• 대한기계학회논문집B
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• 제27권12호
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• pp.1699-1707
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• 2003

Coriolis mass flowmeter(CMF), which can measure the mass flow directly, is getting rapid attention for the industrial and custody transfer purpose. In order to study the characteristics and the applicability of CMF, it is tested with the national flow standard system. Two types of sensing tube, U-type and straight type, are employed in the test. Water, spindle oil and viscosity Standard Reference Material whose viscosities are 1, 20 and, 67 $\textrm{mm}^2$/s, respectively, are studied. It is shown that the linearity of CMF is getting deteriorated as the fluid viscosity increases, which is due to the zero drift and the relaxation time of the fluid. To test its applicability in the case of high pressured gas, it is calibrated using compressed air, It shows 1∼l.6 % deviations compared to the calibration results using water. It concludes that the fluid velocity in CMF should be lower than the sonic velocity. In addition, the effects of the vibration from the pipeline and pump on CMF as well as the long term stability are studied.

• BMB Reports
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• 제45권8호
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• 한국수정란이식학회지
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• 제16권3호
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• pp.239-243
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• 2001

Selection of oocyte cryopreservation method is a prerequisite factor for developing an effective bank system. Compared with slow freezing method, the vitrification has various advantages such as avoiding intracellular ice crustal formation. In our previous, we attempted to employ a vitrification method using ethylene glycol and an electron microscope grid for cryopreservation of mouse oocytes. However, A high incidence of spindle and chromosome abnormalities was detected in thawed oocytes after vitrification. We examined whether the addition of a cystoskeleton stabilizer Taxol $^{TM}$, to the vitrification solution could promote the post-thawed survival and subsequent development of stored oocytes. More oocytes developed to the 4-cell (44.7% vs. 69.7%), 8-cell (31.8% vs. 64.2%), morula (24.7% vs. 54.3%), and blastocyst (20.3% vs. 49.2%) stages after the addition of Taxol$^{TM}$ to the cryoprotectant than after no addition. 21 and 26 mouse pups were born after transfer of blastocyst derived from oocytes vitrified without and with Taxol. The addition of Taxol to vitrification solution greatly promoted post-thaw preimplantation development of ICR morose oocytes.tes.

• 한국분무공학회지
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• 제16권1호
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• pp.1-6
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• 2011

In recent years, the need for more fuel-efficient and lower-emission vehicles has driven the technical development of alternative fuels such as LPG (Liquefied Petroleum Gas) which is able to meet the limits of better emission levels without many modifications to current engine design. LPG has a high vapor pressure and lower viscosity and surface tension than diesel and gasoline fuels. These different fuel characteristics make it difficult to directly apply the conventional gasoline or diesel fuel pump. Self acting lubricated groove design or coating can be used in high-speed and high precision spindle system like a roller-vane type fuel pump, because of its advantages such as low frictional loss, low heat generation, averaging effect leading better running accuracy and simplicity in manufacturing. Those design method can also affect the atomization of fuel from the injector and the formation of fuel film on the intake manifold. In this study, experiments are carried out to get performance characteristics of initial and steady state operation, The characteristics of vane type fuel pump were investigated to access the applicability on LPLi engine.

• Journal of Korean Neurosurgical Society
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• 제30권5호
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• pp.627-632
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• 2001

Hemangioendotheliomas are vascular neoplasms characterized by histologic appearance that are intermediate between hemangiomas and angiosarcomas first described by Weiss and Enzinger in 1982. They are classified into at least 3 subgroups, including epithelioid hemangioendothelioma, spindle cell hemangioendothelioma, and malignant endovascular angioendothelioma, and have been reported principally in soft tissues of the extremities, lung, liver, and bone. The cases involving the central nervous system reported are very rare. We report an intraspinal epithelioid hemangioendothelioma occurring in a 52-year-old man. To our knowledge, it is first case of spinal hemangioendothelioma in Korea.

