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Simultaneous Determination of Heavy Metals in Cosmetic Products by Ion Chromatography (이온 크로마토그래피를 이용한 화장품 중 중금속 동시분석)

  • Lee, So-Mi;Jeong, Hye-Jin;Kim, Han-Kon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.34 no.1
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    • pp.57-62
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    • 2008
  • No matter how small amount of heavy metals it may be cause skin allergies through percutaneous adsorption when existing in cosmetic products as impurities. In order to develop a highly sensitive method for simultaneous determination of $Pb^{2+},\;Fe^{2+},\;Cu^{2+},\;Ni^{2+},\;Zn^{2+},\;Co^{2+},\;Cd^{2+},\;and\;Mn^{2+}$ in coloring agents and cosmetic products with rapidity and accuracy, we carried out the determination on ion chromatography. All of these metals are well separated through a bifunctional ion-exchange column(IonPac CS5A) and detected by post-column reaction and spectrophotometric detection. The calibration graphs are linear($r^2>0.999$) in the range $0.1{\sim}1000{\mu}g/mL$. Detection limits for 200 ${\mu}L$ of sample solution are at the level of ${\mu}g/L$, which is sufficient for judging whether the product is safe or not. The relative standard deviations(RSDs) of the retention time and the peak area are less than 0.21 and 1.24%, respectively. The recovery rates are $97{\sim}104%$. The new method was applied to analyze the amount of heavy metals which were contained in 22 cosmetic products and 11 coloring agents.

Development of Sandwich ELISA for the Detection of Mackerel in Processed Foods (가공식품 중 고등어의 검출을 위한 ELISA의 개발)

  • Shon, Dong-Hwa;Kim, Mi-Hye
    • Korean Journal of Food Science and Technology
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    • v.44 no.1
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    • pp.1-7
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    • 2012
  • There have been few studies related to ELISA for mackerel. In this study we developed a sandwich ELISA for mackerel in processed foods using rabbit polyclonal antibodies against mackerel parvalbumin, the major allergen of mackerel and heat-stable protein. The parvalbumin was purified by ammonium sulfate precipitation and Sephadex G-50 column chromatography. From the standard ELISA curves, the detection limit of parvalbumin was 3 ng/mL and the detection range of mackerel was 5-5,000 ${mu}g/mL$. We further investigated the cross-reactivity of the antibodies toward mackerel, mackerel pike, salmon, flatfish, armorclad rockfish, cod fish, squid, shrimp, blue crab, and lobster. The antibodies were specific for mackerel only. The mean assay recoveries in cooked cream soup, baby food, sausage, and sauce spiked with 0.01 to 0.3% mackerel were 104, 101, 54, and 0%, respectively. In sample tests of 16 commercial items, the qualitative coincidence ratio of assay result and indication was 75%.

A Study of Working Environment for Automotive Painting in Auto Repair Shops and Workers' Exposure to Hazardous Chemicals (자동차 정비업체 도장공정의 작업환경 및 근로자 노출 실태에 관한 연구)

  • Sim, Sang-Hyo;Jeoung, Chun-Hwa;Lim, Jin-Suk;Lee, Hyung-Gu;Kim, Yoon-Shin
    • Journal of Environmental Health Sciences
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    • v.35 no.3
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    • pp.153-161
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    • 2009
  • The purpose of this paper is to evaluate 1) blood lead levels of workers at auto repair shops as Biological Exposure Indices (BEI) of toxic substances such as lead and toluene that are produced during automotive painting process, 2) the differences depending on personal characteristics of workers who have been exposed to toluene by using urine hippuric acid concentration as a marker and 3) the correlation between the concentration of hazardous chemicals in each workplace and the BEL. All subjects were male with a mean age of 36.2 years. In terms of age, most were in the 30 to 40 age group (13 persons, 48.1%). In relation to the length of work experience, the highest proportion had experience of 10 years of less (18 persons, 66.7%). Twenty three workers were cigarette smokers (85.2%) while 4 (14.8%) were non-smokers. In addition, more than 80% of the workers drank alcohol. Dust concentration and toluene exposure during automotive painting showed no significant difference with age, length of work experience, smoking and drinking while a significant difference (p<0.05) has been detected between lead concentration and smoking. The geometric mean of dust concentration, lead concentration and toluene concentration were $0.38mg/m^3,\;0.0021mg/m^3$ and 1.08ppm respectively. In addition, the geometric mean of blood lead levels and urine hippuric acid concentration were $1.70{\mu}g/dl$ and 0.25g/g respectively, which were lower than the standard levels suggested by the Ministry of Labor. To determine the influential factors on blood lead and urine hippuric acid concentrations, a correlation analysis has been conducted with variables of air, lead and toluene concentrations, age, length of work experience and amount of cigarette smoking. According to the analysis, a relatively high correlation (p<0.01) has been observed between air lead concentration and biological sample concentration.

