• Title/Summary/Keyword: Stress Susceptibility

Search Result 210, Processing Time 0.027 seconds

Effects of Dietary L-carnitine Supplementation on Growth Performance, Organ Weight, Biochemical Parameters and Ascites Susceptibility in Broilers Reared Under Low-temperature Environment

  • Wang, Y.W.;Ning, D.;Peng, Y.Z.;Guo, Y.M.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.26 no.2
    • /
    • pp.233-240
    • /
    • 2013
  • The objective of this study was to investigate the effects of L-carnitine on growth performance, organ weight, biochemical parameters of blood, heart and liver, and ascites susceptibility of broilers at different ages reared under a low-temperature environment. A total of 420 1-d-old male Ross 308 broilers were randomly assigned to two dietary treatments with fifteen replicates of fourteen broilers each. Treatment diets consisted of L-carnitine supplementation at levels of 0 and 100 mg/kg. At 11-d of age, low temperature stress was used to increase ascites susceptibility. Blood, heart and liver samples were collected at different ages for analysis of boichemical parameters. The results showed that, there was no significant difference in growth performance with L-carnitine supplementation, but the mortality due to ascites was significantly decreased. Dietary L-carnitine supplementation significantly reduced heart index (HI) and ascites heart index (AHI) on d 21, lung index (LUI) on d 35 and liver index (LI) on d 42. The broilers fed diets containing L-carnitine had significantly lower red blood cell counts (RBC), hemoglobin (HGB) concentration and hematocrit (HCT) on d 42. Dietary L-carnitine supplementation significantly reduced malondialdehyde (MDA) content of heart tissue on d 21 and 35, and significantly increased total superoxide dismutase (T-SOD) and Glutathione peroxidase (GSH-Px) activity of the heart on d 21 and 42. L-carnitine supplementation significantly reduced serum triglyceride (TG) content on d 28 and 35 and serum glucose (GLU) on d 35 and 42, and significantly increased serum total protein (TP) and globulin (GLO) content on d 42. L-carnitine supplementation significantly enhanced liver succinodehydrogenase (SDH), malic dehydrogenase (MDH) and $Na^+$-$K^+$-ATPase activity on d 28, and tended to reduce the lactic acid (LD) level of liver on d 35 (p = 0.06). L-carnitine supplementation significantly reduced serum uric acid (UA) content on d 28, 35 and 42. Based on the current results, it can be concluded that dietary L-carnitine supplementation reduced organ index, red blood cell counts and hematocrit, enhanced antioxidative capacity of the heart, enhanced liver enzymes activity involved in tricarboxylic acid cycle, and reduced serum glucose and triglyceride. Therefore, it is suggested that L-carnitine can potentially reduce susceptibility and mortality due to ascites.

A Study of TNF-${\alpha}$(G308A) Genetic Polymorphism and Risk Factors Associated with Rheumatoid Arthritis by Sasang Constitution (사상체질에 따른 류마티스 관절염의 위해요인 및 TNF-${\alpha}$(G308A) 유전자 다형성간의 연관성 연구)

  • Kim, Su-Young;Chun, Hyung-Jon;Lee, Doo-Ik;Lee, Yun-Ho;Choi, Do-Young;You, Yong-Gu;Lee, Jae-Dong
    • Journal of Acupuncture Research
    • /
    • v.24 no.1
    • /
    • pp.137-159
    • /
    • 2007
  • Objectives: The purpose of this study is to examine the risk factors and the genetic polymorphism of TNF-alpha associated with rheumatoid arthritis by Sasang constitution Methods : This study was planned to detect the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Constitution and to examine the risk factor such as life style and environmental stress (smoking, environmental tobacco smoke, alcohol intake and so on). The genetic polymorphism of TNF-alpha (G308A) were analyzed by PCR-RFLP in rheumatoid arthritis patients and controls. Rheumatoid arthritis patients and matched controls are assessed with QSCCII question for Sasang Typology. Then the genetic polymorphism of patients by Sasang constitution are compared to those of control, which are statistically analyzed and adjusted by age, sex, smoking status, alcohol intake, BMI, and econocmic status. Results: Differential effect of passive smoking on the association between Sasang constitution and rheumatoid arthritis risk was found. This study showed that the genetic polymorphism (TNF-${\alpha}$(G308A)) of rheumatoid arthritis patients and controls associated with the susceptibility to rheumatoid arthritis by sasang constitution was analyzed. Differential effects of TNF-${\alpha}$(G308) genetic polymorphism on the association between rheumatoid arthritis risk and Sasang constitution were found. Conclusion : It is suggested that the genetic polymorphism correlated with susceptibility to rheumatoid arthritis by specific sasang constitution used as its susceptibility marker and further as basic data to prevent the risk factors for rheumatoid arthritis. But larger studies will be needed to confirm these preliminary findings.

