• Natural Product Sciences
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• 제9권2호
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• pp.68-72
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• 2003

Quercetin and its sugar conjugates are the most abundantly distributed bioflavonoids and represent the largest proportion of flavonols in the plant kingdom. The present study was undertaken to demonstrate the effect of quercetin on the role of reactive oxygen species (ROS) in the development of gastric ulcers in rats. Administration of quercetin in doses of 50, 100 and $200\;mg\;kg^{-1}$ twice daily for 5 days, showed dose dependent significant protection against ethanol (EtOH), aspirin (ASP), cold-restraint stress (CRS) and pylorus ligation (PL) -induced gastric ulcer models and the results were comparable with those elicited by sucralfate. The thiobarbituric acid reactive substances in the stomach mucosa, an index of lipid peroxidation and regulation of plasma corticosterone were significantly increased in CRS-induced gastric ulceration. The queroetin $(100\;mg\;kg^{-1})$ and reduced glutathione effectively inhibited gastric lesions induced by CRS with a significant decrease in the lipid peroxidation and plasma corticosterone. These results indicate that quercetin a bioflavonoid exerts its antiulcer effect in light of free radical scavenging and plasma corticosterone in cold restraint stress ulcers.

• 분석과학
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• 제37권1호
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• pp.25-38
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• 2024

The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) to separate, identify and characterize very nominal quantities of degradation products (DPs) of balsalazide along with its process related impurities without isolation from their reaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 ㎛) column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45 (v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. The method shows sensitive detection limit of 0.003 ㎍/mL, 0.015 ㎍/mL and 0.009 ㎍/mL respectively for impurity 1, 2 and 3 with calibration curve liner in the range of 50-300 ㎍/mL for balsalazide and 0.05-0.30 for its impurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products (DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC-MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl) diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoic acid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable for routine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicable for identification of known and unknown impurities of balsalazide.

• Advances in concrete construction
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• 제2권3호
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• pp.229-247
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• 2014

A numerical study of the influence of shear-span/depth ratio on the cohesive crack fracture parameters and double - K fracture parameters of concrete is carried out in this paper. For the study the standard bending specimen geometry loaded with four point bending test is used. For four point loading, the shear - span/depth ratio is varied as 0.4, 1 and 1.75 and the ao/D ratio is varied from 0.2, 0.3 and 0.4 for laboratory specimens having size range from 100 - 500 mm. The input parameters for determining the double - K fracture parameters are taken from the developed fictitious crack model. It is found that the cohesive crack fracture parameters are independent of shear-span/depth ratio. Further, the unstable fracture toughness of double-K fracture model is independent of shear-span/depth ratio whereas, the initial cracking toughness of the material is dependent on the shear-span/depth ratio.

• 가정간호학회지
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• 제22권2호
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• pp.265-279
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• 2015

Purpose: Most research on risky drinking among adults in Korea has focused on problem drinking and high-risk drinking. This paper examines the nature of heavy episodic drinking_(HED) among adults and seeks to identify the risk factors for HED by analyzing differences by gender and age. Method: Participants were 3,886 adults aged 19-64 years from the database of the fifth Korean National Health and Nutritional Examination Survey (KNHANES-V, 2010). Data were analyzed by conducting the Rao_Scott chi-square test, an ANCOVA, and logistic analysis with SAS 9.2. Results: Individuals between 19 and 29 years of age had the highest HED among all age groups. Individuals between 40 and 49 (male adults) and those between 30 and 39 (female adults) showed HED associated with stress, suicidal ideation, smoking, and other health behavior-related variables. Risk factors that affected HED in male adults were age, educational status, and current smoking, while for female adults, the factors were age, educational status, employment, marital status, and current smoking. Conclusions: It is necessary to develop appropriate intervention programs that abate negative emotions and lessen the risk of HED in adults with consideration to gender and age differences.

• Advances in concrete construction
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• 제6권1호
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• pp.29-45
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• 2018

This paper investigates the effect of inclusion of glass fibers on mechanical and fracture properties of binary blend geopolymer concrete produced by using fly ash and ground granulated blast furnace slag. To study the effect of glass fibers, the mix design parameters like binder content, alkaline solution/binder ratio, sodium hydroxide concentration and aggregate grading were kept constant. Four different volume fractions (0.1%, 0.2%, 0.3% and 0.4%) and two different lengths (6 mm, 13 mm) of glass fibers were considered in the present study. Three different notch-depth ratios (0.1, 0.2, and 0.3) were considered for determining the fracture properties. The test results indicated that the addition of glass fibers improved the flexural strength, split tensile strength, fracture energy, critical stress intensity factor and critical crack mouth opening displacement of geopolymer concrete. 13 mm fibers are found to be more effective than 6 mm fibers and the optimum dosage of glass fibers was found to be 0.3% (by volume of concrete). The study shows the enormous potential of glass fiber reinforced geopolymer concrete in structural applications.

