• Radiation Oncology Journal
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• 제34권4호
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• pp.273-279
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• 2016

Purpose: Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). Materials and Methods: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed. Progression-free survival (PFS) and overall survival (OS) rates were analyzed. Results: Most patients had Ann Arbor stage I-II (94.7%), IPI score of 0 (89.5%), and complete remission after chemotherapy (89.5%). The 5-year PFS and OS rates were 74.6% and 80%, respectively. In univariate analysis, the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen resulted in a better PFS than the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen (88.9% vs. 50.0%; p = 0.053). RT dose was related to the survival outcome (p = 0.010 for PFS, p = 0.044 for OS). Patients were classified into the CHOP + RT (>40 Gy) group and R-CHOP + RT (${\leq}40Gy$) group. The 5-year PFS rates were 50% in the CHOP + RT group, and 100 % in the R-CHOP + RT group (p = 0.018). The 5-year OS rates were 66.7% and 100%, respectively (p = 0.087). Conclusion: Primary tonsillar lymphoma patients typically have favorable outcomes. Chemotherapy (R-CHOP) combined with relatively lower dose consolidative RT may be safe and effective for primary tonsillar lymphoma.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.533-538
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• 2008

Purpose: Sensory changes in the upper limb are complications of a mastectomy with immediate breast reconstruction with the treatment of breast cancer. The purpose of this study is to clarify whether immediate breast reconstruction worsens the sensory changes. Methods: From March 2004 to December 2005, 20 patients who had a mastectomy with immediate breast reconstruction(reconstruction group) were compared with 23 patients who had a mastectomy alone(control group). All patients had stage I or II breast cancer. The sensory changes were assessed in a blind manner by one examiner that used light touch sensation, static two-point discrimination, pain, vibration, hot and cold temperature perception. The sensory changes were identified along the sensory dermatome for diagnosing the damaged nerves. The following factors and their relationship with the sensory changes were analyzed : age, complications, and the mastectomy method. Results: There was no statistical difference in the static two-point discrimination, pain, vibration, hot and cold temperature perception between the two groups. However, the ability to recognize light touch was significantly better(p=0.045) in the reconstruction group than in the control group. The main site of sensory change was the proximal and medial portion of the upper limb in both groups. At these sites, the mean value of Semmes-Weinstein monofilament was $1.01g/mm^2$(reconstruction group 0.82, control group 1.17) and 2-point discrimination was 51.74(converted to perfect score of 100; reconstruction group 42.50, control group 59.78). The total rate of early complications was found to be significantly lower(p=0.006) in the reconstruction group than in the control group. Conclusion: These findings suggest that an immediate breast reconstructive procedure following a mastectomy is as safe as or safer than a mastectomy alone with respect to postoperative sensory changes of the ipsilateral upper limb.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1621-1626
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• 2014

Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.

• 원예과학기술지
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• 제29권2호
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• pp.151-155
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• 2011

Botrytis cinerea에 의한 딸기 잿빛곰팡이병은 최대 50%까지 발생하여 큰 피해를 주는 딸기의 주요 병해이다. 약제살포시기는 잿빛곰팡이병의 성공적인 방제를 좌우하는 필수적 요소이다. 딸기 '설향' 품종에 대한 잿빛곰팡이병 방제효과 검정을 위해 fenhexamid + imonoctadine tris, cyprodinil + fludioxonil, Bacillus subtilis QST713을 ex vivo에서 개화전, 개화기, 미착색과, 성숙과 단계부터 처리하여 효과를 비교하였다. 또한 '설향' 품종을 공시하여 ex vivo와 재배포장에서 cyprodinil + fludioxonil 혹은 fludioxonil을 저온($0^{\circ}C$, 5시간) 전후 처리하여 잿빛곰팡이병 방제효과를 조사하였다. 딸기 꽃과 성숙과실은 미착색과실보다 B. cinerea에 더 감수성이었다. ex vivo에서 개화단계별 약제방제효과는 fenhexamid + iminoctadine tris는 개화직전과 개화기, cyprodinil + fludioxonil은 개화기에 효과적이었으나 Bacillus subtilis QST713은 처리간 유의성이 없었다. 2010년 딸기 잿빛곰팡이병 방제효과는 fludioxonil을 개화기에 1주일 간격으로 2회 처리시 효과적이었다. 딸기 'Redpearl'과 '설향' 품종은 '매향'과 'Akihime' 품종보다 저온에 더 감수성이어서 주의를 요했으며 cyprodinil + fludioxonil을 저온처리 전에 살포시 90%이상의 방제효과를 나타냈다. 2010년 재배포장에서 잿빛곰팡이병 방제효과는 저온 발생 전 혹은 저온 발생 후 1주일 간격 2-3회 fludioxonil처리가 효과적이었다. 이런 결과로 딸기 잿빛곰팡이병 방제를 위한 약제의 효과적인 처리시기는 개화와 저온이 밀접한 관련이 있음을 알 수 있었다.

• 대한수의학회지
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• 제36권4호
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• pp.919-927
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• 1996

In the last few years, methods for in vitro culture of early embryo stages from oocytes matured and fertilized in vitro using suitable cell culture systems have been established. But the factors affecting pregnancy rates following transfer of bovine embryos produced in vitro were not evaluated enough. So this study was performed to investigate the effects of quality and stage of embryos, parity and Corpus Luteum quality of recipients on pregnancy rates following non-surgical transfer of bovine embryos produced in vitro. Oocytes aspirated from small antral follicles of ovaries obtained at a local slaughter house were matured, fertilized with frozen-thawed semen and co-cultured for 6-7 days by utilizing co-culture system with bovine oviduct epithelial cell in vitro. After co-culture, embryos were transfered to recipients on day 7 (estrus=day 0). Recipients were monitored by ultrasonic scanning method or observation for estrus and rectal palpation after 50 days from transfer. The results of this study are follows. 1. Of the 70 recipients, 70%(49 of 70) had not showed estrus sign between day 0 and day 50, but 22.9%(16 of 70) was diagnosed not pregnant. Therefore the overall pregnancy rate of this study was 47.1%(33 of 70). 2. The pregnancy rate of recipients transfered with excellent(66.7%) and good(54.5%) embryos were higher than that of recipients transfered with fair embryos(15.8%) (p<0.05). 3. The pregnancy rate of recipients transfered with morula, compacted morula, blastocyst and expanded blastocysts were 46.2, 55.0, 62.5 and 50.0%, respectively. 4. The pregnancy rates of recipients transfered to heifer and cow were 54.5 and 55.2%, respectively. 5. The pregnancy rates of recipients with CL score I, II(66.7, 63.6%) were higher than those of recipients with CL score III (10%), (p<0.05). Success of transfer of embryos produced in vitro depends on many variables. The important factors identified in this study were the quality of embryos and the CL score of recipient animals after non-surgical transfer of embryos matured, fertilized and cultured in vitro.

• 기록학연구
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• 제48호
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• pp.210-252
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• 2016

공동체 아카이브는 공동체가 생산하거나 수집한 기록이며, 축적된 기록은 공동체의 역사를 기억할 수 있도록 해주는 자원이 된다. 이러한 기록 중 어떠한 기록을 남길지는 평가를 통해 결정되며, 이는 결과적으로 그 사회가 어떤 기억을 남길지를 정하는 정치적인 행위의 성격을 지니게 된다. 동일한 역사적 경험을 하였다고 해도 관점이나 입장에 따라 이에 대한 기억은 달라질 수 있기 때문에 공동체는 자신들의 기록이 자신들의 관점에서 남겨지기를 원한다. 이 연구는 기존의 기록평가론이 공동체 아카이브의 평가에 있어서 갖는 의미와 한계는 무엇인지 분석하고 공동체 아카이브를 위한 평가 방향을 제안하기 위한 것이다. 우선 공동체가 자신들의 기록의 수집하고 보존하는 목적은 무엇인지, 공동체가 아카이브가 공동체는 물론 사회적으로는 어떤 의미를 가지는지를 제시하기 위하여 정체성, 기억투쟁, 가치의 개별성, 기억과정을 중심으로 분석하였다. 공동체와 사회에서 공동체 아카이브의 의미 설정은 기록평가의 방향에 큰 영향을 미치기 때문이다. 다음에는 기록평가론의 흐름을 패러다임별로 살펴보았다. 기존의 기록평가론이 대부분 정부기록, 공식조직의 기록에 초점을 맞추고 있기 때문에 이러한 접근법이 비공식조직 및 개인이 주로 생산하는 공동체 아카이브에도 적용될 수 있는지 숙고할 필요가 있다. 특히 공동체 아카이브 평가론이 어떻게 전개되어야 하는지, 평가론의 흐름상 어떤 지점에 위치하게 될지를 생각해본다는 측면에서 분석하였다. 이중 사회적 접근법을 응용하되 공동체 아카이브를 위한 새로운 평가모형을 평가의 목적과 대상, 원칙과 기준, 주체와 협력을 중심으로 제시하였다. 평가의 목적을 평가가 이루어질 수 있는 두 개의 국면으로 나누어 제시하고, 다양성을 중심으로 원칙을 제시하였으며, 평가 주체와 관련하여 공동체와 주류 문화기관의 협력 모형을 제안하였다. 이는 '로컬리티 기록화'를 통해 축적된 다양한 소규모의 '공동체에 관한 아카이브'들을 '공동체 아카이브' 로 전환하는 과정에서 기록관리 전문가집단과 공동체 구성원들이 어떻게 협력해야 할지를 모색하는 데에도 활용될 수 있을 것이다.