  • PDF

The Slow Strain Rate Dependence of Zircaloy-4 Cladding Tube in Iodine Atmosphere (I) (요드분위기에서 지르칼로이 피복재의 저변형율속도 의존성(I))

  • Choi, Y.;Kang, Y.H.;Ryu, W.S.;Rim, C.S.
    • Nuclear Engineering and Technology
    • /
    • v.17 no.3
    • /
    • pp.211-215
    • /
    • 1985
  • The effects of temperature and strain rate on the I-SCC behaviors of Zircaloy-4 were investigated by constant load test at 30$0^{\circ}C$ and constant elongation rate test at 300, 350 and 40$0^{\circ}C$ in 3.34mg $I_2$/㎤. The results showed that I-SCC susceptibility increased as the strain rate decreased or the temperature increased. The empirical relation between the stress and the time to failure at 30$0^{\circ}C$ was given by 1/ $t_{f}$∝exp (0.3$\sigma$/$\sigma$$_{UTS}$-31.5) When the I-SCC susceptibility was expressed by the ratio of fracture energy in iodine atmosphere to that in the inert atmosphere, severe I-SCC susceptibility was found near 7.6$\times$10$^{-6}$ sec at 30$0^{\circ}C$ and the maximum point of I-SCC susceptibility tended to shift to the higher strain rate with increasing the temperature. The quasi-cleavage fracture was observed in I-SCC fracture surface. From these results, it was certain that the film repture step was involved as an important process in the I-SCC mechanism of Zircaloy-4.4.

  • PDF

Stress Day Index to Predict Soybean Yield Response by Subsurface Drainage in Poorly Drained Sloping Paddy Fields (배수불량 경사지 논에서 배수개선에 따른 콩의 수분스트레스 반응해석)

  • Jung, Ki-Yuol;Yun, Eul-Soo;Park, Chang-Young;Hwang, Jae-Bok;Choi, Young-Dae;Park, Ki-Do
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.44 no.5
    • /
    • pp.702-708
    • /
    • 2011
  • There are considerable areas of wet paddy fields in Korea that requires improvement of its drainage system. In poorly drained sloping paddy fields, upland crops can be damaged by either rainfall or capillary rise of the water table caused by percolating water beneath the upper fields during summertime rainy season. The purpose of this study is to evaluate excess water stress of soybean yield by drainage systems. Four drainage methods namely open ditch, vinyl barrier, pipe drainage and tube bundle were installed within 1-m position at the lower edge of the upper paddy fields. Stress Day Index (SDI) approach was developed to quantify the the cumulative effect of stress imposed on a soybean yield throughout the growing season. SDI was determined from a stress day factor (SD) and a crop susceptibility factor (CS). The stress day factor is a measure degree and duration of stress of the ($SEW_{30}$). The crop susceptibility factor (CS) depends of a given excess water on crop stage. The results showed that SDI used to represent the moisture stress index was most low on the pipe drainage 64.75 compared with the open ditch 355.4, vinyl barrier 271.55 and tube bundle 171.55. Soybean grain yield increased continuously with the rate of 3% in Vinyl Barrier, 32% in Pipe Drainage and 16% in Tube Bundle.

