• Journal of Korean Biological Nursing Science
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• 제18권4호
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• pp.274-279
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• 2016

Purpose: Adolescents who experienced the alcohol consumption have gradually increased. Adolescence is a critical period of the neural plasticity in the brain. Neural plasticity is mediated by neurotrophins and has an impact on cognitive function. Environmental enrichment ameliorates the cognitive function and increases neurotrophins. Thus, we investigated the neuroprotective effect of environmental enrichment on ethanol induced cognitive impairment in adolescent rats. Methods: The ethanol groups and the controls groups were injected with ethanol (0.5g/kg) and phosphate buffered saline, respectively, through intraperitoneal from 28th day of birth for 11 days. The environmental enrichment groups were provided larger cages containing toys than the standard cage. Passive avoidance test and Y-maze test were performed to evaluate the spatial memory. Results: Environmental enrichment+ethanol group showed higher alterations than the standard environment+ethanol group in Y-maze test (p<.05). In hippocampus, The environmental enrichment+ethanol group showed significantly higher level of the number of c-fos positive celsl and density of tropomyosin receptors kinase B receptor than the standard environment+ethanol group (p<.05). Conclusion: So, we suggested that the environmental enrichment played a role as a prophylaxis for prevention of memory impairment induced by ethanol exposure in adolescence.

• 한국전자통신학회논문지
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• 제10권7호
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• pp.769-774
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• 2015

사물인터넷의 하부 구조로 센서네트워크는 네트워크의 신뢰성이 중요한 이슈이다. 센서네트워크의 각 노드는 제한된 메모리와 파워로 인해 데이터의 신뢰성을 향상시켜야 한다. 본 연구에서는 센서 노드가 생성한 데이터를 이웃 노드에 복제하는 기법을 제안한다. 네트워크의 신뢰성을 향상시키기 위해서 주변 노드의 메모리 및 파워 잔량이 높은 노드에 사본을 저장하는데 1 홉 이상의 노드들에도 저장하여 공간적인 재해에도 대비한다. 실험을 통해 적절한 사본을 유지하는 것은 네트워크의 수명에 부정적인 영향을 미치지 않으면서도 사물인터넷의 신뢰성을 향상시킴을 확인하였다.

• 한국조경학회지
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• 제32권5호
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• pp.129-138
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• 2004

Cherishing the dead is based in sadness. Designing a memorial space therefore has an inherent challenge to evoke the feeling that is so personal and varied by providing a physical space. The tendency of memorials, especially in the US after the mid 20th century, has been to emphasis each dead individual, as seen at the Vietnam Veterans Memorial in Washington, D. C., the Oklahoma City National Memorial in Oklahoma City, and so forth. In the process of designing the memorial of the Taiwanese Chi-chi earth-quake, Cheng Kim Park Robidoux tried to set up a series of spaces through which not only the relatives of the dead but also unrelated visitors could have their own spatial experiences, private rituals and public events, so that they can finally build up a collective memory. Sky-Well consists of a large bamboo forest enclosing a void. Without a particular entrance and guiding system, visitors stroll and get lost in the bamboo forest before they find the central void. The horror they experienced during the earthquake is melted down into the motion and phenomenology of the bamboo forest whereas the central void is reinterpreted as an empty mind, where people find solace from the sky. Details, such as the bamboo wall to place commemorative flowers and lotus blossom paving, are echoing the theme of rebirth.

• Biomolecules & Therapeutics
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• 제14권2호
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• pp.75-82
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• 2006

Synaptic plasticity, which is a long lasting change in synaptic efficacy, underlies many neural processes like learning and memory. It has long been acknowledged that new protein synthesis is essential for both the expression of synaptic plasticity and memory formation and storage. Most of the research interests in this field have focused on the events regulating transcriptional activation of gene expression from the cell body and nucleus. Considering extremely differentiated structural feature of a neuron in CNS, a neuron should meet a formidable task to overcome spatial and temporal restraints to deliver newly synthesized proteins to specific activated synapses among thousands of others, which are sometimes several millimeters away from the cell body. Recent advances in synaptic neurobiology has found that almost all the machinery required for the new protein translation are localized inside or at least in the vicinity of postsynaptic compartments. These findings led to the hypothesis that dormant mRNAs are translationally activated locally at the activated synapse, which may enable rapid and delicate control of new protein synthesis at activated synapses. In this review, we will describe the mechanism of local translational control at activated synapses focusing on the role of cytoplasmic polyadenylation of dormant mRNAs.

• 한국전자파학회논문지
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• 제13권2호
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• pp.217-224
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• 2002

FDTD 해석법에서 공간적 셀의 크기는 해석의 정확도를 결정하는 중요한 요소이다. 하지만 정확도를 향상시키기 위하여 진의 크기를 줄이게 되면, 해석시간과 기억용량의 증가를 초래하게 되는데 서브 그리딩을 사용하여 이를 해결할 수 있다. 본 논문에서는 관심영역만 세밀하게 해석할 수 있는 3차원 서브 그리딩법을 기술하고 이를 응용하여 몇 가지의 구조를 해석하였다. 제안한 방범의 타당성을 화인하기 위하여 균일 그리딩과 서브 그리딩을 적용하여 특성을 해석하고 그 격과를 비교하였다. 제안한 방법을 사용하였을 경우 동일한 정확도에서 균일 그리딩에 비하여 6배의 해석시간의 줄었고 기억용량은 2.5배 정도 줄어들었다.

