• Biomolecules & Therapeutics
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• v.9 no.4
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• pp.291-297
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• 2001

The bioequivalence of two triflusal products was evaluated with 20 healthy volunteers following single oral dose according to the guidelines of Korea Food and Drug Administration (KFDA). Trisa $l^{R}$ capsule (Whanin Pharm. Corp., Korea) and Disgre $n^{R}$ capsule (Myung-In Pharm. Corp., Korea) were used as test product and reference product, respectively. Both products contain 300 mg of trifusal. One capsule of test product or reference product was orally administered to the volunteers, respectively, by randomized two period crossover study (2$\times$2 Latin square method). Blood samples were taken at predetermined time intervals for 4 hours and the determination of trifusal was accomplished using semi-microbore HPLC equipped with automated column switching system. The analytical method with HPLC was validated according to the Bioanalytic Method Validation guideline by F7A prior to determining the plasma samples. The pharmacokinetic parameters (AU $C_{0-4h}$ $C_{max}$ and $T_{max}$) were calculated and ANOVA test was utilized for statistical analysis of parameters. As a result of the assay validation, the limit of quantification of trifusal in human plasma by current assay procedure was 50 ng/ml using 500 $\mu$l of plasma. The accuracy of the assay was from 97.76% to 116.51% while the intra-day and inter-day coefficient of variation of the same concentration range was less than 15%. Average drug concentration at the designated time intervals and pharmacokinetic parameters calculated were not significantly different between two products (p>0.05). The difference of mean AU $C_{olongrightarrow4hr}$, $C_{max}$, and $T_{max}$ between the two products (2.92, 4.39, and -2.44%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $C_{olongrightarrow4hr}$ and $C_{max}$ were more than 0.8 and less than 0.2, respectively. Although the power for $T_{max}$ was under 0.8, $T_{max}$ of the two products was not significantly different from each other (p>0.05). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two products of triflusal were bioequivalent.quivalent.ent.ent.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.3
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• pp.95-104
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• 2007

This study was focused on the effect of concrete strength and lateral ties of concrete columns subjected to eccentric compressive loads. The twenty-four concrete columns with $200mm{\times}200mm$ square cross-section were tested. The main variables were concrete strength, spacing and configuration of lateral ties, and eccentricity ratios. From the experiment, the followings were investigated ; 1) In all cases, it was observed that the increase of concrete compressive strength led to the decrease of ductility. Also, as the eccentricity ratios increased, the effect of ductility enhancement by lateral ties decreased. 2) As the ties spacing decreased from 100mm to 30mm, the magnitude of axial load acting on the concrete column showed an enhancement of 1.1~1.2 times and the descending curve after a peak moment presented a smooth decline. 3) The high-strength concrete columns required a design of lateral ties to increase the volumetric ratios and density of tie spacing to sustain a proper strength and ductility. Accordingly, regardless of concrete strength, the current AIK design code to specify the maximum tie spacing of concrete columns was proven to lead to the poor strength and ductility for seismic design. Therefore, it is necessary to develop a new seismic design code that connects volumetric ratios and tie spacing of concrete columns with concrete strength.

• Journal of architectural history
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• v.1 no.1 s.1
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• pp.88-105
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• 1992

This dissertation aims to investigate the structure of Palsangjeon, a five story wooden pagoda in Pubjoo Temple which is the only wooden pagoda existing in Korea, by a comparative study of the Palsangjeon with Japanese counterparts. By doing so, the writer of the present investigation attempts to find out its structural originality. The main finding of this study are as follows. The upper part of Palsangjeon is constructed with square log frameworks called GuiTl and Sacheon-Ju around the central column. The four walls along Sacheon-Ju from the 1st level to the 3rd well resists the outside horizontal piressure. And Gui-Tl structure on the 5th level copes much better with shear force. So this frame consisting of Sacheon-Ju and log frameworks might be viewed an semi-core system, This core is supported once again by the frame of Go-Ju. That is to say. Go-Ju supports frame of Sacheon-Ju. And the frame of Pyeong-Ju on the 4th and the 5th levels also supports it. The frame of Go-Ju is supported by the frame of Pyeong-Ju on the 1st and the 2nd levels. So this structure is designed to resist the wind and also keep the balance by properly distributing vertical pressure. The plan and the elevational structure of Palsangjeon keep the balance by the perfect symmetric structure. And the frame of Sacheon-Ju forming semi-core system can resist both the lateral load and the vertical pressure for the balance of its structure. The five story pagoda in Horyuji used to stand on a central which is desigend to support the main body of the pagoda from the first level. The principles of balance is used between the Ha-Aag and short to react the rafter. Sacheon-Ju and edge column is against the lateral load. The structural jointing system is stable thanks to the log framewroks formed on every level. The five story pagoda in Horyuji poseses the structual system originated from the ancient wooden pagoda. The pagoda is found to express simple, sincere and straight forward form. On the other hand, it could be seen as a stucture resisting the earthquake and the lateral load, Palsangjeon is an excellent building which religions function is well harmonized with its structure and appearance. It not only functions extremely well as a regions place like other pagodas, but also excellently shows how multi-story wooden building should be structured.

