• Journal of Animal Science and Technology
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• v.54 no.3
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• pp.165-174
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• 2012

For horse breeders or managers, it is critical to understand the estrous cycle of mares. Breeding of mares cannot be successfully achieved throughout the whole year as mares breed seasonally. Mares are only able to breed when day length is more than 16 h, and this period is known as the breeding season. Their estrous cycle is approximately 21 days with 5-7 days of estrus and 14 to 15 days of a diestrus period. The estrous cycle of the mare is mainly controlled by gonadotropins, which control follicular development and ovulation. Mares exhibit unique ovulatory events which are not observed in other species. A LH surge occurs for several days, with levels of LH reaching their peak after ovulation. The LH level at the time of LH peak is lower than most other species. The unique anatomical structure of the ovaries of mares is known to limit the number of eggs ovulated. Several attempts have been made to develop chemical/hormonal agents which might be used to manipulate the timed ovulation of mares. Agents that have been tested include hCG, native GnRH, Deslorelin (Ovuplant, GnRH-agonist), Buserelin (GnRH analogue), equine pituitary extracts and equine chorionic gonadotropin (eCG or PMSG). However, the function, purity or stability of these agents is not reliable. Recombinant equine LH, an alternative agent for the timed ovulation, has been developed and tested for its biological activities, through the use of both in vitro and in vivo experiments. The reLH was suggested to be a reliable agent in inducing ovulation within 48 h after being administered through injection, when the size of dominant follicle is 35 mm in diameter.

• Fire Science and Engineering
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• v.17 no.3
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• pp.61-73
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• 2003

Most of the accidents occurred from the chemical plants are related to the catastrophic gas release events when the large amount of toxic materials is leaked from its storage tank or transmitting pipe lines. In this case, the greatest concerns are how the spreading behaviors of leakages are depended on the ambient conditions such as air stability and other environmental factors. Hence, we have focused on the risk assessments and consequential analysis for chlorine as an illustrative example. As appeared in the result, Fire & Explosion Index depicted it a bit dangerous with presenting the comprehensive degrees of hazard 90.7. And as a result of Phast6.0/ALOHA, the trends of each scenario appeared considerably identical although there are some differences in the resulting effects according to the input data for the Gas Model. The consequence analysis is performed numerically based on the dense gas mode. In the future, using more correct input data, material properties, and topographical configuration, the method of this research will be useful for the guideline of the risk assessment when the release of toxicants breaks out.

• Journal of the Korean institute of surface engineering
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• v.44 no.4
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• pp.155-164
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• 2011

Electron beam evaporation source is widely used to prepare thin films by physical vapor deposition because it is very effective to vaporize materials and there is virtually no limit to vaporize materials including metals and compounds such as oxide. In this study, evaporation characteristics of various metals and compounds from an electron beam evaporation source have been studied. The 180 degree deflection type electron beam evaporation source which has 6-hearth crucibles and is capable of inputting power up to 10 kW was employed for evaporation experiment. 36 materials including metals, oxides and fluorides have been tested and described in terms of optimum crucible liner, evaporation state, stability, and so on. Various crucible liners have been tried to find out the most effective way to vaporize materials. Two types of crucible liners have been employed in this experiment. One is contact type liner, and the other is non-contact type one. It has been tried to give the objective information and the most effective evaporation method on the evaporation of materials from the electron beam evaporation source. It is concluded that the electron beam evaporation source can be used to prepare good quality films by choosing the appropriate crucible liner.

• Bulletin of the Korean Chemical Society
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• v.33 no.1
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• pp.105-110
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• 2012

A europium (III)-sensitized, spectrofluorimetric (FL) method is presented for the determination of sparfloxacin (SPAR) using an anionic surfactant, sodium dodecyl benzene sulphonate (SDBS). The method is based on the strong fluorescence (FL) enhancement of SPAR after the addition of $Eu^{3+}$ ions as fluorescence probes. The experimental results indicated that the FL intensity of the SPAR-$Eu^{3+}$ system was enhanced markedly by SDBS. The maximum FL emission signal was obtained at about 615 nm when excited at 372 nm. The experimental conditions that affected the FL intensity of the SPAR-$Eu^{3+}$-SDBS system were optimized systematically. The enhanced FL intensity of the system exhibited a good linear relationship with the SPAR concentration over the range of $1.5{\times}10^{-9}-1.2{\times}10^{-7}mol\;L^{-1}$ with a correlation coefficient (r) of 0.9987. The limit of detection ($3{\delta}$) was $4.15{\times}10^{-10}mol\;L^{-1}$ with a relative standard deviation (RSD) of 1.65%. This method was successfully applied for the determination of SPAR in pharmaceuticals, and human serum and urine samples with higher sensitivity, wide dynamic range and better stability. The possible interaction mechanism of the system is also discussed in detail by ultraviolet absorption spectra and FL spectra.

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3284-3288
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• 2013

This paper describes first development and validation of pentafluorophenylprophyl ligand-based liquid chromatography coupled to tandem mass spectrometry (PFPLC-MS/MS) method to determine metformin, a highly polar compound, in human plasma. Metformin and Phenformin (internal standard) were extracted from human plasma 50 ${\mu}L$ with a single-step protein precipitation. The chromatographic separation was performed using a linear gradient elution of mobile phase involving 5.0 mM ammonium formate solution with 0.1% formic acid (A) and acetonitrile (B) over 3.0 min of run time on a Phenomenex Luna PFP column. The detection was performed using a triple-quadrupole tandem mass spectrometer (Waters Quattro micro) with electrospray ionization in the mode of positive ionization and multiple-reaction monitoring (MRM). The developed method was validated with 5.0 ng/mL of lower limit of quantification (LLOQ). The calibration curve was linear over 5-3000 ng/mL of the concentration range ($R^2$ > 0.99). The specificity, selectivity, carry-over effect, precision, accuracy and stability of the method met the acceptance criteria. The method developed in this study had had rapidness, simplicity and ruggedness. The reliable method was successfully applied to high throughput analysis of real samples for a practical purpose of a pharmacokinetic study.

