• 대한암한의학회지
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• 제16권2호
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• pp.35-41
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• 2011

Background : Lung cancer is one of the most common malignancy in the world. Types of lung cancer are Non small cell lung cancer and small cell lung cancer. Subtypes of Non small cell lung cancer are adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Knowing the type of lung cancer is important in determining both treatment and prognosis. Recently, due to newly developed anti-cancer drugs, squamous cell carcinoma has relatively poor prognosis than non-squamous cell carcinoma. Case : We report a squamous cell lung cancer case treated with allergen removed Rhus verniciflua Stokes (aRVS) extract. The patients initially diagnosed stage squamous cell lung carcinoma, but she refused recommended operation. She initiated aRVS extract monotherapy in October. 2006. The follow up Computed tomography in March. 2007, she diagnosed stable disease of tumor response on aRVS treatment. However, this case was lost to follow up for 6 months while she was treated with tomotherapy. In October 2007, she came back to our cancer center after diagnosed stage IV metastasized lung to lung, and aRVS monotherapy was restarted. She had survived 2 years after metastasis of squamous cell lung carcinoma. Conclusion : Allergen removed Rhus verniciflua Stokes(aRVS) sucessfully prolonged overall survival of a squamous cell lung cancer patient.

• Tuberculosis and Respiratory Diseases
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• 제75권6호
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• pp.231-235
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• 2013

Knowledge of molecular pathogenesis of non-small cell lung cancer has increased remarkably and changed the principles of treatment, especially during the past decade. These advancements have been limited mainly to adenocarcinoma of the lung. Recently, genetic alterations in squamous cell lung cancer (SQCLC) have been detailed and positive results of clinical trials using agents targeting these changes have indicated the potential for improved treatment outcomes for SQCLC.

• Clinical and Experimental Pediatrics
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• 제48권2호
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• pp.208-211
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• 2005

저자들은 11세 남아가 내원 1개월 전부터 요통과 3일 전부터 양 하지로의 방사성 동통, 양 하지의 쇠약감을 주소로 본원에 입원하여 방사선학적 검사와 조직학적으로 진단된 기저세포양편평상피세포폐암 1례를 경험하였기에 보고하는 바이다.

• Journal of Chest Surgery
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• 제34권10호
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• pp.805-808
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• 2001

동시성 원발성 폐암은 전체 폐암의 1∼2%정도로 드문 암으로 술전 진단이 어렵고 수술 중이나 수술 후에 진단되는 경우가 대부분이다. 특히 동종 조직학적 특징을 나타내는 경우 진단이 어렵고 술전 폐에서 폐로 전이된 원격 전이로 오인될 수 있다. 본 교실에서는 수술 중 발견된 서로 다른 편편상피암을 가지는 동시성 원발성 폐암을 1례 경험하였기에 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2273-2276
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• 2013

Objectives: This study employed proteomic profiling to identify specific tumor markers that might improve early diagnosis of lung squamous cell carcinoma. Methods: Serum samples were isolated from 30 patients with stage I lung squamous cell carcinoma and 30 age-and gender-matched healthy controls, and proteomic profiles were obtained by matrix-assisted laser desorption ionization time of flight mass spectrometry. Results: Three highly expressed potential tumor markers were identified in the sera of stage I lung squamous cell carcinoma patients, with molecular weights of 3261.69, 3192.07, and 2556.92 Da. One protein peak with molecular weight 3261.69 Da was chosen as the candidate biomarker and identified as a fibrinogen alpha chain through a search of the IPI, NCBI or SWISS-PROT protein databases. Conclusion: As a potential tumor biomarker, fibrinogen alpha chain may be applicable for the early diagnosis and prognosis of lung squamous cell carcinoma patients.

• 대한한방내과학회지
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• 제28권2호
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• pp.385-390
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• 2007

Objective : The aim of the present study is to derive further studies evaluating the effectiveness of oriental medical treatment on recurred squamous cell carcinoma of the lung. We present a case of recurred squamous cell lung carcinoma patient who has survived more than 7 years. Method : We followed all treatments and examinations. We prescribed the patient take Hang-Am-Dan (HAD) three times a day for 6 years. Computed tomography (CT) was performed to evaluate the therapeutic efficacy. Results : The patient has survived for over 7 years. CT showed stable state (SD). Conclusion : This case may give us a possibility of that oriental medical treatment offers potential benefits for patients with recurred squamous cell lung carcinoma.

