• Title/Summary/Keyword: Spinal cord injury

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A Case Report of Complex Korean Medical Treatment for Cervical Spinal Cord Injury and Neurogenic Bladder (한의복합치료 후 호전된 경부척수손상 환자의 사지마비 및 신경인성 방광: 증례보고)

  • Song, Min-Yeong;Jo, Hee-Guen;Kim, Tae-Gwang;Choi, Jin-Bong
    • Journal of Korean Medicine Rehabilitation
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    • v.26 no.3
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    • pp.143-151
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    • 2016
  • A 57-year-old male patient was diagnosed as Incomplete cervical spinal cord injury and Neurogenic bladder after falling accident and suffered from tetraplegia and urinary retention. The patient was hospitalized and treated with Complex Korean Medical treatment such as acupuncture, electro-acupuncture, bee venom pharmacopuncture and herbal medication for 13 weeks. International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) was adopted to evaluate the functional recovery and Korean version of Modified Barthel Index (K-MBI) was adopted to evaluate the recovery of activities of daily living (ADL). After treatment, Total scores of ISNCSCI and K-MBI were improved. Also patient's micturition reflex was recovered and symptoms of neurogenic bladder were improved. This result shows that Korean Medical treatment may be an effective treatment option for spinal cord injury and neurogenic bladder patients. Further clinical studies are needed to clarify the effect of Korean Medical treatment on spinal cord injury.

Effect of Elastic Aids (Bands) on Functional Reach Test in Patients with Spinal Cord Injury: Pilot Study

  • Jong Ho Kang;Tae Sung Park
    • The Journal of Korean Physical Therapy
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    • v.34 no.6
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    • pp.317-320
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    • 2022
  • Purpose: This study aimed: to confirm the balance ability of patients with spinal cord injury in the sitting state through a functional reach test using an elastic aid; and to propose a balance improvement plan. Methods: The study evaluated seven patients with spinal cord injury who could maintain a sitting posture through minimum assistance. A functional reach test was performed before and after wearing an elastic aid while sitting on a chair, and the effects before and after use of the elastic aid were compared and analyzed through a motion analyzer. Results: In the functional reach test, the forward movement distance of the hand was 97.45 mm before wearing the elastic aid, but significantly increased to 131 mm after wearing the aid (p<0.05). Corresponding forward movement distances for the shoulder were 81.26 mm and 113 mm (p<0.05 for the increase). There was no statistically significant change in lateral functional arm extension. Conclusion: It was confirmed, through a functional reach test, that trunk stability in patients with spinal cord injury increased with use of an elastic aid. In future, more efficient rehabilitation treatment programs will be possible if trunk stability in patients with spinal cord injury is improved by using elastic aids, and if various exercise treatments are also included in the rehabilitation programs.

Effects of Oriental Medicinal Drugs on Axonal Regeneration in the Spinal Cord Neurons

  • An Joung-Jo;NamGung Uk;Seo In-Chan;Kim Yoon-Sik
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.6
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    • pp.1640-1646
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    • 2005
  • An oriental medicinal drugs Jahageo (JHG, Hominis placenta) were examined to determine its effects on the responsiveness of central nervous system neurons after injury. We found that JHG was involved in neurite outgrowth of DRG sensory axons. JHG treatment also increased expression of axonal growth-associated protein GAP-43 in DRG sensory neurons after sciatic nerve injury and in the injured spinal cord. JHG treatment during the spinal cord injury increased induction levels of cell division cycle 2 (Cdc2) protein in DRG as well as in the spinal cord. Histochemical investigation showed that induced Cdc2 in the injured spinal cord was found in non-neuronal cells. These results suggest that JHG regulates activities of non-neuronal cells such as oligodendrocyte and astrocyte in responses to spinal cord injury and protects neuronal responsiveness after axonal damage.