• 기술혁신학회지
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• 제12권2호
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• pp.413-429
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• 2009

현 시대가 요구하는 과학기술들이 지속적으로 발전하고 복잡해질수록 소위 융합기술의 개념은 보다 중요해 지고 있다. 주요 선진국들은 미래사회와 세계경제에서의 우위를 점하기 위하여 그들 고유의 융합기술에 대한 비전과 전략들을 제시하고 있다. 한국의 경우, 각 정부 부처들 마다 각각의 융합기술 관련 프로그램들을 지원하며 융합기술 개발의 촉진을 위한 방향을 제시하고는 있으나 각 부처마다 융합기술의 정의에 대한 다양한 해석들로 인해 산발적인 노력에 그치는 경향이 있다. 본 논문은 정부 정책 개발형 융합기술을 정의함에 있어서 기존의 신기술 융합에 의한 기술적 시너지 창출에 그치는 것이 아니라 사회 문화적 수요와 동향을 반영하여 실현 가능성이 높은 신산업 신서비스를 창출하는 광의의 융합기술 개념을 재정의 하였다. 또한 융합기술 연구를 유형별로 나눔에 있어서는, 원천성 융합기술에 대한 중장기적 투자를 통해 미래 시장을 선점하기 위한 연구 (유형 I)와 특정 서비스 및 제품을 목표로 신기술을 융합하여 단기간에 기술적 성과를 상용화하기 위한 연구(유형 II), 그리고 기존 산업을 고도화하여 부가가치를 높이기 위한 연구 영역(유형III)으로 구분하고 거시적 지원방안에 대해서 살펴보았다.

• 성인간호학회지
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• 제13권1호
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• pp.82-95
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• 2001

The purpose of this study was to examine the relationship among perceived health status, self-esteem, self-efficacy and health promoting behavior, and to determine the predictors of health promoting behavior in post-mastectomy patients. The study, a descriptive correlational study, was done with structural questionnaires. A total of 51 post-mastectomy subjects from C university hospital in Kwang-ju, South Korea completed mail-in self-reporting questionnaires during a three month period from March to June, 1999. The data were collected using Lawstone's(1982) perceived health status scale, Rosenberg's(1965) self-esteem scale, the modified self-efficacy scale(Shere et al, 1982), and the modified health promoting lifestyle profile (Walker et al, 1987). The data obtained were analyzed according to percentage, mean and standard deviation, principal component analysis, varimax rotation, t-test, ANOVA, Pearson's correlation, and stepwise multiple regression. The results were as follows: 1. The health promoting behavior measurement resulted in six factors. Each factor was labelled as follows: self-actualization, nutrition, stress management, exercise, health responsibility and interpersonal support. The total percent of variance explained by the six factors was 58.4%. 2. The mean score of health promoting behavior was 85.92(range 58~117). The scores of six factor were nutrition 3.20, self-actualization 2.59, stress management 2.58, interpersonal support 2.58, health responsibility 2.49, and exercise 2.34 on a four point scale. 3. When the score of health promoting behavior factors were compared by general characteristics. Factor I: self-actualization, differed significantly by the frequency of pregnancy (F=3.06, p=.037). Factor II: nutrition differed significantly by drinking experience(t=-2.26, p=.028) and the pre- or post stage of menopause(F=2.69, p=078). FactorIII: stress management differed significantly depending on regularity of mensturation(t=-2.12, p= .042). FactorIV: exercise differed significantly by type of religion (F=2.49, p=.072), marital status(F=5.03, p=.010), and feeding type (F=2.64, p=.036). Factor V: health responsibility differed significantly by regularity of mensturation(t=2.18, p=.037). 4. The total health promoting behavior score was significantly related to self-esteem and perceived health status(r=.610, p.006; r= .378, p=.006). The score of selfactualization also corresponded with selfesteem and perceived health status(r=.556, p=.001; r=.343, p=.013). 5. The predictor to explain the score of health promoting behavior was self-esteem, which accounted for 37.1% of the total variance. The predictor to explain the score of self-actualization was self-esteem, which accounted for 30.9% of the total variance. The score of nutrition was primarily affected by both premenopause and drinking experience, which accounted for 13.1% and 9.5% respectively. Finally, the score of exercise was dictated by marriage, Buddhism, no experience of breast feeding, which accounted for 17%, 9.8%, & 5.2% respectively. In conclusion, self-esteem is the main predictor for health promoting behavior in post-mastectomy women. These findings suggest a need for nursing strategies which promote self-esteem in such patients.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3431-3436
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• 2016