• 성인간호학회지
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• 제26권2호
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• pp.139-148
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• 2014

Purpose: This study was aimed to investigate the factors influencing problem drinking of male drinkers above 19 years old according to the life cycle. Methods: The study subjects consisted of a representative community sample of 2,229 male drinkers aged 19 and older from the 2011 Korean National Health and Nutrition Examination Survey. The collected data were analyzed using descriptive statistics, Rao-Scott $x^2$-test, simple and multiple logistic regressions. Results: The problem drinking rates were 38.7% in adolescence, 44.5% in middle age, and 23.9% in senescence. In adolescence, the predictors of problem drinking included occupation, stress recognition, and smoking. In middle age, the predictors of problem drinking were education level, depression, and smoking. In senescence, the predictors of problem drinking were not identified in this study. Conclusion: The findings of this study suggested that the factors influencing problem drinking of male drinkers were different according to life cycle. Thus different intervention methods should be developed for each age group in order to intervene the problem drinking.

• Child Health Nursing Research
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• 제23권2호
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• pp.249-257
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• 2017

Purpose: The aim of this study was to assess the body weight perception of adolescents and to investigate the difference between mental health and weight control behavior according to body weight perception. Methods: Study data on 12-18 years old adolescents with normal BMI was obtained from the 6th Korea National Health and Nutrition Examination Survey (2013-2015). Rao-Scott Chi-square test and ANOVA were used for the analysis. Results: The percentage of adolescents with a misperception of body weight was 43.3%, and their subjective health status (p=.013), stress perception (p=.001), and depression (p=.001) were worse than for adolescents who had the correct perception of their body weight. The percentage of adolescents who were trying to lose weight while perceiving their body weight as normal was 36.9%. Body weight control behavior had significant differences according to dietary intake (frequency of eating dinner (p=.015)), energy intake (p=.004), and carbohydrate intake (p<.001), but there was no significant difference according to exercise. Conclusion: Parents, school teachers, and nurses should make efforts to ensure that Korean adolescents perceive their body weight correctly, and prevent unhealthy weight control behaviors.

• BMB Reports
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• 제41권8호
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• pp.560-567
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• 2008

The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase $A_2$ ($PLA_2$), which results in the hydrolysis of membrane phospholipids and the release of free fatty acids, including arachidonic acid, a precursor for essential cell-signaling eicosanoids. Reactive oxygen species (ROS, a product of arachidonic acid metabolism) react with cellular lipids to generate lipid peroxides, which are degraded to reactive aldehydes (oxidized phospholipid, 4-hydroxynonenal, and acrolein) that bind covalently to proteins, thereby altering their function and inducing cellular damage. Dissecting the contribution of $PLA_2$ to lipid peroxidation in CNS injury and disorders is a challenging proposition due to the multiple forms of $PLA_2$, the diverse sources of ROS, and the lack of specific $PLA_2$ inhibitors. In this review, we summarize the role of $PLA_2$ in CNS pathologies, including stroke, spinal cord injury, Alzheimer's, Parkinson's, Multiple sclerosis-Experimental autoimmune encephalomyelitis and Wallerian degeneration.

• Molecules and Cells
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• 제28권5호
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• pp.417-422
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• 2009

Mitogen activated protein kinase (MAPK) are known to get activated during various stress signals and transduce the message from the cell membrane to the nucleus for appropriate cellular reorganization. Though, a certain basal activity of MAPK is often observed in the control plants. Prolonged exposure of rice plants to lowered or elevated temperature exhibited a rhythm in the activation of MAPKs. We analyzed existence of a possible endogenous rhythm in the activity of MAPKs in rice plants. The plants growing at constant temperature entrained in 16/8 h day-night cycle showed diurnal rhythm in activity. When the activation of MAPK was tested under continuous conditions by shifting plants to continuous darkness for a period of 72 h, the periodic rhythm persisted and followed a circadian pattern. Analysis of the transcripts of group A, B and C members of MAPKs under above conditions by quantitative real time PCR revealed that the members of group C exhibit periodic rhythm. Our data indicates that the MAP kinase activity in rice follows rhythmic expression in a circadian manner.

• 지역사회간호학회지
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• 제32권2호
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• pp.131-139
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• 2021

Purpose: In adults with chronic diseases, unmet healthcare needs are likely to increase the risk of worsening the illness and complications. This study was conducted to explore factors affecting unmet healthcare needs among adults with chronic diseases. Methods: A cross sectional study was performed using the data from the seventh Korea National Health and Nutrition Examination Survey (KNHANES VII), 2016-2017. The sample of this study consisted of 6,104 adults with chronic diseases. The data were analyzed by Rao-Scott 𝑥² test and logistic regression using complex samples analysis. Results: The proportion of subjects who experienced unmet healthcare needs was 10.9% of adults with chronic diseases. The factors affecting unmet healthcare needs of adults with chronic diseases were age, gender, employment status, household income, subjective health status, activity limitation, and perceived stress. Conclusion: The findings of this study suggest that various factors may be associated with their unmet healthcare needs. Finally, the development of strategies to reduce unmet healthcare needs for people with chronic diseases should consider the associated factors presented in the study.