• Tuberculosis and Respiratory Diseases
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• 제38권2호
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• pp.186-193
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• 1991

Three cases of double primary lung cancer occured synchronously are reported with brief review of literature. The incidence of multiple primary lung cancer relatively rare but may become increasingly prevalent as early detection techinque and cancer therapy has improved. The patients were a 67, 69, and 65-year-old men with doulbe primary lung cancer of different cell type or same cell type with other bronchus origin (squamous cell+small cell, squamous cell+squamous cell, squamous cell+bronchioloaveolar cell) were identified with flexible bronchofiberoscopic biopsies. More careful diagnostic evaluation and management are thought to be necessary.

• Journal of Chest Surgery
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• 제23권2호
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• pp.386-389
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• 1990

Spontaneous Pneumothorax as a complication of lung cancer is rare, as seen from the literature, comprising only 1.13 per cent of all pneumothoraces. All histologic types of lung cancer have been reported principally squamous cell carcinoma probably because of its relatively higher incidence. Beside the fact that it occurs in the same high risk population [Smokers, chronic bronchitis and those with emphysema], pneumothorax may reveal a cancer. Recently, we observed three cases of lung cancer with spontaneous pneumothorax, the one was squamous cell carcinoma and the others were adenocarcinoma. Three cases of spontaneous pneumothoraces occurred as a complication of neoplastic disease.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4819-4822
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• 2013

Background: Lung cancer is the leading cause of cancer mortality in the world. Many factors can protect against or facilitate its development. A TNF family member TRAIL, has a complex physiological role beyond that of merely activating the apoptotic pathway in cancer cells. Vitamin D is converted to its active form locally in the lung, and is also thought to play an important role in lung health. Our goal was to investigate the possible clinical significance of serum sTRAIL and 1,25-dihydroxyvitamin D(3) levels in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Totals of 18 consecutive adenocarcinoma and 22 squamous cell carcinoma patients with stage-IV non-small cell lung cancer referred to our institute were included in this study. There were 12 men and 6 women, with ages ranging from 38 to 97 (mean 60.5) years with adenocarcinoma, and 20 men and 2 women, with ages ranging from 46 to 80 (mean 65) years with squamous cell carcinoma. Serum levels of sTRAIL and 1,25-dihydroxyvitamin D(3) were measured in all samples at the time of diagnosis. Results: sTRAIL levels in NSCLC patients were higher than in the control group. Although there was no correlation between patient survival and sTRAIL levels, the highest sTRAIL levels were correlated with age and cigarette smoking in the adenocarcinoma patients. sTRAIL level in healthy individuals were correlated with serum 1,25-dihydroxyvitamin D(3). Conclusions: Serum sTRAIL concentrations were increased in NSCLC patients, and correlated with age and smoking history, but not with overall survival.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3071-3074
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• 2014

Background: To investigate the related risk factors of postoperative nosocomial pneumonia (POP) in patients withI-IIIa lung cancer. Methods: Medical records of 511 patients who underwent resection for lung cancer between January 2012 to December 2012 were retrospectively reviewed. Risk factors of postoperative pneumonia were identified and evaluated by univariate and multivariate analyses. Results: The incidence of postoperative pneumonia in these lung cancer patients was 2.9% (15 cases). Compared with 496 patients who had no pneumonia infection after operation, older age (>60), histopathological type of squamous cell carcinoma and longer surgery time (>3h) were significant risk factors by univariate analysis. Other potential risk factors such as alcohol consumption, history of smoking, hypersensitivity, hypertension, diabetes mellitus and so on were not showed such significance in this study. Further, the multivariate analysis revealed that old age (>60 years) (OR 5.813, p=0.018) and histopathological type of squamous cell carcinoma (OR 5.831, p<0.001) were also statistically significant independent risk factors for postoperative pneumonia. Conclusions: This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery.