• Journal of Pharmaceutical Investigation
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• v.40 no.2
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• pp.101-107
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• 2010

A rapid and sensitive reversed-phase high performance liquid chromatography (HPLC) method was developed for the determination of N-(-4-Chlorophenyl)-6-hydroxy-7-methoxy-2-chromanecarboxamide (KAL-1120), a novel anti-inflammation agent, in the rat plasma. The method was applied to analyze the compound in the biological fluids such as bile, urine and tissue homogenates. After liquid-liquid extraction, the compound was analyzed on an HPLC system with ultraviolet detection at 275 nm. HPLC was carried out using reversed-phase isocratic elution with a $C_{18}$ column, a mobile phase of a mixture of acetonitril (40 v/v%) at a flow rate of 1.0 mL/min. The chromatograms showed good resolution and sensitivity and no interference of plasma. The calibration curve for the drug in plasma was linear over the concentration range of 0.05-50 ${\mu}g$/mL. The intra- and inter-day assay accuracies of this method ranged from 0.06% to 9.33% of normal values and the precision did not exceed 6.28% of relative standard deviation. The plasma concentration of KAL-1120 decreased to below the quantifiable limit at 1.5 hr after the i.v. bolus administration of 2-10 mg/kg to rats ($t_{1/2,({\alpha})}$ and $t_{1/2,({\beta})$ of 2.15 and 26.7 min at a dose of 2 mg/kg, 3.91 and 33.0 min at a dose of 10 mg/kg, respectively). The steady-state volume of distribution ($V_{dss}$) and the total body clearance ($CL_t$) were not significantly altered in rats given doses from 2 to 10 mg/kg. Of the various tissues tested, KAL-1120 was mainly distributed in the lung and heart after i.v. bolus administration. KAL-1120 was detected in the bile by 30 min after its i.v. bolus administration. However, the concentration in the urine after i.v. bolus administration became too low to measure, suggesting that KAL-1120 is mostly excreted in the bile. In conclusion, this analytical method was suitable for the preclinical pharmacokinetic studies of KAL-1120 in rats.

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.423-431
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• 2011

Recentincreasing awareness of the environmental damage caused by the $CO_2$ emission of fossil fuelsstimulated the interest in alternative and renewable sources of energy. Fuel cell is a representative example of hydrogen energy utilization. In this study, Molten Carbonate Fuel Cell system is simulated by using $Aspen^{TM}$. Stack model is consisted of equilibrium reaction equations using $ACM^{TM}$(Aspen Custom Modeler). Balance of process of fuel cell system is developed in Aspen $Plus^{TM}$ and simulated at steady-state. Analysis of performance of the system is carried out by using sensitivity analysis tool with main operating parameters such as current density, S/C ratio, and fuel utilization and recycle ratio.In Aspen $Dynamics^{TM}$, dynamics of MCFC system is simulated with PID control loops. From the simulation, we proposed operation range which generated maximum power and efficiency in MCFC power plant.

• Journal of Aerospace System Engineering
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• v.12 no.2
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• pp.7-14
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• 2018

In this study, a new check valve was studied to improve the load pressure of a brake system with a small piezoelectric-hydraulic pump. During the pressurization process, the steady-state pressure at the load is affected by the ratio of the cross-sectional area of the check valve the chamber pressure and load pressure. Since the flow path cover of the check valve is made wider than the cross-sectional area of the output flow to prevent backflow, a method of reducing the area ratio is proposed for a higher load pressure by mounting an additional mass to a thin plate spring type check valve. To identify the effect of mounting an additional mass to the existing check valve on the load pressure, a simple brake system with a small piezoelectric-hydraulic pump was modeled using a commercial code AMESim. The AMESim modeling was verified by comparing the simulation results with the experimental results of the pump the existing check valve. The additional mass was added to the verified AMESim modeling and higher load pressure was able to be obtained through simulation. The 35% performance improvement in load pressure identified by carrying out pressurization test of the brake system after adopting the new check valve the small piezoelectric-hydraulic pump.

