• Journal of KIISE:Software and Applications
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• v.33 no.8
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• pp.718-729
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• 2006

There has been increasing interest in automatic term recognition (ATR), which recognizes technical terms for given domain specific texts. ATR is composed of 'term extraction', which extracts candidates of technical terms and 'term selection' which decides whether terms in a term list derived from 'term extraction' are technical terms or not. 'term selection' is a process to rank a term list depending on features of technical term and to find the boundary between technical term and general term. The previous works just use statistical features of terms for 'term selection'. However, there are limitations on effectively selecting technical terms among a term list using the statistical feature. The objective of this paper is to find effective features for 'term selection' by considering various aspects of technical terms. In order to solve the ranking problem, we derive various features of technical terms and combine the features using machine-learning algorithms. For solving the boundary finding problem, we define it as a binary classification problem which classifies a term in a term list into technical term and general term. Experiments show that our method records 78-86% precision and 87%-90% recall in boundary finding, and 89%-92% 11-point precision in ranking. Moreover, our method shows higher performance than the previous work's about 26% in maximum.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1023-1035
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• 2016

The purpose of this study was to investigate the role of colon cancer stem cells (CSCs) during chemically-induced rat multi-step colon carcinogenesis with or without the treatment with a specific cyclooxygenase-2 inhibitor drug (celecoxib). Two experiments were performed, the first, a short term 12 week colon carcinogenesis bioassay in which only surrogate markers for colon cancer, aberrant crypt foci (ACF) lesions, were formed. The other experiment was a medium term colon cancer rat assay in which tumors had developed after 32 weeks. Treatment with celecoxib lowered the numbers of ACF, as well as the tumor volumes and multiplicities after 32 weeks. Immunohistochemical proliferating cell nuclear antigen (PCNA) labeling indexes LI (%) were downregulated after treatment by celecoxib. Also different cell surface antigens known to associate with CSCs such as the epithelial cell adhesion molecule (EpCAM), CD44 and CD133 were compared between the two experiments and showed differential expression patterns depending on the stage of carcinogenesis and treatment with celecoxib. Flow cytometric analysis demonstrated that the numbers of CD133 cells were increased in the colonic epithelium after 12 weeks while those of CD44 but not CD133 cells were increased after 32 weeks. Moreover, aldehyde dehydrogenase-1 activity levels in the colonic epithelium (a known CSC marker) detected by ELISA assay were found down-regulated after 12 weeks, but were up-regulated after 32 weeks. The data have also shown that the protective effect of celecoxib on these specific markers and populations of CSCs and on other molecular processes such as apoptosis targeted by this drug may vary depending on the genetic and phenotypic stages of carcinogenesis. Therefore, uncovering these distinction roles of CSCs during different phases of carcinogenesis and during specific treatment could be useful for targeted therapy.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.517-527
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• 2020

Layer 2/3 pyramidal neurons (L2/3 PyNs) of the cortex extend their basal dendrites near the soma and as apical dendritic tufts in layer 1, which mainly receive feedforward and feedback inputs, respectively. It is suggested that neuromodulators such as serotonin and acetylcholine may regulate the information flow between brain structures depending on the brain state. However, little is known about the dendritic compartment-specific induction of synaptic transmission in single PyNs. Here, we studied layer-specific serotonergic and cholinergic induction of long-term synaptic plasticity in L2/3 PyNs of the agranular insular cortex, a lateral component of the orbitofrontal cortex. Using FM1-43 dye unloading, we verified that local electrical stimulation to layers 1 (L1) and 3 (L3) activated axon terminals mostly located in L1 and perisomatic area (L2/3). Independent and AMPA receptor-mediated excitatory postsynaptic potential was evoked by local electrical stimulation of either L1 or L3. Application of serotonin (5-HT, 10 μM) induced activity-dependent longterm depression (LTD) in L2/3 but not in L1 inputs. LTD induced by 5-HT was blocked by the 5-HT₂ receptor antagonist ketanserin, an NMDA receptor antagonist and by intracellular Ca²⁺ chelation. The 5-HT₂ receptor agonist α-me-5-HT mimicked the LTD induced by 5-HT. However, the application of carbachol induced muscarinic receptor-dependent LTD in both inputs. The differential layer-specific induction of LTD by neuromodulators might play an important role in information processing mechanism of the prefrontal cortex.

• Nuclear Engineering and Technology
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• v.43 no.2
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• pp.149-158
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• 2011

Metal waste generated from the pyroprocessing of 10 MtU of spent fuel was classified by comparing the specific activity of a relevant radionuclide with the limit value of the specific activity specified in the Korean acceptance criteria for a lowand intermediate-level waste repository. A Korean Optimized Fuel Assembly design with a 17${\times}$17 array, an initial enrichment of 4.5 weight-percent, discharge burn-up of 55 GWD/MtU, and a 10-year cooling time was considered. Initially, the mass and volume of each structural component of the assembly were calculated in detail, and a source term analysis was subsequently performed using ORIGEN-S for these components. An activation cross-section library generated by the KENO-VI/ORIGEN-S module was utilized for top-end and bottom-end pieces. As a result, an Inconel grid plate, a SUS plenum spring, a SUS guide tube subpart, SUS top-end and bottom-end pieces, and an Inconel top-end leaf spring were determined to be unacceptable for the Gyeongju low- and intermediate-level waste repository, as these waste products exceeded the acceptance criteria. In contrast, a Zircaloy grid plate and guide tube can be placed in the Gyeongju repository. Non-contaminated Zircaloy cladding occupying 76% of the metal waste was found to have a lower level of specific activity than the limit value. However, Zircaloy cladding contaminated by fission products and actinides during the decladding process of pyroprocessing was revealed to have 52 and 2 times higher specific activity levels than the limit values for alpha and $^{90}Sr$, respectively. Finally, it was found that 88.7% of the metal waste from the 17${\times}$17 Korean Optimized Fuel Assembly design should be disposed of in a deep geological repository. Therefore, it can be summarized that separation technology with a higher decontamination factor for transuranics and strontium should be developed for the efficient management of metal waste resulting from pyroprocessing.