• Journal of Korean Society of Steel Construction
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• v.17 no.4 s.77
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• pp.419-429
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• 2005

The objective of this study is to clarify the structural features of members consisting of a connection, as part of the previous study on the CFT column-to-beam tensile connection with a combined cross diaphragm. This connection has the following merits: it evenly distributes the stress on the beam flange and the diaphragm and reduces the stress concentration by improving the stress transfer route and restraining the abrupt deformation of the diaphragm. Finite element analysis was performed to find out the stress transfer through the sleeve, which is an important member of the connection with a combined cross diaphragm. The length and thickness of the sleeve were used as variables for the analysis. The analysis results showed that the length and thickness of the sleeve did not influence the capacity of the connection and played the role of a medium for the transfer of the stress from the diaphragm to the filled concrete. It was proposed that the appropriate length of the sleeve have the same value as the diameter of the sleeve and that the appropriate ratio of the sleeve diameter to the sleeve thickness be 20. Two equations for the evaluation of the load carrying the capacity of the connection were also proposed through the modification of the evaluation equation suggested in the previous study.

• Neurospine
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• v.15 no.4
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• pp.353-361
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• 2018

Objective: This study is aimed to investigate whether surgical strategies for adult spinal deformity (ASD) treatment differed among Korean physicians. Methods: This study is retrospective questionnaire-based study. ASD is challenging to manage, with a broad range of clinical and radiological presentations. To investigate possible nationality- or ethnicity-related differences in the surgical strategies adopted for ASD treatment, the International Spine Study Group surveyed physicians' responses to 16 cases of ASD. We reviewed the answers to this survey from Korean physicians. Korean orthopedic surgeons (OS) and neurosurgeons (NS) received a questionnaire containing 16 cases and response forms via email. After reviewing the cases, physicians were asked to indicate whether they would treat each case with decompression or fusion. If fusion was chosen, physicians were also asked to indicate whether they would perform 3-column osteotomy. Retrospective chi-square analyses were performed to investigate whether the answers to each question differed according to training specialty or amount of surgical experience. Results: Twenty-nine physicians responded to our survey, of whom 12 were OS and 17 were NS. In addition, 18 (62.1%) had more than 10 years of experience in ASD correction and were assigned to the M10 group, while 11 (37.9%) had less than 10 years of experience and were assigned to the L10 group. We found that for all cases, the surgical strategies favored did not significantly differ between OS and NS or between the M10 and L10 groups. However, for both fusion surgery and 3-column osteotomy, opinions were divided regarding the necessity of the procedures in 4 of the 16 cases. Conclusion: The surgical strategies favored by physicians were similar for most cases regardless of their training specialty or experience. This suggests that these factors do not affect the surgical strategies selected for ASD treatment, with patient clinical and radiological characteristics having greater importance.

