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Effects of Yarrowia lipolytica supplementation on growth performance, intestinal health and apparent ileal digestibility of diets fed to nursery pigs

  • Cheng, Yi-Chi;Duarte, Marcos Elias;Kim, Sung Woo
    • Animal Bioscience
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    • 제35권4호
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    • pp.605-613
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    • 2022
  • Objective: The objective was to evaluate the efficacy of increasing supplementation of Yarrowia lipolytica (YL) up to 3.0% replacing 1.6% poultry fat and 0.9% blood plasma for growth performance, intestinal health and nutrient digestibility of diets fed to nursery pigs. Methods: Twenty-four pigs weaned at 24 d of age (initial body weight at 7.2±0.6 kg) were allotted to three dietary treatments (n = 8) based on the randomized complete block. The diets with supplementation of YL (0.0%, 1.5%, and 3.0%, replacing poultry fat and blood plasma up to 1.6% and 0.9%, respectively) were fed for 21 d. Feed intake and body weight were recorded at d 0, 10, and 21. Fecal score was recorded at every odd day from d 3 to 19. Pigs were euthanized on d 21 to collect proximal and distal jejunal mucosa to measure intestinal health markers including tumor necrosis factor-alpha, interleukin-8, immunoglobulin A and immunoglobulin G. Ileal digesta was collected for apparent ileal digestibility (AID) of nutrients in diets. Data were analyzed using Proc Mixed of SAS. Results: Supplementation of YL (1.5% and 3.0%) replacing poultry fat and blood plasma did not affect growth performance, fecal score and intestinal health. Supplementation of YL at 1.5% did not affect nutrient digestibility, whereas supplementation of YL at 3.0% reduced AID of dry matter (40.2% to 55.0%), gross energy (44.0% to 57.5%), crude protein (52.1% to 66.1%), and ether extract (50.8% to 66.9%) compared to diets without supplementation. Conclusion: Yarrowia lipolytica can be supplemented at 1.5% in nursery diets, replacing 0.8% poultry fat and 0.45% blood plasma without affecting growth performance, intestinal health and nutrient digestibility. Supplementation of YL at 3.0% replacing 1.6% poultry fat and 0.9% blood plasma did not affect growth performance and intestinal health, whereas nutrient digestibility was reduced.

Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs

  • Adsos Adami Passos;Vitor Hugo Cardoso Moita;Sung Woo Kim
    • Animal Bioscience
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    • 제36권12호
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    • pp.1869-1879
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    • 2023
  • Objective: This study was to evaluate the effects of individual or combinational use of phytase, protease, and xylanase on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble (DDGS) fed to pigs. Methods: Each experiment had four 4×4 Latin squares using 16 barrows. Each period had 5-d adaptation and 3-d collection. All experiments had: CON (no enzyme); Phy (CON+phytase); Xyl (CON+xylanase); Pro (CON+protease); Phy+Xyl; Phy+Pro, Xyl+Pro, Phy+Xyl+Pro. Each Latin square had 'CON, Phy, Xyl, and Phy+Xyl'; 'CON, Phy, Pro, and Phy+Pro'; 'CON, Pro, Xyl, and Xyl+Pro'; and 'Phy+Xyl, Phy+Pro, Xyl+Pro, Phy+Xyl+Pro'. Results: The digestible energy (DE), metabolizable energy (ME), and nitrogen retention (NR) of corn were not affected by enzymes but the apparent total tract digestibility (ATTD) of phosphorus (P) was improved (p<0.01) by Phy. The DE and ATTD dry matter (DM) in soybean meal were increased (p<0.05) by Phy+Pro and the ATTD P was improved (p<0.01) by Phy, Phy+Pro, and Phy+Xyl. The DE, ME, and ATTD DM in DDGS were improved (p<0.05) by Phy+Xyl and the ATTD P was improved (p<0.01) by Phy, Phy+Pro, and Phy+Xyl. Conclusion: Phytase individually or in combination with xylanase and protease improved the Ca and P digestibility of corn, soybean meal, and DDGS, from the hydrolysis of phytic acid. The supplementation of protease was more effective when combined with phytase and xylanase in the soybean meal and DDGS possibly due to a higher protein content in these feedstuffs. Xylanase was more effective in DDGS diets due to the elevated levels of non-starch polysaccharides in these feedstuffs. However, when xylanase was combined with phytase, it demonstrated a higher efficacy improving the nutrient digestibility of pigs. Overall, combinational uses of feed enzymes can be more efficient for nutrient utilization in soybean meal and DDGS than single enzymes.

