• 한국해양바이오학회지
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• 제4권1호
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• pp.31-34
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• 2010

The primary function of the skin is to protect the body from the unwanted environmental influences. The outermost layer of the skin is stratum corneum which consists of corneocytes surrounded by lipid regions. Ceramides covalently bound to keratinocytes are essential for the barrier function of the skin, which can be disturbed in the disease, like xerosis. Xerosis is an abnormal dryness of the skin which reduced the thickness of stratum corneum and ceramide content decreasing with age. In this study, 36 seaweed extracts have been tested for screening of xerosis inhibitory agent by in vitro HaCaT keratinocyte assay. Ishige sinicola and Helminthocladia australis induced the significant amount of ceramide-like substance I in HaCaT keratinocyte among the tested seaweed extracts. Sargassum fulvellum, Chondrus ecellatus and Gigartina tenella also induced the ceramide-like substance I whereas Helminthocladia australis and Pachymeniopsis elliptica induced the ceramide-like II from HaCaT keratinocyte.

• 응용통계연구
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• 제18권1호
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• pp.27-41
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• 2005

『전국 장내 기생충 감염실태조사』를 위해 새로운 표본설계를 하였다. 2000년 인구 주택총조사의 10% 표본조사자료를 조사모집단으로 사용하였고, 조사의 특성상 각종 기생충의 감염율이 아주 낮은 관계로 통상적인 분석방법 대신에 상대위험도과 오즈비를 사용하였다. 표본배정은 네이만 배정의 절충형을 사용하였다. 또한 전국 단위와 특성별 추정이 가능하도록 하였고 추정의 정확성을 측정하기 위해 추정량의 분산식을 유도하였다.

• 문화기술의 융합
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• 제3권3호
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• pp.37-42
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• 2017

본 연구는 피부의 각질층에 분포되어 있는 유지질의 변화 상태를 조절하는 구조체계에 대해 고안한다. 피부구조에 유지질 성분이 어떻게 진행되는지 형태학으로 구성하였고, 주어진 세포사이와 세포횡단의 조건으로 기계적으로 조절되는 형태를 구성하였으며, 구조적인 기능으로 조절기능의 변화 상태를 확인하였다. 유지질 성분에서 피부의 모형을 구성하여 각층에 따른 유기질 상태의 피부 임피던스를 피부의 측정 임피던스 시스템으로 구성하여 진행하였다. 측정 임피던스는 ${\lambda}-Lip-RSC$, ${\lambda}-Lip-RSL$, ${\lambda}-Lip-CSG$, ${\lambda}-Lip-CSS$ 와 ${\lambda}-Lip-RSB$로 형성하였고, 세포사이와 세포횡단의 조건으로 변화의 차가 있고, 변환을 제어하는 전달시스템을 구성과 변환모델을 세분화하여 구축하였다. 앞으로 유지질 상태에서 피부의 기능적 효능조절이 가능한 유지질 성분의 조절시스템을 구성하여 지속적인 피부의 개선효과가 진행 될 것으로 예상된다.

• 문화기술의 융합
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• 제3권3호
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• pp.31-36
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• 2017

본 연구는 보습상태에서 피부의 각질층에 변화상태를 구조적으로 모델링한다. 피부구조에 따라 진행되는 형태는 세포사이와 세포횡단의 조건으로 조절 할 수 있도록 하였고, 구조적인 모델링으로 시스템의 변화상태를 확인하였다. 보습조건에서 크기 형태 조합의 모형을 구성하고, 결과적으로 보습상태의 피부 임피던스는 각층에 따라 피부에 측정 임피던스가 ${\xi}-R-SC-RH$, ${\xi}-R-SL-RH$, ${\xi}-R-SG-RH$, ${\xi}-R-SS-RH$ 와 ${\xi}-R-SB-RH$ 로 다른 형태로 나타났다. 보습조건에서 S-Corneum, S-Lucidum, S-Granulosum, S-Spinosum 과 S-Basale의 변화의 차가 있고, 변환을 제어하는 전달시스템을 구성과 변환모델을 세분화하여 구축하였다. 이를 통하여 보습상태에서 피부의 기능적 효능조절이 가능한 보습조절시스템이 구성되어 지속적인 피부의 개선효과가 진행 될 것으로 예상된다. 투과 조절시스템이 구성되어 지속적인 피부의 개선효과가 진행 될 것으로 예상된다.

• Genomics & Informatics
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• 제6권3호
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• pp.117-125
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• 2008

Recently, obesity has become a worldwide public health concern and the use of anorectic drugs has drastically increased. In this study, sibutramine and phendimetrazine, representative marketed anorectics, were repeatedly administered per os on a daily basis into C57BL/6 mice and the effects of these drugs on food intakes, body weight changes and gene expression profiles were monitored for up to following 7 days. Methamphetamine, which has a potent anorectic effect, was used as a positive control. Anorectic effects were sustained only for two days by phendimetrazine or methamphetamine, but for six days by sibutramine. The modulations of gene expressions in the hypothalamus and the striatum were investigated using microarrays on day 2 and day 7 post-administration, which corresponded to the anorectic period and a return of appetite respectively, for all three drugs tested. Differences in overall gene expression profiles in the stratum on day 2 for sibutramine and phendimetrazine seems to reflect difference between the two in terms of the onsets of drug tolerance. According to microarray findings, the Ankrd26 gene appears to have an important anorectic role, whereas the up-regulation of the olfaction system appeared to be involved in the drug tolerance of anorectics. The microarray data presented in this study demonstrates the usefulness of gene expression analysis for gathering information on the efficacy and safety of anorectic drugs.

