• Title/Summary/Keyword: Spi- (sensitive to P2 interference) selection

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A Collaborative Validation Study for the Gpt Delta Mouse Using N-propyl-N-nitrosourea, Diethylnitrosamine, Mitomycin C and Chlorambucil: A Summary Report of the Third Collaborative Study of the Transgenic Mouse Mutation Assay by JEMS/MMS

  • Yajima, Nobuhiro;Hyogo, Atsushi;Tamura, Hironobu;Nakajima, Madoka;Nohmi, Takehiko
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.109-110
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    • 2003

  • To validate a novel mouse model, gpt delta, for in vivo mutagenesis, the Mammalian Mutagenesis Society (MMS), a subgroup of the Environmental Mutagen Society of Japan (JEMS) (JEMS/MMS), performed a collaborative study as the third trial for transgenic animal assay. In this mouse model, point mutations and deletions re separately identified by gpt (6-thioguanine-resistant) and Spi- (sensitive to P2 interference) selections, respectively.(omitted)

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