• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3651-3656
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• 2012

The size-segregated atmospheric aerosols have been collected at 1100 m site of Mt. Halla in Jeju, a background area in Korea, using 8-stage cascade impact air sampler during Asian dust and non-Asian dust storm periods. Their ionic and elemental species were analyzed, in order to examine the pollution characteristics and composition change between Asian dust and non-Asian dust periods. The major ionic species such as nss-$SO_4{^{2-}}$, $NH_4{^+}$, and $K^+$ were predominantly distributed in the fine particles (below $2.1{\mu}m$ diameter), and besides the $NO_3{^-}$ was distributed more in coarse particle fraction than fine particle. On the other hand, the typical soil and marine species i.e., nss-$Ca^{2+}$, $Na^+$, $Cl^-$, and $Mg^{2+}$, were mostly existed in the coarse particles (over $2.1{\mu}m$ diameter). As well in the elemental analysis of aerosols, the major soil-originated Al, Fe, Ca, and others showed prominently high concentrations in the coarse particle fraction, whereas the anthropogenic S and Pb were relatively high in the fine particle fraction. From the comparison of aerosol compositions between Asian dust and non-Asian dust periods, the concentrations of the soil-originated species such as nss-$Ca^{2+}$, Al, Ca, Fe, Ti, Mn, Ba, Sr have increased as 2.7-4.2 times during the Asian dust periods. Meanwhile the concentrations of nss-$SO_4{^{2-}}$ and $NO_3{^-}$ have increased as 1.4 and 2.0 times, and on the contrary $NH_4{^+}$ concentrations have a little bit decreased during the Asian dust periods. Especially the concentrations of both soil-originated ionic and elemental species increased noticeably in the coarse particle mode during the dust storm periods.

• KSBB Journal
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• v.22 no.2
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• pp.91-96
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• 2007

The saccharogenic liquid (SFW) obtained by the enzymatic saccharification of food wastes was used as a medium for production of bacterial cellulose (BC). The enzymatic saccharification of food wastes was carried out by the cultivation supernatant of Tricoderma inhamatum KSJ1 culture. Acetobacter xylinum KJ1 was employed for the BC production culture. Under the scaled-up aeration condition of 1.0 vvm, 5.64 g/L of BC was produced in 3 days cultivation in 50 L air circulation bioreactor using SFW medium with addition of 0.4% agar. The productivity was similar to that of 10 L air circulation bioreactor (5.84 g/L). This cultivation method with 50 L air circulation bioreactor decreasing shear stress and increasing oxygen transfer coefficient ($k_La$) was very useful in BC mass production. The physical properties, such as morphology, molecular weight, crystallinity, and tensile strength of BC produced by the static culture (A), the air circulation culture using 10 L bioreactor (B) and 50 L bioreactor (C) were investigated. The number average molecular weight of BCs produced under the different culture conditions (A-C) showed 2,578,000, 1,975,000, and 1,809,000, respectively. Tensile strength was 1.72 $kg/mm^2$, 1.19 $kg/mm^2$, and 1.18 $kg/mm^2$, respectively. All of the BCs had a form of cellulose I representing pure cellulose. The relative degree of crystallinity showed the range of 86.2$\sim$87.8%. BC production by the air circulation culture mode brought more favorable results in terms of the physical properties and its ease of scale-up. Therefore, it is expected that the new BC production method, the air circulation culture using SFW, would contribute greatly to BC-related manufacturing.

• Earthquakes and Structures
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• v.8 no.3
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• pp.665-679
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• 2015

