• Journal of Acupuncture Research
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• 제22권1호
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• pp.117-130
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• 2005

소요산(逍遙散) 약침(藥針)이 흰쥐의 갱년기(更年期) 우울증(憂鬱症) 및 stress모델의 인지, 학습 및 기억장애와 불안행동에 미치는 효능(效能)을 파악하기 위하여 행동실험 학적 검사와 면역조직화학적 검사를 실시한 결과 다음과 같은 결론을 얻었다. 1. Morris water maze의 학습검사결과 Soyo-san군(群)의 경우, 시간단축이 현저하게 나타나서 제 6일째 $24.69{\pm}8.48$초로 측정되어 Ovx군(群)에 대해 유의성 있는 인지 및 학습력을 보였다. 2. Morris water maze의 기억검사결과 Soyo-san군(群)이 $3.38{\pm}0.82$로 Sham군(群)과 Ovx군(群)에 대해 머문 시간이 유의성있게 증가하였다. 3. Ventral tegmental area의 TH의 발현정도는 Normal군(群)이 $9.14{\pm}0.50$, Sham군(群)은 $9.00{\pm}0.29$, Ovx군(群)은 $10.81{\pm}0.63$, Soyo-san군(群)은 $8.19{\pm}0.42$로 나타났는데 Soyo-san군(群)이 Ovx에 대해 유의성있게 감소하였다. 4. Hippocampus의 CAI부위에서는 ChAT 발현 정도에서 Soyo-san군(群)이 On군(群)에 대해서 유의하게 증가하였다. 이상(以上)의 결과를 종합하면 소요산(逍遙散) 약침(藥針)이 난소 적출 흰쥐의 stress모델의 인지, 학습 및 기억장애를 호전시키는 것으로 나타났으며 이는 갱년기(更年期) 여성(女性)의 우울증(憂鬱症) 및 stress 반응에 대한 적절한 치료제로서 가능하리라 사료된다.

• 동의생리병리학회지
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• 제34권3호
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• pp.117-125
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• 2020

The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD -1.20 [95% CI -1.46 to -0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.

• 한방안이비인후피부과학회지
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• 제34권4호
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• pp.228-236
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• 2021

Objective : The purpose of this study is to report the clinical effectiveness of herbal decoction(Samul-tang hap Soyo-san.) on whole body nummular eczema. Method : A patient suffering from nummular eczema received herbal decoction(Samul-tang hap Soyo-san), acupuncture, and electronic-moxibustion treatment. The effectiveness of treatment was evaluated by EASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, eczema lesions were remarkably improved. Compared to its peak, EASI improved by 69% and DLQI by 53%. According to photo and symptom changes, purulent exudates were stopped and pruritus was decreased. Conclusion : This study suggests that Samul-tang hap Soyo-san could show effectiveness on nummular eczema.

• 대한한의학방제학회지
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• 제25권2호
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• pp.209-222
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• 2017

Objectives : The purpose of this study was to investigate the interpretation of the Soyo-san(SYS) prescription in order to obtain the evidence for clinical applications. Methods and Result : We interpreted on the SYS-related contents based on 25 classic books, analyzed it according to followed categories ; meaning of name, alteration of herbal composition according to age, usage, origin, physiological and pathological situation of SYS, description of each herbal drug Conclusion : 1. So(逍) mean diminish(消), 遙 mean roll(搖). It reflected feature of SYS, that alleviate depression without impairing vital energy(正氣). 2. SYS was first mentioned in the prescription of peaceful benevolent dispensary(太平惠民和劑局方), its essential application was harminizing liver depression and spleen deficiency(肝鬱脾虛) 3. SYS originated from Sayuk-san. Sayuk-san was appropriate for soothe the liver and regulate the spleen(疏肝理脾), while SYS was suitable for depressed liver and blood deficiency(肝鬱血虛) 4. Most medical literature insisted that application situation of SYS is blood deficiency(血虛), depressed liver(肝鬱), spleen deficiency(脾虛). And there is strong correlation between three factors. 5. Bupleurum falcatum L.(柴胡), Mentha arvensis L.(薄荷) alleviates liver depression as "pungent dissipate-qi uprais (辛散氣升)" nature. Angelica gigas Nakai(當歸), Paeonia lactiflora Pall.(白芍藥) emoliates the liver by nourishing the blood. Atractylodes japonica Koidz. ex Kitam.(白朮), Poria cocos(茯苓), Glycyrrhiza uralensis Fisch.(甘草), Zingiber officinale Roscoe(生薑) cultivate the basis as tonifying earth(補土).

• 대한한방부인과학회지
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• 제22권4호
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• pp.46-64
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• 2009

Purpose: The purpose of this study is to discuss the usage of Kamisoyo-san on menopausal disorder by literatual research. Methods: 33 papers and 47 books about Kamisoyo-san and menopausal disorder were used to develop this article. Results: According to the papers and the books, Soyo-san was first appeared in Taepyungheminhwajegookbang. It was modified to Kamisoyo-san and it has been used to treat menopausal disorder for more than several hundreds of years. There is much evidence of the causes, mechanisms, and symptoms of menopausal disorder corresponding with Kamisoyo-san's indications. Currently, scientific research supports that Kamisoyo-san has many effects on the symptoms of menopausal disorder. Conclusions: Kamisoyo-san is effective on menopausal disorder. We suggest that Kamisoyo-san should be given an insurance code for the treatment of menopausal disorder for the benefits to numerous patients suffering from the disorder.

