• 대한수의학회지
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• 제61권1호
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• pp.10.1-10.11
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• 2021

The purpose of this retrospective study was to provide additional data on the use of toceranib in a wide variety of tumor types in small breed dogs, especially < 8 kg (except 5 dogs). This was a retrospective study of 31 dogs with malignant tumors treated with a 2.5 mg/kg median dose of toceranib (Palladia; Zoetis, USA) on a Monday-Wednesday-Friday schedule. Clinical benefit was observed in 13 of 15 dogs (86.7%, 3 with complete response, 4 with partial response, 6 with stable disease) with gross disease. Distant metastasis, response to treatment, and treatment setting were significantly associated with survival time. Negative prognostic factors were multiple chemotherapy and distant metastasis (affecting progression-free survival [PFS]), surgery, regional enlarged lymph nodes, underlying disease, and toxicity (affecting median survival time [MST]). Positive prognostic factors were epithelial and round cell tumor (affecting PFS), epithelial tumor, microscopic disease, no evidence of disease response, and stable disease (MST). In conclusion, a clinical benefit from toceranib treatment was noted in most of the dogs with gross disease in our study. This study suggested that the toceranib is probably selective treatment to various tumor types in small breed dogs.

• 한국지진공학회논문집
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• 제17권5호
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• pp.227-235
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• 2013

Friction energy dissipative devices have been increasingly implemented as structural seismic damage protecting systems due to their excellent seismic energy dissipating capacity and high stiffness. This study develops rotational friction energy dissipative devices and verifies experimentally their cyclic response. Based on the understanding of the differences between the traditional linear-motion friction behavior and the rotational friction behavior, the configuration of the frictional surface was determined by investigating the characteristics of the micro-friction behavior. The friction surface suggested in this paper consists of brake-lining pads and stainless steel sheets and is normally stressed by high-strength bolts. Based upon these frictional characteristics of the selected interface, the rotational friction energy dissipative devices were developed. Bolt torque-bearing force tests, rotational friction tests of the suggested friction interfaces were carried out to identify their frictional behavior. Test results show that the bearing force is almost linearly proportional to the applied bolt torque and presents stable cyclic response regardless of the experimental parameters selected this testing program. Finally, cyclic tests of the rotational friction energy dissipative devices were performed to find out their structural characteristics and to confirm their stable cyclic response. The developed friction energy dissipative devices present very stable cyclic response and meet the requirements for displacement-dependent energy dissipative devices prescribed in ASCE/SEI 7-10.

• 한국공작기계학회논문집
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• 제12권1호
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• pp.92-100
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• 2003

Using a quarter car model, an analytic method for performance estimation of a vehicle suspension system with respect to frequency response, RMS response and performance index is presented. From frequency response function, compromization of response performance to the whole frequency range is verified and from RMS response and performance index, sensitivity of ride md handling characteristics are examined. Using a full car model, sweet area(stable ride area) are determined and performance sensitivity is estimated according to the change of feedback gains. In order to esimate the output sensitivity, response we is displayed using a 3-dimensional contour plot. Design data n suggested for optimal design parameter esimation, which maximize the performance of the given suspension system.

• 한국항만학회지
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• 제13권2호
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• pp.389-398
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• 1999

In the biological immunity, the immune system of organisms regulates the antibody and T-cells to protect the attack from the foreign materials which are virus, germ cell, and other antigens, and supports their stable state. It has similar characteristics that has the adaptation and robustness to overcome disturbances and to control the plant of engineering application. In this paper, we build a model of the T-cell regulated immune response mechanism. We have also designed an immune response controller(IRC) focusing on the T-cell regulated immune response of the biological immune system that include both a help part to control the response and a suppress part to adjust system stabilization effect. We show some computer simulation to control the vibration of building structure system with strong wind forces excitation also demonstrate the efficiency of the proposed controller for applying a practical system even with existing nonlinear terms.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.2532-2537
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• 2005

FIR(Finite Impulse Response) filter is well known to be ideal for the finite time state-space model, but it requires much computation due to its inherent non-recursive structure especially when the measurement interval grows to a large extent. And often a fixed-lag smoother based on the finite time interval is needed to monitor the soundness of the system model and the measurement model, but the computation burden of FIR-type smoother imposes much restriction of its usage for real-time application. Conventional recursive forms of FIR estimator[1]-[4] could not be used for real time applications, since they are numerically unstable in their recursive equations. To cope with this problem, we suggest a stable recursive form FIR estimator(SRFIR) and its usefulness is demonstrated for designing the real-time fixed-lag smoother on the finite time window through an example of detection of rate bias in the anti-aircraft gun fire control system.

• 전력전자학회:학술대회논문집
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• 전력전자학회 1999년도 전력전자학술대회 논문집
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• pp.4-9
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• 1999

A new control method for precision robust position control of a brushless DC (BLDC) motor using asymptotically stable adaptive load torque observer is presented in the paper. Precision position control is obtained for the BLDC motor system approximately linearized using the field-orientation method Recently, many of these drive systems use BLDC motors to avoid backlashe. However, the disadvantages of the motor are high cost and complex control because of nonlinear characteristics. Also, the load torque disturbance directly affects the motor shaft. The application of the load torque observer is published in [1] using fixed gain. However, the motor flux linkage is not exactly known for a load torque observer. There is the problem of uncertainty to obtain very high precision position control. Therefore a model reference adaptive observer is considered to overcome the problem of unknown parameter and torque disturbance in this paper. The system stability analysis is carried out using Lyapunov stability theorem. As a result, asymptotically stable observe gain can be obtained without affecting the overall system response. The load disturbance detected by the asymptotically stable adaptive observer is compensated by feedforwarding the equivalent current which gives fast response. The experimenta results are presented in the paper.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권11호
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• pp.4585-4603
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• 2015

