• Applied Microscopy
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• v.50
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• pp.12.1-12.11
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• 2020

Hot stage microscopy (HSM) is a thermal analysis technique that combines the best properties of thermal analysis and microscopy. HSM is rapidly gaining interest in pharmaceuticals as well as in other fields as a regular characterization technique. In pharmaceuticals HSM is used to support differential scanning calorimetry (DSC) and thermo-gravimetric analysis (TGA) observations and to detect small changes in the sample that may be missed by DSC and TGA during a thermal experiment. Study of various physical and chemical properties such sample morphology, crystalline nature, polymorphism, desolvation, miscibility, melting, solid state transitions and incompatibility between various pharmaceutical compounds can be carried out using HSM. HSM is also widely used to screen cocrystals, excipients and polymers for solid dispersions. With the advancements in research methodologies, it is now possible to use HSM in conjunction with other characterization techniques such as Fourier transform infrared spectroscopy (FTIR), DSC, Raman spectroscopy, scanning electron microscopy (SEM) which may have additional benefits over traditional characterization techniques for rapid and comprehensive solid state characterization.

• ETRI Journal
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• v.44 no.1
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• pp.147-154
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• 2022

We demonstrate a new double-layer structure for stretchable interconnects, where the top surface of a serpentine polyimide support is coated with a thin eutectic gallium-indium liquid metal layer. Because the liquid metal layer is constantly fixed on the solid serpentine body in this liquid-on-solid structure, the overall stretching is accomplished by widening the solid frame itself, with little variation in the total length and cross-sectional area of the current path. Therefore, we can achieve both invariant resistance and infinite fatigue life by combining the stretchable configuration of the underlying body with the freely deformable nature of the top liquid conductor. Further, we fabricated various types of double-layer interconnects as narrow as 10 ㎛ using the roll-painting and lift-off patterning technique based on conventional photolithography and quantitatively validated their beneficial properties. The new interconnecting structure is expected to be widely used in applications requiring high-performance and high-density stretchable circuits owing to its superior reliability and capability to be monolithically integrated with thin-film devices.

• Transactions of the Korean hydrogen and new energy society
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• v.21 no.3
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• pp.214-219
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• 2010

In this study, we fabricated tubular ceramic support for segmented-in-series solid oxide fuel cell (SOFC) by using CSZ(CaO-stabilized $ZrO_2$) as main material and activated carbon as pore former. Thermal expansion properties of ceramic support with different amounts of activated carbon were analyzed by using dilatometer to decide a suitable sintering temperature. The tubular ceramic supports with different amounts of activated carbon (5, 10, 15wt.%) were fabricated by the extrusion technique. After sintering at $1100^{\circ}C$ and $1400^{\circ}C$ for 5h., cross section and surface morphology of tubular ceramic support were analyzed by using SEM image. Also, the porosity, mechanical property, gas permeability of tubular ceramic supports was measured. Based on these results, we established the suitable fabrication technique of tubular ceramic support for segmented-in-series SOFC.

• Journal of Microbiology and Biotechnology
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• v.19 no.5
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• pp.468-473
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• 2009

The antibiotic meroparamycin was produced in the free culture system of Streptomyces sp. strain MAR01. Five solid substrates (rice, wheat bran, Quaker, bread, and ground corn) were screened for their ability to support meroparamycin production in solid-state fermentation. In batch culture, wheat bran recorded the highest antibacterial activity with the lowest residual substrate values. The highest residual substrate values were recorded for both ground corn and Quaker. On the other hand, no antibacterial activity was detected for rice as a solid substrate. The use of the original strength of starch-nitrate medium in the solid-state fermentation gave a lower antibacterial activity compared with the free culture system. Doubling the strength of this medium resulted in the increase in the activity to be equivalent to the free culture. The initial pH (7.0) of the culture medium and 2 ml of spore suspension (1 ml contains $5{\times}10^{9}spores/ml$) were the optima for antibiotic production. The water was the best eluent for the extraction of the antibiotic from the solid-state culture. Ten min was enough time to extract the antibiotic using a mixer, whereas, 60 min was required when shaking was applied. Semicontinuous production of meroparamycin using a percolation method demonstrated a more or less constant antibacterial activity over 4 runs ($450-480{\mu}g/ml$). The semicontinuous production of the antibiotic was monitored in a fixed-bed bioreactor and the maximum activity was attained after the fourth run ($510{\mu}g/ml$) and the overall process continued for 85 days.