Palliative Management of Gastric Cancer with Outlet Obstruction: Stent versus Bypass (위배출구 폐색을 동반한 위암환자의 치료)

  • Kim, Hyung-Ho
    • Journal of Gastric Cancer
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    • v.9 no.1
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    • pp.6-9
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    • 2009
  • Gastric cancer with gastric outlet obstruction has a high incidence of direct invasion into neighboring organs, with a low resection rate and a poor prognosis. Traditionally, open gastrojejunostomy has been the standard palliative treatment in these patients. Recently, endoscopic self-expanding metal stents have been used increasingly for the palliative treatment of malignant gastric outlet obstruction, but the choice of modality to treat the obstruction caused by gastric cancer is still controversial. Many studies have shown that endoscopic stenting is less invasive and offers not only a shorter time to oral intake and length of hospital stay, but also less frequent complications compared to open gastrojejunostomy. However, recurrent obstruction by tumor overgrowth and ingrowth occur more frequently and re-intervention for recurrent obstructive symptoms are more frequently performed after stent placement than after gastrojejunostomy. Thus, stent placement may be associated with more favorable results in patients with a relatively short life expectancy, while gastrojejunostomy is preferable in patients with a more prolonged prognosis. Also, open surgery affords a greater chance for curative surgery. However, most underlying diseases analyzed in previous studies were pancreaticobiliary malignancies, and there have been few prospective studies specific for patients with gastric cancer. Additional randomized controlled trials with larger sample sizes are expected to decide the treatment modality for unresectable gastric cancer with gastric outlet obstruction.

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GNSS Software Receivers: Sampling and jitter considerations for multiple signals

  • Amin, Bilal;Dempster, Andrew G.
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.2
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    • pp.385-390
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    • 2006
  • This paper examines the sampling and jitter specifications and considerations for Global Navigation Satellite Systems (GNSS) software receivers. Software radio (SWR) technologies are being used in the implementation of communication receivers in general and GNSS receivers in particular. With the advent of new GPS signals, and a range of new Galileo and GLONASS signals soon becoming available, GNSS is an application where SWR and software-defined radio (SDR) are likely to have an impact. The sampling process is critical for SWR receivers, where it occurs as close to the antenna as possible. One way to achieve this is by BandPass Sampling (BPS), which is an undersampling technique that exploits aliasing to perform downconversion. BPS enables removal of the IF stage in the radio receiver. The sampling frequency is a very important factor since it influences both receiver performance and implementation efficiency. However, the design of BPS can result in degradation of Signal-to-Noise Ratio (SNR) due to the out-of-band noise being aliased. Important to the specification of both the ADC and its clocking Phase- Locked Loop (PLL) is jitter. Contributing to the system jitter are the aperture jitter of the sample-and-hold switch at the input of ADC and the sampling-clock jitter. Aperture jitter effects have usually been modeled as additive noise, based on a sinusoidal input signal, and limits the achievable Signal-to-Noise Ratio (SNR). Jitter in the sampled signal has several sources: phase noise in the Voltage-Controlled Oscillator (VCO) within the sampling PLL, jitter introduced by variations in the period of the frequency divider used in the sampling PLL and cross-talk from the lock line running parallel to signal lines. Jitter in the sampling process directly acts to degrade the noise floor and selectivity of receiver. Choosing an appropriate VCO for a SWR system is not as simple as finding one with right oscillator frequency. Similarly, it is important to specify the right jitter performance for the ADC. In this paper, the allowable sampling frequencies are calculated and analyzed for the multiple frequency BPS software radio GNSS receivers. The SNR degradation due to jitter in a BPSK system is calculated and required jitter standard deviation allowable for each GNSS band of interest is evaluated. Furthermore, in this paper we have investigated the sources of jitter and a basic jitter budget is calculated that could assist in the design of multiple frequency SWR GNSS receivers. We examine different ADCs and PLLs available in the market and compare known performance with the calculated budget. The results obtained are therefore directly applicable to SWR GNSS receiver design.