Video streaming services make up a large proportion of Internet traffic on both fixed and mobile access throughout the world. Adaptive streaming allows for dynamical adaptation of the bitrate with varying network conditions, to guarantee the best user experience. Adaptive bitrate algorithms face a significant challenge in correctly estimating the throughput as it varies widely over time. In this paper, we first evaluate the throughput estimation techniques and show that the method that we have used offers stable response to throughput fluctuations while maintaining a stable playback buffer. Then, we propose an adaptive bitrate scheme that intelligently selects the video bitrates based on the estimated throughput and buffer occupancy. We show that the proposed scheme improves viewing experience by achieving a high video rate without taking unnecessary risks and by minimizing the frequency of changes in the video quality. Furthermore, we show that it offers a stable response to short-term fluctuations and responds swiftly to large fluctuations. We evaluate our algorithm for both constant bitrate (CBR) and variable bitrate (VBR) video content by taking into account the segment sizes and show that it significantly improves the quality of video streaming.

• 대한전기학회논문지:시스템및제어부문D
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• 제49권3호
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• pp.117-123
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• 2000

A new control method for precision robust position control of a PMSM (Permanent Magnet Synchronous Motor) using asymptotically stable adaptive load torque observer is presented in the paper. Precision position control is obtained for the PMSM system approximately linearized using the field-orientation method. Recently, many of these drive systems use the PMSM to avoid backlashes. However, the disadvantages of the motor are high cost and complex control because of nonlinear characteristics. Also, the load torque disturbance directly affects the motor shaft. The application of the load torque observer is published in [1] using fixed gain. However, the motor flux linkage is not exactly known for a load torque observer. There is the problem of uncertainty to obtain very high precision position control. Therefore, a model reference adaptive observer is considered to overcome the problem of unknown parameter and torque disturbance in this paper. The system stability analysis is carried out using Lyapunov stability theorem. As a result, asymptotically stable observer gain can be obtained without affecting the overall system response. The load disturbance detected by the asymptotically stable adaptive observer is compensated by feedforwarding the equivalent current which gives fast response. The experimental results are presented in the paper using DSP TMS320c31.

• 한국정보통신학회논문지
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• 제10권6호
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• pp.1025-1031
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• 2006

본 논문에서는 FIR 근사를 기반으로한 전역통과 시스템에 대한 deconvolution 필터링 기법을 제안한다. 제안한 기법은 안정한 non-causal deconvolution 필터를 FIR 근사에 의해 안정한 causal deconvolution 필터로 변환시키는 것이다. 본 논문에서 보인바와 같이 전역통과시스템에 대한 deconvolution 필터의 임펄스 응답은 전역통과 시스템 자체의 임펄스 응답의 거울 영상(mirror image) 임을 알 수 있다. 이와 같이 전역통과 시스템에 대한 임펄스 응답과 그 시스템의 deconvolution 필터에 대한 임펄스 응답의 대칭성 때문에, 제안한 기법은 전역 통과 필터의 차수에 상관없이 동일하게 적용할 수 있다. 제안한 기법의 성능을 보이기 위하여 1차, 2차 및 400차의 전역통과 시스템에 대한 컴퓨터 시뮬레이션 결과를 포함한다.

• 한국임상약학회지
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• 제23권2호
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• pp.151-157
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• 2013

Purpose: Warfarin is the most widely used anticoagulant drug for preventing cardiovascular diseases after ischemic stroke and thromboembolism related to atrial fibrillation, artificial heart valves, deep vein thrombosis, and pulmonary embolism. Warfarin is commonly used in combination with other drugs such as diuretics in order to treat the comorbidity. Although several warfarin-diuretics interactions have been reported, the results are conflicting. Therefore, the initial aim of this study was to identify the effects of diuretics on the warfarin response in patients with atrial fibrillation. Methods: One hundred forty six patients with atrial fibrillation who were on anticoagulation therapy with warfarin and maintained INR levels of 2-3 for three consecutive times were followed up, retrospectively. Stable warfarin doses and INR per stable warfarin dose were compared according to age, gender, comorbidity, and concurrent medication. The stable warfarin dose was defined as the maintenance dose of warfarin of the measured patient whose INR was within the target INR range more than 3 times consecutively. Results: The differences of stable warfarin doses in patients with ($3.22{\pm}1.21$ mg/day) and without ($3.58{\pm}1.14$ mg/day) diuretics were marginally significant (P=0.069). On the other hand, stable warfarin doses were $2.97{\pm}1.10$ mg/day in patients with thiazide (n=36) and $3.58{\pm}1.14$ mg/day in patients without diuretics (n=82), which was statistically significant (p=0.009). INR values per stable warfarin dose in patients with diuretics and thiazide were $0.84{\pm}0.31$ and $0.90{\pm}0.34$, respectively, which were statistically different from those without diuretics ($0.72{\pm}0.21$, P=0.010 and P=0.006, respectively). Age, gender, and concurrent use of thiazide diuretics were found to have significant influence on the warfarin response from multivariate analysis. Conclusion: Our study showed that the concurrent use of thiazide diuretics could increase the response of warfarin in patient with atrial fibrillation. Therefore, clinicians should be aware that warfarin dose needs to be adjusted when it is used with thiazide diuretics concomitantly.