• 셀메드
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• 제10권2호
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• pp.16.1-16.8
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• 2020

Standardization of drug deals with confirmation of drug identity and determination of drug quality and purity. Unani herbal formulations are used in traditional medicine for the treatment of various diseases. Cancer is a disease which causes abnormal, uncontrolled growth of body tissue or cells, which tend to proliferate in an uncontrolled way. Spread of cancer from site of origin to other organs of the body is called metastasis. It is a hyper proliferative disorder involving, transformation, dysregulation of apoptosis, invasion and angiogenesis. The present study aimed to standardize a classical Unani formulation (CUF) described as anticancer properties. The CUF has been used for anti-cancerous activity (Dāfi'-i-saraṭān) in human population by Unani physicians for centuries. The standardization parameters carried out for classical Unani formulation are pharmacognostical studies, physicochemical parameters, high-performance thin layer chromatography (HPTLC), microbial load, aflatoxins, and heavy metals revealing specific identities and to evaluate Pharmacopoeial standards. Experiment and the data obtained established the Pharmacopoeial standards for this formulation for identification and quality control purpose. The CUF has been successfully standardized and standard operating procedures (SOPs) for its preparation has been laid down which may serve as a standard reference in future. The standardization data of this formulation may be used as a standard guideline for preparation of the formulation in future.

• Nuclear Engineering and Technology
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• 제53권6호
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• pp.2038-2045
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• 2021

The main objective of this work is to propose a reliable routine standard operation procedures (SOP) for structural health monitoring and diagnosis of nuclear power plants (NPPs). At present, NPPs have monitoring systems that can be used to obtain the quantitative health record of containment (CTMT) buildings through system identification technology. However, because the measurement signals are often interfered with by noise, the identification results may introduce erroneous conclusions if the measured data is directly adopted. Therefore, this paper recommends the SOP for signal screening and the required identification procedures to identify the dynamic characteristics of the CTMT of NPPs. In the SOP, three recommend methods are proposed including the Recursive Least Squares (RLS), the Observer Kalman Filter Identification/Eigensystem Realization Algorithm (OKID/ERA), and the Frequency Response Function (FRF). The identification results can be verified by comparing the results of different methods. Finally, a preliminary CTMT healthy record can be established based on the limited number of earthquake records. It can be served as the quantitative reference to expedite the restart procedure. If the fundamental frequency of the CTMT drops significantly after the Operating Basis Earthquake and Safe Shutdown Earthquake (OBE/SSE), it means that the restart actions suggested by the regulatory guide should be taken in place immediately.

• 한국유체기계학회 논문집
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• 제13권6호
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• pp.36-41
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• 2010

Design, manufacture and calibration procedures of a venturi pipe flowmeter for airflow measurement in altitude engine test were discussed. Altitude engine test using venturi pipe was given as an example. The venturi was designed per the ISO standard of ISO5167, and was intented to include the entire airflow range in the test envelope of the gas turbine engine. Measurement uncertainty analysis was performed in the design procedure to investigate the effect of venturi geometry and sensor specification upon the measurement uncertainty. Manufacturing process was designed to minimize the deviation from the geometry of design. Calibration was performed to get the relationship between the discharge coefficient and the pipe Reynolds number. Then the uncertainty was assessed again using real data acquired during engine test. Through these procedures, it was possible to maintain the uncertainty of airflow measurement under 1 % for most of the operating envelope of the gas turbine engine. The discharge coefficient of the venturi pipe showed agreement with the value suggested in the ISO standard ISO5167-4 within 0.6 %.

• 한국연초학회지
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• 제33권1호
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• pp.28-38
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• 2011

This experiment was conducted as a part of Asia collaborative study on purpose of verifying the difference between CM6 and CM7 including 3R4F for reference. It carried out using various analytical categories for example, main stream, sidestream and Av. smoke. Additional analysis such as physical properties, blending ratio, combustibility and general leaf component analysis also implemented in order to investigate the difference. We complied with ISO standard and CORESTA recommended method during analytical operating procedures. In this study, we described that comparative analytical result for CM6 and CM7 known as reference or monitoring cigarettes including 3R4F for reference. All sample cigarettes were conditioned at $22^{\circ}C$, 60% relative humidity for 48 hours. Av. Smoke, MS and SS smoke analysis were performed over five times with two smoking condition, ISO and Health Canada with the exception of Av. smoke analysis. We complied with ISO standard method during analytical operating procedures. And, we conducted additional analysis, such as physical properties, blending ratio, combustibility and leaf component analysis also in order to investigate the difference. In conclusion, we found out some differences between CORESTA monitoring cigarette No. 6 and No 7. The smoke components such as total particulate matters, NFDPM, nicotine and carbon monoxide contents of CM7 were a little lower than CM6. And, these phenomena were the same as not only main stream smoke but also side stream smoke and Av. smoke. This tendency was consistent with ISO and Health Canada smoking condition. Besides, leaf constituents' color of CM7 was darker than CM6. In case of combustibility, it showed short combustion time approximately 30 seconds.