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A Study on the Body Characteristics of Korean Obese Women (Part II)

  • Yi, Kyong-Hwa
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.6
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    • pp.982-996
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    • 2010
  • This study classified the body shapes of Korean obese women and investigated the differences of each body shape, using 2004 Size Korea data. For selecting the obesity sample, 7 obesity judgment indices were chosen through previous clothing-related studies. A total of 636 females defined as "obese" by 5 out of 7 indices were selected as subjects and 54 body measurements and obesity judgment indices were used in this study. Firstly, mean, standard deviation, minimum, and maximum values of each measurement and item were obtained from the descriptive analysis of 53 measurements. According to the descriptive analysis, all measurements and obesity judgment indices of the subjects demonstrated a serious obesity level shown by BMI 27.11, R$\ddot{o}$hrer index 1.76, Vervaeck index 104.77, Relative weight 133.00, WHR 0.90, and waist circumference 86.71cm. In addition, the measurements and indices showed considerable differences between minimum and maximum values. Significant differences were identified in all measurements and items at a significant level, p=.001. Each distribution of body types according to age, stature, bust, and waist circumference groups was provided in this study. Secondly, factor analyses were conducted using 38 measurement items to extract the body characteristics of obese women. Factor 1 was "circumference measurements & obesity judgment indices," Factor 2 was "heights & arm-related lengths," and Factor 3 was "size and ratio of waist circumference & hip circumference." Factor 4 was "lengths in upper body," Factor 5 was "back width in upper body," Factor 6 was "side neck point to bust & bust circumference," Factor 7 was "length in lower body & arm circumferences" and Factor 8 was "neck base circumference & front width in upper body." These 8 factors explained 76.54% of the total variance. Finally, 5 body types were selected in the cluster analysis. Type 1 (with big back widths & arm circumferences) was 15.5% of the entire subjects, Type 2 (the shortest and fattest, with big upper body) was 18.8%, Type 3 (with big breast) was 27.8%, Type 4 (the tallest and longest in arm lengths, with the smallest arm circumferences and lengths in torso) was 22.5%, and Type 5 (with big hips compared to waist circumferences, smaller height and upper body) was 15.5%. Fundamental differences were identified in all measurements and items at the significant level of p=.001. In addition, each distribution of body type according to age, height, bust, and waist circumference groups was provided in this study.

An evaluation of the composition and elements in Korean traditional interior space - On Choosa-Gotack in the Chosun dynasty - (한국전통 실내공간의 구성방법과 요소 분석을 통한 의미 고찰 - 조선조 추사고택을 중심으로 -)

  • 천진희
    • Archives of design research
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    • no.16
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    • pp.101-110
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    • 1996
  • CHOOSA GORACK which is a typical example of traditional houses in the CHO SEON dynasty consists of the four terraced builfing group. Among those,SADANG CHAI are located in the highest level,and SADANG CHAI and SADANG CHAI are toward south direction.It means that building orientation and level were influenced by the distinction of social level and the idea of ancester worship. Floor and ceiling level in the same building is different which was caused by the distinetion of social level in the CHO SEON dynasty and an ariental dual as a variety of openings,exposed ceilings,and furniture against a wall were creating a typical Korean visual harmony. Although the furniture and equipments were very important elements in ONDOL BANG the occupance ratio of these were low because the free space in BANG should be utilized effectively to accommodate the space variation.Both an AN CHAI and SARANG CHAI were composed by the standard space module called KAN.And interior elements were established by several factors such as the human scale,the behavior pattern in traditional sitting life style, and the lumber size of post and lintel construction of Korean house.BANG and DAE GHUNG, composed of KAN,were expanded and arranged side by side so that the natural light and ventilation through them could be used in the result of the kind of lay out,traffic circulation was disturved.In conclusion,CHOOSA GOTACK was formed by the sirect effice of the KOREAN penisula. However this study was based on one sample. It may not enough to deduct soild conclusion.Therefore continuous and farher study is needed for the sestemane evaluation.

