• 제목/요약/키워드: Stage I, II

검색결과 1,183건 처리시간 0.031초

흉선종의 임상적 고찰 (A Clinical Analysis of Thymoma)

  • 이헌재
    • Journal of Chest Surgery
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    • 제23권4호
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    • pp.715-719
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    • 1990
  • Thymoma is defined as a neoplasm of the epithelialreticular framework cells of the thymus. The treatment of choice and the prognosis for patients with thymoma are still controversial subjects due to lack of a uniform histological classification and standardized criteria for typing thymic tumors. Between June 1985 and May 1989, eight patients underwent thymomectomy at the Department of Thoracic and Cardiovascular Surgery, Korea University Medical Center. A clinical analysis was performed and the following result was obtained. In histologic cell type, epithelial type was 2 cases, lymphocytic type 3 cases, and mixed type was 3 cases. The clinical stage was classified by Masaoka’s classification that Stage I was 4 cases, Stage II; 2 cases, Stage III; 2 cases and Stage IV was none. Myasthenia Gravis was associated with thymoma in 5 patients. In 8 patients, thymomectomy were performed. Adjuvant radiotherapy was performed in one patient with Stage I due to suspicious tumor remnant and in Stage II, III patients routinely. Combined chemotherapy was performed in one patient with Stage III due to local recurrence. We concluded that the most important prognostic factor of thymoma is extent of tumor invasion. And the presence of Myasthenia Gravis is no more prognostic factor. Surgical resection of thymoma is treatment of choice, If local invasion or distant dissemination is present, postoperative radiotherapy and /or combined chemotherapy is recommended.

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초기 후두암의 치료 (Treatment of Early Laryngeal Cancer)

  • 최건;채성원;박호정;정광윤;최종욱
    • 대한기관식도과학회지
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    • 제4권1호
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    • pp.91-95
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    • 1998
  • Background: Laryngeal cancer, the most common malignancy of head and neck, is being detected and treated in earlier and more effectively due to introduction of endoscope, continuous development of radiographic technology, and advancement in new surgical techniques such as laser surgery and conservation laryngeal surgery Objectives To compare the different treatment results for early laryngeal cancer to determine which methos provides the good prognosis. Materials and Methods: Retrospective study was done for 135 patients with early laryngeal squamous cell carcinoma(Stage I or II) who were treated at our institute between 1989 to 1996. There were 105 patients with glottic cancer(Stage I: 68 patients, Stage II:37 Patients) and 30 patients with supraglottic cancer(Stage I: 12 patients, Stage II:18 patients) Initial treatment included radiation therapy for 54 patients, endoscopic laser surgery for 8 patients, laryngofissure and cordectomy for 8 patients, vertical partial laryngectomy for 37 patients, supraglottic laryngecomy for 14 patients and supracricoid laryngectomy for 5 patiens, and total laryngectomy for 9 patients. Results : Salvage treatments, such as total laryngectomy, conservation laryngeal surgery, radiation therapy and neck dissection were performed for initial treatment failure with 9 patients after radiation therapy, 8 patients after conservation laryngeal surgery, 2 patients after endoscopic laser and 3 patients after total laryngectomy. Overall 3-year survival rate for glottic 71 was 92.4%, glottic f 84.3%, supraglottic 7172.7%, and supraglottic f was 63.%%. However, survival rate of the same stage was variable according to the choice of initial treatment. Conclusion New classification of the early laryngeal cancer was necessary and helpful for the choice of the initial treatment.

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동적탄력튜빙 보행훈련 프로그램이 만성 파킨슨병 환자의 자세정렬과 보행능력과 삶의 질에 미치는 영향 : 사례연구 (Effects of Dynamic Tubing Gait Training on Postural Alignment, Gait, and Quality of Life in Chronic Patients with Parkinson's Disease : Case Study)