• 대한한의학방제학회지
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• 제10권2호
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• pp.57-72
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• 2002

To investigate the effect of Qi promoting-agents, clearing heat of deficiency type-agent, clearing heat of excessive type-agent, warming interior part of body-agent and Shihoieokgan-Tang against the immobilization stress, Cypri Rhizama, Auranti pericarpium, Aucklandiae Radix and Bupleuri Radix, Soyo-San, Hwangyeonhaedok-Tang, Geongangbuja-Tang and Shihoieokgan-Tang was administered intragastically 1hr prior to immobilizaiton stress and the change of corticosterone level has been measured by the flurometric method. The results obtained are as follows: 1. Qi promoting-agents(Cypri Rhizama, Auranti pericarpium, Aucklandiae Radix and Bupleuri Radix) showed mildly reducing effect or did not shown the reducing effect against the elevated coritocostereone level induced by the immobilization stress in the mice. 2. Hwangyeonhaedok-Tang, Gungangbuza-Tang, and Soyo-San did not show the reducing effect against the elevated corticostereone level induced by the immobilization stress in the mice. 3. Shihoieokgan-San was effective against the elevated corticosterone level induced by the immobililzation stress at 1g／kg, 3g／kg respectively. Consequently these data proved that Qi pomoting-agents as single herb(Cypri Rhizama, Auranti pericarpium, Aucklandiae Radix and Bupleuri Radix), clearing heat of deficiency type-agent(Soyo-San), warming interior part of the body(Gungangbuza-Tang), clearing heat of excessive type-agent(Hwangyeonhaedok-Tang) have no effect to decrease the elevated corticosterone level in mice exposed to the immobilization stress. Therefore our study revealed that Shihoieokgan-San which has the effects of herbs and formulae mentioned above decreased the elevated corticosterone level in mice exposed to the immobilization stress significantly.

• 동의신경정신과학회지
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• 제19권3호
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• pp.255-264
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• 2008

The purpose of this study is to identify the effect on a patient with bulimia nervosa-purging type and depression according to the oriental medical treatment and cognitive-behavioral therapy. In this case, a 28 year-old female patient had a binge eating and reward behaviors for 2 years. This patient was treated with acupunture therapy, Soyo-san for 5 months after cognitive-behavioral therapy for 12 sessions(2 times a week). The result of this research showed that bulimia nervosa with depression was improved by our treatment.

• 대한한방부인과학회지
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• 제33권3호
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• pp.136-148
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• 2020

Objectives: Hot flush and sweating is the most of common symptoms and the main cause of treatment in Menopause. This study aims to report the therapeutic effect of Korean medicine for menopausal sweating by analysis for the patients hospitalized in a Korean Medicine Hospital. Methods: To analyze treatment of menopausal sweating, we studied 21 patients complaining of menopausal sweating hospitalized in Kyung Hee University Hospital at Gangdong from 1^st January 2015 to 31^th May 2020 with retrospective chart review. Results: All 21 subjects are treated by acupuncture, moxibustion and cupping therapy during hospitalization for an average of 11.3±9.14 days. The most common used korean herbal medicine was Gwibi-tang-gagambang, Soyo-san-gagambang, and Dangwiyukhwang-tang-gagambang, every 6 case (20%), followed by Ojeok-san with 2 cases (6.7%). The improvement rate averaged 56.4% for daytime sweating and 53.6% for night sweating. Conclusions: The results suggest that menopausal sweating could improve by treatment of korean medicine, confirming significant treatment effects.

• 동의생리병리학회지
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• 제29권6호
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• pp.458-466
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• 2015

The purpose of this study was to review the research on treating depression in Traditional Chinese Medicine(TCM) over the last 5 years to set the foundation for further studies. We searched for and analyzed articles about depression in CNKI(China National Knowledge Infrastructure) from January 2010 to December 2014. The results were as follows : The most frequently used diagnostic criteria was CCMD-3(The Chinese Classification of Mental Disorders-3), and the most used evaluation criteria was HAMD(Hamilton Depression Rating Scale). Prescription of decoction of medical herbs was most frequently used as a therapeutic method. Acupuncture, traditional Chinese psychotherapy, and music therapy were also used for some studies. The most frequent TCM Syndrome Differentiation Type was stagnation of liver-QI. For decoction of Chinese herbs, Soyo-san(Xiaoyao-san) and Sihosogan-san(Chaihushugan-san) were most often prescribed, and Bupleuri Radix, Paeoniae Radix Alba, Curcumae Radix, Poria cocos wolf, Angelicae Gigantis Radix, Atractylodis Rhizoma Alba were mainly used for medical herbs. BaekHoi(GV20) and Yindang(Ex-HN3) were often used as acupuncture sites. Post-Stroke Depression was the most common case of intercurrent or secondary depression. According to the Jadad Quality Assessment Scale, the quality of the reports was not high as most of the reports had a score of 3 or below. Most systematic reviews on depression were conducted by Chinese researchers. The problem with Clinical research on depression, according to those reviews, was that there were no standardized criteria for the diagnosis and treatment and the trials were usually not randomized nor controlled. We found out there are various clinical methods for treating depression in TCM, and hope that this research could provide the preliminary data for designing and conducting clinical trials for depression.

• 한방안이비인후피부과학회지
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• 제34권4호
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• pp.198-209
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• 2021

Objectives : The purpose of this study is to report 3 cases of Korean medical treatment on adult atopic dermatitis. Methods : Three patients with adult atopic dermatitits were treated with herbal medicine (Soyo-san hap Samul-tang), acupuncture, and moxibustion. Psychosomatic symptoms were considered the main criteria for treatment. The effects of treatment were evaluated through photographs of the lesions, using EASI and DLQI scores. Results : After treatment, EASI and DLQI scores on three atopic dermatitis patients improved significantly. Conclusions : This clinical case study has demonstrated that Korean medicine may be an effective option for treating adult atopic dermatitis. In addition, considering psychosomatic symptoms when treating atopic dermatitis may also lead to effective treatment.