• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1787-1791
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• 2012

Objective: The p53 tumor suppressor pathway plays an important role in gastric cancer (GC) development. Auto-regulatory feedback control of p53 expression is critical to maintaining proper tumor suppressor function. So far, several studies between p53 Arg72Pro polymorphism and GC have generated controversial and inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 19 publications. Eligible studies were identified by searching the Pubmed database. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess any link. Results: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR = 1.05, 95%CI = 1.01-1.08; Pro/Pro vs. Arg/Arg: OR = 1.13, 95%CI = 1.04-1.22). Moreover, on stratified analysis by race, significantly increased risk was found for Asian populations (Pro-allele vs. Arg-allele: OR = 1.06, 95%CI = 1.02-1.10; Pro/Pro vs. Arg/Arg: OR = 1.16, 95%CI = 1.07-1.26; Pro/Pro+Pro/Arg vs. Arg/Arg: OR = 1.58, 95%CI = 1.09-2.27). Conclusions: Our study provided evidence that the p53 72Pro allele may increase GC risk in Asians. Future studies with larger sample size are warranted to further confirm this association in more detail.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.243-248
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• 2013

Background: Associations between elevated C-reactive protein (CRP) and cancer risk have been reported for many years, but the results from prospective cohort studies remains controversial. A meta-analysis of prospective cohort studies was therefore conducted to address this issue. Methods: Eligible studies were identified by searching the PubMed and EMBASE up to October 2012. Pooled hazard ratios (HR) was calculated by using random effects model. Results: Eleven prospective cohort studies involving a total of 194,796 participants and 11,459 cancer cases were included in this meta-analysis. The pooled HR per natural log unit change in CRP was 1.105 (95% confidence interval (CI): 1.033-1.178) for all-cancer, 1.308 (95% CI: 1.097-1.519) for lung cancer, 1.040 (95% CI: 0.910-1.170) for breast cancer, 1.063 (95% CI: 0.965-1.161) for prostate cancer, and 1.055 (95% CI: 0.925-1.184) for colorectal cancer. Dose-response analysis showed that the exponentiated linear trend for a change of one natural log unit in CRP was 1.012 (95% CI: 1.006-1.018) for all-cancer. No evidence of publication bias was observed. Conclusions: The results of this meta-analysis showed that the elevated levels of CRP are associated with an increased risk of all-cancer, lung cancer, and possibly breast, prostate and colorectal cancer. The result supports a role of chronic inflammation in carcinogenesis. Further research effort should be performed to identify whether CRP, as a marker of inflammation, has a direct role in carcinogenesis.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2018년도 춘계 학술논문 발표대회
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• pp.316-317
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• 2018

Thailand and other Southeast Asian countries are experiencing frequent floods due to heavy rainfall and are using the Flood Rapid Defense System(FRDS) for an emergency. However, they are expensive and has a wedge-shaped panel suitable for the dirt bank, making it unsuitable for applications in Southeast Asia, a relatively underdeveloped country. In this study, the direction of development of FRDS was derived through domestic and overseas case analysis. Future studies should be carried out to develop the actual FRDS according to the development directions presented here. These results will be effective in preventing flooding of buildings in Southeast Asia as well as in Korea.

• Asian Journal of Atmospheric Environment
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• 제7권2호
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• pp.114-119
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• 2013

The characteristics of Asian dust (AD) in Korea between 1997 and 2005 were investigated, focusing on peak 1-hour $PM_{10}$ concentrations during AD events at seven cities over the Korean Peninsula. The frequency of AD events decreased from Seoul to Busan, indicating the major pathway of AD in Korea was from northwest to southeast. AD events were most frequent in 2001 while peak concentrations during AD events were much higher in 2002. Recent works show that the trajectories from northerly directions increased during the 2000s and later (Chun, 2009; Kim, 2008). In this work, the fraction of trajectories from the northwest was the largest on the whole, although trajectories from each direction varied by city and year. It is presumed that high concentrations of $PM_{10}$ during AD events are generally associated with trajectories from the northwest rather than from the source region.

• 수완나부미
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• 제6권1호
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• pp.193-221
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• 2014

Archipeligiality, a concept continuously being developed by the scholar, is one that attempts to articulate the Filipino sense of place as discoursed in/through its literatures. As a country composed of 7,107 islands, the very fragmentation and division of the country, as well as its multiculturality and multilinguality, have become the very means by which Filipino writers have "imagined" so to speak-that is, also, constructed, into a singular, united frame-the "nation." This, the author supposes, is an important aspect to explore when it comes to discoursing the larger Southeast Asian imagination, or poetic, as similar situations (i.e. Indonesia, Malaysia, and Singapore), may soon compel for a comparative critico-literary perspective. This paper continues this exploratory "geoliterary" discourse by looking at a Filipino canonical work in English by Cirilo F. Bautista, the epic The Trilogy of Saint Lazarus, the title of which already signals a geographic allusion to the first map-name granted by the Spanish colonizer to the Philippines in the region, and consequently the first signification of the country's subjected existence in the colonial imagination. The work, published between 1970 and 1998, is composed of three parts: The Archipelago, Telex Moon, and Sunlight on Broken Stones, which won the 1998 Philippine Independence Centennial Literary Prize. In these epics, notions of Philippine history and situation were discoursed, and Filipino historical figures were engaged in dialogue by the poet/the poet's voice, with the end of locating the place [where history and time had brought it; or its direction or trajectory as a nation, being true to the Filipino maxim of ang di lumingon sa pinanggalingan, di makararating sa paroroonan (the one who does not look back to his origins would not reach his destination)]. of the Philippines not only in the national imagination, but in this paper, in the wider regional consciousness. The paper proposes that the archipelagic concept is an important and unique characteristic of the Southeast Asian situation, and thus, may be a means to explicate the clearly connected landscapes of the region's imagination through literature. This paper focuses on Sunlight on Broken Stones.

