• Title/Summary/Keyword: Southern

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Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans

  • Hao Shi ;Jiamin Zhao ;Yiwen Li ;Junjie Li ;Yunjia Li;Jia Zhang ;Zhantu Qiu ;Chaofeng Wu ;Mengchen Qin ;Chang Liu ;Zhiyun Zeng ;Chao Zhang ;Lei Gao
    • Journal of Ginseng Research
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    • v.47 no.4
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    • pp.524-533
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    • 2023

  • Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.

  • https://doi.org/10.1016/j.jgr.2022.11.005 인용 PDF

Is "Southern Literature" Alive?: Machine Dream's Incomplete Memories and Their Materiality (미국'남부문학'은 현존하는가?-『머쉰 드림』에 나타난 미완성의 기억과 기억의 물질성)

  • Yu, Jeboon
    • Journal of English Language & Literature
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    • v.59 no.4
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    • pp.545-567
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    • 2013

  • Keeping in mind the hybridity and plurality of Southern Literature, this paper discusses the traits of Southern literature in Jayne Ann Phillips's first novel, Machine Dream. The novel's frequent use of memory and oral reconstruction of a family history accompanied by the feeling of loss in the process of depicting the South's past typically signifies "The Southern" which reminds us of the works of William Faulkner, Katherine Ann Porter, and Eudora Welty. Nevertheless, Phillips's South is more fragmented and her narrative is more evasive and varied than any of her Southern predecessors. The South of the twentieth century from the period of Depression until 1972 is reconstructed differently depending on memories and desires of the four members of Hampson family in this novel, either as a place of nostalgia or as the place of trauma or as the place to survive only in memory. The oxymoronic title of the novel, "machine dreams" signifies that dream and memory of the South cannot remain independent in its epistemological entity but exist as a mixture of materiality of every day life in the modern South. The hybridity of this dream and of the South is what defines itself as Southern. Yet Phillips retains feeling of loss and lament enough to create a modern Southern novel rooted in Southern Literature. Thus, the title itself works an antinomic signifier of both the presence and absence of the dream of the South and of Southern Literature.