Meta-analysis of Associations between the MDM2-T309G Polymorphism and Prostate Cancer Risk

  • Chen, Tao;Yi, Shang-Hui;Liu, Xiao-Yu;Liu, Zhi-Gang
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권9호
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    • pp.4327-4330
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    • 2012
  • The mouse double minute 2 (MDM2) gene plays a key role in the p53 pathway, and the SNP 309T/G single-nucleotide polymorphism in the promoter region of MDM2 has been shown to be associated with increased risk of cancer. However, no consistent results were found concerning the relationships between the polymorphism and prostate cancer risk. This meta-analysis, covering 4 independent case-control studies, was conducted to better understand the association between MDM2-SNP T309G and prostate cancer risk focusing on overall and subgroup aspects. The analysis revealed, no matter what kind of genetic model was used, no significant association between MDM2-SNP T309G and prostate cancer risk in overall analysis (GT/TT: OR = 0.84, 95%CI = 0.60-1.19; GG/TT: OR = 0.69, 95%CI = 0.43-1.11; dominant model: OR = 0.81, 95%CI= 0.58-1.13; recessive model: OR = 1.23, 95%CI = 0.95-1.59). In subgroup analysis, the polymorphism seemed more likely to be a protective factor in Europeans (GG/TT: OR = 0.52, 95%CI = 0.31-0.87; recessive model: OR = 0.58, 95%CI = 0.36-0.95) than in Asian populations, and a protective effect of the polymorphism was also seen in hospital-based studies in all models (GT/TT: OR = 0.74, 95%CI = 0.57-0.97; GG/TT: OR = 0.55, 95%CI = 0.38-0.79; dominant model: OR = 0.69, 95%CI = 0.54-0.89; recessive model: OR = 0.70, 95%CI = 0.51-0.97). However, more primary studies with a larger number of samples are required to confirm our findings.

투자자-국가 분쟁해결(ISDS)의 대상이 된 투자자 보호원칙에 관한 연구 (A Study on the Investor Protection Principle as a Legal Basis of Investor - State Dispute Settlement(ISDS))

  • 김경배
    • 한국중재학회지:중재연구
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    • 제19권1호
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    • pp.121-145
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    • 2009
  • South Korea has investment agreements such as FTAs, BITs with several countries. Up to now, no single case has been registered against the Korean government on breach of investment agreements, but it is likely that the number of such cases would increase. Therefore, an investor-state dispute settlement system, an arbitral procedure by which a foreign investor may seek compensation of damage against the host country, is gaining its importance. The provision of the ISDS has been one of the hottest issues in Korea while the Kor-US FTA was being signed. In this respect, with the growing number of regional agreements such as BITs and FTAs, a careful scrutiny on the ISDS is necessary for Korea. I have therefore studied theoretically subjects including the National Treatment(NT), the Most-Favored Nation(MFN), Fair and Equitable Treatment and Expropriation - those that have been the objects of protection on investors. And I have analyzed ICSID arbitral awards and provided implications. In the ICSID arbitral awards, the Fair and Equitable Treatment turned out to be the most recognized violation on investors by the host State in terms of investor protection. On the other hand, Indirect Expropriation - a matter of which public anxiety was shown led by civic groups - was not generally recognized in arbitral awards. This study is written for sake of governments, local autonomous entities and public enterprises that are in charge of FTAs and BITs.

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전역 최적 경로가 향상되지 않는 반복 탐색 횟수를 고려한 개미 집단 시스템 (Ant Colony System Considering the Iteration Search Frequency that the Global Optimal Path does not Improved)

  • 이승관;이대호
    • 한국컴퓨터정보학회논문지
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    • 제14권1호
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    • pp.9-15
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    • 2009
  • 개미 집단 시스템은 조합 최적화 문제를 해결하기 위한 메타 휴리스틱 탐색 방법이다. 기존 개미 집단시스템은 전역갱신과정에서 탐색된 전역 최적 경로에 대해서만 페로몬 갱신을 수행하는데, 전역 최적 경로가 탐색되지 않으면 페로몬 증발만 일어나며 주어진 종료 조건을 만족할 때까지 아무리 많은 반복 수행에도 페로몬 강화가 일어나지 않는다. 본 논문에서 제안된 개선된 개미 집단시스템은 전역 최적 경로의 길이가 주어진 반복 사이클 횟수 동안 더 이상 향상되지 못하면 국부최적에 빠졌다고 평가하고 상태전이 규칙에서 파라미터 감소를 통해 다음 노드를 선택하게 하였다. 이로 인해, 상태전이 규칙에서 파라미터 감소에 의한 다양화 전략으로 탐색하는 결과가 최적 경로 탐색뿐만 아니라, 평균 최적 경로 탐색과 평균 반복횟수의 성능이 우수함을 보여 주었으며, 실험을 통해 그 성능을 평가하였다.