The strain rate of reinforced concrete (RC) structures stimulated by earthquake action has been generally recognized as in the range from $10^{-4}/s$ to $10^{-1}/s$. Because both concrete and steel reinforcement are rate-sensitive materials, the RC beam-column joints are bound to behave differently under different strain rates. This paper describes an investigation of seismic behavior of RC beam-column joints which are subjected to large cyclic displacements on the beam ends with three loading velocities, i.e., 0.4 mm/s, 4 mm/s and 40 mm/s respectively. The levels of strain rate on the joint core region are correspondingly estimated to be $10^{-5}/s$, $10^{-4}/s$, and $10^{-2}/s$. It is aimed to better understand the effect of strain rates on seismic behavior of beam-column joints, such as the carrying capacity and failure modes as well as the energy dissipation. From the experiments, it is observed that with the increase of loading velocity or strain rate, damage in the joint core region decreases but damage in the plastic hinge regions of adjacent beams increases. The energy absorbed in the hysteresis loops under higher loading velocity is larger than that under quasi-static loading. It is also found that the yielding load of the joint is almost independent of the loading velocity, and there is a marginal increase of the ultimate carrying capacity when the loading velocity is increased for the ranges studied in this work. However, under higher loading velocity the residual carrying capacity after peak load drops more rapidly. Additionally, the axial compression ratio has little effect on the shear carrying capacity of the beam-column joints, but with the increase of loading velocity, the crack width of concrete in the joint zone becomes narrower. The shear carrying capacity of the joint at higher loading velocity is higher than that calculated with the quasi-static method proposed by the design code. When the dynamic strengths of materials, i.e., concrete and reinforcement, are directly substituted into the design model of current code, it tends to be insufficiently safe.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.105-114
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• 2020

Background: Exploring the pharmacokinetic (PK) changes of various active components of single herbs and their combinations is necessary to elucidate the compatibility mechanism. However, the lack of chemical standards and low concentrations of multiple active ingredients in the biological matrix restrict PK studies. Methods: A putative multiple reaction monitoring strategy based on liquid chromatography coupled with mass spectrometry (LC-MS) was developed to extend the PK scopes of quantification without resorting to the use of chemical standards. First, the compounds studied, including components with available reference standard (ARS) and components lacking reference standard (LRS), were preclassified to several groups according to their chemical structures. Herb decoctions were then subjected to ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis with appropriate collision energy (CE) in MS² mode. Finally, multiple reaction monitoring transitions transformed from MS² of ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were used for ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry to obtain the mass responses of LRS components. LRS components quantification was further performed by developing an assistive group-dependent semiquantitative method. Results: The developed method was exemplified by the comparative PK process of single herbs Radix Ginseng (RG), Radix Polygala (RP), and their combinations (RG-RP). Significant changes in PK parameters were observed before and after combination. Conclusion: Results indicated that Traditional Chinese Medicine combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies.

• The Transactions of the Korea Information Processing Society
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• v.7 no.10
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• pp.3236-3246
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• 2000

XML is a meta-language as SGML and also can be xonsructed as an Internet versionof simplified SGML being used in confunction with XLL. Xpointer and XSL. Also W3C established DTDless Well-Formed XML document to use XML document on the Web. But it isnt offered system that consists of browsing, link and DTD generating facihty, and efficiently processes DTDless Well-Formed XML document. This paper studies on an implementation and design of system to process DTDless Well-Formed XML document on the client-side. This system consists of Well-Formed XML viewer displaying Well-Formed XML documet, XLL Processor processing Xll and Auto DTD generator constructing automatically DTDs based on multiple documents of the same class. This study focuses on automatic DTD generation during hyperlink navigation and an implementation of extended links based on XLL and Xpointer. ID and Xpointer location address are used as the address mode in the links. As a result of implement of this system, it conforms to validationof extended link facihties, extracts DTD from Well-Fromed XML Documents including same root element at the same class and constructs generalized DTD.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.12
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• pp.1753-1757
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• 2012

A new liquid chromatographic tandem mass spectrometric (LC-MS/MS) assay for the quantification of ginsenoside Rb1 in human plasma was developed and validated. The separation was performed on a Agilent C18 column ($4.6mm{\times}150mm$, particle size 5 ${\mu}m$) with a gradient elution of 0.1% formic acid in water and 0.1% formic acid in methanol and a flow rate of 0.9 mL/min. The analyte was determined using electrospray positive ionization mass spectrometry in the multiple reaction monitoring (MRM) mode (m/z 1131.714${\rightarrow}$365.303). Human plasma samples were extracted with acetone : water (50:50) by the liquid-liquid extraction method. The method was linear over the dynamic range of 10~500 ng/mL with a correlation coefficient of r=0.9995. The intra-and inter-day precision over the concentration range of ginsenoside Rb1 was lower than 5.8% (correlation of variance, CV), and the accuracy was between 96.0~104.6%. This LC-MS/MS assay of ginsenoside Rb1 in human plasma is applicable for quantification in a pharmacokinetic study.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.6
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• pp.1047-1055
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• 2006

