• Journal of Korean Neurosurgical Society
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• 제62권6호
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• pp.723-726
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• 2019

We report two rare cases of spontaneously regressed Rathke's cleft cyst (RCC). A 52-year-old woman presented with headache. A pituitary hormone study was normal. Brain magnetic resonance imaging (MRI) showed a $0.45-cm^3$ cystic sellar lesion. The cyst was hyperintense on T1-weighed imaging and hypointense on T2-weighted imaging without rim enhancement, comparable to a RCC. Six months later, brain MRI showed no change in the cyst size. Without any medical treatments, brain MRI 1 year later revealed a spontaneous decrease in cyst volume to $0.05cm^3$. A 34-year-old woman presented with headache and galactorrhea lasting 1 week. At the time of the visit, the patient's headache had disappeared. Her initial serum prolactin level was 81.1 ng/mL, and after 1 week without the cold medicine, the serum prolactin level normalized to 11.28 ng/mL. Brain MRI showed a RCC measuring $0.71cm^3$. Without further treatments, brain computed tomography 6 months later showed a spontaneous decrease in cyst volume to $0.07cm^3$. Another 6 months later, brain MRI revealed that the cyst had remained the same size. Neither patient experienced neurological symptoms, such as headache or visual disturbance, during the period of cyst reduction. The RCCs in both patients underwent spontaneous regression without any medical treatment during a period of 6 months to 1 year. Although spontaneous regression of a RCC is rare, it is still possible and a sufficient follow-up period should be considered.

• Journal of Chest Surgery
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• 제52권2호
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• pp.119-123
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• 2019

Spontaneous regression of lung cancer is a very rare and poorly understood phenomenon. A 64-year-old man presented to Dong-A University Hospital with a shrunken nodule in the right lower lobe. Although the nodule showed a high likelihood of malignancy on needle aspiration biopsy, the patient refused surgery. The nodule spontaneously regressed completely in the next 17 months. However, the subcarinal lymph node was found to be enlarged 16 months after complete regression was observed. We pathologically confirmed metastasis of squamous cell carcinoma and performed neoadjuvant chemotherapy, surgery, and adjuvant chemoradiation. Regardless of tumor size reduction, it is preferable to perform surgery aggressively in cases of operable lung cancer.

• Tuberculosis and Respiratory Diseases
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• 제75권5호
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• pp.214-217
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• 2013

Treatment of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) is difficult because the mortality rate after surgery or chemotherapy is high for these patients. Spontaneous regression of cancer is rare, especially in lung cancer. A 62-year-old man, previously diagnosed with IPF, presented with stage IIIC (T2N3M0) non-small cell lung cancer. About 4 months later, spontaneous regression of the primary tumor was observed without treatment. To the best of our knowledge, this is the first report of spontaneous regression of lung cancer in a patient with IPF.

• 한국임상수의학회지
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• 제39권3호
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• pp.121-125
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• 2022

A 1-year-old neutered male Maltese dog was presented with a mass on the upper eyelid of the left eye (OS). A pinkish and alopecic mass was located in the nasal portion of the upper eyelid of OS. The mass was firmly attached to the eyelid and round-shaped with a diameter of 11 mm. Any spread to conjunctiva was not identified. On a cytological examination, cutaneous histiocytoma was confirmed, with the presence of small lymphocytes indicating later regression stage. The patient received no treatment and complete regression of the mass was verified 2 months later. The cytological examination was helpful for the diagnosis and staging of cutaneous histiocytoma. Canine eyelid histiocytoma can regress spontaneously, and thus medical or surgical treatment for removal should be considered carefully.

• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.275-278
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• 2017

Small cell lung carcinoma (SCLC) is a cancer that shows aggressive behavior, early spread to distant sites, and frequent association with distinct paraneoplastic syndromes. Spontaneous remission of cancer, particularly of SCLC, is a rare biological event. Cases involving spontaneous regression of SCLC were reported, and were associated with paraneoplastic syndromes of the nervous system. This article reports on a 78-year-old man with SCLC in remission, with neurological symptoms. The patient visited the hospital because of generalized weakness, and imaging studies revealed a mass in the lower lobe of the left lung, pathological evaluation showed SCLC. The patient refused oncologic treatment and was treated only with conservative care. In follow-up study the diameter of the mass had decreased from initial 32 mm, 9 months after admission to 20 mm, 17 months after admission to 13 mm. The patient kept complaining of generalized weakness, dizziness, and paresthesia of limbs. We assumed that, in this case, the spontaneous remission of lung cancer was related to the immunologic response directed against the tumor, which is believed to be an important factor in the pathogenesis of paraneoplastic neurologic syndromes.

