• 대한구순구개열학회지
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• 제14권1_2호
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• pp.45-56
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• 2011

Face transplantation has been reported over the last six years, and it started in 2004 with the announcement of Cleveland Clinic granting the world's first IRB approval to proceed with human face transplantation. Composite tissue allografts (CTAs) in the facial region are considered to be more immunogenic than other solid organ transplants, so these kinds of animal experiments were also considered as challengeable activities to the facial reconstructive surgeons. For the better understanding of CTAs in the oral and maxillofacial fields, we reviewed several recent articles about facial composite transplantation animal model, and summarized some knowledges of composite midface allotransplantation model with sensory and motor reinnervation in this review article.

• 대한임상검사과학회지
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• 제51권2호
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• pp.198-204
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• 2019

여러가지 약물에도 발작의 증세가 조절되지 않는 난치성 뇌전증 환자에서 다양한 치료법들을 시도해 볼 수 있다. 하지만 그 중 수술적인 방법이 필요한 환자에서는 수술 전 검사를 통해 발작부위의 절제부분을 결정한다. 정확한 병변의 측정과 안전한 수술을 위해 뇌 피질에 전극 삽입술을 시행한다. 피질에 삽입된 전극으로 단순히 뇌파만을 기록하는 것이 아니라 다양한 검사를 시도해 그 부위가 갖는 기능을 확인할 수 있고 그런 검사법 중 하나로 유발전위 검사법이 있다. 2015년 1월부터 2018년 12월까지 70명의 환자를 대상으로 측정된 파형의 경향이 의미하는 바를 분석하였다. 뇌 피질에 삽입된 전극에서 기록된 체성감각유발전위는 중심고랑의 주행경로를 찾아 일차운동영역 및 일차감각영역을 피해 수술 할 수 있다. 또한 청각유발전위와 시각유발전위를 이용해 청각피질과 시각피질에서 기능적 피질의 확인과 뇌파검사상 나타난 발작초점부위와의 관계를 비교해 절제부위를 결정하는데 도움을 주고 수술 후에 발생할 수 있는 기능적 장애를 최소화 할 수 있다.

• Annals of Clinical Neurophysiology
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• 제1권2호
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• pp.112-117
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• 1999

부중심소엽 주변의 경막하 전극들에서 기록한 PTSEP는 전극의 위치에 따라 다양한 파형을 나타내며, 파형의 최대치는 주로 부중심소엽의 후 상부에 위치한다. 특히 최대값이 주변보다 확연히 차이 나며 10uV이상의 파형으로 기록될 경우는 40 msec에서 양극성을 나타낸다. 또한 주변의 전극과 상역전을 형성할 수 있는데 최대 전극의 뒤에서 형성될 경우는 더욱 분명한 상역전을 관찰할 수 있다. 따라서 경막하전극을 통한 PTSEP는 내측 반구의 부중심소엽 주변의 위치를 파악하는데 도움을 줄 수 있다고 생각된다.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.64-74
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• 2002

The SSEP(SomatoSensory Evoke Potentials) test is a valid and repeatable technique which correlates with clinically assessed joint position & vibration sense, skin touch & pressure sense. Also SSEP study is a simple and quantitative test, and has been used to evaluate the sensoty system along the somatosensory pathway from peripheral sensory receptor to the cortex. The ascending pathway of SSEP has been know to be posterior column-lemniscal pathway, but not without controversy. There are two kind of test mathods : one of test is median nerve SSEP and other test is posterior tibial nerve SSEP. Recently, SSEP used to performed to evaluate the usefulness of dermatomal SSEP(D-SSEP) and segmental SSEP(5-SSEP) for the diagnosis of lumbasacral radiculopathy, and it can be measure of ingual ahd palatine evoked potentials & indicator of medullary function useful for the diagnosis of brain death.

• 대한물리의학회지
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• 제1권1호
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• pp.125-137
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• 2006

Purpose : The purpose of the study was to examine lumbar pain through literature reviews about herniated intervertebral disc (HIVD). Methods : Diagnosis was made by patient's history, physical examination, simple radiography, myelography, spinal computerized tomography, electromyography, somatosensory evoked potential, etc. Results : There are two treatment modalities, one is conservative and the other is operative. About 90% of patients with HIVD have been recovered only by conservative treatment and therapeutic exercise was the most effective one among these conservative treatments. Conclusion : We consider HIVD can be treated with therapeutic exercise which can correct muscular imbalance and facet joint problems and make the degenerative process of intervertebral disc slower.

