• Food preservation and processing industry
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• v.6 no.1
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• pp.31-38
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• 2007

매실의 생리활성을 검정하여 신약개발 이나 건강기능성 식품 개발의 기초 자료 제공을 목적으로 실험한 결과는 아래와 같다. 1) methanol, water, hexane, ethylacetate 및 ether 추출물의 항균활성 검색 결과 methanol에서 가장 크게 나타났고, hexane과 ether에서는 유의적인 활성이 나타나지 않았다. 2) 품종별 차이는 적은 반면 수확시기가 늦어짐에 따라 항균활성이 증가함을 확인할 수 있었다. 3. 용매에 따른 전자공여능은 methanol > ethylacetate > water > ether > hexane 순으로 높게 나타났으며 품종간의 차이는 크지 않았다. 4) 매실 methanol 추출물을 silica gel column chromatography와 HPLC등을 이용해서 분리, 정제하였고 LC-Mass spectrum분석 결과를 LC-Mass에 내장된 Wiley Database와 비교한 결과 dl-Malic disodium salt 로 추정되었다.

• Journal of Korea Society of Digital Industry and Information Management
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• v.15 no.2
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• pp.19-28
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• 2019

The purpose of this study is to examine the trends on machine learning and deep learning research in the published journals from the Web of Science Database. To achieve the study purpose, we used the abstracts of 20,664 articles published between 1990 and 2017, which include the word 'machine learning', 'deep learning', and 'artificial neural network' in their titles. Twenty major research topics were identified from topic modeling analysis and they were inclusive of classification accuracy, machine learning, optimization problem, time series model, temperature flow, engine variable, neuron layer, spectrum sample, image feature, strength property, extreme machine learning, control system, energy power, cancer patient, descriptor compound, fault diagnosis, soil map, concentration removal, protein gene, and job problem. The analysis of the time-series linear regression showed that all identified topics in machine learning research were 'hot' ones.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3378-3384
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• 2015

The problem of fast search for raman spectrum has attracted much attention recently. By far the most simple and widely used method is to calculate and compare the Euclidean distance between the given spectrum and the spectra in a database. But it is non-trivial problem because of the inherent high dimensionality of the data. One of the most serious problems is the high computational complexity of searching for the closet codeword. To overcome this problem, The fast codeword search algorithm based on the mean pyramids of codewords is currently used in image coding applications. In this paper, we present three new methods for the fast algorithm to search for the closet codeword. the proposed algorithm uses two significant features of a vector, mean values and variance, to reject many unlikely codewords and save a great deal of computation time. The Experiment results show about 42.8-55.2% performance improvement for the 1DMPS+PDS. The results obtained confirm the effectiveness of the proposed algorithm.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.1
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• pp.52-62
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• 2017

Objectives The purpose of this study is to review pre-existing clinical practice guidelines for autism spectrum disorders, and refer those in developing a new practice guideline. Methods A total of 9 existing clinical practice guidelines for autism spectrum disorder developed from 2010 to 2016 were searched by Google scholar and Pubmed, and were reviewed those literatures in three parts: general, diagnosis & evaluation, and intervention. Results There were no consistency in the recommendation methods of 9 clinical care guidelines (such as the method of rating and recommendation intensity for diagnosis, evaluation, and treatment). However, in the diagnosis and evaluation section, frequently used evaluation and diagnostic tools are mentioned in most clinical practice guidelines, and the types of pharmacologic and non-pharmacological treatments that are mainly recommended in treatment are equally mentioned in most clinical practice guidelines could confirm. Conclusions 1. Some guideline recommendations are graded according to each criterion. Recommendations presented in various databases were based on systematic reviews or other literatures. The most utilized database were PsycINFO, CINAHL, Cochrane. 2. DSM-5 and ICD-10 were the most common used diagnostic criteria, and DSM-IV was used as a diagnostic standard in the guideline published before 2013. The tools used for diagnosis and evaluation were also varied. However, most recommended ones were ADI-R, ADOS-G, and DISCO. 3. Treatment was largely divided into pharmacological intervention and non-pharmacological intervention. In some guideline, the interventions were divided into pediatric and adult. Most of the pharmacological interventions were not recommended due to lack of evidence, but in cases in which specific symptoms were aimed, they recommended to seek professional help. 4. In addition to interventions, each guideline referred to supportive interventions that may be helpful in the daily life of patients with ASD, which may need to be addressed in future clinical guidelines.

