• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.457-463
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• 2004

Schizencephaly is a form of the porencephaly in which there is a cystic cavity in the cerebral hemispheres. Schizencephaly is a congenital disease which consist of clefts that extend through the entire hemisphere from the ependymal lining of the lateral ventricles to the pial covering of the cortex. The etiology and the pathogenesis of this malady are not clearly estalilished. Typical symtoms is seizures, mental retardation, spastic tetraplegia and blindness. A case of schizencephaly which was treated through methods of the Oriental Medicine, and that met with good results, is reported.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.11a
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• pp.34-35
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• 1993

Glycine은 GABA와 함께 뇌에 작용하는 중요한 억제성 신경전달 물질이다. GABA가 대뇌등에서 중요한 역할을 하는 반면, GLYCINE은 연수, 척수, 간뇌에 특히 다량 존재한다. GLYCINE은 GLYCINE RECEPTOR에 작용하여 수용체와 연결된 chloride channel의 conductance를 증가시킴으로써 target세포의 활성을 억제한다. 그러므로, glycine의 신경전달체계에 이상이 오면 spastic mouse등에서 볼수 있는 것처럼 neuromuscular disorder가 유발된다. 신경전달 물질은 presynaptic 세포에 자극이 오면 synaptic cleft로 분비가 된후 presynaptic이나 Postsynaptic 세포에 위치한 수용체에 작용하여 생리 활성을 나타내거나, 분해효소에 의해서 생리활성이 없는 물질로 바뀌든지, presynaptic cell에 위치한 transporter(수송체)에 의해서 presynaptic 세포로 reuptake되서 cycle를 끝낸다. Glycine의 경우는 synaptic cleft로 분비된 후 glycine transporter에 의해서 reuptake된다. 그러므로 glycine transporter의 활성 정도는 sysnapse내의 glycine의 농도를 조절하며 더 나아가 glycine이 glycine receptor에 작용하는 시간에 영향을 줌으로써 target 세포의 활성정도를 결정한다.

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.86-86
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• 1996

연축성 발성장애(spasmodic dysphonia)는 아직까지 그 원인을 정확히 밝혀내지 못하고 있는 만성적인 발성장애로 과거에는 경직성 발성장애(spastic dysphonia)로 불리던 질환이다. 연축성 발성장애는 두 종류 즉, 내전형(adductor)과 외전형(abductor)으로 나누어지며 이중 내전형이 대부분이다. 외전형 연축성 발성장애는 발성도중에 성대가 갑자기 불수의적으로 외전되면서 음성이 중단되므로 원활히 대화하기가 힘든 질환이다. 이러한 질환은 국소적 근긴장이상(fecal dystonia)의 일종이다. 현재까지 연축성 발성장애의 치료법으로 사용되고 있는 것으로는 언어치료, botulium 독소주입술, 편측반회후두신경절 단술, 반회후두신경분쇄술, 상후두신경절단술, 갑상연골성형술, implantable stimulator 등이 있다. 연축성 발성장애 환자에 $Botox^{circledR}$ 주입에 관한 보고는 주로 내전형에 대해서만 보고되고 있으며 외전형에 대하여 보고된 예는 매우 적다. (중략)

• The Journal of Korean Physical Therapy
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• v.23 no.6
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• pp.55-59
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• 2011

Purpose: The aims of this study were to assess the degrees of foot abnormalities by comparing foot abnormalities after stroke using the FPI, and to investigate the relationship between the FPI and spasticity. Methods: 33 hemiplegic patients (patient group) and 39 healthy subjects (control group) were evaluated foot posture by the FPI. Spasticity in patient group was measured by the MAS. And the relationship between Foot posture and spasticity in patients group were investigated. Results: Hemiplegic feet in patients were supinated feet compare with non-hemiplegic feet in hemiplegic patients and the foot in control group. The degree of spasticity affected foot posture. Conclusion: Foot posture is related to stroke impairments, stroke patients with more severe spasticity have more severe foot abnormalities as supinated foot.

• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.349-350
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• 2012

본 연구에서는 경첩 발목 보조기(Hinged Ankle Foot Orthoses, HAFO)의 착용이 경직성 뇌성마비 아동의 보행 시 신체 질량 중심점(Center of Mass, COM)에 미치는 영향을 알아보고자 한다. 실험은 보조 기구의 사용 없이 독립적인 보행이 가능한 경직성 뇌성마비 아동(하지마비 아동 8명, 편마비 아동 5명) 13명이 참여하였다. 34개의 적외선 반사 마커를 신체에 직접 부착한 뒤, 6대의 동작분석 카메라로 맨발 보행과 HAFO착용 보행을 각 5회 촬영하였다. 전-후방, 내-외측, 수직 방향으로의 COM의 이동과 COM 속도를 계산하여 HAFO착용 전 후를 대응표본 T검정으로 분석하였다. HAFO 착용은 양하지 마비 아동 그룹은 COM의 전방 이동이 유의하게 증가하였고(p<0.01), COM 속도는 내-외측과 수직 방향에서 유의하게 증가하였다(p<0.01). 반면 편마비 아동 그룹은 COM 이동과 속도가 모든 방향에서 유의하게 증가하였다(p<0.01). 따라서 HAFO는 뇌성마비 아동의 보행 기능을 개선시킨다고 할 수 있다.

