• Journal of the Korean Institute of Rural Architecture
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• v.25 no.2
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• pp.9-16
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• 2023

This study attempted to analyze the aspect of seeking a characteristic regeneration of low-rise residential areas through the Urban Regeneration New Deal Project in Seohak-dong Art Village in Jeonju, while the urban regeneration new deal projects are being carried out in various regions, nationwide. Time-series changes in aerial photographs in the study area, age, number of floors, and uses of buildings were examined. The main street structure, lots, and changes in buildings were reviewed, and through this, spatial zones that could extract the unique characteristics of the target area were classified. The characteristics of each area was linked to the proposal of an appropriate regeneration plan through the analysis. This study is meaningful in showing a case of characteristics of low-rise residential areas regeneration plan suitable for the specific region while the number of old low-rise residential areas is increasing.

• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.1036-1044
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• 2023

The combination of MCNP6 and the FISPACT codes was used to predict inventories of radioisotopes produced by neutron exposure of a sample in a research reactor. The detailed MCNP6 model of the Budapest Research Reactor and the specific irradiation geometry of the NAA channel was established, while realistic material cards were specified based on concentrations measured by PGAA and NAA, considering the precursor elements of all significant radioisotopes. The energy- and spatial distributions of the neutron field calculated by MCNP6 were transferred to FISPACT, and the resulting activities were validated against those measured using neutron-irradiated small and bulky targets. This approach is general enough to handle different target materials, shapes, and irradiation conditions. A general agreement within 10% has been achieved. Moreover, the method can also be made applicable to predict the activation properties of the near-vessel concrete of existing nuclear installations or assist in the optimal construction of new nuclear power plant units.

• Journal of the Korean Institute of Rural Architecture
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• v.24 no.4
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• pp.97-106
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• 2022

During the Japanese colonial period, Japan exploited the entire Korean Peninsula and targeted not only cities but also rural areas. The exploitation of rural area was accelerated with the support of Oriental colonization Company and The countryside was a living scene of direct exploitation. However, most of the research was concentrated in representative port cities such as Kunsan, which transports logistics such as rice and grains. There was insufficient research on how Japanese entered the country, how Korean were plundered, and the rural villages that were the target of exploitation. The contents of hi-exploitation were also historical and historical humanities such as colonial land ownership and farm management, and the spatial structure of the existing traditional villages were insufficiently investigated. Hwaho-ri, Shin Taein-eup, Jeollabuk-do, centered on Yongseo Village, there are many traces of farm houses, hospitals, employee residences, schools, churches, and Oriental colonization Company This study aims to study what changes traditional rural villages have brought by the Japanese colonial rule, centering on Hwaho-ri Village.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1528-1539
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• 2023

Since the leakage of sodium in an SFR (sodium-cooled fast reactor) causes an explosion upon reaction with air and water, sodium leakages represent an important safety issue. In this study, a novel technique for improving the reliability of sodium leakage detection applying DDVR (dynamic data validation and reconciliation) is proposed and verified to resolve this technical issue. DDVR is an approach that aims to improve the accuracy of a target system in a dynamic state by minimizing random errors, such as from the uncertainty of instruments and the surrounding environment, and by eliminating gross errors, such as instrument failure, miscalibration, or aging, using the spatial redundancy of measurements in a physical model and the reliability information of the instruments. DDVR also makes it possible to estimate the state of unmeasured points. To validate this approach for supporting sodium leakage detection, this study applies experimental data from a sodium leakage detection experiment performed by the Korea Atomic Energy Research Institute. The validation results show that the reliability of sodium leakage detection is improved by cooperation between DDVR and hardware measurements. Based on these findings, technology integrating software and hardware approaches is suggested to improve the reliability of sodium leakage detection by presenting the expected true state of the system.

• Geomechanics and Engineering
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• v.34 no.1
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• pp.29-41
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• 2023

The 3D geospatial modeling of geotechnical information can aid in understanding the geotechnical characteristic values of the continuous subsurface at construction sites. In this study, a geostatistical optimization model for the three-dimensional (3D) mapping of subsurface stratification and the SPT-N value based on a trial-and-error rule was developed and applied to a dam emergency spillway site in South Korea. Geospatial database development for a geotechnical investigation, reconstitution of the target grid volume, and detection of outliers in the borehole dataset were implemented prior to the 3D modeling. For the site-specific subsurface stratification of the engineering geo-layer, we developed an integration method for the borehole and geophysical survey datasets based on the geostatistical optimization procedure of ordinary kriging and sequential Gaussian simulation (SGS) by comparing their cross-validation-based prediction residuals. We also developed an optimization technique based on SGS for estimating the 3D geometry of the SPT-N value. This method involves quantitatively testing the reliability of SGS and selecting the realizations with a high estimation accuracy. Boring tests were performed for validation, and the proposed method yielded more accurate prediction results and reproduced the spatial distribution of geotechnical information more effectively than the conventional geostatistical approach.

