• Title/Summary/Keyword: Stress Mechanism

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Metallothioneins and oxidative stress

  • Beattie, John H.;Trayhurn, Paul
    • Proceedings of the Korean Nutrition Society Conference
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    • 2002.11a
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    • pp.73-82
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    • 2002
  • The low molecular weight zinc-binding protein metallothionein (U) contains 32% cysteine and has been shown to efficiently scavenge hydroxyl radicals in vitro. MT expression is induced by oxidative stress and an antioxidant role for this protein has therefore been proposed. This review mainly focuses on the evidence for this role arising from studies using genetically modified animals and cells which either over- or under-express MT. Despite some considerable disparity of results in the literature, reported studies do generally support an antioxidant role. Nevertheless, oxidant stress at non-physiological treatment levels has been the preferred experimental model and there is little information about the role of MT in physiological oxidative stress. Although it is presumed that the mechanism by which MT has an antioxidant effect involves oxidation of cysteinal thiols, it is possible that zinc release from MT is in itself an important signalling factor.

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The Effect of Dynamic Strain Aging on the High Temperature Plastic Deformation Behaviour of Al-Mg Alloy (Al-Mg 합금의 고온 소성 변형 특성에 미치는 동적 변형 시효의 영향)

  • 이상용;이정환
    • Transactions of Materials Processing
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    • v.5 no.4
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    • pp.327-336
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    • 1996
  • The effect of dynamic strain aging on high temperature deformation behaviour of the A-Mg alloy was investigated by strain rate change tests and stress relaxation tests between 20$0^{\circ}C$and 50$0^{\circ}C$. Yield point, short stress transient and periodic discontinuities on the stress-strain curve were considered as an evidence of the effect of dynamic strain aging. With this criterion two distinct strain rate-temperature regimes could be manifested. Dynamic strain aging was considered to be effective in the high temperature-low strain rate regime, whereas dynamic recovery was a dominant deformation mechanism in the low temperature-high strain rate regime. It was found that dynamic strain aging in the high temperature deformation was governed by the mechcanism of diffusion-controlled, viscous dislocation movement.

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The Effects of Pass Strain and Rolling Temperature on Flow Stress and Flow Strain of AA5083 Alloy (AA5083 합금의 고온유동응력 및 연신율에 미치는 압연온도와 패스변형량의 영향)

  • 고병철;박도현;유연철
    • Transactions of Materials Processing
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    • v.8 no.2
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    • pp.169-177
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    • 1999
  • Different pass strains and rolling temperatures were applied to understand the effects of pass strain and rolling temperature on flow stress and flow strain of AA5083 alloy. The specimens were prepared by conventional casting process followed by hot rolling. Hot torsion tests were conducted at temperature ranges of 350 to 52$0^{\circ}C$ under a strain rate of 1.0/sec. During the process, hot-restoration mechanisms, dynamic recovery(DRV) or dynamic recrystallization (DRX), of the AA5083 alloy were analyzed from the flow curves and deformed microstructures. It was found that while the rolling strain per pass and rolling temperature have little effect on the folw stress, they have significant effect on the failure strain. The DRV was responsible for the hot restoration mechanism of the hot-rolled specimen. heavily elongated grains and small subgrains containing dislocations were obtaned during the hot deformation. This was due to the presence of Al6Mn precipitate in the alloy.

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Overexpressed Mitochondrial Thioredoxin Protects PC12 Cells from Hydrogen Peroxide and Serum-deprivation

  • Lee, Yun-Song;Yu, Seung-A
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.1
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    • pp.33-37
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    • 2003
  • Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective roles in organisms under oxidative stress through redox reaction by using reducing equivalents of cysteines at a conserved active site, Cys-X-X-Cys. Whereas biological and physiological properties of Trx1 are well characterized, significance of mitochondrial thioredoxin (Trx2) is not well known. Therefore, we addressed physiological role of Trx2 in PC12 cells under oxidative stress. In PC12 cells, transiently overexpressed Trx2 significantly reduced cell death induced by hydrogen peroxide, whereas mutant Trx2, having serine residues instead of two cysteine residues at the active site did not. In addition, stably expressed Trx2 protected PC12 cells from serum deprivation. These results suggest that Trx2 may play defensive roles in PC12 cells by reducing oxidative stress to mitochondria.

Finite Element Analysis of the Stress Distribution Characteristics in the Compliant Press-Fit Pin Connection (Compliant Press-Fit Pin 결합에서 발생하는 음력분포특성에 대한 유한요소해석)

  • 김병탁
    • Journal of Ocean Engineering and Technology
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    • v.14 no.4
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    • pp.79-85
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    • 2000
  • Press-fit pin connection is the solderless interference-fit between pins and plated through holes(PTH) in the printed curcuit board(PCB). Because of not only its simple assembly and absence of problems associated with soldering, but also its good mechanical and electrical characteristics, the press-fit pin connection technology has quickly gained wide acceptance in the telecommunications and computer industries. In this paper, the contact stress characteristics of the domestic CPF pin when inserted into the friction coefficients were compared and the stress variations of the compliant part of the pin, which have an influence on the performance, were displayed with the time and arc length after complete connected. It is supposed that the results will provide useful data to improve the performance of the pin-PCB interconnection mechanism.