• Bulletin of the Korean Chemical Society
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• v.22 no.7
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• pp.761-764
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• 2001

• Journal of Digital Contents Society
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• v.19 no.3
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• pp.497-503
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• 2018

RHEL 7, the leader in the enterprise Linux market, has dramatically increased the maximum support specification, such as file system size, file size, etc., by changing the default file system from EXT to XFS. It's not just an increase in support specifications, it's working on daemons, and it's showing excellent performance on high-performance disks such as high-capacity disks and solid state drives. Changes in the file system mean changes in direct operating techniques, such as changing related commands, changing backup tools, and changing disk quota settings. The changes to the XFS file system are making a lot of changes to the operation of the Linux system, but we believe that the position of the Linux operating system in the server field will become stronger.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.sup1
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• pp.1-6
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• 2008

Previous infant feeding guidelines recommended a delayed introduction of solids to beyond 6 months of age to prevent atopic diseases. However, scientific evidence supporting a delayed introduction of solids for prevention of atopic diseases is scarce and inconsistent. Current evidence does not support a major role for maternal dietary restrictions during pregnancy or lactation in the prevention of atopic disease. In studies of infants at high risk of developing atopic disease, there is evidence that exclusive breastfeeding for at least 4 months compared with feeding intact cow milk protein decreases the incidence of atopic dermatitis, cow milk allergy, and wheezing in early childhood. For infants at high risk of developing atopic disease who are not breastfed exclusively for 4 to 6 months, there is modest evidence that atopic dermatitis may be delayed or prevented by the use of extensively or partially hydrolyzed formulas, compared with cow milk formula, in early childhood. There is no convincing evidence that a delayed introduction of solid foods beyond 4 to 6 months of age prevents the development of atopic disease. For infants after 4 to 6 months of age, there are insufficient data to support a protective effect of any dietary intervention for the development of atopic disease.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2381-2384
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• 2014

A solid-phase synthetic approach is reported for the synthesis of an ascorbic acid (ASA)-dipeptide conjugate that exhibited enhanced antioxidant activity. The N-terminal amino group of dipeptide (Ala-Ala) on a resin support was first activated by 1,1'-carbonyldiimidazole (CDI), and then reacted with an ASA derivative. The addition of a base, triethylamine (TEA), promoted nucleophilic acylation of ASA derivative and yielded a desired product (ASA-Ala-Ala) with enhanced purity, when cleaved from the resin. Compared to the approach where a C3 hydroxyl group of ASA was first activated with CDI and then reacted with the amino group of dipeptide on the resin, this new approach allowed a significant reduction of a total reaction time from 120 h to 8 h at $25^{\circ}C$. As-prepared ASA-dipeptide conjugate (ASA-Ala-Ala) showed improved antioxidant activity compared to ASA.

• Membrane and Water Treatment
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• v.2 no.4
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• pp.207-223
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• 2011

Supported Liquid Membranes (SLMs) have been widely studied as feasible alternative to traditional processes for separation and purification of various chemicals both from aqueous and organic matrices. This technique offers various advantages like active transport, possibility to use expensive extractants, high selectivity, low energy requirements and minimization of chemical additives. SLMs are not yet used at large scale in industrial applications, because of the low stability. In the present paper, after a brief overview of the state of the art of SLM technology the facilitated transport mechanisms of SLM based separation is described, also introducing the small and the big carrousel models, which are employed for transport modeling. The main operating parameters (selectivity, flux and permeability) are introduced. The problems related to system stabilization are also discussed, giving particular attention to the influence of membrane materials (solid membrane support and organic liquid membrane (LM) phase). Various approaches proposed in literature to enhance SLM stability are also reviewed. Modification of the solid membrane support, creating an additional layer on membrane surface, which acts as a barrier to LM phase loss, increases system stability, but the membrane permeability, and then the flux, decrease. Stagnant Sandwich Liquid Membrane (SSwLM), an implementation of the SLM system, results in both high flux and stability compared to SLM. Finally, possible large scale applications of SLMs are also reviewed, evidencing that if the LM separation process is opportunely carried out (no production of byproducts), it can be considered as a green process.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.5
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• pp.747-754
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• 2002

We propose a Web-based collaborative CAD system which is independent from any platforms, and develop a 3D solid modeler in the system. We developed a new prototype of 3D solid modeler based on the web using Java 3D API, which could be executed without any 3D graphics software and worked collaboratively interacting with each user. The modeler can create primitive objects and get various 3D objects by using loader. The interactive control is available to manipulate-objects such as picking, translating, rotating, zooming. Users connect to this solid modeler and they can create 3D objects and modify them as they want. When this solid modeler is imported to collaborative design system, it will be proved its real worth in today's CAD system. Moreover, if we improve this solid modeler adding to the 3D graphic features such as rendering and animation, it will be able to support more detail design and effect view.