• 한국수산과학회지
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• 제45권5호
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• pp.445-453
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• 2012

This study examined microbial contamination during seasoned and dried squid Dosidicus gigas processing, including the apparatus, machines, and employee's gloves at each step in processing at two companies. The numbers of bacteria floating in air in each processing area were also examined. The numbers of Staphylococcus aureus (3.6-6.0 log CFU/g) and Escherichia coli (1.3-1.4 log MPN/100 g) in domestic and imported daruma (a semi-processed product of seasoned and dried squid) at companies A and B exceeded the regulatory limits of the Food Sanitary Law of Korea (S. aureus, ${\leq}2.0$ log CFU/g; E. coli, negative). S. aureus in both daruma was reduced to below the detection limit or 3.6 log CFU/g after the roasting step, but increased again to 3.3 and 5.5 log CFU/g after the mechanical tearing step at companies A and B, respectively. E. coli showed similar tendencies at both companies. The surfaces of the apparatus, machines, and employee's gloves that contacted daruma were also contaminated with S. aureus (1.0-5.5 log CFU/$m^2$) and E. coli (negative-to 3.5 log MPN/$m^2$). The numbers of bacteria floating in air were high (1.7-5.1 log CFU/$m^3$) at both companies. These results suggest that sanitation standard operating procedures (SSOP) must be developed to control of microbial cintamination in seasoned and dried squid.

• 환경영향평가
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• 제21권2호
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• pp.327-338
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• 2012

Environmental specimen banks provide the baselines for the scientists and decision makers to do research using the past and present specimens to expect the possible contaminant implications of the future. Many chemicals that are considered harmless now but not found may be found and pose threats in the future. Collected specimens of animals and plants should be conserved without contamination for future analysis. To ensure the availability of samples for the retrospective analysis, the establishment and maintenance of specimen banks in the developing and developed nations has become absolutely necessary. National Environmental Specimen Bank (NESB) established at National Institute of Environmental Research (NIER) in 2009. For the application of NESB, several activities such as standard operating procedures (SOPs) development have been prepared. This study applied the guidelines for sampling and sample treatment of five environmental specimens which had been prepared from 2007 to 2009. The target species were shoots of red pine and Korean pine, leaves of Mongolian oak, eggs of domestic pigeon and muscles and livers of common carp. The NESB will enhance the quality of environmental assessment and environmental monitoring based on real time and retrospective analysis.

• 한국화재소방학회논문지
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• 제31권5호
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• pp.78-86
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• 2017

우리나라의 재난환경은 산업고도화 및 도시노후화의 영향으로 인하여 점차 다양하고 복잡한 양상으로 전개되고 있다. 따라서 컨트롤타워와 현장인원간에 재난현장의 각종 정보를 신속하고 정확하게 공유할 수 있는 재난통신체계의 확보는 재난대응의 성공을 위하여 그 어느 때보다 절실히 요구된다. 본 연구는 재난관리 선진국인 미국의 국가재난관리체계, 재난통신 운영체계 및 표준운영절차 분석을 통해 우리나라 재난통신체계의 개선책을 다음과 같이 제안한다. 첫째, 재난통신조직이 보다 체계화되어야 한다. 중앙정부 재난통신조직과 지방정부 재난통신조직은 각각 상이한 역할 및 목표에 따라 운영되어야 하며, 상호운영성에 의거하여 유기적으로 공조해야 한다. 둘째, 재난통신 협의체는 재난 관련단체의 대표자들로 구성되어야 하며, 전국단위 및 지방단위로 각각 구성 및 운영되어야 한다. 셋째, 재난통신의 목표를 달성하기 위한 표준운영절차에는 운영적 요소와 기술적 요소가 모두 포함되고 각 재난통신체계 구성원들의 역할과 책임이 명확하게 수립되어야 한다. 이러한 개선책은 재난통신체계가 현장에서 정확하게 작동되도록 할 것이며, 이는 재난대응의 성공확률을 향상시킬 것으로 예상한다.

