• 제목/요약/키워드: Solid circulation

검색결과 91건 처리시간 0.026초

Bacillus subtilis BK-17 유래 혈전용해효소(Bacillokinase)의 고체배양 (Solid Cultivation of Fibrinolytic Enzyme (Bacillokinase) from Bacilis subtilis BK-17)

  • 정영기;백현;서민정;김민정;이혜현;주우홍;김정인;최영현;정경태
    • 생명과학회지
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    • 제19권10호
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    • pp.1478-1483
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    • 2009
  • 곡물을 소재로 혈행개선에 효과 있는 물질을 개발하기 위하여 Bacillus subtilis BK-17을 이용하여 고체 배양을 시도하였다. 고체배양에 접종하는 미생물은 영양세포보다 포자 접종이 혈전용해효소 생산에 효과적이었다. 포자 생산을 위한 배지는 SFM (0.8% nutrient broth, 0.05% yeast extract, $10^{-1}$ M $MgCl_2$, $10^{-3}$ M $FeCl_3$, $10^{-4}$ $MnCl_2$, $10^{-5}$ M dipicolic acid, pH 6.5)이 최적이었고, 포자 생성에 대한 최적 pH 와 온도는 각각 pH6과 $30^{\circ}C$였으며 포자는 배양 후 60 시간에서 가장 많은 생산을 보였다. 각종 곡물을 기질로 하였을 때 녹두가 혈전용해능이 가장 높았으며 강낭콩, 검정콩, 대두, 옥수수는 녹두의 약 90% 수준의 활성으로 높은 혈전용해능을 보였다. 반면에 보리와 밀과 같은 탄수화물 곡물은 낮은 활성을 보였다. 고체 배양한 발효 대두는 단백질과 지질 함량에 있어 발효하지 않은 대두보다 약 10% 이상의 높은 수치를 보였다. 또한 필수 아미노산과 일반 아미노산의 함량 역시 발효 대두 쪽이 약 5 - 20% 높은 것으로 보아 혈행개선기능성 뿐만 아니라 식품으로 실용 가능성이 높은 것으로 사료된다.

입자 순환식 열교환기의 상승관 설계방법 (Riser Design Approach for Particle-Circulation-Type Heat Exchangers)

  • 전용두
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2002년도 학술대회지
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    • pp.311-312
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    • 2002
  • In this paper a systematic design approach to determine the optimum size (height) of circulating fluidized bed heat exchanger for exhaust gas heat recovery is prososed. Unlike the convensional heat exchangers where the length of the heat exchanger section is not very much emphasized, the vertical length of heat exchanger tube in the case of fluidized bed heat exchangers is important because this length determines the time interval during which particles reside and transfer heat in the heat exchanger section. For particles initial conditions are nearly stationary, accelerating particles motion should be considered rather than simply assuming fully developed condition. A way to estimate optimum tube length at different fluid velocity and particle sizes is suggested based on the required conditioning time for heat transfer from the flue gas to solid particles.

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Tumour Lysis Syndrome: Implications for Cancer Therapy

  • Mika, Denish;Ahmad, Sabrina;Guruvayoorappan, C.
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권8호
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    • pp.3555-3560
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    • 2012
  • The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may, rarely, occur spontaneously. Though TLS is seldom observed in relation to solid tumours, there have been reports of connections with examples such as lung, liver, breast, gastric carcinomas. The clinical manifestations of TLS include hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. These indications if untreated lead to life-threatening complications such as acute renal failure, cardiac arrhythmias, seizures, and eventually death due to multiorgan failure. Therefore early detection of TLS is of vital importance. This can be accomplished by identification of high risk patients, implementation of suitable prophylactic measures andmonitoring of the electrolyte levels in patients undergoing chemotherapy.

식물성절연유의 유동속도와 온도에 따른 절연파괴전압 (Dielectric Breakdown Voltage According to Flow Velocity and Temperature of Vegetable Oils)

  • 최순호;허창수
    • 전기학회논문지
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    • 제61권6호
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    • pp.821-826
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    • 2012
  • The streaming electrification process of vegetable insulating oils occurring when the oils contacted with solid material in a high power transformer circulation system seems to cause electrical discharge incidents and may cause failures. We therefore measured the dielectric breakdown voltage tendency of vegetable insulating oils flowing on the surface of the charging device with various velocity and temperature. First, the relation between the velocity and breakdown voltage tendency of vegetable oils, can be explained by volume effect and v-t effect. Second, experimental results show that applied voltage have little effect on dielectric breakdown voltage, when vegetable insulating oils used for large power transformer.

Immersed Solid Method 를 이용한 외접형 기어 펌프의 수치해석 (Numerical Simulation of External Gear Pump Using Immersed Solid Method)

  • 윤용한;박병호;한용운;홍병주;심재술
    • 대한기계학회논문집B
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    • 제38권1호
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    • pp.95-101
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    • 2014
  • 본 연구는 고속 회전형(~10,000 rpm) 기어펌프의 질량유량과 효율을 예측하기 위해서 2 차원 immersed solid method(ISM)를 이용한 수치해석을 수행하였다. 기어펌프와 하우징의 순환유동을 고려하기 위하여 유체 유동을 난류 유동으로 가정하였고, 기어 펌프의 입 출구의 일정 압력 조건하에 기어펌프의 회전 속도를 부가하였다. 기어펌프의 다양한 회전 속도 및 기어 끝 단과 하우징 사의의 서로 다른 간극에 대한 질량유량 및 효율을 검토하였다. 해석 결과로서, 회전 속도가 증가할수록 평균 질량유량 및 효율은 증가하였고, 기어펌프와 하우징의 간격이 증가할수록 평균 질량유량 및 효율은 감소하였다. 간격이 없는 조건하의 6,000 rpm, 8,000 rpm, 10,000 rpm 회전속도에의 효율은 각각 85.11 %, 90.94 %, 93.62 % 를 얻었고, 간격이 0 m, 0.00001 m, 0.00003 m 에 대해서 효율은 각각 93.62 %, 93.29 %, 92.74 % 를 얻었다.

기경팔맥(奇經八脈)의 생리적 특성에 대한 고찰 -『난경(難經)·이십칠난(二十七難)』"맥유기경팔맥자(脈有奇經八脈者), 부구어이십경(不拘於十二經)"에 대한 해석을 중심으로- (A Study on the physiological characteristics of Eight Extra Meridians - Focused on the interpretation of "There are Eight Extra Meridians and they don't be arrested by Twelve Regular Meridians" in Nanjing 27Nan -)

  • 류정아;정창현
    • 대한한의학원전학회지
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    • 제26권4호
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    • pp.71-87
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    • 2013
  • Subject : The physiological characteristic of Eight Extra Meridians. Objective : This study research physiological characteristic of Eight Extra Meridians that differentiate from the physiological characteristic of Twelve Regular Meridians. Method : First, we researched the meaning of "There are Eight Extra Meridians and they don't be arrested by Twelve Regular Meridians" in Nanjing 27Nan compared with the contents of regular Meridians circulation in Huangdineijing. Second, we studied on the origin of Eight Extra Meridians and researched their route. Third, from these researches we drew some physiological characteristics of Eight Extra Meridians. Conclusion : In Huangdineijing, the regular Meridians circulation include the route of Governor Meridian, Conception Meridian, and Heel Meridian. So the sentence in Nanjing 27Nan is contradictory to the contents of Huangdineijing. The origin of Eight Extra Meridians could be found in Huangdineijing. The collateral Meridians of the Uterus and Epiglottis Meridian are specifically formulated to supplying for the Uterus or Epiglottis. Eight Extra Meridians have third qualities of Meridian, collateral Meridian, and the solid viscera keep the Essence Gi, so named 'Extra'. And they have an intimate association with Extraordinary Organs. They place at the middle axis of human body, thus do higher physiological function that control and regulate the function of Twelve Regular Meridians and Five Viscera & six Bowels for adaptation to the environment.