• Korean Journal of Healthcare-Associated Infection Control and Prevention
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• v.21 no.2
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• pp.50-56
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• 2016

Background: Alternatives to carbapenem are increasingly needed to decrease the usage of carbapenem. We evaluated the possibility of using non-carbapenem antibiotics against urinary tract infections (UTI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE). Methods: This retrospective study was performed at 2 university hospitals between October 2010 and December 2012. All diagnosed adult cases of ESBL-PE UTI were identified from the microbiological database. The subjects were divided into 3 groups based on the empirical antibiotic classes and susceptibility: carbapenem (C) group, susceptible non-carbapenem (SNC) group, and non-susceptible non-carbapenem (NSNC) group. Results: A total of 84 patients were eligible for analysis. For empirical therapy, 41, 23, and 20 patients were included in the NSNC, SNC, and C empirical groups, respectively. During the empirical therapy, 7 patients (17.1%) in the NSNC group, 18 patients (78.3%) in the SNC group, and 19 patients (78.3%) in the C group experienced clinical improvement. No significant difference was observed between the SNC and C empirical groups (P=0.192). Severe sepsis or shock was the predictor of empirical SNC treatment failure (P=0.048). There was a tendency to use carbapenem as a definite therapy in cases of NSNC. In contrast, empirical SNC was maintained as a definite therapy. Conclusion: SNC could be considered as an alternative to carbapenems for treating ESBL-PE UTI. This strategy might decrease the usage of carbapenem without clinical deterioration. However, it should be noted that SNC therapy may fail in the case of severe sepsis or shock.

• Korean Journal of Mineralogy and Petrology
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• v.36 no.4
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• pp.259-271
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• 2023

Since the short-wave infrared spectrum has a significant range of variation depending on the production environment, countries with advanced resource exploration are collecting the spectrum and building a database. Representative organizations include the USGS and CSIRO, and they are currently carrying out a project in China that can synthesize and use a large number of existing data. The USGS library provides a total of 2,457 spectra targeting not only minerals but also various materials that respond to infrared radiation. Among these, there are 1,276 mineral spectra, which are about half of the total. The spectrum title includes information, such as analysis devices (NIC4, BECK, ASDNG, etc.), purity codes (a, b, c, d, u), and measurement methods (AREF, RREF, RTGC, TRAN). Analyzed raw data are provided in ASCII and GIF format. The CSIRO library has a total of 502 spectra, of which the majority, 493, correspond to mineral spectra. The USGS library is a free, publically available resource, while the CSIRO library is bundled with TSG8 or must be purchased separately. Among these, when comparing the eight spectra whose spectral shapes can be analyzed with the spectra of domestic illite, the positions of the absorption peaks are significantly different from those of domestic illite, except for one Japanese illite. Additional research will be needed to determine the causes of such differences, and the domestically relevant databases should be established as well.

• Journal of Plant Biotechnology
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• v.29 no.3
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• pp.161-170
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• 2002

For the hairy root of Panax ginseng, we have got mass spectrums from MALDI/TOF/MS analysis and Tandem mass spectrums from ESI/Q-TOF/MS analysis. While mass spectrum provides the molecular weights of peptide fragments digested by protease such as trypsin, tandem mass spectrum produces amino acid sequence of digested peptides. Each amino acid sequences can be a query sequence in BLAST search to identify proteins. For the specimens of animals or plants of which genome sequences were known, we can easily identify expressed proteins from mass spectrums with high accuracy. However, for the other specimens such as ginseng, it is difficult to identify proteins with accuracy since all the protein sequences are not available yet. Here we compared the mass spectrums and the peptide amino acid sequences with ginseng expressed sequence tag (EST) DB. The matched EST sequence was used as a query in BLAST search for protein identification. They could offer the correct protein information by the sequence alignment with EST sequences. 90% of peptide sequences of ESI/Q-TOF/MS are matched with EST sequences. Comparing 68% matches of the same sequences with the nr database of NCBI, we got more matches by 22% from ginseng EST sequence search. In case of peptide mass fingerprinting from MALDI/TOF/MS, only about 19% (9 proteins of 47 spots) among peptide matches from nr DB were correlated with ginseng EST DB. From these results, we suggest that amino acid sequencing using tandem mass spectrum analysis may be necessary for protein identification in ginseng proteome analysis.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.3
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• pp.130-139
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• 2016