• Mass Spectrometry Letters
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• v.14 no.4
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• pp.147-152
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• 2023

The increasing demand for two-dimensional imaging analysis using optical or electronic microscopic techniques has led to an increase in the use of simple one-dimensional and two-dimensional mass spectrometry imaging. Among these imaging methods, secondary-ion mass spectrometry (SIMS) has the best spatial resolution using a primary ion beam with a relatively insignificant beam diameter. Until recently, SIMS, which uses high-energy primary ion beams, has not been used to analyze molecules. However, owing to the development of cluster ion beams, it has been actively used to analyze various organic molecules from the surface. Researchers and commercial SIMS companies are developing cluster ion beams to analyze biological samples, including amino acids, peptides, and proteins. In this study, a water droplet ion beam for surface analysis was realized. Water droplets ions were generated via electrospraying in a vacuum without desolvation. The generated ions were accelerated at an energy of 10 keV and collided with the target sample, and secondary ion mass spectra were obtained for the generated ions using ToF-SIMS. Thus, the proposed water droplet ion-beam device showed potential applicability as a primary ion beam in SIMS.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.281-290
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• 2024

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis owing to its desmoplastic stroma. Therefore, therapeutic strategies targeting this tumor stroma should be developed. In this study, we describe the heterogeneity of cancer-associated fibroblasts (CAFs) and their diverse roles in the progression, immune evasion, and resistance to treatment of PDAC. We subclassified the spatial distribution and functional activity of CAFs to highlight their effects on prognosis and drug delivery. Extracellular matrix components such as collagen and hyaluronan are described for their roles in tumor behavior and treatment outcomes, implying their potential as therapeutic targets. We also discussed the roles of extracellular matrix (ECM) including matrix metalloproteinases and tissue inhibitors in PDAC progression. Finally, we explored the role of the adaptive and innate immune systems in shaping the PDAC microenvironment and potential therapeutic strategies, with a focus on immune cell subsets, cytokines, and immunosuppressive mechanisms. These insights provide a comprehensive understanding of PDAC and pave the way for the development of prognostic markers and therapeutic interventions.

• Anatomy and Cell Biology
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• v.55 no.4
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• pp.507-511
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• 2022

A three-dimensional (3D) segmentation and model reconstruction is a specialized tool to reveal spatial interrelationship between multiple internal organs by generating images without overlapping structures. This technique can also be applicable to mummy studies, but related reports have so far been very rare. In this study, we applied 3D segmentation and model reconstruction to computed tomography images of a Korean mummy with congenital diaphragmatic hernia. As originally revealed by the autopsy in 2013, the current 3D reconstruction reveals that the mummy's heart is shifted to the left due to the liver pushing up to thoracic cavity thorough diaphragmatic hernial defect. We can generate 3D images by calling up the data exclusively from mummy's target organs, thus minimizing the confusion of diagnosis that could be caused by overlapping organs.

• Progress in Medical Physics
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• v.26 no.1
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• pp.28-35
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• 2015

In this study, we investigated the effects of an iterative reconstruction algorithm and an automatic exposure control (AEC) technique on image quality and radiation dose through phantom experiments with coronary computed tomography (CT) angiography protocols. We scanned the AAPM CT performance phantom using 320 multi-detector-row CT. At the tube voltages of 80, 100, and 120 kVp, the scanning was repeated with two settings of the AEC technique, i.e., with the target standard deviations (SD) values of 33 (the higher tube current) and 44 (the lower tube current). The scanned projection data were reconstructed also in two ways, with the filtered back projection (FBP) and with the iterative reconstruction technique (AIDR-3D). The image quality was evaluated quantitatively with the noise standard deviation, modulation transfer function, and the contrast to noise ratio (CNR). More specifically, we analyzed the influences of selection of a tube voltage and a reconstruction algorithm on tube current modulation and consequently on radiation dose. Reduction of image noise by the iterative reconstruction algorithm compared with the FBP was revealed eminently, especially with the lower tube current protocols, i.e., it was decreased by 46% and 38%, when the AEC was established with the lower dose (the target SD=44) and the higher dose (the target SD=33), respectively. As a side effect of iterative reconstruction, the spatial resolution was decreased by a degree that could not mar the remarkable gains in terms of noise reduction. Consequently, if coronary CT angiogprahy is scanned and reconstructed using both the automatic exposure control and iterative reconstruction techniques, it is anticipated that, in comparison with a conventional acquisition method, image noise can be reduced significantly with slight decrease in spatial resolution, implying clinical advantages of radiation dose reduction, still being faithful to the ALARA principle.

• Journal of Korea Water Resources Association
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• v.55 no.12
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• pp.1041-1052
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• 2022

This study is to estimate the optimal ecological flow and analysis the spatial distribution of fish habitat for Andong dam downstream reach (4,565.7 km²) using PHABSIM (Physical Habiat Simulation System) and River2D. To establish habitat models, the cross-section informations and hydraulic input data were collected uisng the Nakdong river basic plan report. The establishment range of PHABSIM was set up about 410.0 m from Gudam streamflow gauging station (GD) and about 6.0 km including GD for River2D. To select representative fish species and construct HSI (Habitat Suitability Index), the fish survey was performed at Pungji bridge where showed well the physical characteristics of target stream located downstream of GD. As a result of the fish survey, Zacco platypus was showed highly relative abundance resulting in selecting as the representative fish species, and HSI was constructed using physical habitat characteristics of the Zacco platypus. The optimal range of HSI was 0.3~0.5 m/s at the velocity suitability index, 0.4~0.6 m at the depth suitability index, and the substrate was sand to fine gravel. As a result of estimating the optimal ecological flow by applying HSI to PHABSIM, the optimal ecological flow for target stream was 20.0 m³/sec. As a result of analysis two-dimensional spatial analysis of fish habitat using River2D, WUA (Weighted Usable Area) was estimated 107,392.0 m²/1000 m under the ecological flow condition and it showed the fish habitat was secured throughout the target stream compared with Q₃₅₅ condition.