혈관부착 생비골 중첩 이식술 (Free Vascularized Fibular Transfer with Double Barrel Fashion)

  • 정덕환
    • Archives of Reconstructive Microsurgery
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    • 제7권1호
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    • pp.54-61
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    • 1998
  • Free vascularized fibular is the most usuful bony donor of the long bone reconstruction in reconstructive microsurgical field. It has many benifits such as very strong strut tubular bone, very reliable vascular anatomy with large vascular diameter with long pedicle, minimal donor site morbity too. In that situations of the huge long bone defects in distal femur or proximal tibia, the defective bony shape and strength of the transplanted fibular bone is not enough if only one strut of the fibula is transfered. The bony circulation of the fibula has two ways, one from nutrient artery via peroneal artery through nutrient foramen which makes endosteal arterial network inside of the fibula, another way is periosteal network through outside encircling vascular network of the bone which distributed in muscle sleeves of the fibular diaphysis. Authors modified free vascularized fibular bone graft with transverse osteotomy is made from the anterolateral aspect of the fibular shaft just distal to entry of the nutrient artery. This produces two vascularized bone struts that may be folded pararell to each other but that remain connected by the periosteum and muscle cuff surrounding the peroneal artery and veins. The proximal strut is vascularized by both a periosteal and endosteal blood supply, whereas the distal strut is vascularized by a periosteal blood supply alone. This procedure can call "doule barrel" free vascularized fibular graft. We performed 7 cases of doule barrel fashined fibular transplantation on distal femur and proximal tibial large defects. Average bone union time takes 7 months from that procedure. There were no significant bone union time differences between both proximal and distal struts. After solid union of the transfered double barrel fibular graft, there were no stress fracture in our series. We can propose double barrel free vascualized fibular graft is usuful method in that cases with very large bone defect on large long bones especially metaphyseal defects.

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연소기체로부터 CO2를 포집하는 기포 유동층 공정에 관한 모델 (A Model on a Bubbling Fluidized Bed Process for CO2 Capture from Flue Gas)

  • 최정후;윤필상;김기찬;이창근;조성호;류호정;박영철
    • Korean Chemical Engineering Research
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    • 제50권3호
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    • pp.516-521
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    • 2012
  • 본 연구는 연소기체로부터 $CO_2$ 기체를 포집하는 기포 유동층 흡착 및 재생 반응기 공정의 주요 운전변수의 영향을 조사하기 위해서 단순화된 공정모델을 개발하였다. 반응속도와 반응기에서 고체입자의 평균체류시간을 이용하여 흡착탑과 재생탑에서 각 반응 전환율을 계산하였다. 실험실 규모 기포 유동층 공정에 적용하여 $CO_2$ 포집효율에 대한 온도, 기체유속, 고체순환속도, 연소기체 중 수분농도의 영향을 조사하였다. $CO_2$ 포집효율은 흡착탑의 온도 혹은 유속이 증가함에 따라서 감소하였다. 그러나 연소기체의 수분농도 혹은 재생탑의 온도가 증가함에 따라서 증가하였다. 계산된 $CO_2$ 포집효율은 측정값과 잘 일치하였다. 그러나 본 모델은 $CO_2$ 포집효율에 대한 고체순환속도의 영향과 잘 일치하지 않았다. 이의 해석을 위해서는 기체-고체 접촉효율에 대한 이해가 더 필요하였다.