EFFECTS OF AMMONIATION, IODINATION AND SUPPLEMENTATION OF AVOPARCIN ON THE NUTRITIONAL VALUE OF RAPESEED MEALS

  • Paik, I.K.;Chung, J.S.;An, M.S.;Um, J.S.;Namkung, H.
    • Asian-Australasian Journal of Animal Sciences
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    • 제4권1호
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    • pp.47-57
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    • 1991
  • Supplementation of iodine at the level of 3.5mg/kg reduced weight gain of the rats fed rapeseed oil meal (ROM) diets. Treatment of ROM with ammonia at the level of 2 or 4% tended to increase metabolizable energy value and availability of dry matter, crude protein and crude ash of ROM in the chicken. Potential goitrin level of ROM was reduced by ammoniation at 6% level, while the level of potential isothiocyanates was increased by ammoniation. Treatment of ROM with ammonia at the level of 3% and above reduced weight gain of the chickens fed treated ROMs. Weight of thyroid glands of the birds increased as the level of ammoniation of ROM increased. Supplementation of Avoparcin to the diets containing ROM improved weight gain and dressing percentage of the broiler chickens.

의정부시 주택 현황에 관한 연구 (A Study on The Present State of Housing in Uijeongbu City)

  • 김종환
    • 한국디지털건축인테리어학회논문집
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    • 제4권2호
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    • pp.19-25
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    • 2004
  • This study is to furnish basic data for establishing the improvement counterplan of Housing environment and to solve the problem of Housing supply resulting from the continuous increase of population and to examine the historical flowing, the present condition and problems of Housing in Uijeongbu city. Including of the multi-house to the number of Housing, the supply ratio of Housing is 95% in quantity of the Housing in Uijeongbu city in 2004. Now, it is important time in the respect of quality as well as the quantity in supply matter of Housing. In fact, the main viewpoint in housing supply policy has been brought focus into the economic profits more than public interests. As a result of that, the residence environment has been worse. From now on, a Local autonomous entity including the construction authorities and Uijeongbu city authorities must focus on the public interests in solving problems of Housing.

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Semantics of Focus

  • Yoon, Young-Eun
    • 한국언어정보학회지:언어와정보
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    • 제1권
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    • pp.137-179
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    • 1997
  • This paper discusses several basic issues of the 'focus' phenomenon. One of them is the issue of the nature of focus, i.e., what constituent of the sentences gets focused. Another is the issue of to what aspect of meaning the focus contributes. The other is the issue of the functions of focus-sensitive operators. As for the first issue, it is observed that the basic function of focus is to mark all and only the new information of the sentence. But for the cases in which this principle is not observed, it is proposed that the focus in these cases in general plays a secondary function of triggering an additional emphatic scalar meaning. And yet, in these cases, the state of the matter is different between free focus and bound focus. It is also shown that contrary to the general belief that free focus contributes to the meaning semantically. Concerning focus-sensitive operators, we classify them into two groups, i.e., quantificational and scalar operators, and try to formalize their meaning in the framework of Pulman's(1997) 'higher order unification theory'.

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Donald Trump Presidency and the Transformation of Sino-American Relations: Does Asymmetric Economic Interdependence Matter?

  • Grabowski, Marcin;Duggan, Niall
    • Journal of Contemporary Eastern Asia
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    • 제20권2호
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    • pp.174-196
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    • 2021
  • Even though Sino-American relations of the Donald Trump era were perceived as predominately confrontational, with a symbolic trade war between the two, the scale of economic interdependencies between the United States and China results in either a need for collaboration or in serious losses on both sides in the case of lack of cooperation. The paper aims at analyzing economic relations between the United States of America and the People's Republic of China at the time of the Trump presidency. Analysis is based on the complex interdependence theory of Robert Keohane and Joseph Nye. The main hypothesis analyzed in the paper states: Asymmetric interdependence between the People's Republic of China and the United States of America limits the scope, intensity and length of a trade war. For the sake of the paper, economic interdependence will be analyzed. Apart from the reference to the state of the art, the document analysis and descriptive statistics are to be applied in the paper.

Enhanced MPR Selection Strategy for Multicast OLSR

  • Matter, Safaa S.;Al Shaikhli, Imad F.;Hashim, Aisha H.A.;Ahmed, Abdelmoty M.;Khattab, Mahmoud M.
    • International Journal of Computer Science & Network Security
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    • 제22권10호
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    • pp.137-144
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    • 2022
  • Wireless community networks (WCNs) are considered another form of ownership of internet protocol (IP) networks, where community members manage and own every piece of equipment in a decentralized way, and routing for traffic is done in a cooperative manner. However, the current routing protocols for WCNs suffer from stability and scalability issues. In this paper, an enhanced routing protocol is proposed based on the optimized link state routing (OLSR) protocol to meet the standards of efficiency in terms of stability and scalability. The proposed routing protocol is enhanced through two phases: multicasting expansion and multipoint relay (MPR) selection based on an analytical hierarchical process (AHP). The experimental results demonstrate that the proposed routing protocol outperforms the OLSR protocol in terms of network control overhead and packet delivery ratio by 18% and 1% respectively.