• Journal of the Korea Concrete Institute
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• v.21 no.3
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• pp.291-302
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• 2009

A compression lap splice can be calculated longer than a tension lap splice in high strength concrete according to current design codes. New criteria for the compression lap splice including the effects of concrete strength are required for practical purpose of ultra-high strength concrete. Characteristics of compression lap splice have been extensively investigated and main parameters are derived. In addition, an experimental study has been conducted with column specimens in concrete strength of 40 and 60 MPa. The strength of the compression lap splice consists of bond and end bearing and two contributors are combined. Therefore, combined action of bond and end bearing should be assessed. Compared with tension splices, concrete strength significantly affects the strength of compression splices due to short splice length and existence of end bearing. Test results show that the splice strength can be evaluated to be proportional to square root of compressive strength of concrete. The stress states of concrete surrounding spliced bars govern the strengths of bond and end bearing. Because the axial stress of the concrete is relatively high, the splice strength is not dependent on clear spacing. End bearing strength is not affected by splice length and clear spacing and is expressed with a function of the square root of concrete strength. The failure mode of specimens is similar to side-face blowout of pullout test of anchors and the strength of end bearing can be evaluated using the equation of side-face blowout strength. Because the stresses developed by bond in compression splices are nearly identical to those in tension splices, strength increment of compression splices is attributed to end bearing only.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.5
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• pp.163-181
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• 2023

Improving the detection performance of facilities corresponding to the sensors of autonomous vehicles helps driving safety. In the road and transportation field, research is being conducted to improve the detection performance of sensors by road infrastructure or facilities. As part of this on the development of autonomous driving support infrastructure, the shape of traffic cones and drums to ensure sufficient LiDAR detection performance even rainy conditions and maintain the line-of-sight guidance function in construction zones improvement effect. The principle was to increase reflection performance and ensure no significant difference in shape from existing facilities. Traffic cones were manufactured in square pyramid shapes instead of cones, and drums were manufactured in hexagonal and octagonal pillar shapes instead of cylinders. LiDAR detection data for the facility was confirmed on a clear day and with 20 mm/h and 40 mm/h rainfall. The detection performance of the square pyramid-shaped traffic cone and octagonal column-shaped drum was to the existing facility. On the other hand, deviations occurred due to repeated measurements, and significance could not be confirmed through statistical analysis. By reflecting these results, future studies will seek a form in which data can be obtained uniformly despite the diversity of measurement environments.

• Journal of Korea Game Society
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• v.12 no.5
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• pp.67-78
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• 2012

Summed area table allows filtering of arbitrary-width box regions for every pixel in constant time per pixel. This characteristic makes it beneficial in image processing applications where the sum or average of the surrounding pixel intensity is required. Although calculating the summed area table of an image data is primarily a memory bound job consisting of row or column-wise summation, previous works had to endure excessive access to the high latency global memory in order to exploit data parallelism. In this paper, we propose an efficient algorithm for generating the summed area table in the GPGPU environment where the input is decomposed into square sub-images with intermediate data that are propagated between them. By doing so, the global memory access is almost halved compared to the previous methods making an efficient use of the available memory bandwidth. The results show a substantial increase in performance.

• Journal of Satellite, Information and Communications
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• v.8 no.4
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• pp.43-46
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• 2013

Active use of images in the same place as the religion according to the height of the screen is determined by the height of the main speakers. This causes the 'sound image mismatch' and 'bass boost' sound like a failure occurs. Front seats are good seats in visual acoustics is a bad place. To minimize these obstacles acoustical speakers to actively apply the front fill needed. Higher sound pressure difference between the main speaker and the distance must be determined in accordance with the appropriate capacity. Actively using the front speakers to the sound image field by implementing the agreement to increase the concentration of sound. The relatively high inflow enhance alto lacking the front seat can be implemented evenly in the frequency response. Column in front of the main seat of the main speakers to supplement the deficiencies can be implemented more comfortable acoustic environment. Front fill speaker needs to be actively introduced, thereby presenting a detailed estimate, is needed.

• Journal of Korean Society of Steel Construction
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• v.26 no.5
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• pp.453-461
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• 2014

In this study, the stub columns of built-up H-section and square hollow section subjected to eccentrical loads are tested to evaluate the applicability of the structural members with 800MPa high-strength steel (HSA800) on current design specification. Analytical studies of FE model are conducted to validate the test results and then the verified FE models are used for extensive parametric studies for checking up the applicability of current design code. The parameters are width-to-thickness ratios and axial load ratios. From P-M correlations on parameter models, all stub columns with non-compact sections exceed the current design requirements about axial force and flexural strength ratios are sufficiently secured as the axial load ratios are decreased. The built-up hollow sections with slender section model do not satisfy the current design specification about axial force.