• 환경영향평가
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• 제21권6호
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• pp.823-839
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• 2012

Environmental Specimen Banks (ESBs) are playing pivotal role in monitoring the effect of environmental pollution on the ecosystem based on the retrospective analysis of the representative samples collected regularly and stored in cryogenic condition. In Korea, National Environmental Specimen Bank (NESB) was established in 2009 and the standard operating procedures (SOPs) for sampling, and cryogenic milling and storage had been prepared during 2007-2010. Since then, the tentative SOPs for the seven kinds of specimens (shoots of Red Pine (Pinus densiflora) and Korean Pine (Pinus koraiensis), leaves of Mongolian Oak (Quercus mongolica) and Zelkova Tree (Zelkova serrata), eggs of Feral Pigeon (Columba livia var. domestica), muscles and organs of Common Carp (Cyprinus carpio), and Freshwater Bivalve (Unio (Nodularia) douglasiae)) have been put to test in the field and laboratory as well against the practicality and feasibility. The SOPs were improved by reflecting the findings from the research and the following discussion regarding the selection of specimen (Feral Pigeon suffering from a control management), sample size (a problem of decreasing number of sampling trees related to increasing sampling time) and period (a problem related to a bud growth), and sampling methods etc.. In addition, barcoding system for the management of the specimen information, and monitoring system of the cryogenic storage to regulate the optimum temperature and the liquid nitrogen level were also developed for the efficient and effective control of the samples. Lastly, the safety guide and emergency protocol were augmented to guarantee a safe work environment with the cryogenic facility. These improvements of the SOPs are expected to contribute to more stable operation of the NESB.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 춘계종합학술대회
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• pp.749-752
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• 2003

HLA(High Level Architecture)는 미 국방성에서 제안한 분산 시뮬레이션을 위한 실시간 분산 데이터 공유를 위한 객체, 시간, 인터페이스 규격을 말한다. 이 HLA는 (1) Rules, (2) Interface Specification, (3) Object Model Template 둥의 3가지 구성요소로 정의되며, 인터페이스 명세를 구현한 것이 RTI(Run-Time Infrastructure)이다. RTI는 분산 운영체계가 응용 프로그램에게 서비스를 제공하는 것과 유사한 방법으로 Federation을 구성하고 있는 Federate들에게 상호연동에 필요한 서비스를 제공한다. 모든 서비스들이 표준에 적합하게 구현되었는지 테스트하기 위한 방법은 DMSO에서 제안한 RTI를 검증하기 위한 2단계 과정을 통해 테스트된다. 본 논문에서는 1단계 테스트를 위한 테스트 절차와 그 방법에 대해 논한다 테스트 결과를 토대로 각 영역에서 DMSO에서 제안한 Level One Test Procedures에 따라 RTI가 Interface Specification에 적합하게 구현되었는지 확인하며, 각 단계마다 올바른 명령과 예상된 결과가 나오는지 테스트하기 위한 Test Suite를 개발한다.

• 셀메드
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• 제11권4호
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• pp.21.1-21.9
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• 2021

Background: Unani System of Medicine (USM) has its origin to Greece. To ensure and develop the quality, authenticity of Unani drugs, standardization on modern analytical parameter is essential requirement for drugs. Objectives: The aimed of the present study was to develop a standard profile of "Qurṣ-e-Mafasil" by systematic study through authenticated ingredients, pharmacognostic identification followed by physicochemical, TLC, HPTLC fingerprinting analysis as per standard protocol. Material and Methods: In this study three batches of "Qurṣ-e-Mafasil" QM were prepared by standard method as per UPI had been followed by organoleptic properties of formulation such as appearance, color, odor, taste. Powder Microscopy and physicochemical studies were carried out such as Uniformity of weight, Friability, Disintegration time, hardness, LOD, ash vales and extractive values in like aqueous, alcohol & hexane. Further qualitative tests such as Thin-Layer Chromatography (TLC), and High-Performance Thin Layer Chromatography (HPTLC) studies were also carried out to develop fingerprint pattern of the alcoholic solvent extract of QM. Phytochemical screening was carried out in different solvent extracts such as alcoholic, aqueous and chloroform extracts to detect the presence phytoconstituents in the formulation QM. Heavy metals, Microbial Load Contamination and pesticidal residues were also determined. Results: Qurṣ-e-Mafasil showed tablet-like appearance, light brown colour, mild pungent odour and acrid taste. Uniformity of weight (mg), friability (rpm), and hardness (kg/cm) and disintegration time was ranged between (500 to 503), (0.0340 to 0.038), (8.40 to 8.67) and (4-5 minutes) respectively for the three batches. Loss in weight on drying at 105℃ was ranged between (8.3425 to 8.7346). Extracted values were calculated in distilled water ranged between (30.9091 to 31.4358), hexane (1.1419 to 1.4281), and alcohol (3.3352 to 3.3962). The ash values recorded were ranged between (3.7336 to 3.8378), and acid insoluble ash (0.5859 to 0.6112).