• Hwankyungkyoyuk
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• v.2 no.1
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• pp.107-116
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• 1991

In this study, the goals and the short and long term plan to attain the goals were set up through the analysis of non-government environmental protection organizations actual conditions which were grasped through interview and questionnaire. The goals and the plan were modified and elaborated through 3 times environment experts conferences and a public hearing. The goals were as follows: a) Laying down the guidelines on the organizations. b) Establishing a view of environment. c) Paying a public attention to importance of environment. d) Activations the practice in environmental protection movement. e) Harmonizing the relations between the organizations themselves. government and the organizations, industries and the organizations. f) Establishing the government support system to the organizations in leagal. administrative and financial aspects. g) Enhancing the potentialities on research and development in environmental protection technology. In the short and long term plan, the specific activities to be driven up to the year 2000 were presented by stages.

• Journal of Korean Society for Atmospheric Environment
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• v.12 no.4
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• pp.473-478
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• 1996

Using data observed from 1966 to 1994, long-term trends of visibility at 15:00 in Seoul and Chunchon were analyzed. Annual average visibility in Seoul has been decreased continuously. In particular, annual number of days for visibility more than 15km was remarkably reduced since 1980. Also, the trend of the visibility in Chunchon was similar to that of Seoul. But the variations were small to compare with Seoul. Long-term trends of relative humidity (RH) and specific humidity (q) at 15:00 in Seoul have been slightly decreased. Cumulative frequency distributions of visibility for ranges of RH (0 $\sim 50%, 50 \sim 60%, 60 \sim 70%, 70 \sim 80%, 80 \sim 90%, 90 \sim 100%$) at 15:00 in Seoul and Chunchon were generally decreased during the second period (1984 $\sim$ 1994) as compared with the first period (1973 $\sim$ 1983), except for the range of 90 to 100% RH. Despite of decreasing phenomena of RH, characteristics of urban climates in Seoul, visibility degraded due to an increase of air pollution.

• Environmental Engineering Research
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• v.17 no.2
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• pp.103-110
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• 2012

This study was performed mainly to examine whether a city with a metal industrial presence presents different characteristics in ambient volatile organic compound (VOC) concentrations compared to residential (RES) and commercial/residential combined (CRC) areas of another city by using long-term monitoring data (from January 2006 to February 2009). For most target VOCs, ambient concentrations in the metal-industrialized city were lower than for the RES and CRC areas. Aromatic compounds were the predominant VOC groups for the metal industry city as well as for other land uses. The ambient concentrations of aromatic VOCs were higher in the winter and spring seasons than in the summer and fall seasons, whereas those of chlorinated VOCs did not show any distinctive variations. In addition, higher concentrations were observed during daytime hours. The correlations between the ambient target compounds were statistically significant, except for the correlation between benzene and ozone.

• Journal of Information Technology Applications and Management
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• v.21 no.2
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• pp.149-165
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• 2014

This paper has studied whether cultural factors have an effect on privacy concern of Internet users in Korea and China. The result has shown that power distance, individualism, uncertainty avoidance, and long-term orientation are positively related to privacy concern, while masculinity is negatively related to privacy concern. This study has also found some similarities and differences between the two countries. First, privacy concern of Korean Internet users is significantly higher than that of Chinese users. Second, individualism and uncertainty avoidance significantly affect privacy concern in both Korea and China, although individualism in Korea has stronger effect than that in China. Third, long term orientation has a significant effect in only Korea while power distance is significant only in China. These results suggest that an online company doing businesses in multiple countries should have country-specific privacy policies to deal with the privacy concern of Internet users in different countries.

• Proceedings of the Zoological Society Korea Conference
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• 1995.10b
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• pp.82-82
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• 1995

Regulation of enzyme synthesis by transcriptional and translational control systems provides rather stable adaptation to change of amino acid level in the growth medium, while manipulation of enzyme activity through endproduct feedback inhibition represents rather short-term and reversible ways of adjusting metabolic fluctuation of amino acid level. Various control mechanisms interplay to regulate genes encoding enzymes for amino acid biosynthesis in the yeast, Sacchromyces cerevisiae. When amino acids are in short supply, genes under a cross-pathway regulatory mechanism Or general amino acid control (general control) increase their action, in which Gcn4p is the major positive regulator of gene expression. When cells are cultured in minimal medium, basal level expression is also regulated by supplementary control elements, where inorganic phosphate level is additionally involved. Most of amino acid biosynthetic genes are also regulated by the level of endproduct of the pathway. This pathway-specific regulatory mechanism is called specific amino acid control (specific controD, under which gene expression is reduced when endproduct is present in the medium. Derepression of a gene through general control can be usually overridden by repression through specific control, where the endproduct level of that particular pathway is high and not limiting. In this presentation, regulatory factors for basal level expression and general control of yeast amino acid biosynthesis will be discussed, m addition to pathway-specific repression patterns and interaction between CrOSS- and specific-control mechanisms. Preliminary results are also presented from the investigation of the cloned genes in the threonine biosynthetic pathway of the yeast. yeast.

• Journal of the korean veterinary medical association
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• v.17 no.3
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• pp.47-60
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• 1981

Lymphocytes that secrete antibodies can be made immortal by fusing them with myeloma tumor cells (cell fusion) and cloning the hybrids (hybridomas). Each clone is a long-term source of substantial quantities of a single highly specific antibody (monoclona