• Journal of Pharmaceutical Investigation
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• 제24권2호
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• pp.67-72
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• 1994

Bioequivalence (BE) test of biphenyl dimethyl dicarboxylate (DDB) tablets was performed. Normal healthy male volunteers (n = 20) were randomly divided into 2 groups, and reference $(Nissel{\circledR})$ and test $(Livital{\circledR})$ tablets of DDB $(25mg{\times}8\;Tab.\;= \;200\;mg)$ were given orally by balanced two-period cross-over design. The serum concentration was determined by high performance liquid chromatography. The pharmacokinetic parameters, AUC, $C_{max}$, and $T_{max}$ obtained after drug administration were statistically analyzed. Statistical evaluation of the data involved an analysis of variance (ANOVA) for cross-over design. The results were within 20% differences of mean value in AUC, $C_{max}$, and $T_{max}$ between reference and test tablets. The results of ANOVA showed no significant differences for "between group or subject" and "period". The test tablet was bioequivalent with the reference tablet in the AUC, $C_{max}$, and $T_{max}$.

• 약학회지
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• 제33권4호
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• pp.229-236
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• 1989

Even though two different preparations are chemically equivalent, the variance of bioavailability differenciates the clinical effect of preparations, so that the preparations need to be evaluated by comparing bioavailability in vivo as well as chemical equivalence. In this study, bioequivalence tests of commercially available isoniazid tablets A, B, C and D (standard) were performed to give some guidelines to bioequivalence test. The bioavailability parameters obtained by drug administeration were statistically analyzed. Statistical evaluation of the data involved an analysis of variance for a cross over design. Cross over design was employed with 8 healthy volunteers. The results were within 20% difference of mean value in the AUC, Cmax, Tmax and amount of urinary excretion (Au) between standard and isoniazid tablets. The results of ANOVA showed no significant differences for 'group or sequence', but almost not for 'between subjects'. The tablet. A, B and D were within 20 min, but tablet C was within 50 min. Tablet A was biologically equivalent in the Au. tablet B biologically equivalent in the Au and AUC. Tablet C was biologically equivalent in the Au. The relationship between the dissolution rate and Au was significant.

• 천문학회보
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• 제41권1호
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• pp.78.4-79
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• 2016

This study aims to overview research articles on extrasolar planets using Kepler mission data during the period of 2009-2015 in order to discover research trends in them. Kepler space observatory is a NASA space observatory for extrasolar planet expedition launched in March 2009, contributed to the discovery and tracking of extrasolar planets and its candidates. In order to achieve the goal of this study, we classified research subjects from studies on Kepler mission data year by year and found the most frequent research topics each year. We also conducted a comparative analysis on the research subjects based on time series and examined any changes with respect to the goal of Kepler mission. Statistical meta-analysis is employed as the analysis method for the key words presented in the research articles. This study is a part of on-going research to find the correlation between the physical parameters of the host star and extrasolar planets. The results of this study could offer new directions in researches utilizing Kepler mission data as those meta-analyses in social sciences often suggest new opportunities. We have high expectations that more extrasolar planet studies will follow as we make further progresses in various analyses.

• 대한족부족관절학회지
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• 제18권3호
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• pp.124-128
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• 2014

Purpose: The purpose of this study was to assess the treatment outcomes and prognosis of Lisfranc joint fracture and dislocation according to the mechanism of injury and treatment method. Materials and Methods: Twenty six patients with Lisfranc fracture-dislocation who had been treated surgically were included in this retrospective study. The patients were divided into two groups according to mechanism of injury: direct crushing injury (16 patients) and indirect rotational or compressive injury (10 patients). The patients were also divided into three groups according to the surgical methods. The parameters used were radiographic evaluation, patients' subjective satisfaction levels, length of hospital stay, and the American Orthopaedic Foot and Ankle Society (AOFAS) midfoot score. Statistical analysis was performed. Results: The mean postoperative AOFAS midfoot score was 78.7. The mean length of stay was 39.6 days. Statistically significant differences in subjective satisfaction, AOFAS midfoot score, and length of hospital stay were observed between the two groups (p<0.05). However, no significance differences were observed between the three groups who were divided according to the different surgical methods (p>0.05). Conclusion: Mechanism of trauma and the severity of soft-tissue injury were significant prognostic factors affecting the surgical outcomes of Lisfranc joint fracture and dislocation.

• 한국도로학회논문집
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• 제18권1호
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• pp.91-97
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• 2016

PURPOSES : The objective of this paper is to develop a pavement performance model based on the Bayesian algorithm, and compare the measured and predicted performance data. METHODS : In this paper, several pavement types such as SMA (stone mastic asphalt), PSMA (polymer-modified stone mastic asphalt), PMA (polymer-modified asphalt), SBS (styrene-butadiene-styrene) modified asphalt, and DGA (dense-graded asphalt) are modeled in terms of the performance evaluation of pavement structures, using the Bayesian algorithm. RESULTS : From case studies related to the performance model development, the statistical parameters of the mean value and standard deviation can be obtained through the Bayesian algorithm, using the initial performance data of two different pavement cases. Furthermore, an accurate performance model can be developed, based on the comparison between the measured and predicted performance data. CONCLUSIONS : Based on the results of the case studies, it is concluded that the determined coefficients of the nonlinear performance models can be used to accurately predict the long-term performance behaviors of DGA and modified asphalt concrete pavements. In addition, the developed models were evaluated through comparison studies between the initial measurement and prediction data, as well as between the final measurement and prediction data. In the model development, the initial measured data were used.