• Journal of Auto-vehicle Safety Association
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• v.5 no.2
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• pp.24-31
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• 2013

This paper describes a coordinated control algorithm for rear-side collision avoidance. In order to assist driver actively and increase driver's safety, the proposed coordinated control algorithm is designed to combine lateral control using a steering torque overlay by Motor Driven Power Steering (MDPS) and differential braking by Vehicle Stability Control (VSC). The main objective of a combined control strategy is twofold. The one is to prevent the collision between the subject vehicle and approaching vehicle in the adjacent lanes. The other is to limit actuator's control inputs and vehicle dynamics to safe values for the assurance of the driver's comfort. In order to achieve these goals, the Lyapunov theory and LMI optimization methods has been employed. The proposed coordinated control algorithm for rear-side collision avoidance has been evaluated via simulation using CarSim and MATLAB/Simulink.

• Magazine of the Korean Society of Agricultural Engineers
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• v.33 no.2
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• pp.112-119
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• 1991

Some experiments were carried out to investigate the effects of freezing and thawing on the strength and strain characteristics of alluvial silty clay under the different temperatures, loading and moisture conditions. The results were as follows; 1. The soil used was proved to be consisted of silty clay with honey-combed structure, and showed higher dilatancy, frost activity and lower stability in natural state. 2. Soil treated with freezing and thawing cycles showed lower compressive strength compared with the non treated, The strength decreased with incement of freezing and thawing cycles. It's shapes of stress-strain curves were flat and did not formulate a peak while the peak strength of higher moisture content soil decreased with the increment of moisture content. It's decrement ratio was most distinctly shown at the first one cycle of freezing and thawing. 3. The cohesion decreased due to freezing and thawing cycles but internal frcition angle was not changed. 4. The liquid limit decreased with increment of freezing and thawing cycles, and became almost constant after three cycles of freezing and thawing. 5. The strength under simple loading at failure mode was appeared to be higher compared with the cyclic loading after freezing and thawing but initial moisture content effect was not observed. 6. Ice lense was not observed within 50% of ice content ratio but observed over 100%. The higher the ice content ratio, the higher the peak strength. As a matter of fact, it seems that an optimum ice content ratio exists for plastic mode and the least compressive strength.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.1
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• pp.17-27
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• 2004

A new earthquake design method performing iterative calculations using secant stiffness was developed. The proposed design method has the advantages of convenience and stability in numerical analysis because it uses elastic analysis. At the same time, the proposed design method can accurately estimate the strength and ductility demands on the members because it performs the analysis on the inelastic behavior of structure using iterative calculation. In the present study, the procedure of the proposed design method was established, and a computer program incorporating the proposed method was developed. Design examples using the proposed method were presented, and its advantages were presented by the comparisons with existing design methods using elastic or inelastic analysis. The proposed design method, as an integrated method of analysis and design, can address the earthquake design strategy devised by the engineer. such as ductility limit on each member, the design concept of strong column - weak beam, and etc. In addition, through iterative calculations on the structure preliminarily designed only with member sizing, the strength and ductility demands of each member can be directly calculated so as to satisfy the given design strategy. As the result. economical and safe design can be achieved.

• Journal of Korean Association for Spatial Structures
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• v.18 no.3
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• pp.57-66
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• 2018

Recently various composite beams in which concrete is filled in the U-shaped steel plate have been developed for saving story height and reducing construction period. Due to the high flexural stiffness and strength, they are widely being used for the building with large loads and long spans. The semi-slim AU composite beam has proven to take highly improved stability compared to the existing composite beams, because it consists of the closed steel section by attaching cap-type shear connectors to the upper side of U-shaped steel plate. In this study the finite element analyses were performed to evaluate the safety of the AU composite beam with unconsolidated concrete which were sustained through the closed steel section during the construction phase. The analyses were performed on the two types of cross section applied to the fabrication of AU composite beams, and the results were compared to the those of 2-point bending tests. In addition, the flexural performance according to the space of intermittent cap-type shear connectors and the location of reinforcing steel bars for compression was comparatively investigated. Through the results of analytical studies, it is preferable to adopt the yield moment of AU composite beam for evaluating the safety in the construction phase, and to limit the space of intermittent shear connectors to 400 mm or less for the construction load.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.569-580
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• 2008

If slope height was more than 20 meters, we conducted an analysis of stereographic projection and limit equilibrium at this slope. We proposed reduction of slope face angle and reinforcement of rock bolt depending on analysis. Blasting design : Standard pattern based on result of local test blasting was made for blasting design. Vibration criterion was set for less than 3.0mm/s because of outworn buildings and inhabitants opinions. Production blasting and Controlled blasting has been done as Construction standard pattern. After Vibration Monitoring has been done, so that we can control of complement. "Bidding Document" and AASHTO 2001 "A Policy on Geometric Design of Highways and Streets" were so for design criteria of earthwork but they were different actual design criteria and left something to be desired in Afghanistan. Therefore, although "Bidding Document" and "AASHTO 2001" were basic design criteria, domestic design criteria was reflected in this design criteria for complement by discussion with supervisor. Drainage design : For stability ratio, ditch of arch block and stonework was designed by rainfall data for the 13 years and discussion with supervisor. Pavement was designed as flexible pavement. Because these days in Afghanistan postwar repair works, especially urgent repairing of roads and newly making of roads, are very highly in progress, I think that Afghanistan is the region about which our construction technical experts should have great concerns.