• 한국통신학회논문지
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• 제16권6호
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• pp.545-555
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• 1991

본 논문에서는 단층 퍼센트론 모델의 학습기능과 신경회로망 형성메모리의 오류정정 능력이 서로 보완적으로 결합된 새로운 적응 패턴인식 시스템의 광학적구현을 실현하였다. 여기서, 단층 퍼센트론 모델은 2차원 LCTV 공간 광변조기를 이용하여 편광인코딩방법과 비전형 양자화 방법으로 구현하였으며, Hopfield 연장메모리는 2차원 모델로 황장하고multifocus holoens를 이용하여 광학적으로 구현하였다. 아리비아 숫자 짝.홀수 판별에 고나한 광학적 실험 결과, 오류 및 부분 입력에 대한 정확한 패턴 분류가 됨을 확인함으로서, 본 논문에서 제시한 새로운 적응 광 패턴인식 시스템이 실제로 영상처리, 패턴인식 등의 분야에서 그 응용 가능성을 제시하였다.

• 한국인터넷방송통신학회논문지
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• 제19권2호
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• pp.127-133
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• 2019

지금까지의 빈발 항목 추출에서는 FP-Tree에 대한 순회와 패턴의 탐색이 필수적인 과정이기 때문에 마이닝 데이터를 트리에 저장하는데 공간이 필요하고 탐색하는데 CPU시간이 필요하기 마련이다. 이러한 단점을 극복하기 위하여 본 논문에서는 조건부 FP-Tree의 의존하지 않고 트랜잭션 데이터의 각 항목들의 위치 정보를 부여하여 트랜잭션 데이터를 2차원의 위치정보 Look-Up테이블로 변환하여 시간과 공간적인 접근성을 용이하게 한다. 또한 항목과 항목의 위치에 대한 매핑배열을 병행하여 시간 복잡도를 줄이는 방법을 고려하는 알고리즘을 제안한다. 실험 결과를 통하여 제안된 방법은 FIMI 저장소 웹 사이트에서 얻은 데이터 세트를 기반으로 많은 실행 시간과 메모리 사용을 줄일 수 있음을 보였다.

• Journal of Korean Biological Nursing Science
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• 제24권2호
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• pp.77-85
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• 2022

Purpose: Aging process comes with cognitive impairment due to decreased neuronal cell number, activity, and neuronal circuit. Alteration of inhibitory neurons contributes to cognitive impairment in normal aging and is responsible for disrupting the excitation/inhibition balance by reducing the synthesis of gamma-aminobutyric acid (GABA). Morus nigra (Mulberry) is a natural physiologically active substance that has been proven to have anti-oxidant, anti-diabetic, and anti-inflammatory effects through many studies. This study aimed to evaluate the effects of the mulberry extract (ME) on cognitive function through anti-oxidant enzyme and GABAergic neuronal activity in aged rat brain. Methods: Sprague Dawley rats were randomly assigned as the young group (8 weeks, n= 8), aging group (67 weeks, n= 8), and aging+ mulberry extract group (67 weeks, n= 8). The aging+ mulberry extract group was orally administered 500 mg/kg/d mulberry extract for 6 weeks. Results: The aging+ mulberry extract group improved spatial and short-term memory. The antioxidant potential of ME increased the expression of superoxide dismutase-1 (SOD-1) and decreased inducible nitric oxide synthase (iNOS). Also, the aging+ mulberry extract group significantly increased the expression of GABAergic interneuron in hippocampus cornu ammonis1 (CA1) compared to the aging group. Conclusion: The number of GABAergic inhibitory interneurons was deceased and memory functions in the aging process, but those symptoms were improved and restored by mulberry extract administration.

• Journal of Information Processing Systems
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• 제18권1호
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• pp.97-114
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• 2022

Interest is increasing in electrocardiogram (ECG) signal analysis for embedded devices, creating the need to develop an algorithm suitable for a low-power, low-memory embedded device. Linear approximation of the ECG signal facilitates the detection of fiducial points by expressing the signal as a small number of vertices. However, dynamic programming, a global optimization method used for linear approximation, has the disadvantage of high complexity using memoization. In this paper, the calculation area and memory usage are improved using a linear approximated template. The proposed algorithm reduces the calculation area required for dynamic programming through local optimization around the vertices of the template. In addition, it minimizes the storage space required by expressing the time information using the error from the vertices of the template, which is more compact than the time difference between vertices. When the length of the signal is L, the number of vertices is N, and the margin tolerance is M, the spatial complexity improves from O(NL) to O(NM). In our experiment, the linear approximation processing time was 12.45 times faster, from 18.18 ms to 1.46 ms on average, for each beat. The quality distribution of the percentage root mean square difference confirms that the proposed algorithm is a stable approximation.

• The Korean Journal of Pain
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• 제35권3호
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• pp.261-270
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• 2022

Background: The rostral ventromedial medulla (RVM) is a critical region for the management of nociception. The RVM is also involved in learning and memory processes due to its relationship with the hippocampus. The purpose of the present study was to investigate the molecular mechanisms behind orexin-A signaling in the RVM and hippocampus's effects on capsaicin-induced pulpal nociception and cognitive impairments in rats. Methods: Capsaicin (100 g) was applied intradentally to male Wistar rats to induce inflammatory pulpal nociception. Orexin-A and an orexin-1 receptor antagonist (SB-334867) were then microinjected into the RVM. Immunoblotting and immunofluorescence staining were used to check the levels of cyclooxygenase-2 (COX-2) and brain-derived neurotrophic factor (BDNF) in the RVM and hippocampus. Results: Interdental capsaicin treatment resulted in nociceptive responses as well as a reduction in spatial learning and memory. Additionally, it resulted in decreased BDNF and increased COX-2 expression levels. Orexin-A administration (50 pmol/1 µL/rat) could reverse such molecular changes. SB-334867 microinjection (80 nM/1 µL/rat) suppressed orexin's effects. Conclusions: Orexin-A signaling in the RVM and hippocampus modulates capsaicin-induced pulpal nociception in male rats by increasing BDNF expression and decreasing COX-2 expression.