• Journal of the Microelectronics and Packaging Society
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• v.16 no.2
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• pp.43-50
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• 2009

Although thin PCBs(Printed Circuit Boards) have recently been required for high density interconnection, high electrical performance, and low manufacturing cost, the utilization of thin PCBs is severely limited by warpage and reliability issues. Warpage of the thin PCB leads to failure in solder-joints and chip. The $B^2it$(Buried Bump Interconnection Technology) for PCB has been developed to achieve a competitive manufacturing price. In this study, chip temperature, package warpage, chip stress and solder-joints stress characteristics of the PCB prepared with $B^2it$ process have been calculated using thermo-mechanical coupled analysis by the FEM(Finite Element Method). FEM computation was carried out with the variations in bump shapes and kinds of materials under 1.5W power of chip and constant convection heat transfer. The results show that chip temperature distribution reached more quickly steady-state status with PCB prepared with $B^2it$ process than PCB prepared with conventional via interconnection structure. Although $B^2it$ structures are effective on low package warpage and chip stress, with high strength bump materials arc disadvantage for low stress of solder-joints. Therefore, it is recommended that optimized bump shapes and materials in PCB design should be considered in terms of reliability characteristics in the packaging level.

• Journal of Navigation and Port Research
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• v.39 no.6
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• pp.457-463
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• 2015

A gas turbine engine plays an important role as a prime mover that is used in the marine transportation field as well as the space/aviation and power plant fields. However, it has a complicated structure and there is a time delay element in the combustion process. Therefore, an elaborate mathematical model needs to be developed to control a gas turbine engine. In this study, a modeling technique for a gas generator, a PLA actuator, and a metering valve, which are major components of a gas turbine engine, is explained. In addition, sub-models are obtained at several operating points in a steady state based on the trial running data of a gas turbine engine, and a method for controlling the engine speed is proposed by designing an NPID controller for each sub-model. The proposed NPID controller uses three kinds of gains that are implemented with a nonlinear function. The parameters of the NPID controller are tuned using real-coded genetic algorithms in terms of minimizing the objective function. The validity of the proposed method is examined by applying to a gas turbine engine and by conducting a simulation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.866-872
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• 2010

In this paper, we developed a digital soldering station based on PID controller, which supply stable power by controlling the current of heater of soldering iron. The proposed system designed PID controller to converge quickly to the set up temperature by user, and regain the lost of heat by external factors quickly. PID controller, designed by Ziegler-Nichols' tuning method, decides triac's trigger timing using setting temperature and present temperature to control the phase of AC 24V power that supply to the heater. Also, we give the function that shows present temperature and setting temperature of iron, and working time by graphic LCD. And during the rest time, we decided the power saving and extension of iron tip by dropping to the optimal temperature. Two experiments had implemented in $25^{\circ}C$ laboratory to confirm the performance of proposed method. The first experiment took 12sec, 13sec, 16sec, 18sec, reaching to $200^{\circ}C$, $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ respectively which result showed shorten of rising time than previous method. In the loading experiment of $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ steady state showed temperature drop of $3.8^{\circ}C$, $4.1^{\circ}C$, $4.5^{\circ}C$ which result showed the low temperature deviation than previous method.

• Clean Technology
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• v.27 no.1
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• pp.61-68
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• 2021

Selective catalytic reduction (SCR) is widely used as a method of removing nitrogen oxide in large-capacity thermal power generation systems. Uniform mixing of the injected ammonia and the inlet flue gas is very important to the performance of the denitrification reduction process in the catalyst bed. In the present study, a computational analysis technique was applied to the ammonia injection system design process of a denitrification facility. The applied model is the denitrification facility of an 800 MW class coal-fired power plant currently in operation. The flow field to be solved ranges from the inlet of the ammonia injection system to the end of the catalyst bed. The flow was analyzed in the two-dimensional domain assuming incompressible. The steady-state turbulent flow was solved with the commercial software named ANSYS-Fluent. The nozzle arrangement gap and injection flow rate in the ammonia injection system were chosen as the design parameters. A total of four (4) cases were simulated and compared. The root mean square of the NH3/NO molar ratio at the inlet of the catalyst layer was chosen as the optimization parameter and the design of the experiment was used as the base of the optimization algorithm. The case where the nozzle pitch and flow rate were adjusted at the same time was the best in terms of flow uniformity.

• Journal of the Korean Society of Propulsion Engineers
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• v.26 no.2
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• pp.12-19
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• 2022

Propellant grains with embedded metal wires have been used for enhancement of burning rate while maintaining high loading density. For the performance design of a solid rocket motor using propellant grain with embedded metal wires, burn-back analysis is required according to number, location, arrangement angle of metal wires, and augmentation ratio of the propellant burning rate near a wire region. In this study, a numerical method to quickly calculate a burning surface area was developed in response to the design change of the propellant grain with embedded metal wires. The burning surface area derived from the developed method was compared with the results of a CAD program. Error rate decreased as the radial size of the grid decreased. Analysis for characteristics of burning surface area was performed according to the number and location of metal wires, the initial and final phases were shortened and the steady-state phase was increased when the number of metal wires increased. When arranging the metal wires at different radii, the burning surface area rapidly increased in the initial phase and sharply decreased in the final phase compared to the case where the metal wires were disposed in the same radius.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5D
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• pp.831-838
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• 2006

An experimental/analytic study has been conducted to understand the adverse effects of low vehicle speed, high axle load and high tire pressure on the performance of asphalt pavements. Of 33 asphalt sections at KHC test road, two sections having different base layer thickness (180 mm versus 280 mm) are adopted for rollover tests. During the test, a standard three-axle dump truck maintains a steady state condition as moving along the wheel path of a passing lane, and lateral offsets and real travel speed are measured with a laser-based wandering system. Test results suggest that vehicle speed affects both longitudinal and transverse strains at the bottom of asphalt layer (290 mm and 390 mm below the surface), and even slightly influences the measured vertical stresses at the top of subbase and subgrade due to the dynamic effect of rolling vehicle. Since the anisotropic nature of asphalt-aggregate mixtures, the difference between longitudinal and transverse strains appears prominent throughout the measurements. As the thickness of asphalt pavement increases, the measured lateral strains become larger than its corresponding longitudinal strains. Over the limited testing conditions, it is concluded that higher axle weight and higher tire pressures induce more strains and vertical stresses, leading to a premature deterioration of pavements. Finally, a layered elastic analysis overestimates the maximum strains measured under the 1st axle load, while underestimating the maximum vertical stress in both pavement sections.

• Journal of Service Research and Studies
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• v.14 no.3
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• pp.172-187
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• 2024

This paper deals with asymptotic approximations analysis of M/M/s and M/D/s queues. For M/M/s queue, we observe "economies of scale" under the fixed utilization ρ and the fixed probability α that customer waits in system, how the average system size vary according to the number of servers s increasing. Simulation results show that as s increases, the number of servers who are idling increases, that is, the slack n-E[Q_n] diverges. In addition, through changing the waiting probability α under the M/M/s system, α was not highly sensitive to the behavior of the system size. And, it is shown that using ${\rho}_n\,=\,1-k/\sqrt{n}$ to handle heavy-traffic regime is only appropriate for k = 1 by observing the effect on the performance of the system with different values of k. For the M/D/s queue, two approximations are used to evaluate the expected system size under the fixed ρ and α. Simulations and comparison of these two approximations show that Cosmetatos' approximation performs quite well when the number of servers is small and traffic intensity is heavy, but it overestimates the true value for the large number of servers. Meanwhile, the modified approximation gives good results for the steady state count of the system although the number of servers grows large.