Background: Carcinogenesis is a multifaceted intricate cellular mechanism of transformation of the normal functions of a cell into neoplastic alterations. Metastasis may result in failure of conventional treatment and death Hence, research on metastatic suppressors in cancer is a high priority. The metastatic suppressor gene CD82, also known as KAI1, is a member of the transmembrane 4 superfamily which was first identified in carcinoma of prostate. Little work has been done on this gene in breast cancer. Herein, we aimed to determine the gene and protein level expression of CD82/KAI1 in breast cancer and its role as a prognosticator. Materials and Methods: In this study, 83 histologically proven cases of breast cancer and a similar number of controls were included. Patient age ranged from 18-70 years. Quantitative Real Time Polymerase Chain Reaction (q-RT PCR) and immunohistochemistry (IHC) were used to investigate KAI1 expression at gene and protein levels, respectively. Statistical analysis was done to correlate expression of KAI1 and clinicopathological parameters. Results: It was revealed that: (i) KAI1 was remarkably diminished in metastatic vs non metastatic breast cancer both at the gene and the protein levels (P < .05); (ii) KAI1 expression levels were strongly correlated with TNM staging, histological grade and advanced stage (p<0.001) and no association was found with any other studied parameter; (iii) Lastly, a significant correlation was observed between expression of KAI1 and overall median survival of BC patients (P = 0.04). Conclusions: Our results suggest that lack of expression of the KAI1 might indicate a more aggressive form of breast cancer. Loss of KAI1 may be considered a significant prognostic marker in predicting metastatic manifestation. When evaluated along with the clinical and pathological factors, KAI1 expression may be beneficial to tailor aggressive therapeutic strategies for such patients.

• Clinical and Experimental Reproductive Medicine
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• 제23권1호
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• pp.103-108
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• 1996

Through the previous studies(I,II), it was observed that human follicular fluid(HFF) was more effective than human fetal cord serum(HFCS) on promoting meiotic resumption of oocytes and improving embryonic development of mouse in vitro. On the basis of these results, we have gradually exchanged HFCS with HFF as protein supplement in human ART. This study was performed to investigate the efficiency of HFF on improving the pregnancy rate in ART. Oocytes were retrieved transvaginally from patients treated with pituitary suppression with GnRH-agonist and ovarian stimulation with human menopausal gonadotro-pin(HMG) and pure follicle stimulating hormone(FSH). Aspirated oocytes were rinsed and cultured in TCM-199 containing HFF, and the concentrations of HFF were adjusted to 10, 20, and 30% according to the use for insemination, embryo growth and embryo transfer, respectively. As possible as, we tried to do embryo transfer into fallopian tube to mimic the coincidence of the cell stage with the place of sojourn in vivo, so we performed various ART programs(IVF & ET; in vitro fertilization, ZIFT; zygote intra fallopian-tube transfer, ZIFT & ET) according to the tubal conditions of patients. On the while, intra cytoplasmic sperm injection(ICSI) was used to assist IVF of the patients who had shown poor standard IVF results by immunological or severe male factor. Of the 255 cycles of ART programs using HFF as protein supplement, 118 cycles were turn out to be succeeded in pregnancy(46.2%, per cycle, p<0.05), while 21 pregnancies were achieved in the 69 cycles using HFCS(30.4%). The 255 cycles using HFF were subdivided into cycles with the type of ART programs, and each pregnancy rate of the ART programs were 44.7% (IVF & ET, 76/170 cycles), 53.4%(ZIFT, 31/58 cycles) and 40.7% (ZIFT & ET, 11/27 cycles), respectively. In the 61 ICSI cycles using HFF, 28 cycles succeed in pregnancy(45.9%), while 7 pregnancies were obtained in the 17 ICSI cycles using HFCS. Also the ongoing pregnancy rate in the group using HFF(78.8%, 93/118 cycles) was higher than that in the group using HFCS(61.9%). Therefore, we found that the use of HFF as protein supplement was more suitable and effective than the use of HFCS to improve the pregnancy rate in ART.