• 수완나부미
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• 제14권2호
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• pp.269-303
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• 2022

Since the creation of the Association of Southeast Asian Nations (ASEAN) in 1967, the main objective of creating a "prosperous and peaceful community of Southeast Asian Nations" through regional integration remains slow. While the aims and purposes of the ASEAN include accelerating, promoting active collaboration and mutual assistance on matters concerning culture and cultural development, the desired ASEAN Integration through culture is still in question. As a multicultural region, the richness and diversity of cultures constitute both prospects and challenges. This paper discusses 1) the concept of integration vis-a-vis the ASEAN; 2) the ASEAN's goals, policies, and initiatives, concerning culture as stipulated in the key documents of ASEAN Socio-Cultural Community-Culture and Arts sector; and 3) the ASEAN identity and community vis-a-vis culture. In the end, this paper proposes a framework on the ASEAN integration through culture in the context of a single identity amidst cultural diversity.

• 국제지역연구
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• 제14권3호
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• pp.477-498
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• 2010

본 연구는 다른 국가에 비해 무역개방도가 높은 동아시아 국가의 특징을 고려한 조건부 수렴현상을 패널분석 하였다. 이는 동아시아 국가는 무역개방도가 높은 특징이 나타나고 있기 때문에 경제성장의 수렴현상을 분석하기 위해서는 무역개방도를 추가적으로 통제할 필요가 있기 때문이다. 분석결과 인적자본, 투자율을 통제하였을 때 보다 무역개방도를 추가로 통제하였을 때 수렴현상이 더욱 뚜렷하게 나타났고 수렴속도도 더욱 빨라진 것으로 분석되었다. 추가적으로 동아시아 국가들을 동남아 국가와 동북아 국가로 구분하여 분석하였다. 동북아 국가에서는 절대적 수렴과 조건부수렴 현상이 모두 나타났지만, 동남아 국가에서는 무역개방도를 추가로 통제시킨 조건부 수렴현상만이 나타났다.분석결과를 종합하면 동아시아 국가의 높은 무역개방도를 통제시킨 조건부 수렴에서 수렴현상이 더욱 강하게 나타났다. 본 연구의 분석결과를 바탕으로 시사점을 도출하면 첫째로, 대외무역의존도가 높은 동아시아 국가들의 무역개방도가 경제성장의 수렴에 있어서 상당한 긍정적인 영향을 미쳤다. 둘째, 동아시아 국가의 지역경제통합 성립을 위해서는 동북아시아 국가와 동남아시아 국가의 경제성장 격차를 줄여 나갈 필요성이 있다.

• 동남아시아연구
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• 제27권2호
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• pp.273-295
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• 2017

2016년 두테르테 대통령의 당선 이후 추진된 마약과의 전쟁, 돌출발언과 파격적 외교 행보에 의한 국제관계의 악화 등 여러 대내외적 불안정성에도 불구하고 필리핀의 경제는 동남아국가들 중 가장 높은 GDP 성장률을 나타냈다. 두테르테 현상을 둘러싼 사회적 맥락과 정치동학은 오늘날 민주주의의 현주소와 신자유주의 경제체제 하의 정치현상을 이해하는데 한국을 비롯한 세계 국가들에게 중요한 질문과 과제를 던졌다. 자주외교를 강조하며, 기존 패권질서에 파열음을 일으킨 필리핀의 선택이 단일국가의 실험으로 끝을 맺을지, 아니면 인접국가 또는 아세안 국가들 전반에 새로운 힘을 형성할 계기가 될 것인지 향후 귀추가 주목된다.

• 동남아시아연구
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• 제21권3호
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• pp.105-138
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• 2011

The 11th Congress of the Vietnamese Communist Party(VCP) held in January 2011 was the forum to reconfirm the gradual reform. By analysing the documents submitted to the Congress, it can be realized that the VCP's reform policy reveals the compromise between conservative and progressive perspectives by "the Socialist-oriented Market Economy". The VCP proposes to proceed the balanced reform for the sustainable development by multi-sector economy to achieve the basis of the modern state by 2020 on the one hand and also urges to strive against "the peaceful evolution" to defend the socialist regime from abroad as well as within the party itself on the other hand. In personnel structure of the Central Committee and Politburo, this term of the Party still keeps the balance of the localities and sectors of the society. No big change was in the selection of top leaders, as almost of them were promoted slightly in the existing echelon of the Politburo. On the prospect of the reform process Vietnam will continue the reform as gradual as before.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1077-1082
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• 2015

Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer. However, whether or not RASAL1 suppresses tumor growth in vivo remains to be determined. In the present study, we investigated the role of RASAL1 in gastric carcinogenesis using an in vivo xenograft model. A lentiviral RASAL1 expression vector was constructed and utilized to transfect the human poorly differentiated gastric adenocarcinoma cell line, BGC-823. RASAL1 expression levels were verified by quantitative real-time RT-PCR and Western blotting analysis. Then, we established the nude mice xenograft model using BGC-823 cells either over-expressing RASAL1 or normal. After three weeks, the results showed that the over-expression of RASAL1 led to a significant reduction in both tumor volume and weight compared with the other two control groups. Furthermore, in xenograft tissues the increased expression of RASAL1 in BGC-823 cells caused decreased expression of p-ERK1/2, a downstream moleculein the RAS/RAF/MEK/ERK signal pathway. These findings demonstrated that the over-expression of RASAL1 could inhibit the growth of gastric cancer by inactivation of the RAS/RAF/MEK/ERK pathway in vivo. This study indicates that RASAL1 may attenuate gastric carcinogenesis.