• The Korean Journal of Pain
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• v.6 no.2
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• pp.261-264
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• 1993

A 26 year old male patient had admitted to the department of plastic surgery for the treatment of skin defect of forearm and spastic contracture of right hand, attributable to burn injury following carbon monoxide intoxication. After receiving skin graft the patients tenotomy of flexor tendons, the patients was consulted to pain clinic for further evaluation and treatment of allodynia, hyperalgesia, and hyperpathia with marked emotional insufficiency. The patient was treated with stellate ganglion blocks, intermittent or continuous epidural blocks, and intermittent brachial plexus blocks for 3 months. with this treatment the patient's pain level improved to(VAS 10 to 4~5) and was discharged. The patient was readmitted 3 months later, due to the aggrzvation of pain. Brachial plexus blocks were given again by interscalene, supraclavicular, or axillary route, sometimes using a catheter, together with cervical epidural blocks. Tricyclic antidepressant was also prescribed. The results were remarkably good(VAS 2~3) and the patient did not require any further analgesic medication.

• The Korean Journal of Pain
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• v.7 no.1
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• pp.34-38
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• 1994

The common disorder called tennis elbow exhibits typical clinical characteristics, i.e. painful condition at the lateral aspect of elbow joint on resisted wrist extension. However an exact cause for this painful condition has not yet been established. Many observers believe that the usual lesion of tennis elbow is a partial rupture of the extensor tendon at the tenoperiosteal juction on the lateral epicondyle of humerus. However the mechanism of the tendon rupture has never been explained. Conservative treatments on the tender area have been the most common therapeutic modalities for pain relief of tennis elbow. Based on my clinical experiences and anatomical studies, I discerned that tennis elbow is a periostitis of lateral epicondyle of humerus secondary to spastic contraction of muscular belly of extensor carpi radialis after over-stretched injury. Therefore, spasmolytic treatment on the extensor carpi radialis muscle provided a favorable result for permanent relief for tennis elbow pain.

• Journal of Korean Neurosurgical Society
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• v.39 no.6
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• pp.451-454
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• 2006

We present a case of a 68-year-old female with an atypical form of spinal tuberculosis, which involved posterior elements with multiple foci in two noncontiguous vertebral levels. The lesions caused spastic paraparesis and urinary hesitation. There was no evidence of pulmonary or other extrapulmonary tuberculous disease. Based on clinical and radiographic findings, this atypical spinal tuberculosis was preoperatively misdiagnosed as metastatic spine tumor. The histopathologic finding confirmed tuberculosis and the patient was treated successfully with surgery and antituberculous therapy. In case of a spinal lesion of unknown origin, it is important to be aware that atypical spinal tuberculosis can mimic metastatic spine tumor and tuberculosis should always be considered.

• Phonetics and Speech Sciences
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• v.10 no.4
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• pp.173-177
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• 2018

Purpose: The primary goal of this study was to discover whether the articulatory diadochokinesis (sequential motionrate, SMR) collected using the Motor Speech Disorder Assessment (MSDA) software module can diagnose dysarthria and determine its severity. Methods: Two subject groups, one with spastic dysarthria (n=26) and a control group of speakers (n=30) without neurological disease, were set up. From both groups, the SMR was collected by MSDA at a time, and then analyzed using descriptive statistics. Results: For the parameters of syllable rate, jitter, and the mean syllable length (MSL) at the front and back, the control group displayed better results than the dysarthria patients. Conclusions: At the level of articulatory diadochokinesis, the results showed that the use of MSDA software in clinical practice was generally suitable for quickly recording the parameters of syllable rate, jitter, and mean syllable length.

• The Journal of Korean Physical Therapy
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• v.32 no.6
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• pp.359-364
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• 2020

Purpose: This study was undertaken to compare the efficacy of instrument assisted soft tissue mobilization (IASTM) and a neural dynamic technique (NDYT). As an intervention to treat spastic lower limb muscle tone, stiffness, and static balance in stroke patients. Methods: Totally, 26 participants were assigned randomly to two groups: the IASTM (n=13) and NDYT (n=13) groups. Both groups were subjected to their respective technique for 15 minutes, 5 times a week, for 6 weeks. Muscle tone, stiffness, and static balance were evaluated before and after training, to compare both group changes. Results: IASTM group showed significant decrease in the gastrocnemius medial region and semitendinosus muscle tone and stiffness (p<0.05) compare to NDYT group; however, no significant different was observed in static balance between groups (p>0.05). Conclusion: The results suggest that IASTM is an effective method for decreasing the muscle tone and stiffness in acute stroke patients.