High-Level Cervical Spinal Cord Stimulation Used to Treat Intractable Pain Arising from Transverse Myelitis Caused by Schistosomiasis

  • Kim, Jin-Kyung;Hong, Seok-Ho;Lee, Jung-Kyo
    • Journal of Korean Neurosurgical Society
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    • v.47 no.2
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    • pp.151-154
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    • 2010
  • The efficacy of spinal cord stimulation (SCS) for treatment of various chronic painful conditions is well established. Very few reports have documented the use of SCS for treatment of chronic pain after spinal cord injury. We present a case showing a good outcome after such treatment, and suggest that high cervical stimulation may be efficacious. A 53-year-old male underwent SCS on the C1-3 level for treatment of intractable neuropathic pain below the T3 level, and in the upper extremities, arising from spinal cord injury resulting from transverse myelitis caused by schistosomiasis. High cervical SCS significantly improved the pain in the upper extremities and at the T3-T10 dermatome level. The patient continues to report excellent pain relief 9 months later. The present case suggests that high cervical stimulation may improve chronic pain in the upper extremities and the T3-T10 dermatome level arising from spinal cord injury.

Effects of Tumor Necrosis Factor Alpha Blocker Adalimumab in Experimental Spinal Cord Injury

  • Borcek, Alp Ozgun;Civi, Soner;Ocal, Ozgur;Gulbahar, Ozlem
    • Journal of Korean Neurosurgical Society
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    • v.57 no.2
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    • pp.73-76
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    • 2015
  • Objective : Tumor necrosis factor alpha (TNF-${\alpha}$) have proven effects in pathogenesis of neuroinflammation after spinal cord injury (SCI). Current study is designed to evaluate the effects of an anti-TNF-${\alpha}$ agent, adalimumab, on spinal cord clip compression injury in rats. Methods : Thirty two male adult Wistar rats were divided into four groups (sham, trauma, infliximab, and adalimumab groups) and SCI was introduced using an aneurysm clip. Animals in treatment groups received 5 mg/kg subcutaneous adalimumab and infliximab right after the trauma. Malondialdehyde (MDA) levels were studied in traumatized spinal cord tissues 72 hours after the injury as a marker of lipid peroxidation. Results : Animals that received anti-TNF-${\alpha}$ agents are found to have significantly decreased MDA levels. MDA levels were significantly different between the trauma and infliximab groups (p<0.01) and trauma and adalimumab groups (p=0.022). There was no significant difference in neurological evaluation of the rats using Tarlov scale. Conclusion : These results suggest that, like infliximab, adalimumab has favorable effects on lipid peroxidation induced by spinal cord trauma in rats.

Combined Korean Medicine Treatment of Paraplegia Cause by Spinal Cord Infarction: Case Report (척수경색으로 인한 하지마비 환자의 복합한방치료: 증례보고)

  • Jeong, JiHong;Kim, SoonJoong
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.1
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    • pp.175-185
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    • 2021
  • The objective of this study was to purpose korean medicine treatment for paraplegia and hypoesthesia after spinal cord infarction, and report its effectiveness. We treated a 74-year-old male patient diagnosed with spinal cord infarction using various methods, including acupuncture, herbal medication, moxibustion, physical therapy, western medication. We evaluated patient's motor ability using the manual muscle test (MMT), active range of motion (AROM), walking index for spinal cord injury II( WISCI II) and sense ability using International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). After treatment, motor and sense ability of patient was improved after treatment. The MMT, AROM, WISCI II scores and ISNCSCI scores were numerically improved. According to these results, this study suggested effectiveness of combined Korean medical treatment for spinal cord infarction. However, More studies are required in the future.

Psychological Change and Adaptation Process in Patients with Spinal Cord Injury (척수손상환자의 심리변화와 적응과정)

  • Yoon, Hong-Il
    • Journal of Korean Physical Therapy Science
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    • v.4 no.4
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    • pp.529-538
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    • 1997
  • Rehabilitation after spinal cord injury(SCI) is complex process involving an array of adaptation to change in both physical and psychological function. It is generally accepted that psychological disorder and change are sificant psychological problem among the patients with spinal cord injury. The psychological problems that they have are depressor, anxiety, and fear etc. This study was designed to know of psychological state of patients with SCI after injury, such as psychological change and adaptation process, and change of needs.