  • 이동률
    • 한국엔터테인먼트산업학회논문지
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    • 제15권8호
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    • pp.363-377
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    • 2021
  • 본 연구에서는 만성 파킨슨병 환자의 동적탄력튜빙 보행 훈련 (I, II)이 자세정렬, 보행, 삶의 질에 미치는 영향을 조사하였다. 총 3명의 만성 파킨슨병 환자를 모집하여 사례 연구를 시행하였다(Hoehn 및 Yahr 1-3단계 각 1명). 동적탄력튜빙 보행 훈련 (I 및 II)은 파킨슨병 환자에게 하루 30분, 주 5일, 5주 동안 25세션 적용되었다. 본 연구의 효과를 알아보기 위해, 자세정렬검사, 근 활성도검사, 보행분석 및 파킨슨병 환자의 삶의 질을 평가하였다. Dynamic tubing 보행 훈련(I, II) 중재 후 몸통 굽힘은 감소되었다. 또한 초기 접촉기(IC)에서 중간 디딤기(Mst)까지 보행 시 넙다리네갈래근, 뒤넙다리근, 앞정강근(TA)의 근 활성도가 증가하고 장딴지근의 근활성도가 감소하였다. 척추세움근(ES T12, L3)의 근활성도는 H&Y I, III 단계에서 증가하고 H&Y II 단계에서 감소하였다. 압력 중심(COP) 매개변수인 보행선의 길이, 한 발 지지선, 앞/뒤 위치, 좌우대칭 값이 개선되었다. 시공간 보행 매개변수인 보폭, 보폭, 의 속도는 증가하고 분당걸음수는 감소되었다. 나아가 파킨슨 병 환자의 삶의 질도 개선되었다. 이러한 연구 결과를 바탕으로 동적탄력튜빙 보행 훈련 (I 및 II)은 약물 내성이 절반으로 감소된 5년 이상된 만성 파킨슨병 환자의 자세, 보행, 삶의 질을 개선하기 위한 새로운 접근 방식으로 적용될 수 있을 것이다.

대구 지역 청소년 및 미혼 여성 자궁내막증 환자의 임상 특성에 관한 비교연구 (Comparison of Clinical Menifestations between Adolescents and Unmarried Young Women with Endometriosis in Daegu)

  • 김윤정;최민혜;정민지;이정호;이택후
    • Clinical and Experimental Reproductive Medicine
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    • 제34권3호
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    • pp.167-172
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    • 2007
  • 목 적: 본 연구는 청소년기와 성인 미혼 여성에서의 자궁내막증의 특징을 비교해 보고 청소년기에 조기 발견 및 치료의 중요성에 대해 알아보고자 한다. 연구방법: 000년 1월부터 2007년 9월까지 대구 소재 두 대학병원을 방문하여 수술을 시행한 환자를 대상으로 청소년 (14$\sim$21세, 23예)과 성인 미혼 여성 (22$\sim$26, 107예)의 자궁내막증의 임상양상, 진단과정, 수술소견, 혈액검사소견(CA-125) 등을 의무 기록 분석을 통한 후향적인 방법으로 비교하였다. 결 과: 대구 지역 청소년은 cyclic pain을 주증상으로 흔히 호소하였다. 청소년은 52.2%가 stage I, II였으며, stage III는 47.8%, stage 4는 없었다. 반면에 성인에서는 stage I이 1.86%에 불과하였으며, stage II 및 stage III가 82.2%로 대다수를 차지하였으며 stage IV도 15.8%차지하였다. 청소년에서도 CA-125가 상승되어 있는 경우가 많았고 이를 병의 경과 관찰에 이용할 수 있을 것이다. 청소년에서 순수 자궁내막증을 의심하여 수술한 경우는 전체 23예 중에 10예에 불과하였으며 이외 13예는 다른 진단으로 시행한 수술에서 우연히 발견되었다. 이는 전체 56.5%로 많은 비중을 차지하며, 성인 여성에서 27.5%에 불과한 것과는 대조적이다. 결 론: 대구 지역 청소년들을 대상으로 시행한 이번 연구에서는 청소년기에서 주기성 통증이 우세하였으며 이는 임상증상 만으로도 조기 발견에 도움이 될 수 있을 것이다. 자궁내막증은 진행하는 병임은 틀림없으므로 만성 골반통이 있는 청소년을 대상으로 적절한 산부인과적 검사를 통한 조기 진단 및 치료가 중요할 것으로 사료된다.

Coprinus congregatus의 분화와 Phenoloxidase와의 관계 (Phenoloxidases and Photomorphogenesis in Coprinus congregatus)

  • 최형태
    • 한국식물학회:학술대회논문집
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    • 한국식물학회 1987년도 식물생명공학 심포지움 논문집 Proceedings of Symposia on Plant Biotechnology
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    • pp.157-167
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    • 1987
  • The have been many reports that phenoloxidase are correlated with development in many fungi. C. congregatus, one of nushroom-forming basidiomycetes, which requires light for its development also has phenoloxidases. In C. congragatus, there are two sets of membrane-associated phenoloxidase (PHO I and PHO II) which are differentiated by their isozyme patterns, and each enzyme set consists of two different subtrate specific enzyme protein; o-tolidine reacting enzyme, and DOPA reacting enzyme. PHO I which is localized by a protoplast-concanavalin A technique by using a new solidifying agent, Pluronic Polyol F 127, instead of agar appears in the vegetative hyphae, and PHO II appears at the early primordial stage on agar and at the sclerotial stage of liquid shake cultures. Inhibition of PHO I with the enzyme inhibitors inhibits mushroom formation as well as melanization of the vegetative hyphae at concentrations which do not inhibit the vegetative growth. PHO I deficient mutants do not form mushrooms or melanins, and the mutants show abnormal nuclear migration patterns. PHO II has roles; possibly cementing the adjacent hyphae during the actual three dimensonal structure formation, and melanizing mushrooms and sclerotia. The possible roles of PHO I in the light reception complex and in melanin formation, the function of malanin, and possible roles of postulated post translational modifying enzymes which regulate the phenoloxidases, nuclear migration pattern, and self-nonself recognition mechanism are discussed.

