women Golfers (여자 골프선수들의 수면양상조사)

  • Park, Soo Yeon;Shin, Won-Chul
    • Sleep Medicine and Psychophysiology
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    • v.21 no.2
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    • pp.80-84
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    • 2014
  • Introduction: Sleep has numerous important physiological and cognitive functions that may be particularly important to elite athletes. Sleep deprivation can have significant effects on athletic performance. However, there are few published data related to the amount of sleep obtained by elite athletes. We investigated sleep patterns of Korean women golfers using sleep-related questionnaires. Methods: For this study, 98 Korean university women golfers and 46 age- and sex-matched controls were recruited. All subjects were asked to complete the self-administered sleep questionnaire consisting of questions about habitual sleep patterns (sleep onset time, sleep latency, awakening time in the morning, day time napping time), exercise habits, Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISS), Pittsburgh Sleep Quality Index (PSQI), validation of the Perceived Stress Scale (PSS), and Beck Anxiety Inventory (BAI). Results: The sleep onset time was significantly earlier (pm 23 : $05{\pm}00$ : 52 and 00 : $14{\pm}00$ : 51 ; t = 5.287, p < 0.001), the waking time was later (am 07 : $21{\pm}01$ : 09 and 6 : $35{\pm}00$ : 32; t = -2.715, p = 0.008), the weekday total sleep time was greater ($417.77{\pm}78.18$ minute and $351.52{\pm}77.83$ minute ; t = 4.406, p = 0.001), and the daytime nap time was greater ($77.73{\pm}41.28$ minute and $20.22{\pm}33.03$ minute ; t = 7.623, p < 0.001) in the golf athletes compared to the controls. The PSQI scores were significantly lower, but estimated sleep latency and ESS, ISS, PSS, and BAI scores were not different among the two groups. Conclusion: This study suggests that Korean university women golfers have good sleep patterns resulting in no difference in sleep-related stress compared to age- and sex-matched control students.

The Characteristics of Illness Behavior in Patients with Somatization (신체화에 따른 질병행동의 특성에 관한 연구)

  • Song, Ji-Young;Yum, Tae-Ho;Oh, Dong-Jae;Cho, Seong-Wook
    • Korean Journal of Psychosomatic Medicine
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    • v.5 no.2
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    • pp.176-184
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    • 1997
  • Abnormal illness behavior in patients with somatoform disorders were known formed by their traditional disease concepts and somatization-prone socio-cultural factors. The authors evaluated the characteristics of abnormal illness behavior in patients with somatoform disorders(who had somatization) by using abnormal illness behavior questionnaire. Methods : 29 somatoform disorders(SD) and 57 disease controls were compared by clinical characteristics, severity of pain, state anxiety(by Spielberger's State & Trait Anxiety Inventory), depression(by Beck's Depression Inventory) and level of psychosocial stess(by DSM-III-R). The illness behavior was measured by illness Behavior Questionnaire(IBQ). Results SD group had longer period of somatic symptoms with less severity in pain. The degree of anxiety and depression were higher in SB compared with controls. However, the degree of psychosocial stress was almost same between both groups. In IBQ, SD showed higher scores in general hypochondriasis, disease conviction, and affective disturbance subscales compared to control group. Conclusion: High disease conviction and hypochondriacal nature revealed by IBQ seemed to be a role in making somatization by way of somatic focusing and hypervigilance. And those tended to lead patients visit hospital frequently and report various somatic complaints. Evaluating abnormal illness behavior in somatoform disorders would be not only helpful in understanding the natures of somatoform disorders but also useful differentiating SD with other psychiatric conditions.

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A Study on the Characteristics according to Sasangin - Targeting the Group of Ordinary Adolescents - (사상인(四象人)의 성격(性格) 특성(特性)에 관(關)한 연구(硏究) -정상(正常) 청소년(靑少年) 집단(集團)을 대상(對象)으로 -)

  • Whang, Man-Ki;Hwang, Ui-Wan;Kim, Jong-Woo
    • Journal of Oriental Neuropsychiatry
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    • v.15 no.2
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    • pp.71-88
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    • 2004
  • Objectives : The aims of this report are to examine the personal characteristics and to determine the different reactions against stress by constitutions. To achieve these goals, the statistical research was adopted. Methods : First of all, the total numbers of 398 middle school students were classified into three constitutions by QSCC II. According to each type of constitutions, both of the KPI Personality Test and Multidimensional Encountering Scale (MES) on how to deal with stress were conducted. Summary of the findings : 1. Based on the findings assessed by the QSCC II test, the constitutional distribution reveals the difference according to genders. In Chi-square test, the girl reveals significantly high (p<0.05) distribution in Soyangin. 2. In Independent T-test regarding KPI personality, the girl reveals high significance (p<0.05) in terms of 'Sociability', 'Responsibility', 'Synchronism' and 'Self-feminity' (or Feminization) while the boy reveals high significance in 'Goal-driven' (p<0.05). 3. In Independent T-test regarding the multidimensional encounter scaling, the girl reveals high significance (p<0.05) in D (expression of emotion). 4. In case of the boy, the Soeumin shows low significance (p<0.05) in 'Leadership' and 'Sociability' compared to the Taeumin or the Soyangin. On the other hand, the Soeumin reveals high significance (p<0.05) in 'Responsibility' and 'Self-control' compared to the Soyangin and additionally, shows high significance (p<0.05) in 'Self-feminity' (or Feminization) compared to the Taeumin or the Soyangin. Furthermore, the Soyangin shows high significance (p<0.05) in 'Self-confidence' compared to the Soeumin or the Taeumin. 5. In case of the girl, the Soyangin reveals high significance in 'Sociability' and 'Self-confidence' compared to the Soeumin or the Taeumin while the Soeumin has high significance in 'Synchronism' compared to the Taeumin or Soyangin. On the other hand, the Soeumin has high significance in terms of 'Responsibility', 'Self-control', and 'Self-feminity' (or Feminization) while showing low significance in 'Flexibility' compared to the Soyangin. 6. For boys, the Soeumin has low significance in 'Sociability' in comparison with both the Soyangin and the Taeumin, whereas for girls, the Soyangin reveals high significance in 'Sociability' in comparison with both the Soeumin and the Taeumin. As per the 'Self-confidence' and 'Responsibility', it has been proved that there is no notable difference between the boy and the girl, but to the contrary, as per the 'Self-confidence', both for the girl and the boy, the Soyangin has high significance (p<0.05) in comparison with the Soeumin and the Taeumin. In addition, in 'Responsibility' side, it is recognized that the Soeumin shows high significance (p<0.05) in comparison with the Soyangin both for boys and girls. Only the difference between genders, as to the 'Self-confidence', is that the Soeumin shows low distribution compared to the Taeumin in the case of boys, while the Taeumin shows low distribution compared to the Soeumin in the case of girls. In 'Self-feminity' (or Feminization), for boys the Soeumin shows high significance in comparison with both the Soeumin and the Taeumin, but to the contrary, for girls the Soeumin shows high significance (p<0.05) only against the Soyangin. 7. In case of boys, as to 'Conformability (compromise)', the Taeumin compared to the Soeumin reveals high significance (p<0.05), while for girls, the Soeumin compared to the Soyangin or the Taeumin reveals high significance (p<0.05). Consequently, it presents that the Soyangin has a tendency not to confirm (compromise) relatively in comparison with other constitutions regardless of the genders. Conclusions : In general, except that it shows some constitutional deviation by genders, the statistical findings of this report agree and comply with the personal characteristics of Sasangin presented by Je-Ma Lee.

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