We patterned nano-width lines on a super hard bulk diamond substrate by varying the ion beam current and ion beam sources with a dual beam field ion beam (FIB). In addition, we successfully fabricated two-dimensional nano patterns and three-dimensional nano plate modules. We prepared nano lines on a diamond and a silicon substrate at the beam condition of 30 kV, 10 pA $\sim$ 5 nA with $Ga^+$ ion and $H_2O$ assisted ion sources. We measured each of the line-width, line-depth, etched line profiles, etch rate, and aspect ratio, and then compared them. We confirmed that nano patterning was possible on both a bulk diamond and a silicon substrate. The etch rate of $H_2O$ source can be enhanced about two times than that of Ga source. The width of patterns on a diamond was smaller than that on a silicon substrate at the same ion beam power The sub-100 nm patterns on a diamond were made under the charge neutralization mode to prevent charge accumulation. We successfully made a two-dimensional, 240 nm-width text of the 300-lettered Lord's Prayer on a gem diamond with 30 kV-30 pA FIB. The patterned text image was readable with a scanning electron microscope. Moreover, three dimensional nano-thick plate module fabrication was made successfully with an FIB and a platinum deposition, and electron energy loss spectrum (EELS) analysis was easily performed with the prepared nano plate module.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.74-74
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• 2010

One-dimensional nanosturctures such as nanowires and nanotube have been mainly proposed as important components of nano-electronic devices and are expected to play an integral part in design and construction of these devices. Silicon carbide(SiC) is one of a promising wide bandgap semiconductor that exhibits extraordinary properties, such as higher thermal conductivity, mechanical and chemical stability than silicon. Therefore, the synthesis of SiC-based nanowires(NWs) open a possibility for developing a potential application in nano-electronic devices which have to work under harsh environment. In this study, one-dimensional nanowires(NWs) of cubic phase silicon carbide($\beta$-SiC) were efficiently produced by thermal chemical vapor deposition(T-CVD) synthesis of mixtures containing Si powders and hydrocarbon in a alumina boat about $T\;=\;1400^{\circ}C$ SEM images are shown that the temperature below $1300^{\circ}C$ is not enough to synthesis the SiC NWs due to insufficient thermal energy for melting of Si Powder and decomposition of methane gas. However, the SiC NWs are produced over $1300^{\circ}C$ and the most efficient temperature for growth of SiC NWs is about $1400^{\circ}C$ with an average diameter range between 50 ~ 150 nm. Raman spectra revealed the crystal form of the synthesized SiC NWs is a cubic phase. Two distinct peaks at 795 and $970\;cm^{-1}$ over $1400^{\circ}C$ represent the TO and LO mode of the bulk $\beta$-SiC, respectively. In XRD spectra, this result was also verified with the strongest (111) peaks at $2{\theta}=35.7^{\circ}$, which is very close to (111) plane peak position of 3C-SiC over $1400 ^{\circ}C$ TEM images are represented to two typical $\beta$-SiC NWs structures. One is shown the defect-free $\beta$-SiC nanowire with a (111) interplane distance with 0.25 nm, and the other is the stacking-faulted $\beta$-SiC nanowire. Two SiC nanowires are covered with $SiO_2$ layer with a thickness of less 2 nm. Moreover, by changing the flow rate of methane gas, the 300 sccm is the optimal condition for synthesis of a large amount of $\beta$-SiC NWs.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.4
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• pp.354-361
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• 2004

This Paper describes a crack scattering model for SH wave based on the boundary integral equation(BIE) method, where the fundamental unknown is crack opening displacement(COD). When a time harmonic plane wave was incident on a 2-D isolated crack (slit) of width 2a, the COD distributions were numerically calculated as a function of ka. The calculated COD agreed well with results obtained with other methods. The far-field scattering amplitude, which completely characterizes the flaw response, was calculated in two ways. The Kirchhoff approximation and the BIE-COD exact formulation were compared in terms of incidence angle and frequency ka in a pulse-echo mode. Maximum response was obtained for both methods at the specular reflection direction. Away from the specular direction, the Kirchhoff approximation becomes less accurate. The time domain crack response was also calculated using a band-limited spectrum of center frequency 10 MHz. At oblique incidence to the crack both methods show the existence of an antisymmetric flash points occurring from the crack edge. The Kirchhoff approximation provides an exact time interval between flash points, although it unrealistically gives the same amplitude.