투수성 잔디블록 포장 하부 토양의 물리성 (Physical Properties of Soils under the Grass Block Porous Pavements)

  • 한승호;김원태;강진형
    • 한국조경학회지
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    • 제34권4호
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    • pp.96-104
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    • 2006
  • Impervious pavement is primary contributor to the malfunctioning of the urban water circulation system. The aim of this research is to provide basic information and data for new pavement materials and paving technology which could enhance the urban water circulation system. For the study purposes, physical properties of soils sampled from 16 stations were analyzed. The sampling spots were paved with grass block porous pavement material. The findings from the analysis are as follows. The hardness of soils under the pavement was $17{\sim}22mm$ for thoroughfare and $6{\sim}32mm$ for parking areas. The bulk density was $1.42{\sim}1.81g/cm^{3}$ for thoroughfare and $1.38{\sim}1.75g/cm^{3}$ for parking area. The solid phase ration was $46.9{\sim}62.5m^{3}/m^{3}$ for thoroughfare and $45.6{\sim}61.3m^{3}/m^{3}$ for parking area. The porosity was $37.5{\sim}53.1m^{3}/m^{3}$ for thoroughfare and $38.7{\sim}54.4m^{3}/m^{3}$ for parking area. The saturated hydraulic conductivity was $8{\sim}164mm/hr$ for thoroughfare and $14{\sim}201mm/hr$ for parking area. The saturated hydraulic conductivity of the H sample area (the area was completed three months ago) and that of the other area were compared. There was up to 80% decreases of the saturated hydraulic conductivity within one year after the completion of pavement. After the first year, decrease in the saturated hydraulic conductivity was modest. Also there are changes in both surface and under soil physical properties of the grass block porous pavement depending on compaction. The extent of change depends on the degree of compaction. All these factors are combined to influence the permeability of the soil under the pavements. The results of this suggest that it is required to develop a new pavement technology which ensures both the durability and porosity of the pavement to improve the water circulation system by applying Ecological Area Rate.

건설폐기물을 최소화한 비용 효율적 잔디 블록 기법 개발 및 평가 (Development and Cost-effective Evaluation of Grass Blocks Minimizing Construction Waste)

  • 전민수;홍정선;전제찬;김이형
    • 한국습지학회지
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    • 제19권3호
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    • pp.359-365
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    • 2017
  • 도로 및 주차장과 같은 불투수면은 건기시 중금속과 입자상 물질을 축적하여 강우시 하천 수질을 악화시키는 원인으로 작용하며, 도시의 물순환 체계를 왜곡시킨다. 이에 정부는 최근 인도와 주차장의 불투수면을 투수가 가능한 LID 시설 중 하나인 투수 및 잔디 블록으로 대체하는 정책을 추진 중에 있다. 그러나 불투수면을 투수 및 저류가 가능한 잔디 블록으로 대체할 때 발생하는 건설폐기물은 환경을 오염시킬 뿐만 아니라 공사비용을 증가시킨다. 따라서 본 연구는 건설폐기물을 최소화 할 수 있는 비용 효율적인 주차장 시공방법을 제안하기 위해 수행되었다. 본 연구는 Lab-scale 실험을 통해 기존의 시공방법과 본 연구에서 제안하는 방법에 대한 물순환 능력 및 경제성 등의 비교분석을 수행하였다. 본 연구에서 제안하는 시공방법은 기존 아스팔트 천공, 투수기층재 및 부설층 포설 및 다짐, 노상다짐, 블록 포설, 틈새재 포설 및 다짐의 순이며, Lab-scale 실험 결과 기존 방법과 제안 기법에서 표면유출량, 침투량, 저류량 및 강우유출 지체시간은 큰 차이가 없는 것으로 분석되었다. 반면 폐기물 발생량 및 경제성 평가에서는 본 제안기법이 기존 시공법보다 약 86% 건설폐기물이 적게 발생하며, 이에 따른 비용이 약 70% 절감되는 것으로 나타났다. 본 연구에서 제안하는 시공 방법이 기존 방법과 물순환 효과는 비슷하지만, 시공절차가 용이하고 경제성이 높은 것으로 평가되었다.