• Analytical Science and Technology
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• v.32 no.5
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• pp.163-172
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• 2019

Methamphetamine (MA) is currently the most abused illicit drug in Korea and its major metabolite is amphetamine (AP). As MA exist as two enantiomers with the different pharmacological properties, it is necessary to determine their respective amounts in a sample. Thus a chiral stationary phase liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for identification and quantification of d-MA, l-MA, d-AP, and l-AP in human urine. Urine sample ($200{\mu}L$) was diluted with pure water and purified using solid-phase extraction (SPE) cartridge. A $5-{\mu}L$ aliquot of SPE treated sample solution was injected into LC-MS/MS system. Chiral separation was carried out on the Astec Chirobiotic V2 column with an isocratic elution for each enantiomer. Identification and quantification of enantiomeric MA and AP was performed using multiple reaction monitoring (MRM) detection mode. Linear regression with a $1/x^2$ as the weighting factor was applied to generate a calibration curve. The linear ranges were 25-1000 ng/mL for all compounds. The intra- and inter-day precisions were within 3.6 %, while the intra- and inter-day accuracies ranged from -5.4 % to 11.8 %. The limits of detection were 2.5 ng/mL (d-MA), 3.5 ng/mL (l-MA), 7.5 ng/mL (d-AP), and 7.5 ng/mL (l-AP). Method validation parameters such as selectivity, matrix effect, and stability were evaluated and met acceptance criteria. The applicability of the method was tested by the analysis of genuine forensic urine samples from drug abusers. d-MA is the most common compound found in urine and mainly used by abusers.

• Korean Journal of Optics and Photonics
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• v.17 no.5
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• pp.412-419
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• 2006

We design and fabricate an autostigmatic null lens system assembled in a fixed tube mount in order to evaluate the shape of an aluminum hyperbolic mirror with the diameter of 300 mm and the f-number of 1.98, which is fabricated by a high precision aspherical DTM (diamond turning machine). Also, we evaluate the degree of shape of the aspherical mirror by this autostigmatic null lens testing method. The autostigmatic null lens system assembling in a fixed tube mount has several advantages of light weight, good mechanical stability, etc. The permissible fabricating limits of null lenses and a mount are determined by considering various tolerances to assure the measurement reliability.

• Mass Spectrometry Letters
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• v.12 no.4
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• pp.200-205
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• 2021

Polynemoraline C, a pyridocoumarin alkaloid, exhibits anticholinergic, anti-inflammatory, antitumor, and antimicrobial activities. A sensitive analytical method of polynemoraline C in mouse plasma was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Polynemoraline C and ¹³C-caffeine (internal standard) in mouse plasma were extracted using a liquid-liquid extraction method coupled with ethyl acetate. This extraction method resulted in high and reproducible extraction recovery in the range of 73.49%-77.31% with no interfering peaks around the peak retention time of polynemoraline C and ¹³C-caffeine. The standard calibration curves for polynemoraline C were linear over the range of 0.5-200 ng/mL with r² > 0.985. The accuracy, precision, and the stability of the data were within acceptable limits on the FDA guideline. After intravenous and oral administration of polynemoraline C at doses of 5 and 30 mg/kg, respectively, the present method was successfully applied to the pharmacokinetic study of polynemoraline C. Polynemoraline C in mouse plasma showed a multi-exponential elimination pattern with a high volume of distribution values. This compound's absolute oral bioavailability was found to be 17.0%. Polynemoraline C's newly developed LC-MS/MS method can be used for further studies on the efficacy, toxicity, and biopharmaceutics of polynemoraline C, as well as its pharmacokinetic studies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.420-427
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• 2019

The purpose of this study was to evaluate hot spring water (HSW) from Deokgu as a cosmetic ingredient in the preparation of a body lotion. The HSW was tested for its suitability as an aqueous-phase main component. Microbiological and chemical stability tests of the HSW were carried out. Microorganisms including E. coli were not detected or detected below the detection limits, and no harmful heavy metals were found. The cytotoxicity of the HSW was also considered, and its pH determined over a period of three months. Further, sensory characteristics were assessed for consumer acceptance by performing sensory tests on body lotions formulated using either Deokgu HSW or distilled water. Skin moisturization, irritation and tension reinforcement were found to be enhanced when using the HSW lotion rather than that formulated with distilled water. Taken together, the results of this study show that the use of HSW in cosmetic formulations contributes to the efficacy of these products.

• Tribology and Lubricants
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• v.35 no.1
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• pp.65-70
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• 2019

Self-loosening of bolts owing to external forces occurs in several machines that are clamped by bolts and nuts. This study focuses on the self-loosening of the aiming bolt of the head lamp in a vehicle. It is important to prevent the aiming bolt from self-loosening as it has a decisive effect on the angle of the head lamp. A nut clamped with a bolt, known as a retainer, is made of plastic and has a partial screw thread. In addition, a transverse load has a considerable impact on the self-loosening of a bolt. We concentrate on the self-loosening of a bolt by a transverse load. The aim of this study is to define the limits of the external force that loosen the bolt. Based on the above conditions, we derive a theoretical equation and develop a numerical analysis program that can calculate the limiting forces for self-loosening. To verify the developed program, we design a test device that can measure the self-loosening by applying sliding forces to the aiming bolt. Using this method, we can draw the following conclusions. First, the developed testing device is suitable to prove the theory for calculating the self-loosening force. Second, the equation confirms the relationship of bolt self-loosening between resistance torque and shear force. Finally, the equation obtains the minimum value of the resistance torque required to decrease the change in the angle of the head lamp, thereby improving the possibility of increasing the stability of the head lamp.