• Journal of Korean Neurosurgical Society
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• 제30권10호
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• pp.1224-1228
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• 2001

Germinoma is a rare central nervous system neoplasm in children and young adults. It is well known that a malignant primary neoplasm can be cured by conventional radiation therapy alone or reduced-volume and field irradiation in combination with chemotherapy. The authors report a very rare case of a pineal germinoma, which was completely disappeared after repeated diagnostic brain computed tomography(CT) with review of pertinent literature. There has been neither tumor recurrence nor metastasis during follow-up period.

• 대한두개안면성형외과학회지
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• 제20권2호
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• pp.121-125
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• 2019

Merkel cell carcinoma is a rare cutaneous carcinoma, featured by an aggressive clinical course and a mortality rate of 28% at 2 years. A 71-year-old female was affected by a 4.1-cm-wide locally advanced Merkel cell carcinoma of the upper eyelid, previously misdiagnosed as chalazion, with involvement of the extraocular muscles. Although the tumor showed a macroscopic spontaneous regression in size after the incisional biopsy, the mass was treated with neoadjuvant chemotherapy and surgical excision. Good functional and aesthetic result with preservation of the eyeball and absence of tumor recurrence were achieved at 3-year follow-up. In our experience, the combination of the inflammatory cascade due to the incisional biopsy and neoadjuvant chemotherapy led to the regression of a locally advanced large Merkel cell carcinoma of the eyelid.

• Journal of Chest Surgery
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• 제37권12호
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• pp.1025-1028
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• 2004

폐 유상피 혈관내피종은 조직학적으로는 혈관내피에서 발생하는 양성종양이나 임상적으로는 전이와 재발을 보이는 매우 드문 악성종양 중의 하나이다. 무증상의 좌하엽 폐암으로 진단받은 29세의 남자에서 좌하엽 폐절제술, 좌상엽 페 쐐기 절제술, 횡격막 부분절제술을 시행하여 좌하엽 폐의 병변에서는 유상피 혈관내피종으로 확진되었으나 좌상엽 폐와 횡격막의 병변은 유상피 혈관내피종이 자연 관해되어 석회화만 남은 것으로 진단되었다. 술 후 10개월과 19개월 두 차례에 걸쳐 폐 유상피 혈관내피종으로부터 피하 전이를 일으킨 환자를 수술 치험하였기에 보고한다.

• Journal of Chest Surgery
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• 제30권2호
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• pp.205-208
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• 1997

심장 횡문근종은 영아나 소아기에서 가장 발생빈도가 높은 원발성 심장종양으로서 결절성 경화증을 빈번히 동반하고, 자연 퇴화가 보고된다 할지라도 좌심실 유출로 폐쇄를 동반한 종양은 아직까지는 예후가 불량하고 수술적 치료가 적응이 된다. 생후 4 일된 신생아가 청색증과 빈 호흡을 주소로 내원하여 생후 4일째에 정중흉골절개를 통한 체외 순환하에 수술을 시행하여 좌심실 유출로를 막고있는 0.7$\times$0.9$\times$0.4cm크기의 종괴를 제거하였다. 수술 후 합병증은 발생하지 않았으며 수술후 14일째에 건강하게 퇴원하였다.

• 대한골관절종양학회지
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• 제20권2호
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• pp.80-84
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• 2014

봉입체 섬유종증은 주로 1세 이내의 소아 수지 및 족지에 발생하는 무통성의 섬유성 연부조직 종양이다. 병리학적으로는 치밀한 방추형 세포로 이루어져 있으며, 세포질 내에 항산성 봉입체가 관찰된다. 종양은 자발적 퇴행을 하는 것으로 알려져 있으나, 변형이나 기능장애를 일으키는 경우 수술적 치료를 요하며, 수술하는 경우 약 60%에서 다시 재발하는 것으로 보고되고 있다. 저자들은 비교적 높은 연령의 소아 수지에서 발병하였으며, 술 후 접촉성 병변이 발견된 봉입체 섬유종증 1예를 보고하고자 한다.