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User experience of MV2000-MT (SU:M2)® as a Mechanical Ventilator: A Comparative Clinical Study on Usability, Safety, and Medical Staff Satisfaction

  • Jeon, Soeun;Kim, Hae Kyu;Lee, Dowon;Kim, Hyae Jin;Park, Eun Ji
    • Journal of Biomedical Engineering Research
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    • v.40 no.6
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    • pp.260-267
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    • 2019
  • In the present study, we aimed to demonstrate that MV2000-MT(SU:M2)® (MV, MEK-ICS, Paju, Korea), a domestic ventilator, is not inferior in terms of usability, safety, and medical staff satisfaction as compared to Hamilton G5 (G5, Hamilton Medical AG, Rhäzuns, Switzerland). A total of 39 patients who applied MV (group M) or G5 (group H) were included in the study sample. Usability was evaluated by the following factors: the number of alarm errors, replacement requirement of breathing circuit, replacement requirement of a right-angle connector, and ease of ventilator weaning. For safety evaluation, the number of ventilator replacements due to malfunction of the ventilator was evaluated. Items for medical staff satisfaction survey were as follows: the number of MV and G5 uses, hardware, and software assessment. In the usability evaluation, the replacement requirement of the right-angle connector was lower in Group M than in Group H (mean ± standard deviation, Group M: 7.39 ± 6.72, Group H: 14.19 ± 10.24, p = 0.021); however, the evaluations of other parts were not significantly different between the two groups. The number of ventilator replacements due to a malfunction of the ventilator did not differ between two groups. The number of MV and G5 uses was 3.0 [3.0-4.0] and 10.0 [5.0-10.0] (median [interquartile range], p < 0.001). Overall, the mean medical staff satisfaction score of Hamilton G5 was higher than that of MV2000-MT(SU:M2)®. The usability of MV is comparable to that of G5. However, medical staff satisfaction with Hamilton G5 was higher than that with MV2000-MT(SU:M2)®, and this difference could be due to the difference in the number of uses. In order to improve the penetration rate of the domestic mechanical ventilator, it is necessary to find ways to increase familiarity of medical staff with domestic mechanical ventilators.

RPC Model Generation from the Physical Sensor Model (영상의 물리적 센서모델을 이용한 RPC 모델 추출)

  • Kim, Hye-Jin;Kim, Jae-Bin;Kim, Yong-Il
    • Journal of Korean Society for Geospatial Information Science
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    • v.11 no.4 s.27
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    • pp.21-27
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    • 2003
  • The rational polynomial coefficients(RPC) model is a generalized sensor model that is used as an alternative for the physical sensor model for IKONOS-2 and QuickBird. As the number of sensors increases along with greater complexity, and as the need for standard sensor model has become important, the applicability of the RPC model is also increasing. The RPC model can be substituted for all sensor models, such as the projective camera the linear pushbroom sensor and the SAR This paper is aimed at generating a RPC model from the physical sensor model of the KOMPSAT-1(Korean Multi-Purpose Satellite) and aerial photography. The KOMPSAT-1 collects $510{\sim}730nm$ panchromatic images with a ground sample distance (GSD) of 6.6m and a swath width of 17 km by pushbroom scanning. We generated the RPC from a physical sensor model of KOMPSAT-1 and aerial photography. The iterative least square solution based on Levenberg-Marquardt algorithm is used to estimate the RPC. In addition, data normalization and regularization are applied to improve the accuracy and minimize noise. And the accuracy of the test was evaluated based on the 2-D image coordinates. From this test, we were able to find that the RPC model is suitable for both KOMPSAT-1 and aerial photography.

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Evaluation of quantitative on T-spine exhalation technique and T-spine breathing technique of natural breathing (T-spine exhalation technique과 자연스런 호흡 상태에서 촬영하는 T-spine breathing technique의 정량적 평가)

  • Son, Soon-Yong;Choi, Kwan-Woo;Min, Jung-Whan;Son, Jin-Hyun;Kim, Ki-Won;Jung, Jae-Hong;Jeong, Hoi-Woun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.9
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    • pp.4429-4436
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    • 2013
  • Measurements of CNR(Contrast to Noise Ratio) and SNR(Signal to Noise Ratio) of T-spine breathing technique (TBT) using spontaneous breathing and T-spine exhalation technique (TET) with full exhalation were carried out, and with which the more appropriate method was suggested. Both TBT and TET were examined in a sample of fifty-three patients who visit to our hospital for spinal disease from June 2012 to November 2012. All images were evaluated with CNR measured from the differences between the mean pixels and contrast density as setting ROI of spinous process, pedicle, vertebral body, intervertebral foramen, and intervertebral disk using Image J. SNR was measured with the mean pixels and the standard deviation as setting ROI of vertebral body using Image J. In CNR comparison and SNR comparison of TET and TBT, TBT was indicated as excellent in ROI of pedicle, vertebral body, intervertebral foramen and intervertebral disk, and statistical analysis were significant(p<.01). As TBT indicated excellent images compared to the existing T-spine lateral radiography, T-spine lateral radiography would be reestablished and significant as applying to various medical institutions.