• 한국소음진동공학회논문집
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• 제25권10호
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• pp.685-691
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• 2015

In this work, to identify effective parameter for performance of piezoelectric jetting dispenser, experimental investigation is carried out based on design of experiment. After preparing jetting dispenser using two stack-type piezoelectric actuators, basic working principle of the jetting dispenser is described. Eight operating conditions are chose as main factors and it is assumed that each factor has two levels. To reduce number of experiments for performance evaluation, the experimental sets are designed based on factional factorial design method. Experimental setup is established and the weight of single dot is measured by using precision scale. The main and interaction effects of factors are analyzed using commercial statistical program and optimal operating condition for small amount and small variation of weight of dispensed single dot are determined.

• 대한조선학회지
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• 제27권3호
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• pp.100-106
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• 1990

본(本) 연구(硏究)에서는 304스테인리스강을 사용한 평활재와 작은 인공피트재의 고온 피로시험(疲勞試驗)과 크리프 시험(試驗)을 $593^{\circ}C$의 대기중에서 실시하고, 표면의 분포균열을 실온에서 레프리카법으로 연속적으로 관찰하고, 표면균열의 발생, 성장, 합체 거동을 관측하여, 균열 밀도(密度) 길이의 분포등의 정량적인 통계적(統計的) 성질(性質)에 대하여 검토하는 동시에, 파괴역학적으로 시험편의 수명을 지배하는 주균열의 성장거동 및 수명예측을 실시한 것이다. 또 실온의 결과와 고온피로(疲勞) 및 크리프 경우의 미소 분포균열의 통계적(統計的) 결과를 비교 검토하였다.

• 대한조선학회논문집
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• 제32권4호
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• pp.136-141
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• 1995

용접작업시 적정용접조건의 설정과 용접결과의 개선을 위한 용접변수의 최적화는 용접품질 및 생산성과 직결되는 중요한 과제이다. 본 연구에서는 복잡한 용접변수 및 용접결과의 상호관계를 관련이론식의 분석과 실험결과의 통계적 분식 및 경험적 지식의 분석을 통하여 체계적으로 조사하였고 조사된 결과는 경험식과 퍼지룰 및 인공지능적 지식의 형태로 표현되어 지식베이스로 구축되었다. 또한 퍼지 전문가시스템의 근접추론기법을 활용하여 지식베이스에 포함된 정보로부터 적절한 용접조건의 제안과 주어진 용접결과에 대한 사용자의 평가에 기초하여 보다 개선된 용접결과를 얻기 위한 용접변수의 최적화 과정을 실현하였다.

• Environmental Engineering Research
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• 제24권2호
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• pp.279-288
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• 2019

To obtain insightful knowledge of geochemical process controlling fluoride enrichment in groundwater of the villages near Shilabati river bank, West Bengal, India, multivariate statistical techniques were applied to a subgroup of the dataset generated from major ion analysis of groundwater samples. Water quality analysis of major ion chemistry revealed elevated levels of fluoride concentration in groundwater. Factor analysis (FA) of fifteen hydrochemical parameters demonstrated that fluoride occurrence was due to the weathering and dissolution of fluoride-bearing minerals in the aquifer. A strong positive loading (> 0.75) of fluoride with pH and bicarbonate for FA indicates an alkaline dominated environment responsible for leaching of fluoride from the source material. Mineralogical analysis of soli sediment exhibits the presence of fluoride-bearing minerals in underground geology. Hierarchical cluster analysis (HCA) was carried out to isolate the sampling sites according to groundwater quality. With HCA the sampling sites were isolated into three clusters. The occurrence of abundant fluoride in the higher elevated area of the observed three different clusters revealed that there was more contact opportunity of recharging water with the minerals present in the aquifer during infiltration through the vadose zone.

• Membrane and Water Treatment
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• 제10권4호
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• pp.313-320
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• 2019

Increasing the concentration of nitrate ions in the soil solution and then leaching it to underground aquifers increases the concentration of nitrate in the water, and can cause many health and ecological problems. This study was conducted to evaluate the vulnerability of Meymeh aquifer to nitrate pollution. In this research, sampling of 10 wells was performed according to standard sampling principles and analyzed in the laboratory by spectrophotometric method, then; the nitrate concentration zonation map was drawn by using intermediate models. In the drastic model, the effective parameters for assessing the vulnerability of groundwater aquifers, including the depth of ground water, pure feeding, aquifer environment, soil type, topography slope, non-saturated area and hydraulic conductivity. Which were prepared in the form of seven layers in the ARC GIS software, and by weighting and ranking and integrating these seven layers, the final map of groundwater vulnerability to contamination was prepared. Drastic index estimated for the region between 75-128. For verification of the model, nitrate concentration data in groundwater of the region were used, which showed a relative correlation between the concentration of nitrate and the prepared version of the model. A combination of two vulnerability map and nitrate concentration zonation was provided a qualitative aquifer classification map. According to this map, most of the study areas are within safe and low risk, and only a small portion of the Meymeh Aquifer, which has a nitrate concentration of more than 50 mg / L in groundwater, is classified in a hazardous area.