• Proceedings of the Ginseng society Conference
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• 1988.08a
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• pp.92-98
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• 1988

The present study was performed to find the effects of ginseng and its saponins. which is written in Chung Yao Ta Tsu Tien as anti-amnesia in its chief indication. on experimental amnesia in mice. In the step through test. ginsenoside $Rb_1\;(GRb_1)\;and\;GRg_1$ facilitated the registration of memory and antagonized the electroconvulsive shock (ECS)-induced inhibition of the retention of memory. Moreover. $GRg_1$ antagonized the EtOH-induced inhibition of the retrieval of memory. In the step down test. $GRb_1\;GRb_2\;and\;GRg_1$ antagonized the ECS-induced inhibition of the retention of memory. Moreover. $GRg_1$ antagonized the EtOH-induced inhibition of the retrieval of memory and facilitated the acquisition of short term memory. In the shuttle hox and lever press tests. they have no effects on acquisition and retrieval of memory. except $GRb_1\;GRb_1$ depressed the retrieval of conditioned avoidance response in the shuttle box test. After the end of four tests. the effects of these orally administered drugs on sedative. analgesic. antipyretic and anticonvulsant actions. and on spontaneous and exploratory movements were tested in doses of less than 500mg/kg. but they had none of these effects. Present study may indicate that $GRg_1$ had effects on the retrieval of memory and on the acquisition process of learning response. The recent research on the role of NGF for the survival. regeneration and regulation of brain in adult animals. indicated the importance of NGF on dementia and amnesia. During our research on the specificity of the neurite out growth induced by NGF. we found that the effect of NGF was potentiated by $GRb_1$ in organ cultures of chick embryonic dorsal root ganglia. Then. the effect of $GRb_1$ on neuronal cell survivalin cell culture system was studied. $GRb_1$ potentiated the NGF-mediated increase of neurofilaments in cell cultures of chick embryonic sensory and sympathetic neurons. NGF with $GRb_1$ also showed a tendency to increase the number of surviving neurons of rat embryonic cerebral cortex. NGF increased choline acetyl transferase activity in cell cultures of rat embryonic septum area neurons. but $GRb_1$ did not potentiate NGF activity in cell cultures of rat embryonic septum area neurons. Present study may indicate that $GRb_1$ plays an important role for the survival or regeneration of neurons in the brain.

• Journal of Korean Society of Steel Construction
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• v.10 no.3 s.36
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• pp.553-564
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• 1998

Recently, more and more steel-deck structural system for two story roads has been adopted as a solution against traffic congestion in urban area, mainly because of fast construction, reduced self-weight, higher stiffness and efficient erection compared to that of concrete decks. The main objective is to study on the unit-elective optimal type and proportioning of a rational steel-deck system for two story roads using an optimum design program specifically developed for steel-deck systems. The objective function for the optimization is formulated as a minimum cost design problem. The behavior and design constraints are formulated based on the ASD(Allowable Stress Design) criteria of the Korean Bridge Design Code. The optimum design program developed in this study consists of two steps - the first step for the optimization of the steel box or plate girder viaducts, and the second step for the optimum design of the steel-decks with closed or open ribs. A grid model is used as a structural analysis model for the optimization of the main girder system, while the analysis of the deck system is based on the Pelican-Esslinger method. The SQP(Sequential Quadratic Programming) is used as the optimization technique for the constrained optimization problem. By using a set of application examples, the rational type related to the optimized steel-deck system designs is investigated by comparing the cost effectiveness of each type. Based on the results of the investigation it may be concluded that the optimal linear box girder and deck system with closed ribs may be utilized as one of the most rational and economical viaducts in the construction of two-story roads.

• Journal of Korean Society of Steel Construction
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• v.26 no.6
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• pp.511-522
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• 2014

In this study, an innovative steel stair system is presented which enables rapid erection and high quality control in both residential and office building construction. This system features two lightweight steel stringers of box shape, bolted connections easy to absorb construction tolerance, and stair steps movable transversely (or sliding steps) such that the work space needed for concrete stairway wall could be easily provided. In this type of stairway system, other than providing robust connecting details, ensuring vibration performance is especially important since this system may be vibration-sensitive due to lightweight nature and/or probable low damping. To tackle these issues, a series of full-scale mock-up tests were conducted by using box-shape stringer members with or without concrete-fill. The connection system was shown to be sufficiently stiff and strong, or it remained elastic even under the 160% of service load level. Among the seven stringer alternatives, five exhibited satisfactory vibration performance according to the related North American and European acceptance criteria.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.77-104
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• 2001