• Journal of the Korean Geotechnical Society
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• v.35 no.5
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• pp.43-51
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• 2019

At present, the ground anchor method is commonly applied to securing the slope stability in Korea. The ground anchor is reported to decrease in tensile load due to aging and environmental influences with time such as corrosion, relaxation, creep and so on. In Korea, the lift-off test is performed for the periodic inspection or cases when the symptoms of deterioration on anchors and the residual tensile load of the anchors is checked. However, the current lift-off test standard (MOLIT, 2010) is not fully specified in details. In this study, the factors affecting the lift-off test were investigated based on the previous research and foreign standards and lift-off tests were performed with consideration for the loading and unloading cycle, load increment method, and tensioning tendon method. Based on the results, this paper proposes improved testing and evaluation procedures of the lift-off test considering the workability and time limits in the field.

• Journal of the Korean GEO-environmental Society
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• v.20 no.12
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• pp.49-55
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• 2019

Slope failure analysis entails proper understanding of various factors as well as the characteristics of ground conditions, which are difficult to achieve due to technological limits. Despite a number of past studies to clarify possible factors triggering slope failures, the impact of rainfall characteristics and infiltration rate, which are the key to estimation of slope stability in wet condition, on slope failures still remains unclear. This study has estimated permeability against various unit weights of soil based on constant head permeability tests using Jumunjin standard silica sand. One dimensional infiltration tests were conducted to estimate the infiltration capacity and the amount of infiltration taking into account the permeability and rainfall intensity. The applicability of existing empirical equations for the estimation of infiltration to granular soils was verified on the basis of the test results.

• Journal of the Korean Geotechnical Society
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• v.36 no.12
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• pp.125-132
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• 2020

Embedded joints in the rock mass are a major constituent influencing its mechanical behavior. Numerical analysis requires a rigorous modeling methodology for the rock mass with detailed information regarding joint properties, orientation, spacing, and persistence. This paper provides a mechanical model for a jointed rock mass based on the implicit joint-continuum approach. Stiffness tensors for rock mass are evaluated for an assemblage of intact rock separated by sets of joint planes. It is a linear summation of compliance of each joint sets and intact rock in the serial stiffness system. In the application example, kinematic analysis for a planar failure of rock slope is comparable with empirical daylight envelope and its lateral limits. Since the developed implicit joint-continuity model is formulated on a continuum basis, it will be a major tool for the numerical simulations adopting published plenteous thermal-hydro-chemical experimental results.

• The Journal of Korean Physical Therapy
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• v.34 no.5
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• pp.212-217
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• 2022

Purpose: This study sought to investigate the effects of visual cue deprivation balance training by applying head control feedback to the balance function and the fall index in older people. Methods: The study was conducted on 26 older people at the S Hospital in Gyeongsansi. The patients were randomly divided into the experimental groupI (EGI, n=9), the experimental groupII (EGII, n=9), and the control group (CG, n=8). The three groups were trained for 30 minutes three times a week for four weeks. To assess the patients' static balance function, their limits of stability (LOS) was measured using the BioRescue system, (RM Ingenierie, France), composed of a pressure platform that can measure force in diverse ways, a computer, and a monitor. The dynamic balance function was measured using the Berg Balance Scale (BBS). Also, the fall index was measured to evaluate the risk of falling. A paired t-test was performed to compare pre- and post-training performance within the groups. One-way ANOVA was performed for comparing the three groups. A post hoc least significant difference (LSD) test was also performed. Results: The results of the LOS showed a significant difference after training in the EGI and EGII groups (p<0.05). As a result of the difference between the three groups, there was a significant difference after training (p<0.05). The results of the BBS showed a significant difference after training in the EGI group (p<0.05). As a result of the difference between the three groups, there was a significant difference after training (p<0.05). Conclusion: Visual cue deprivation balance training applying head control feedback is effective in improving the dynamic balance function in older people. It is also necessary to constantly maintain the head orientation by feedback and to properly control the head movement.

• Structural Monitoring and Maintenance
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• v.8 no.4
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• pp.345-360
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• 2021

This paper presents an analytical approach to calculate the buckling load of the cylindrical ring structures subjected to both hydrostatic and hydrodynamic pressures. Based on the conservative law of energy and Timoshenko beam theory, a theoretical formula, which can be used to evaluate the critical pressure of buckling, is first derived for the simplified cylindrical ring structures. It is assumed that the hydrodynamic pressure can be treated as an equivalent hydrostatic pressure as a cosine function along the perimeter while the thickness ratio is limited to 0.2. Note that this paper limits the deformed shape of the cylindrical ring structures to an elliptical shape. The proposed analytical solutions are then compared with the numerical simulations. The critical pressure is evaluated in this study considering two possible failure modes: ultimate failure and buckling failure. The results show that the proposed analytical solutions can correctly predict the critical pressure for both failure modes. However, it is not recommended to be used when the hydrostatic pressure is low or medium (less than 80% of the critical pressure) as the analytical solutions underestimate the critical pressure especially when the ultimate failure mode occurs. This implies that the proposed solutions can still be used properly when the subsea vehicles are located in the deep parts of the ocean where the hydrostatic pressure is high. The finding will further help improve the geometric design of subsea vehicles against both hydrostatic and hydrodynamic pressures to enhance its strength and stability when it moves underwater. It will also help to control the speed of the subsea vehicles especially they move close to the sea bottom to prevent a catastrophic failure.