• Applied Microscopy
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• 제50권
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• pp.12.1-12.11
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• 2020

Hot stage microscopy (HSM) is a thermal analysis technique that combines the best properties of thermal analysis and microscopy. HSM is rapidly gaining interest in pharmaceuticals as well as in other fields as a regular characterization technique. In pharmaceuticals HSM is used to support differential scanning calorimetry (DSC) and thermo-gravimetric analysis (TGA) observations and to detect small changes in the sample that may be missed by DSC and TGA during a thermal experiment. Study of various physical and chemical properties such sample morphology, crystalline nature, polymorphism, desolvation, miscibility, melting, solid state transitions and incompatibility between various pharmaceutical compounds can be carried out using HSM. HSM is also widely used to screen cocrystals, excipients and polymers for solid dispersions. With the advancements in research methodologies, it is now possible to use HSM in conjunction with other characterization techniques such as Fourier transform infrared spectroscopy (FTIR), DSC, Raman spectroscopy, scanning electron microscopy (SEM) which may have additional benefits over traditional characterization techniques for rapid and comprehensive solid state characterization.

• ETRI Journal
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• 제44권1호
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• pp.147-154
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• 2022

We demonstrate a new double-layer structure for stretchable interconnects, where the top surface of a serpentine polyimide support is coated with a thin eutectic gallium-indium liquid metal layer. Because the liquid metal layer is constantly fixed on the solid serpentine body in this liquid-on-solid structure, the overall stretching is accomplished by widening the solid frame itself, with little variation in the total length and cross-sectional area of the current path. Therefore, we can achieve both invariant resistance and infinite fatigue life by combining the stretchable configuration of the underlying body with the freely deformable nature of the top liquid conductor. Further, we fabricated various types of double-layer interconnects as narrow as 10 ㎛ using the roll-painting and lift-off patterning technique based on conventional photolithography and quantitatively validated their beneficial properties. The new interconnecting structure is expected to be widely used in applications requiring high-performance and high-density stretchable circuits owing to its superior reliability and capability to be monolithically integrated with thin-film devices.

• 한국수소및신에너지학회논문집
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• 제21권3호
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• pp.214-219
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• 2010

In this study, we fabricated tubular ceramic support for segmented-in-series solid oxide fuel cell (SOFC) by using CSZ(CaO-stabilized $ZrO_2$) as main material and activated carbon as pore former. Thermal expansion properties of ceramic support with different amounts of activated carbon were analyzed by using dilatometer to decide a suitable sintering temperature. The tubular ceramic supports with different amounts of activated carbon (5, 10, 15wt.%) were fabricated by the extrusion technique. After sintering at $1100^{\circ}C$ and $1400^{\circ}C$ for 5h., cross section and surface morphology of tubular ceramic support were analyzed by using SEM image. Also, the porosity, mechanical property, gas permeability of tubular ceramic supports was measured. Based on these results, we established the suitable fabrication technique of tubular ceramic support for segmented-in-series SOFC.

• Journal of Microbiology and Biotechnology
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• 제19권5호
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• pp.468-473
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• 2009

The antibiotic meroparamycin was produced in the free culture system of Streptomyces sp. strain MAR01. Five solid substrates (rice, wheat bran, Quaker, bread, and ground corn) were screened for their ability to support meroparamycin production in solid-state fermentation. In batch culture, wheat bran recorded the highest antibacterial activity with the lowest residual substrate values. The highest residual substrate values were recorded for both ground corn and Quaker. On the other hand, no antibacterial activity was detected for rice as a solid substrate. The use of the original strength of starch-nitrate medium in the solid-state fermentation gave a lower antibacterial activity compared with the free culture system. Doubling the strength of this medium resulted in the increase in the activity to be equivalent to the free culture. The initial pH (7.0) of the culture medium and 2 ml of spore suspension (1 ml contains $5{\times}10^{9}spores/ml$) were the optima for antibiotic production. The water was the best eluent for the extraction of the antibiotic from the solid-state culture. Ten min was enough time to extract the antibiotic using a mixer, whereas, 60 min was required when shaking was applied. Semicontinuous production of meroparamycin using a percolation method demonstrated a more or less constant antibacterial activity over 4 runs ($450-480{\mu}g/ml$). The semicontinuous production of the antibiotic was monitored in a fixed-bed bioreactor and the maximum activity was attained after the fourth run ($510{\mu}g/ml$) and the overall process continued for 85 days.

• Bulletin of the Korean Chemical Society
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• 제22권7호
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• pp.761-764
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• 2001

• 디지털콘텐츠학회 논문지
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• 제19권3호
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• pp.497-503
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• 2018

엔터프라이즈 리눅스 시장의 대표주자인 RHEL 7에서 기본 파일 시스템을 EXT에서 XFS로 변경하면서 파일 시스템의 크기, 파일 크기 등과 같이 최대 지원 사양을 대폭 증가시켰다. 단순히 지원 사양만 증가시킨 것 아니라, 데몬 기반으로 동작하면서 고용량 디스크 및 SSD(solid state drive)와 같은 고성능 디스크에서 탁월한 성능을 보이는 것으로 나타나고 있다. 파일 시스템의 변경은 관련 명령어의 변경, 백업 도구의 변경, 디스크 쿼터 설정 변경과 같은 직접적인 운영 기법의 변화를 의미한다. XFS 파일시스템의 변경은 리눅스 시스템 운영에 많은 변화를 주고 있지만 서버 분야에서 차지하는 리눅스 운영체제의 위치를 더욱 굳건히 하게 되는 계기가 될 것으로 판단된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.1-6
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• 2008