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원발성 폐암 수술의 장기성적 (Long-term Results of Surgical Treatment for Primary Lung Cancer)

  • 함시영;성숙환;김주현
    • Journal of Chest Surgery
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    • 제20권4호
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    • pp.730-744
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    • 1987
  • From Nov. 1980 to Jun. 1987, 270 primary lung cancer patients were operated on at the department of Thoracic & Cardiovascular Surgery, Seoul National University Hospital. There Were 223 males & 47 females with 55.5 years of mean age. There were 151 [55.9%] squamous cell ca., 43 [18.8%] adenoca., 8 [3.5%] undiff. large cell, 9 [3.9%] undiff. small cell ca. & 18 [7.9%] mixed type, and also composed of 65 [28.3%] stage I, 31 [13.5%] stage II and 133 [58.1%] of stage III cases. They received 78 [34.1%] lobectomies, 62 [27.1%] pneumonectomies and 60 [26.2%] exploratory thoracotomies with 70% resectability rate. The five year actuarial survival rate of all patients was 37%. According to TNM stage, five year survival rate of the patients in stage I was 71%, those of stage II was 29% and of stage III 21%. According to histological cell type, five year actuarial survival rate of the squamous cell ca. was 35%, of adenoca. 49%, of undiff. large cell. 22%, 2 year survival rate of undiff. small cell was 31% and 3 year survival rate of mixed type was 47%. Hospital death was 2 case with a 1.3% early postop. mortality rate.

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동진광산의 지질과 금은광화작용 (Geology and Gold-Silver Mineralization of Dongjin Mine)

  • 정재일;김선영
    • 자원환경지질
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    • 제29권3호
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    • pp.395-405
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    • 1996
  • The Donjin deposits which is located in the Chinan Basin, are emplaced along $N10{\sim}40^{\circ}E$ trending fissure sets. So it is a sort of fissure-filling ore deposits. The results of paragenetic studies suggest two stages of hydrothermal mineralization; stage I: base-metal sulfides stage, stage II: late base-metal sulfides, electrum and silver-bearing sulfosalts stage. Au: Ag ratios of the electrums show that Ag atomic% are higher than that of Au. The temperature and salinity of the Donjin deposits estimated from fluid inclusion and sulfur isotope geothermometry are as follows; stage I: $240{\sim}315^{\circ}C$, 2.4~7.1 NaCl eq. wt.%, stage II: $190{\sim}268^{\circ}C$, 4.6~8.4 NaCl eq. wt.%. The estimated oxygen and sulfur fugacity during first stage mineralization, based on phase relation of associated minerals, range from $10^{-35}{\sim}10^{-39.7}$ atm. and$10^{-11}{\sim}10^{-13.4}$ atm., respectively. All these evidences suggest that the Dongjin deposits are polymetallic meso-epithermal ore deposits.

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인시목 곤충의 성충체액단자질에 관한 생리성화학적 연구 1. 가잠의 성충특이체액단자질의 검출 (Physiological and Biochemical Studies on the Adult Hemolymph proteins in Lepidoptera. 1. Appearance of Adult Specific Proteins in the Hemolymph of the Silkworm, Bombyx mori.)

  • 성주일;문재유
    • 한국잠사곤충학회지
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    • 제30권1호
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    • pp.20-24
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    • 1988
  • 누에의 우화와 함께 새로이 출현하는 성충특이체액단자질(ASP-I, ASP-II)의 검출, 성특이성, 품종간 분포 및 변이성에 관하여 PAGE 전기영동법을 이용 실험한 결과, 1. 우화와 함께 알, 유충, 번데기의 발육시기에는 출현하지 않는 2가지의 새로운 성충특이단자질 영동대가 검출되었으며, 이동도가 느린 영동대를 ASP-I(Adult specific protein of slow mobility), 빠른 영동대를 ASP-II(Adult specific protein of slow mobility)로 명명하였다. 2. 성충특이체액단자질(ASP-I, ASPII)은 성특이성이 없었다. 3. 실험에 사용된 모든 누에 품종의 성충체액에서 ASP-I 및 ASP-II가 검출되었으나, 품종간의 변이성은 인정되지 않았다.