Transient Thermoelastic Analysis and 3 Dimensional Stress Analysis of Carbon/Carbon Brake Disks (탄소/탄소 브레이크 디스크의 과도기 열탄성 해석과 3차원 응력해석)

  • 오세희;유재석;김천곤;홍창선;김광수
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2000.11a
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    • pp.147-152
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    • 2000
  • This paper presents the thermoelastic analysis and 3-D failure analysis of the carbon/carbon brake disk. The mechanical properties of the carbon/carbon brake disk were measured for both in-plane and out of plane directions. The mechanical properties were used as the input of the thermoelastic analysis and 3-D stress analysis for the brake disk. The gap between rotor clip and clip retainer was an important parameter in the loading transfer mechanism of the rotor. The change of gap was considered separating the mechanical deformation and thermal deformation. Because the rotor clip and clip retainers were not contacted, the clip retainers and rivets were excluded from the rotor analysis model. The disk was modeled by using the cyclic symmetry condition and the contact problem between the rotor disk and rotor clip was considered. From the results of the 3-D stress analysis, the stress concentration at the key hole of the brake disk was confirmed.

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A fracture criterion for high-strength steel cracked bars

  • Toribio, J.
    • Structural Engineering and Mechanics
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    • v.14 no.2
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    • pp.209-221
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    • 2002
  • In this paper a fracture criterion is proposed for cracked cylindrical samples of high-strength prestressing steels of different yield strength. The surface crack is assumed to be semi-elliptical, a geometry very adequate to model sharp defects produced by any subcritical mechanism of cracking: mechanical fatigue, stress-corrosion cracking, hydrogen embrittlement or corrosion fatigue. Two fracture criteria with different meanings are considered: a global (energetic) criterion based on the energy release rate G, and a local (stress) criterion based on the stress intensity factor $K_I$. The advantages and disadvantages of both criteria for engineering design are discussed in this paper on the basis of many experimental results of fracture tests on cracked wires of high-strength prestressing steels of different yield strength and with different degrees of strength anisotropy.

Prediction on Fatigue Life of Messenger Wire with Service Environments (사용환경에 따른 조가선의 피로수명 예측)

  • Chang Seky;Kim Yong-Ki
    • Journal of the Korean Society for Railway
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    • v.8 no.6 s.31
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    • pp.525-532
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    • 2005
  • Fatigue life of catenary wires in various environments is reduced when stress is concentrated on some points, which are often found in corroded areas by surrounding pollutants. Therefore, the fatigue test were performed in order to investigate the effect of the surface corrosion on the destructive behavior in service environment and accelerated corrosion environment as well as th examine the corrosive property and mechanism of the catenary wires. In the fatigue test of the messenger stranded wire, the corrosion degraded materials showed 35~50% of fatigue life at a same stress amplitude compared to original material. Because the catenary wires have variable load by the interaction of periodic contacts with pantographs the maximum stresses of trolley wire and messenger wire calculated by simulation at the messenger wire during operation was estimated thought the corrosion behavior interpretation of variable stress and fatigue test.

Separation Mode Analysis of Track Assembly of Main Battle Tank (궤도형 전투차량의 궤도박리 발생 및 성장모드 예측에 관한 연구)

  • Lee, Kyoung-Ho;Park, Byoung-Hoon
    • Journal of the Korea Institute of Military Science and Technology
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    • v.10 no.3
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    • pp.173-180
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    • 2007
  • In this paper, we have proposed a simple finite element model for separation mode analysis on the roadwheel and track assembly of main battle tank and established a contact stress-based mechanism which could explain the initiation and growth of separation defect occurred during the test of padreplacable track. It was proved that the longitudinal contact shear stress component on the pin hole region of the track shoe body which is parallel to the driving direction is consistent with the crack initiation at the bonding surface between track shoe and wheel-side rubber. The longitudinal shear stress increased locally near the separated region after the separation initiated. So we could assume that the local stress concentration accelerates the separation growth according to the shear mode.

The Analysis of the Residual Stress and Bending Characteristics on the Heterogeneous Materials by Laser Welding (레이저 용접에 의한 이종재료의 잔류응력과 굽힘 특성 분석)

  • 오세헌;민택기
    • Journal of Welding and Joining
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    • v.22 no.3
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    • pp.45-49
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    • 2004
  • Generally, it is used the compensation spring to compensate the inaccuracy of screen image induced by thermal deformation in CRT monitor. Its mechanism is hi-metallic system made of heterogeneous metals and these springs are bonded by laser welding. But laser welding induces a non-uniform temperature distribution, and residual stress is yielded locally by these temperature deviation. Therefore, this study measures the curvature constant to assess functions of the compensation spring of shadow mask with respect to increment temperature and estimates the effect of residual stress on the performance of tri-metal used to compensation spring.