The effects of the oriental herbal medicine Saenghyetang(SHT, 生慧湯), which consists of Rehmanniae Radix (熟地黃 九蒸: was made by 9th steam) 40g, Corni Fructus(山茱黃) 16g, Polygalae Radix(遠志) 8g, Zizyphi Spinosae Semen(酸棗仁) 2g, Biotae Semen(柏子仁 去油: oil ingredient was removed) 20g, Poria Cocos(茯笭) 12g, Ginseng Radix(人蔘) 12g, Acori Graminei Rhizoma(石菖蒲) 2g, Sinapis Semen(白芥子) 8g, on learning ability and memory were investigated. Hot water extract(HWE) and ethanol extract(EE) from SHT were used for the studies. Learning ability and memory are related to modifications of synaptic strength among neurons that interactive. Enhanced synaptic coincidence detection leads to improved learning ability and memory. If the NMDA receptor, a synaptic coincidence detector, acts as a graded switch for memory formations, enhanced signal detection by NMDA receptors should enhance learning ability and memory. It was shown that NR2B was increased in the forebrains of oriental medicine-administrated mice, leading to enhanced activation of NMDA receptors and facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These HWE-SHT treated mice exhibited that superior ability in learning and memory when performing various behavioral tasks, showing that NR2B is enhanced by HWE-SHT treatment and also is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA receptor-dependent modifications, which were mediated in part by HWE administration, of synaptic efficacy, therefore, represent a mechanism for associative learning ability and memory. Results suggest that oriental medical enhancement of NR2B contributes to increase intelligence and memory in mammals On the other hand, to examine the effects of EE-SHT on the learning ability and memory in experimental mice, EE-SHT was tested on passive and active avoidance responses. The EE-SHT ameliorated the memory retrieval deficit induced by ethanol in mice, but not other memory impairments. EE-SHT(10, 20mg/100 g, p.o.) did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests and the ambulatory activity of normal mice in a normal condition. However, EE-SHT at 20 mg/kg significantly decrease the spontaneous motor activity during the shuttle box test, and also to extend the sleeping time induced by pentobarbital in mice. These results suggest that SHT has an ameliorating effect on memory retrieval impairments and a weak tranquilizing action.

• Korean Journal of Applied Biomechanics
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• v.31 no.1
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• pp.72-78
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• 2021

Objective: The purpose of this study was to investigate relations and effectiveness about mountain climbling exercise with different level of support surfaces by analyzing heart rate and EMG data. A total of 10 male college students with no musculoskeltal disorder were recruited for this study. Method: The biomechanical analysis was performed using heart rate monitor (Polar V800, Polar Electro Oy, Finland), step-box, exercise mat, and EMG device (QEMG8, Laxtha Inc. Korea, sampling frequency = 1,024 Hz, gain = 1,000, input impedance > 1012 Ω, CMRR > 100 dB). In this research, step-box were used to create different surface levels on the upper body (flat surface, 10% of subject's height, 20% of subject's height, and 30% of subject's hight). Based on these different conditions, data was collected by performing mountain climbing exercise during 30 seconds. Subjects were given 5 minutes of break to prevent muscular fatigue after each exercise. For each dependent variable, a one-way analysis of variance with repeated measures was conducted to find significant differences and Bonferroni post-hoc test was performed. Results: The results of this study showed that exercise intensity was reduced statistically as increased surface level on the upper body. Muscle activity of the upper rectus abdominis and biceps femoris for 30% of surface level was significantly higher than the corresponding values for flat surface. However, the opposite was found in the rectus femoris. In general, muscle activity of the lower rectus abdominis, erector spinae, external oblique abdominis, and gluteus maximus increased when surface level increased, but the differences were not significant. Conclusion: As a result, the increase in surface level of the body would change muscle activity of the upper body, indicating that different surface level of the upper body may cause significant effect on particular muscles to be more active during mountain climbing exercise. Based on results of this study, it is suggested to set up an appropriate surface level to target particular muscle to expect an effective training. It is also important to set adequate surface levels to create an effective training condition for preventing exercise injuries.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.1
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• pp.22-28
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• 2021

This is a basic study on the development of deep learning-based algorithms to detect smoke before the smoke detector operates in the event of a ship fire, analyze and utilize the detected data, and support fire suppression and evacuation activities by predicting the spread of smoke before it spreads to remote areas. Proposed algorithms were reviewed in accordance with the following procedures. As a first step, smoke images obtained through fire simulation were applied to the YOLO (You Only Look Once) model, which is a deep learning-based object detection algorithm. The mean average precision (mAP) of the trained YOLO model was measured to be 98.71%, and smoke was detected at a processing speed of 9 frames per second (FPS). The second step was to estimate the spread of smoke using the coordinates of the boundary box, from which was utilized to extract the smoke geometry from YOLO. This smoke geometry was then applied to the time series prediction algorithm, long short-term memory (LSTM). As a result, smoke spread data obtained from the coordinates of the boundary box between the estimated fire occurrence and 30 s were entered into the LSTM learning model to predict smoke spread data from 31 s to 90 s in the smoke image of a fast fire obtained from fire simulation. The average square root error between the estimated spread of smoke and its predicted value was 2.74.