Previous infant feeding guidelines recommended a delayed introduction of solids to beyond 6 months of age to prevent atopic diseases. However, scientific evidence supporting a delayed introduction of solids for prevention of atopic diseases is scarce and inconsistent. Current evidence does not support a major role for maternal dietary restrictions during pregnancy or lactation in the prevention of atopic disease. In studies of infants at high risk of developing atopic disease, there is evidence that exclusive breastfeeding for at least 4 months compared with feeding intact cow milk protein decreases the incidence of atopic dermatitis, cow milk allergy, and wheezing in early childhood. For infants at high risk of developing atopic disease who are not breastfed exclusively for 4 to 6 months, there is modest evidence that atopic dermatitis may be delayed or prevented by the use of extensively or partially hydrolyzed formulas, compared with cow milk formula, in early childhood. There is no convincing evidence that a delayed introduction of solid foods beyond 4 to 6 months of age prevents the development of atopic disease. For infants after 4 to 6 months of age, there are insufficient data to support a protective effect of any dietary intervention for the development of atopic disease.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2381-2384
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• 2014

A solid-phase synthetic approach is reported for the synthesis of an ascorbic acid (ASA)-dipeptide conjugate that exhibited enhanced antioxidant activity. The N-terminal amino group of dipeptide (Ala-Ala) on a resin support was first activated by 1,1'-carbonyldiimidazole (CDI), and then reacted with an ASA derivative. The addition of a base, triethylamine (TEA), promoted nucleophilic acylation of ASA derivative and yielded a desired product (ASA-Ala-Ala) with enhanced purity, when cleaved from the resin. Compared to the approach where a C3 hydroxyl group of ASA was first activated with CDI and then reacted with the amino group of dipeptide on the resin, this new approach allowed a significant reduction of a total reaction time from 120 h to 8 h at $25^{\circ}C$. As-prepared ASA-dipeptide conjugate (ASA-Ala-Ala) showed improved antioxidant activity compared to ASA.

• Membrane and Water Treatment
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• 제2권4호
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• pp.207-223
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• 2011

Supported Liquid Membranes (SLMs) have been widely studied as feasible alternative to traditional processes for separation and purification of various chemicals both from aqueous and organic matrices. This technique offers various advantages like active transport, possibility to use expensive extractants, high selectivity, low energy requirements and minimization of chemical additives. SLMs are not yet used at large scale in industrial applications, because of the low stability. In the present paper, after a brief overview of the state of the art of SLM technology the facilitated transport mechanisms of SLM based separation is described, also introducing the small and the big carrousel models, which are employed for transport modeling. The main operating parameters (selectivity, flux and permeability) are introduced. The problems related to system stabilization are also discussed, giving particular attention to the influence of membrane materials (solid membrane support and organic liquid membrane (LM) phase). Various approaches proposed in literature to enhance SLM stability are also reviewed. Modification of the solid membrane support, creating an additional layer on membrane surface, which acts as a barrier to LM phase loss, increases system stability, but the membrane permeability, and then the flux, decrease. Stagnant Sandwich Liquid Membrane (SSwLM), an implementation of the SLM system, results in both high flux and stability compared to SLM. Finally, possible large scale applications of SLMs are also reviewed, evidencing that if the LM separation process is opportunely carried out (no production of byproducts), it can be considered as a green process.

• 한국정보통신학회논문지
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• 제6권5호
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• pp.747-754
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• 2002

본 논문은 인터넷 웹 상에서 협동작업으로 이루어지는 CAD시스템의 3차원 솔리드 모델러를 보여준다. 협동CAD시스템의 클라이언트는 자바 애플릿을 통해 웹 상에서 접근하고 솔리드 모델러 서버는 접속을 통제하는 접속관리자, 작업 그룹의 동기화를 유지하며 공유작업공간을 확보하는 작업관리자, 그리고 3차원 도형 객체를 생성하고 변형시키는 솔리드 모델러로 이루어져 있다. 솔리드 모델러의 시스템 라이브러리는 워크스페이스 클래스, 뷰 클래스, 평행투영 뷰 클래스, 원근투영 뷰 클래스, 솔리드 클래스 등으로 되어 있다. 기본도형을 생성하여 이동, 회전, 확대·축소하고, 다른 툴을 이용하여 제작한 오브젝트를 불러올 수 있다. 트리 형태의 장면그래프를 사용하므로 전체 구조를 쉽게 알 수 있고, 부분적 결합이 가능하며 오브젝트의 선택이나 조작에 있어서 하위계층을 쉽게 제어할 수 있다. Java 3D를 이용하여 개발함으로 써 많은 그래픽 라이브러리들의 특징을 편리하게 이용할 수 있으며, 다른 라이브러리에서 사용하지 않는 뷰, 렌더렁, 애니메이션 등과 같은 새로운 기술들을 포함시킬 수 있다.