• 대한기계학회논문집A
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• 제25권8호
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• pp.1173-1182
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• 2001

Recent noticeable advances of CNC machine tools have considerably improved productivity and precision in manufacturing processes. However, in the respect of productivity some defects still remain because selection of machining conditions entirely depends on the experiences of programmers. Usually, machining conditions such as feed rate and spindle speed have been selected conservatively by considering the worst cases, and it has brought the loss of machining efficiency. Thus, the improvement of cutting force controller has been done to regulate cutting force constantly and to maximize feedrate simultaneously in case that machining conditions change variously. In this study, sliding mode control with boundary layer is applied to milling process for cutting force regulation and in a commercial CNC machining center data transfer between PC and PMC (programmable machine controller) of CNC machine is done using a standard interface method. And in the cutting force measurement, an indirect cutting force measuring system using current signal of AC servo is adopted in order not to use high-priced equipment like tool dynamometer. The purpose of this study is to maximize the productivity in milling process, thus its results can be applied to cases such as rough cutting process.

• 한국정밀공학회지
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• 제23권10호
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• pp.113-120
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• 2006

A cam profile CNC grinding machine is developed for manufacture of high precision contoured cams. The developed machine is composed of the high precision spindle using boll bearings, the high stiffness box layer type bed and the three axis CNC controller with the high resolution AC servo motor. In this paper, structural and modal analysis for the developed machine is carried out to check the design criteria of the machine. The analysis is carried out by FEM simulation using the commercial software, CATIA V5. The machine is modeled by placing proper shell and solid finite elements. And also, this paper presents the measurement system and experimental investigation on the modal analysis of a grinding machine. The weak part of the machine is found by the experimental evaluation. The results provide structure modification data for good dynamic behaviors. And safety of the machine was confirmed by the modal analysis of modified machine design. Finally, the cam profile grinding machine was successfully developed.

• 한국기계가공학회지
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• 제15권5호
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• pp.1-7
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• 2016

In the present study, a plastic surface end-milling was implemented to investigate the effects of processing parameters on surface quality. The end milling can be considered an efficient method for rapid prototyping of thermoplastic bio-systems since it exhibits several beneficial functions including short fabrication time and high dimensional accuracy. In this regard, putative biocompatible thermoplastic materials, such as PMMA, PET, and PC, were chosen as workpiece materials. Among the relevant processing parameters influencing the surface quality of the final product, depth of cut, feed rate, and spindle speed were considered in the present study. The roughness of surfaces machined under various conditions was measured to elucidate the effect of each parameter. We found that the cut depth was the most significant factor. Heat generation during machining also had a remarkable effect. From these investigations, an appropriate combination of processing conditions specific to each type of use and end-product could be found. This optimization can be useful in end-milling of thermoplastic bio-systems.

• 한국생산제조학회지
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• 제24권5호
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• pp.502-507
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• 2015

In this study, a microscale drilling process was conducted to evaluate the cutting characteristics of functionally graded materials. A mixture of M2 and Cu powders were formed and sintered to produce disk specimens of various compositions. Subsequently, a microscale hole was created in the specimen by using a desktop-size micro-machining system. By using design of experiments and analysis of variance, it was found that the M2-Cu composition, spindle speed, and the interactions between these two factors had significant effects on the magnitude of cutting forces. However, the influence of feed rate on the cutting force was negligible. A mathematical model was established to predict the cutting force under a wide range of process conditions, and the reliability of the model was confirmed experimentally. In addition, it was observed that increasing the wt% of Cu in an M2-Cu specimen increased the high-frequency amplitude of cutting forces.

• 대한기계학회논문집A
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• 제30권12호
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• pp.1634-1641
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• 2006

High-precision centerless grinding machines are emerging as a means of finishing the outer diameter grinding process required for ferrules, which are widely used as fiber optic connectors. In this study, a sensitivity analysis for structural and thermal characteristics was carried out using a virtual prototype of a centerless grinding machine to realize systematic design technology and performance improvements required to manufacture ferrules. The prototype consisted of a concrete-filled bed, hydrostatic grinding wheel (GW) and regulating wheel (RW) spindle systems, a hydrostatic RW table feed mechanism, a RW swivel mechanism, and on-machine GW and RW dressers. The results of the structural sensitivity analysis illustrated that the vertical stiffness of hydrostatic guideway for the RW table feed system greatly influenced the horizontal loop stiffness, and the results of the thermal sensitivity analysis illustrated that the heat generation rates at hydrostatic bearings and belt pulley greatly influenced the temperature rise of hydrostatic bearings and the deviation of thermal displacement between GW and RW.