The effects of child abuse prevention education on parents' response to positive emotion, parenting stress, and child abuse potential: A randomized controlled pretest posttest design (아동학대 예방교육이 부모의 긍정정서 반응, 양육 스트레스, 아동학대 잠재성에 미치는 영향: 무작위 대조군 사전·사후 연구)

  • Kim, Mi Hyun;Park, Bu Kyung
    • The Journal of Korean Academic Society of Nursing Education
    • /
    • v.30 no.1
    • /
    • pp.19-28
    • /
    • 2024
  • Purpose: The purpose of this study was to develop a child abuse prevention education program for parents. Furthermore, the aim was to investigate the impact of child abuse prevention education on parents' response to positive emotion, parenting stress, and potential for child abuse. Methods: A randomized controlled pretest posttest design was used. A total of 60 participants, who were parents with children aged 1~5 and attending 8 nurseries and kindergartens located in Daegu, were recruited. They were randomly assigned to an experimental group (n=30) and a control group (n=30). The collected data were analyzed by an independent t-test, paired t-test, and χ2-test along with descriptive statistics using IBM SPSS Statistics 25.0. Child abuse prevention education for the experimental group included four modules on child rights, understanding child abuse, proper child discipline, and positive parenting attitudes. Results: The experimental group showed a significant difference in positive rumination from the control group (t=2.15, p=.036). The experimental group reported a significant difference in dampening from the control group (t=-2.49, p=.016). Additionally, the experimental group reported a significant difference in parenting stress from the control group (t=-2.12, p=.038) and also reported significant differences in child abuse potential from the control group (t=-2.26, p=.028). Conclusion: The results of this study indicate that child abuse prevention education for parents can improve positive rumination, reduce dampening, and reduce parenting stress and child abuse potential. Therefore, this study is useful in demonstrating how parental susceptibility to child abuse can be decreased. Future studies should pursue long-term programs and counseling programs.

Evaluation of Scc Susceptibility of Welded HAZ in Structual Steel(II) -Frcature Behavior in Cathodic Protection- (강 용접부의 응력부식크랙 감수성 평가에 관한 연구 II -음극방식에서의 파괴거동-)

  • 임재규;조정운;나의균
    • Journal of Welding and Joining
    • /
    • v.11 no.3
    • /
    • pp.61-74
    • /
    • 1993
  • The cause of corrosion failure found in structures or various components operating in severe corrosive environment has been attributed to stress corrosion cracking(SCC) which is resulting from the combined effects of corrosive environments and static tensile stress. Cathodic protection is an electrochemical method of corrosion control that is widely used in marine environment and primarily on carbon steel. A number of criteria are used to determine whether or not a structure is cathodically protected. In practice, -0.8V versus Ag/AgCl is the most commonly used for marine structures. This paper showed the combined effects of cathodic potential and slow, monotonic straining on the tensile ductility and fracture morphology of parents and friction welded joints for SM45C, SCM440 and SM20C steels in syntheic sea water(S.S.W.,pH:8.2). For the parent materials in cathodic potentials, the higher tensile strength is, the more susceptible SCC is. And the welded HAZ is more susceptible than the parent materials.

  • PDF

OxyR Regulon Controls Lipid Peroxidation-mediated Oxidative Stress in Escherichia coli

  • Yoon, Seon-Joo;Park, Ji-Eun;Yang, Joon-Hyuck;Park, Jeen-Woo
    • BMB Reports
    • /
    • v.35 no.3
    • /
    • pp.297-301
    • /
    • 2002
  • Membrane lipid peroxidation processes yield products that may react with DNA and proteins to cause oxidative modifications. The oxyR gene product regulates the expression of enzymes and proteins that are needed for cellular protection against oxidative stress. Upon exposure to tert-butylhydroperoxide (t-BOOH) and 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH), which induce lipid peroxidation in membranes, the Escherichia coli oxyR overexpression mutant was much more resistant to lipid peroxidation-mediated cellular damage, when compared to the oxyR deletion mutant in regard to growth kinetics, viability, and DNA damage. The deletion of the oxyR gene in E. coli also resulted in increased susceptibility of superoxide dismutase to lipid peroxidation-mediated inactivation. The results indicate that the peroxidation of lipid is probably one of the important intermediary events in free radical-induced cellular damage. Also, the oxyR regulon plays an important protective role in lipid peroxidation-mediated cellular damage.