• 한국가구학회지
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• 제21권1호
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• pp.1-16
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• 2010

Furniture is a medium to interconnect the living space to human, and it is the closest environmental element that limits the functions of the space, defines the style of the living, and adjusts the actions and behaviors of human. Therefore the furniture can be said to be one of the craft arts that reflects the culture and living style as they are according to the periodical, regional, and social stratum characteristics. Within this context, this study tries to suggest new design and living culture that can harmonize with the modern residence living culture and incorporate the traditional varnishing technique with lacquer that had been discontinued. Coming to the modern days, the varnishing with lacquer is getting attention again with its environment friendly characteristics and antibiotic functions, and is being applied to various applications. To inherit and maintain such an excellent traditional culture, I would like to improve the practicality by applying to modern furniture, and to contribute to develop and tell the world about the superiority of our culture.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.974-979
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• 2008

The purpose of this study was to evaluate the effect of vegetation on the cutting slope applied by vegetation system in the whole land. The engineering characteristics of slopes were investigated using the face mapping and physical tests. From the statistical methods, a relationship between a geologic stratum and degree of covering was independent. Therefore, the afforestation of slope was affected more by condition of vegetation as direction and opening of joints, and a topsoil state than by conventional classification of layer. It was concluded that the adjustable vegetation on the slope considering condition of geometric shape of slope, joint data and spontaneous type could make useful early afforestation.

• Geomechanics and Engineering
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• 제21권4호
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• pp.379-390
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• 2020

The behavior of a piled raft system in multi-layered soil subjected to vertical loading has been studied numerically using 3D finite element analysis. Initially, the 3D finite element model has been validated by analytically simulating the field experiments conducted on vertically loaded instrumented piled raft. Subsequently, a comprehensive parametric study has been conducted to assess the performance of a combined piled raft system in terms of optimum pile spacing and settlement of raft and piles, in multi-layered soil stratum subjected to vertical loading. It has been found that a combined pile raft system can significantly reduce the total settlement as well as the differential settlement of the raft in comparison to the raft alone. Two different arrangements below the piled raft with the same pile numbers show a significant amount of increase of load transfer of piled raft system, which is in line with the load transfer mechanism of a piled raft. A methodology for the factor of safety assessment of a combined pile raft foundation has been presented to improve the performance of piled raft based on its serviceability requirements. The findings of this study could be used as guidelines for achieving economical design for combined piled raft systems.

• Journal of Preventive Medicine and Public Health
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• 제50권1호
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• pp.18-28
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• 2017

Objectives: Low birth weight (LBW) is a major public health concern, especially in developing countries, and is frequently related to child morbidity and mortality. This study aimed to identify key determinants that influence the prevalence of LBW in selected developing countries. Methods: Secondary data analysis was conducted using 10 recent Demography and Health Surveys from developing countries based on the availability of the required information for the years 2010 to 2013. Associations of demographic, socioeconomic, community-based, and individual factors of the mother with LBW in infants were evaluated using multivariate logistic regression analysis. Results: The overall prevalence of LBW in the study countries was 15.9% (range, 9.0 to 35.1%). The following factors were shown to have a significant association with the risk of having an LBW infant in developing countries: maternal age of 35 to 49 years (adjusted odds ratio [aOR], 1.7; 95% confidence interval [CI], 1.2 to 3.1; p<0.01), inadequate antenatal care (ANC) (aOR, 1.7; 95% CI, 1.1 to 2.8; p<0.01), illiteracy (aOR, 1.5; 95% CI, 1.1 to 2.7; p<0.001), delayed conception (aOR, 1.8; 95% CI, 1.4 to 2.5; p<0.001), low body mass index (aOR, 1.6; 95% CI, 1.2 to 2.1; p<0.001) and being in the poorest socioeconomic stratum (aOR, 1.4; 95% CI, 1.1 to 1.8; p<0.001). Conclusions: This study demonstrated that delayed conception, advanced maternal age, and inadequate ANC visits had independent effects on the prevalence of LBW. Strategies should be implemented based on these findings with the goal of developing policy options for improving the overall maternal health status in developing countries.

• 한국환경생태학회지
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• 제19권4호
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• pp.358-366
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• 2005

본 연구는 인천시 백마도시자연공원을 대상으로 현존식생 유형과 특성을 파악하여 산림 식생관리를 위한 기초자료 제시를 위해 실시하였다. 현존식생유형 분석 결과 총 39개 유형으로 분류되었다. 인공식재림 유형중 아까시나무림이 가장 넓게 분포하였고($34.0\%$), 자연식생 유형은 신갈나무림이 가장 넓은 면적을 점유하고($12.1\%$) 있었다. 현존식생유형의 층위구조와 식생발달 경향, 환경요인 등을 기준으로 현존식생 특성도를 작성하여 총 16개 유형으로 재분류하였으며 각 유형 별 관리방안을 제안하였다.