• Journal of the Korea Concrete Institute
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• v.25 no.4
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• pp.429-438
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• 2013

An object oriented numerical analysis program of axial-flexural elements and the step-by-step method (SSM) has been developed to analyze concrete long-term behaviors of structures constrained internally and externally. The results of the numerical analysis for simple and continuous prestressed (PS) concrete box and composite girders, pre-cast slab of continuous steel composite girder, and simple preflex composite girder show that the adjusting coefficient decreases by increasing constraint. The loss rates of pre-tension force were not sensitive but those of pre-compression force were increased rapidly by decreasing adjusting coefficient. This indicates that the design based on the loss rate of pre-tension can over-estimate the pre-compression force in a concrete section constrained internally and externally. The adjusting coefficients which satisfy results of the numerical analysis are 0.35~0.95, and it can be used as an index of constraint of concrete long-term deformation. The adjusting coefficient 0.5 of Bridge Design Specifications can under-estimate residual stress of PS concrete slab, and the coefficient 0.7 or 0.8 of LRFD Bridge Designing Specifications can under-estimate the loss rates of continuous PS concrete girders. The adjusting coefficient of hybrid structures should be less then 0.4.

• Journal of the Korea Institute of Military Science and Technology
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• v.20 no.5
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• pp.688-699
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• 2017

Model-based test, a well-known method of the black box tests, is consisted of the following four steps : model construction using requirement, test case generation from the model, execution of a SUT (software under test) and detection failures. Among models constructed in the first step, state-based models such as UML standard State Machine are commonly used to design event-based embedded systems (e.g., weapon control systems). To generate test cases from state-based models in the next step, coverage-based techniques such as state coverage and transition coverage are used. Round-trip path coverage technique using W-Method, one of coverage-based techniques, is known as more effective method than others. However it has a limitation of low failure observability because the W-Method technique terminates a testing process when arrivals meet states already visited and it is hard to decide the current state is completely same or not with the previous in the case like the GUI environment. In other words, there can exist unrevealed faults. Therefore, this study suggests a Extended W-Method. The Extended W-Method extends the round-trip path to a final state to improve failure observability. In this paper, we compare effectiveness and efficiency with requirement-item-based technique, W-Method and our Extended W-Method. The result shows that our technique can detect five and two more faults respectively and has the performance of 28 % and 42 % higher failure detection probability than the requirement-item-based and W-Method techniques, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.254-261
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• 2005

The effects on memory and learning ability of the Korean herbal medicine, Xingyo-tang(XGT, 神交湯), which consists of Ginseng Radix(人蔘) 4 g, Liriopis Tuber(麥門冬) 40 g, Morindae Officinalis Radix(巴戟天) 40 g, Biotae Semen(柏子仁) 20 g, Dioscoreae Rhizoma(山藥) 40 g, Euryales Semen(?實) 20 g, Scrophulariae Radix(玄蔘) 40 g, Salviae Miltiorrhizae Radix(丹蔘) 12 g, Poria(茯神) 12 g, Cuscutae Semen(免絲子) 40 g, was investigated. The effects of XGT on learning and memory performance were examined in normal or memory impaired mice by using avoidance tests, Pentobarbital -induced sleep test, fear conditioning task, novel object recognition task, and water maze task. Hot water extract from XGT was used for the studies. Learning ability and memory are based on modifications of synaptic strength among neurons that are simultaneously active. Enhanced synaptic coincidence detection leads to better learning and memory. The XGT-treated (30 mg/100 g and 60 mg/100 g, p.o.) mice exhibit superior ability in learning and memorizing when performing various behavioral tasks. XGT did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests, and the ambulatory activity of normal mice in normal condition. In contrast, XGT produced ameliorating effects on the memory retrieval impairment induced by ethanol. XGT also improved the memory consolidation disability induced by electric convulsive shock (ECS). XGT extended the sleeping time induced by pentobarbital dose-dependently, suggesting its transquilizing or antianxiety action. These results suggest that XGT has an improving effect on the impaired learning through the effects on memory registration and retrieval.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.26 no.2
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• pp.61-69
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• 2020

As post-harvest processes of onions are carried by a 20 kg-net package which results in high-cost and low-efficiency, especially, the insufficient drying and physical damage of onions after harvesting leads to a huge second loss in storage, we had developed a low-cost, high-efficiency post-harvest bulk handling machinery system by collecting onions on a farm using ton-bags, drying with forced air circulation, and sorting/packaging. The post-harvest bulk handling machinery system consisted of 6 devices, and this study designed an automatic feed hopper with a feeding rate control device, an inclined belt conveyor with a two-step chute, and an automatic pallet unloading device for feeding onions into the sorting/packing line. This study also analyzed the performance and control of the total system. The device had 1-ton handling capacity, but the operational condition was set to increase the capacity. The three-step filling method of pallet by the velocity control of the inclined belt conveyor was applied in the post-harvest bulk handling machinery system for the prevention of physical damage. If one worker was set to operate the total system, the time required to complete one palletized load was approximately 5 minutes and 5 seconds. The calculated daily handling capacity was approximately 94 tons, when the daily actual working time was 8 hours. When the developed system was applied to the managerial size of 2,000 ton, the processing cost per ton of the system was decreased by 19.5%, compared with the existing 20 kg-net package-based handling. The developed post-harvest bulk handling machinery system would be a good substitute for the rapid decline and aging of rural labor.