Current Status and Prospects of Quality Evaluation in Sesame (참깨의 품질평가 현황과 전망)

  • 류수노;김관수;이은정
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.47
    • /
    • pp.140-149
    • /
    • 2002
  • Sesame (Sesamum indicum L.) is probably the most ancient oilseed crop known in the world. Sesame seed is known for its high nutritional value and for having oil (51%) and protein (20%) content. The fatty acid composition of sesame oil is palmitic acid (7.8%), stearic acid (3.6%), oleic acid (45.3%), and linoleic acid (37.7%). Sesame oil is characterized by a very high oxidative stability compared with other vegetable oils. Two lignan-type compounds, sesamin and sesamolin, are the major constituents of sesame oil unsaponifiables. Sesamol (a sesamolin derivative) can be present in sesame seeds and oils in very small amount. Other lignans and sesamol are also present in sesame seeds and oils in very small amount as aglycones. Lipid oxidation activity was significantly lower in the sesamolin-fed rats, which suggests that sesamolin and its metabolites contribute to the antioxidative properties of sesame seeds and oil and support that sesame lignans reduce susceptibility to oxidative stress. Sesaminols strongly inhibit lipid peroxidation related to their ability to scavenge free radical. The sesame seed lignan act synergistically with vitamin I in rats fed a low $\alpha$-tocopherol diet and cause a marked increase in a u-tocopherol concentration in the blood and tissue of rats fed an $\alpha$-tocopherol containing diet with sesame seed or its lignan. The authors are reviewed and discussed for present status and prospects of quality evaluation and researched in sesame seeds to provide and refers the condensed informations on their quality.

ROLE OF GRAIN BOUNDARY CARBIDES IN CRACKING BEHAVIOR OF Ni BASE ALLOYS

  • Hwang, Seong Sik;Lim, Yun Soo;Kim, Sung Woo;Kim, Dong Jin;Kim, Hong Pyo
    • Nuclear Engineering and Technology
    • /
    • v.45 no.1
    • /
    • pp.73-80
    • /
    • 2013
  • The primary water stress corrosion cracking (PWSCC) of Alloy 600 in a PWR has been reported in the control rod drive mechanism (CRDM), pressurizer instrumentation, and the pressurizer heater sleeves. Recently, two cases of boric acid precipitation that indicated leaking of the primary cooling water were reported on the bottom head surface of steam generators (SG) in Korea. The PWSCC resistance of Ni base alloys which have intergranular carbides is higher than those which have intragranular carbides. Conversely, in oxidized acidic solutions like sodium sulfate or sodium tetrathionate solutions, the Ni base alloys with a lot of carbides at the grain boundaries and shows less stress corrosion cracking (SCC) resistance. The role of grain boundary carbides in SCC behavior of Ni base alloys was evaluated and effect of intergranular carbides on the SCC susceptibility were reviewed from the literature.

Role of residual ferrites on crevice SCC of austenitic stainless steels in PWR water with high-dissolved oxygen

  • Sinjlawi, Abdullah;Chen, Junjie;Kim, Ho-Sub;Lee, Hyeon Bae;Jang, Changheui;Lee, Sanghoon
    • Nuclear Engineering and Technology
    • /
    • v.52 no.11
    • /
    • pp.2552-2564
    • /
    • 2020
  • The crevice stress corrosion cracking (SCC) susceptibility of austenitic stainless steels was evaluated in simulated pressurized water reactor (PWR) environments. To simulate the abnormal condition in temporary clamping devices on leaking small bore pipes, crevice bent beam (CBB) tests were performed in the oxygenated as well as hydrogenated conditions. No SCC cracks were found for SS316 in both conditions. SS304 also showed good resistance in the hydrogenated condition. However, all SS304 specimens showed SCC cracks in the oxygenated condition, indicating poor crevice SCC resistance. It was found that residual ferrites were selectively dissolved because of the galvanic corrosion coupled with the neigh-bouring austenite phase, resulting in SCC initiation in SS304. Crack morphologies were mostly transgranular assisted by the damaged δ-ferrite and deformation-induced slip bands.