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Effects of Low and Moderate Intensity Treadmill Exercise on Functional Recovery and Histological Changes After Spinal Cord Injury in the Rats (척수손상 백서모델에서 저강도 및 중강도 트레드밀 운동이 운동기능회복 및 조직학적 변화에 미치는 영향)

  • Kim, Gi-Do;Kim, Gye-Yeop;Kim, Eun-Jung
    • Physical Therapy Korea
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    • v.16 no.2
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    • pp.41-49
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    • 2009
  • This study was designed to investigate the effects of treadmill exercise of low-intensity and moderate- intensity on the functional recovery and histological change in spinal cord injury (SCI) rats. SCI was induced by the spinal cord impactor dropped after laminectomy. Experimental groups were divided into the Group I (normal control), Group II (non-treatment after SCI induction), Group III (low-intensity treadmill exercise after SCI induction), Group IV (moderate-intensity treadmill exercise after SCI induction). After operation, rats were tested at modified Tarlov scale at 2 days with divided into 4 groups, and motor behavior test (BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in spinal cord, histopathological studies were performed at 21 days by H & E, and BDNF(brain-derived neutrophic factor) & Trk-b immunohistochemistry studies were performed at 1, 3, 7, 14, 21 days. According to the results, treadmill exercise can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, moderate-intensity treadmill exercise after SCI induction was most improvement in functional recovery and histological change.

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Improved Regenerative Responses of Injured Spinal Cord Nerve Fibers by the Treatment of Sukjihwang(Rehmanniae radix preparat)

  • Han, Kyu-Sul;Seol, In-Chan;Ryu, Ho-Ryong;Jo, Hyun-Kyung;An, Jung-Jo;NamGung, Uk;Kim, Yoon-Sik
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.6
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    • pp.1569-1575
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    • 2007
  • In oriental medicine, Sukjihwang (SJH, Rehmanniae radix preparat) has been used as one of the key ingredients for the prescription of several herbal decoctions and applied clinically for the treatment of several diseases including nervous system and cardiovascular disease. Here, possible growth-promoting effects of SJH on injured spinal cord axons were investigated in the rats. SJH administration increased levels of active form of ERK1/2 protein and Cdc2 proteins in the injured spinal cord tissue. Anterograde DiI-tracing of corticospinal tract axons showed that SJH-treatment enhanced axonal arborization in the injury area and extensive axonal extension into the caudal area. In SJH-treated group, glial scar formed after spinal cord injury was confined in a smaller area compared to the control group, and the trabecula structure was well observed within the injury cavity. Furthermore, increased proliferation and migration of astrocytes in the injury cavity were observed by SJH treatment. Thus, these present data provide a biological evidence on potential importance of SJH therapy for the treatment of injured spinal cord.

Effects of Hominis Placenta Pharmacopuncture and Electroacupuncture Neuroprotection in Contused Spinal Cord of Rats (척수손상 흰쥐에서 자하거 약침과 침전기 자극이 신경성장인자 발현에 미치는 영향)

  • Kim, Eun-Jung;Kim, Gye-Yeop
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.2
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    • pp.257-263
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    • 2011
  • This study was designed to investigate the effects of Hominis placenta pharmacopuncture treatment and electroacupuncture therapy on the functional recovery and histological change, protein expression in spinal cord injury(SCI) rats. Experimental groups were divided into the Group I(normal control rat), Group II(Non-treatment after spinal cord injury induction), Group III(Hominis placenta pharmacopuncture treatment after SCI induction), Group IV (Electroacupuncture therapy after SCI induction), Group V(Hominis placenta pharmacopuncture treatment and electroacupuncture therapy after SCI induction). After operation, rats were tested at modified Tarlov test at 1 to 3 days with divided into 4 groups, and motor behavior test(BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in muscle and spinal cord, histopathological studies were performed at 21 days by H & E stain, and BDNF & NT-3 protein expression studies were performed at 21 days. Acco rding to the results, Hominis placenta pharmacopuncture treatment and electroacupuncture therapy can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, Hominis placenta pharmacopuncture treatment and electroacupuncture combimed therapy after SCI induction was most improvement in functional recovery, BDNF, and NT-3 protein synthesis.