• Annals of Clinical Neurophysiology
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• 제5권2호
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• pp.214-216
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• 2003

High voltage electrical injury can cause considerable damage to the nervous system including spinal cord, but, the pathophysiology of myelopathy remains to be studied. A 44-year old man with paraparesis after electrical injury was diagnosed as electrical injury induced- myelopathy by normal spine MRI and somatosensory evoked potential showing central conduction abnormality. It implicates that the presumed mechanism of the myelopathy prefers the electroporation or electroconformational protein denaturation to the joule heating.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.459-466
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• 2016

본 연구는 아급성기 뇌졸중 환자에서 로봇 보조치료법이 운동능력 및 기능적인 회복에 미치는 효과를 알아보고자 하였다. 환자 53명이 연구에 참여하였다. 로봇보조 보행치료군은 고식적인 치료에 추가로 Lokomat$^{(R)}$ 이용하여 하루에 삼십분씩, 일주일에 5회, 4주 동안 시행하였으며, 대조군은 고식적인 치료에 추가로 하루에 삼십분씩 고식적인 치료를 시행 받았다. 모든 환자들은 임상지표의 비교를 위해, 치료 전과 4주간의 치료 후 Fugl-Meyer assessment, Motricity index, functional ambulation category, Berg balance scale, 10m 보행검사, 한국판 수정 바델지수, 한국판 간이 정신 상태검사와 벡 우울증 척도를 평가 받았다. 환자들은 기능회복과 체성 감각 유발전위 검사 결과의 관계를 알아보기 위해 유발 전위 검사를 시행하였다. 아급성기 뇌졸중 환자에서 로봇 보조 보행치료군에서 대조군에 비해 하지의 운동기능, 보행 능력, 일상생활능력의 유의한 호전이 나타났다. 체성 감각 유발 전위 검사의 결과는 임상 지표들의 관련성 분석에서 Motricity index와 한국판 수정 바델지수와 관련이 있는 것으로 나타나 아급성기 뇌졸중 환자의 기능을 예측하는데 유용할 것으로 생각된다. 로봇 보조 보행치료는 아급성기 뇌졸중 환자의 운동기능과 보행기능의 회복을 촉진하는 것으로 생각된다.

• Journal of Korean Neurosurgical Society
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• 제52권1호
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• pp.32-36
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• 2012

Objective : Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of the present study is to investigate the effect of rolipram, a phosphodiesterase 4 inhibitor, against alcohol-induced neuropathy in rats. Methods : Allodynia was induced by administering 35% v/v ethanol (10 g/kg; oral gavage) to Spraue-Dawley rats for 8 weeks. Rolipram and saline (vehicle) were administered intraperitoneally. Mechanical allodynia was measured by using von Frey filaments. Somatosensory evoked potential (SEP) was proposed as complementary measure to assess the integrity of nerve pathway. Results : The ethanol-induced mechanical allodynia began to manifest from 3 week, and then peaked within 1 week. Beginning from 3 week, latency significantly started to increased in control group. In rolipram treated rats, the shorter latency was sustained until 8 weeks (p<0.05). The mechanical allodynia, which began to manifest on the 3 weeks, intraperitoneal injections of rolipram sustained statistical difference until 8 weeks, the final week of the study (p<0.05). Conclusion : This study suggests that rolipram might alleviate mechanical allodynia induced by alcohol in rats, which clearly has clinical implication.

• Journal of Korean Neurosurgical Society
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• 제56권6호
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• pp.513-516
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• 2014

We report a case of cervicomedullary compression by an anomalous vertebral artery treated using microsurgical decompression with intraoperative monitoring. A 68-year-old woman presented with posterior neck pain and gait disturbance. MRI revealed multiple abnormalities, including an anomalous vertebral artery that compressed the spinal cord at the cervicomedullary junction. Suboccipital craniectomy with C1 laminectomy was performed. The spinal cord was found to be compressed by the vertebral arteries, which were retracted dorsolaterally. At that time, the somatosensory evoked potential (SSEP) changed. After release of the vertebral artery, the SSEP signal normalized instantly. The vertebral artery was then lifted gently and anchored to the dura. There was no other procedural complication. The patient's symptoms improved. This case demonstrates that intraoperative monitoring may be useful for preventing procedural complications during spinal cord microsurgical decompression.

• 대한임상전기생리학회지
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• 제5권2호
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• pp.47-59
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• 2007

The purpose of this study were to investigate the effects of electroacupuncture(EA) on sensory nerve function in acute hyperglycemia rats. Male Sprague-Dawley rats weighing 250~270 g(8 weeks of age) were used in this study, and the induced hyperglycemia rats were produced by intraperitoneal injection of streptozotocin(70 mg/kg body weight). Only animals with blood glucose levels of 300 mg/dl or higher were used in this study. Animal were divided into two groups: the control group and EA group (n=7 in each group). For EA, two stainless-steel needles were inserted into Zusanli (ST36) which is located at the anterior tibial muscle and about 10mm below the knee joint. Pulsed current(2 Hz, 0.3 ms) were applied to the inserted needle for 20 mim. We measured glucose level, weigh, sensory nerve conduction and somatosensory evoked potential(5EP) before and after injecting streptozotocin, 2 weeks, 4 weeks. The change of blood glucose on EA group trended to decrease compared with the control group and there were significant differences(p<0.05). The body weight of the EA group trended to be reduced compared with the control group and there were significant differences(p<0.05). The amplitude of sensory nerve action potential on EA group to increase compared with the control group and there were significant differences(p<0.05). There were no significant differences in SEP. These results suggest that EA has beneficial effect on diabetic neuropathy and this effect may be related in part with prevention of hyperglycemia.