A frequency of earthquake occurrence in the Republic of Korea is increasing over the past few decades. In this situation, an importance of earthquake prevention comes to the fore because the earthquake does damage to structures and causes severe damage of human life. For the earthquake prevention, a real-time vibration measurement for structures is important. As an example, the United States of America and Japan have already been monitoring real-time earthquake acceleration for the important structures and the measured acceleration data has been managed by forming database. This database could be used for revising the seismic design specifications or predicting the damage caused by earthquake. In Korea, Earthquake Recovery Plans Act and Enforcement Regulations are revised and declared lately. Ministry of Public Safety and Security is constructing a integrated management system for the measured earthquake acceleration data. The purpose of this research is to develop a real-time vibration monitoring and analysis system for structures which links to the integrated management system. The developed system contains not only a monitoring function to show real-time acceleration data but also an analysis system to perform fast fourier transform, to obtain natural frequency and earthquake magnitude, to show response spectrum and power spectrum, and to evaluate structural health. Additionally, this system is designed to be able to link to the integrated management system of Ministry of Public Safety and Security. It is concluded that the developed system can be useful to build a safety management network, minimize maintenance cost of structures, and prevention of the structural damage due to earthquake.

• Earthquakes and Structures
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• v.5 no.2
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• pp.129-142
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• 2013

Linear and nonlinear time history analyses have been becoming more common in seismic analysis and design of structures with advances in computer technology and earthquake engineering. One of the most important issues for such analyses is the selection of appropriate acceleration time histories and matching these histories to a code design acceleration spectrum. In literature, there are three sources of acceleration time histories: artificial records, synthetic records obtained from seismological models and accelerograms recorded in real earthquakes. Because of the increase of the number of strong ground motion database, using and scaling real earthquake records for seismic analysis has been becoming one of the most popular research issues in earthquake engineering. In general, two methods are used for scaling actual earthquake records: scaling in time domain and frequency domain. The objective of this study is twofold: the first is to discuss and summarize basic methodologies and criteria for selecting and scaling ground motion time histories. The second is to analyze scaling results of time domain method according to ASCE 7-05 and Eurocode 8 (1998-1:2004) criteria. Differences between time domain method and frequency domain method are mentioned briefly. The time domain scaling procedure is utilized to scale the available real records obtained from near fault motions and far fault motions to match the proposed elastic design acceleration spectrum given in the Eurocode 8. Why the time domain method is preferred in this study is stated. The best fitted ground motion time histories are selected and these histories are analyzed according to Eurocode 8 (1998-1:2004) and ASCE 7-05 criteria. Also, characteristics of both near fault ground motions and far fault ground motions are presented by the help of figures. Hence, we can compare the effects of near fault ground motions on structures with far fault ground motions' effects.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.7
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• pp.626-634
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• 2015

In the present study, numerical predictions of infrared spectra for $CO_2$ molecule were conducted. Absorption coefficients of $CO_2$ which are required for simulating the spectra, were calculated by using a line-by-line method and by adopting spectroscopic parameters from the radiation databases, HITEMP2010 and CDSD-4000. Simulations were made in the 2.7, 4.3, and $15{\mu}m$ band regions, and the results were compared with the measurements of other researchers. It was found that the calculated results are well matched with the various measurements. However, in the $4.3{\mu}m$ band region, the CDSD-4000 based calculation yields a better fit to the measurement than the HITEMP2010 based calculation does.