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과배란 처리 가토에서 수정란의 비외과적 회수와 외과적 회수의 비교 (Comparison of Non-surgical and Surgical Recovery of Fertilized Eggs in Superovulated Rabbits)

  • 심금섭;변태호;이재근
    • 한국가축번식학회지
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    • 제8권1호
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    • pp.16-21
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    • 1984
  • This experiment was carried out to compare with the nonsurgical and surgical recovery of fertilized eggs in super-ovulated rabbits. Sixty-four eggs recovered were transferred to twelve synchronized, pseudopregnant rabbits to test the viability of the eggs by surgical transfer. Each group(I, II, III) received a single subcutaneous injection of 5mg PGF2${\alpha}$/kg B.W. at 24(Group I), 48(Group II) and 72 hours (Group III) after mating, respectivity. After the administration of PGF2${\alpha}$, vaginal washings were conducted at 3, 6, 9, 12 and 24 hrs, and frequency of vaginal washing was 5 times for the each group (I, II, III). In Group (IV, V, Ⅵ), the rabbits were killed to recover the fertilized eggs from the genital tract at 24(Group Ⅵ), 48(Group V) and 72 hours (Group Ⅵ) after mating, respectively. The results obtained were as follows: 1. Of the total eggs, 69.3%, 73.4% and 66.9% were recovered for Group I, II and III, respectively from the vagina within 6 hrs after PGF2${\alpha}$ injection and particularly for Group III. 2. The rates of egg recovery versus the number of corpora lutea were 55 (51.6-60%), 35.8 (24-52.6%), 33.4 (25-47%) and 72 (70.7-73.0)%, 60.3 (50-71.4)%, 449(44.4-45.5)% in Group I, II, III and Group IV, V, Ⅵ, respectively. 3. Most of eggs recovered were one-cell stage in Group Iand Group IV. More than one half of the eggs recovered in Group II and V were over eight-cell stage, and most of the eggs were so in Group III and Ⅵ. 4. When sixty-four eggs recovered between 24 to 72 hours after mating were transferred to pseudopregnant rabbits. Three recipients were pregnant, and the rate of pregnancy was 25%.

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감계 동(銅)-연(鉛)-아연(亞鉛)-금(金)-은광상(銀鑛床) 광석광물(鑛石鑛物)과 유체포유물(流體包有物) 연구(硏究) (Ore Minerals and Fluid Inclusions Study of the Kamkye Cu-Pb-Zn-Au-Ag Deposits, Repubulic of Korea)

  • 이현구;김상중
    • 자원환경지질
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    • 제28권1호
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    • pp.9-17
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    • 1995
  • The Kamkye Cu-Pb-Zn-Au-Ag deposits occur as quartz veins that filled fault-related fractures of NW system developed in the Cretaceous Gyeongsang basin. Three major stages of mineral deposition are recognized: (1) the stage I associated with wall rock alteration, such as sericite, chlorite, epidote and pyrite, (2) the early stage II of base-metal mineralization such as pyrite, hematite, and small amounts of sphalerite and chalcopyrite. and the middle to late stage II of Cu-As-Sb-Au-Ag-S mineralization, such as sphalerite, chalcopyrite, galena with tetrahedrite, tennantite, pearceite, Pb-Bi-Cu-S system, argentite and electrum. (3) the stage III of supergene mineralization, such as covellite, chalcocite and malachite. K-Ar dating of alteration sericite is a late Cretaceous ($74.0{\pm}1.6Ma$) and it may be associated with granitic activity of nearby biotite granite and quartz porphyry. Fluid inclusion data suggest a complex history of boiling, cooling and dilution of ore fluids. Stage II mineralization occurred at temperatures between 370 to $220^{\circ}C$ from fluids with salinities of 8.4 to 0.9 wt.% NaCl. Early stage II($320^{\circ}C$, 2.0 wt.% NaCl) may be boiled due to repeated fracturing which opened up the hydrothermal system to the land surface, and which resulted in a base-metal sulfide. Whilst the fractures were opened to the surface, mixing of middle-late stage II ore fluids with meteoric waters resulted in deposition of Cu-As-Sb-Au-Ag minerals from low temperature fluids(${\leq}290^{\circ}C$). Boiling of ore fluids may be occured at a pressure of 112 bar and a depth of 412 m. Equilibrium thermodynamic interpretation of sphalerite-tetraherite assemblages in middle stage II indicates that the ore-forming fluid had log fugacities of $S_2$ of -6.6~-9.4 atm.

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